GB736372A - Fluorene derivatives - Google Patents

Fluorene derivatives

Info

Publication number
GB736372A
GB736372A GB12637/53A GB1263753A GB736372A GB 736372 A GB736372 A GB 736372A GB 12637/53 A GB12637/53 A GB 12637/53A GB 1263753 A GB1263753 A GB 1263753A GB 736372 A GB736372 A GB 736372A
Authority
GB
United Kingdom
Prior art keywords
hydrochloride
morpholine
ethylfluorenyl
methylfluorenyl
ethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB12637/53A
Inventor
Stephen Munro Olin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Corp
Original Assignee
Miles Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Miles Laboratories Inc filed Critical Miles Laboratories Inc
Priority to GB12637/53A priority Critical patent/GB736372A/en
Priority to FR1085563D priority patent/FR1085563A/fr
Publication of GB736372A publication Critical patent/GB736372A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18—Fluorenes; Hydrogenated fluorenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

The invention comprises bases and salts thereof, the bases having the formula <FORM:0736372/IV (b)/1> wherein R1 is alkyl, n is a digit greater than one, y is a digit and -NR2 is selected from dialkylamino and saturated heterocyclic radicals. Such compounds are obtained by the reaction of 9-alkyl-fluorenes with monochloralkyl tertiary amines using sodium amide as the condensing agent or by the condensation of a 9 - alkyl - 9 - (o - chloroalkyl)fluorine with morpholine or other secondary amine. As salts are mentioned the hydrochloride, sulphate, hydrobromide, phosphate and citrate. In example (1) N-[2-(9-methylfluorenyl-9)-ethyl]dimethylamine hydrochloride is prepared by reacting b -chloroethyldimethylamine with the reaction product from 9-methylfluorene and sodium amide. Similarly prepared are (2) 4 - [3 - (9 - methylfluorenyl - 9) - propyl]morpholine hydrochloride; (3) N-[2-(9-ethylfluorenyl-9)-ethyl]dimethylamine hydrochloride; (4) 4-[2 - (9 - ethylfluorenyl - 9) - ethyl]morpholine hydrochloride; (5) 1-[3-(9-ethylfluorenyl-9)-propyl]piperidine hydrochloride; (7) 4-[2-(9-methylfluorenyl - 9) - 1 - methylethyl]morpholine hydrochloride; (8) 1-[2-(9-methylfluorenyl-9) - 1 - methylethyl]piperidine hydrochloride. In example (6) 4-[4-(9-ethylfluorenyl-9)-butyl]-morpholine hydrochloride is prepared by refluxing 9 - ethyl - 9 - (4 - chlorobutyl)fluorene and morpholine in isopropanol.
GB12637/53A 1953-05-06 1953-05-06 Fluorene derivatives Expired GB736372A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GB12637/53A GB736372A (en) 1953-05-06 1953-05-06 Fluorene derivatives
FR1085563D FR1085563A (en) 1953-05-06 1953-10-23

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB12637/53A GB736372A (en) 1953-05-06 1953-05-06 Fluorene derivatives

Publications (1)

Publication Number Publication Date
GB736372A true GB736372A (en) 1955-09-07

Family

ID=10008362

Family Applications (1)

Application Number Title Priority Date Filing Date
GB12637/53A Expired GB736372A (en) 1953-05-06 1953-05-06 Fluorene derivatives

Country Status (2)

Country Link
FR (1) FR1085563A (en)
GB (1) GB736372A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3409640A (en) * 1959-07-22 1968-11-05 Schering Corp 5-(3'-dimethylamino-2'-methyl-propyl)dibenzocycloheptenes

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA18763A1 (en) * 1979-03-12 1980-10-01 Lilly Co Eli PROCESS FOR THE PREPARATION OF 9-AMINOALKYLFLUORENES

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3409640A (en) * 1959-07-22 1968-11-05 Schering Corp 5-(3'-dimethylamino-2'-methyl-propyl)dibenzocycloheptenes

Also Published As

Publication number Publication date
FR1085563A (en) 1955-02-03

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