GB932487A - Piperidine derivatives - Google Patents
Piperidine derivativesInfo
- Publication number
- GB932487A GB932487A GB2639161A GB2639161A GB932487A GB 932487 A GB932487 A GB 932487A GB 2639161 A GB2639161 A GB 2639161A GB 2639161 A GB2639161 A GB 2639161A GB 932487 A GB932487 A GB 932487A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compounds
- hydrogen atom
- formula
- pyridine
- hydrazide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
The invention comprises compounds of the formula:-<FORM:0932487/IV(a)/1> (wherein R1 is a phenyl, benzyl, trifluoromethylphenyl, fluorophenyl or chlorophenyl radical, R2 is a hydrogen atom or a lower alkyl or lower hydroxyalkyl radical, and R3 is a hydrogen atom or an amino, lower alkyl, lower monodi- and tri-hydroxyalkyl radical) and their non-toxic acid salts, e.g. hydrochloride, hydrobromide, tartrate, maleate, methobromide, ethochloride and ethobromide. The compounds are prepared by treating an alkoxycarbonyl pyridine with a primary or secondary amine or hydrazine, catalytically hydrogenating the pyridine carboxamide or hydrazide obtained and alkylating the resulting piperidine carboxamide or hydrazide by reaction with a primary alkyl halide of the formula <FORM:0932487/IV(a)/2> itself prepared by condensation of an o -haloalkyl phenyl ketone with an aralkyl Grignard reagent R1MgX. The invention is illustrated by 22 detailed examples. The compounds display anti-inflammatory activity and other pharmacological properties.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4489160A | 1960-07-25 | 1960-07-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB932487A true GB932487A (en) | 1963-07-31 |
Family
ID=21934891
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB2639161A Expired GB932487A (en) | 1960-07-25 | 1961-07-20 | Piperidine derivatives |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB932487A (en) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0055997A2 (en) * | 1979-03-07 | 1982-07-14 | Imperial Chemical Industries Plc | Oxirane and halohydrin compounds |
EP0213080A3 (en) * | 1985-08-27 | 1987-10-21 | Ciba-Geigy Ag | Hydrogenated pyridine derivatives |
US4904673A (en) * | 1988-01-14 | 1990-02-27 | Dr. Karl Thomae, Gmbh | Agent for treating bradycardia and bradyarrhythmia |
US4957928A (en) * | 1986-06-26 | 1990-09-18 | Ciba-Geigy Corporation | Hydrogenated 1-benzooxacycloalkylpyridinecarboxylic acid compounds |
WO2005021505A1 (en) * | 2003-09-03 | 2005-03-10 | Galapagos Nv | The claimed invention relates to novel 4-piperidinecarboxamide and the use thereof for the preparation of medicaments against 5-ht2a receptor-related disorders |
US7867992B2 (en) | 2004-07-21 | 2011-01-11 | Aicuris Gmbh & Co. Kg | Substituted quinolones |
US7977349B2 (en) | 2006-02-09 | 2011-07-12 | Aicuris Gmbh & Co. Kg | Substituted quinolones III |
-
1961
- 1961-07-20 GB GB2639161A patent/GB932487A/en not_active Expired
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0055997A2 (en) * | 1979-03-07 | 1982-07-14 | Imperial Chemical Industries Plc | Oxirane and halohydrin compounds |
EP0055997A3 (en) * | 1979-03-07 | 1982-08-04 | Imperial Chemical Industries Plc | Oxirane and halohydrin compounds |
EP0213080A3 (en) * | 1985-08-27 | 1987-10-21 | Ciba-Geigy Ag | Hydrogenated pyridine derivatives |
US4833169A (en) * | 1985-08-27 | 1989-05-23 | Ciba-Geigy Corporation | Hydropyridine derivatives |
US4939160A (en) * | 1985-08-27 | 1990-07-03 | Ciba-Geigy Corporation | Hydropyridine derivatives |
US4957928A (en) * | 1986-06-26 | 1990-09-18 | Ciba-Geigy Corporation | Hydrogenated 1-benzooxacycloalkylpyridinecarboxylic acid compounds |
US5112855A (en) * | 1986-06-26 | 1992-05-12 | Ciba-Geigy Corporation | Hydrogenated 1-benzooxacycloalkylpyridinecarboxylic acid compounds and compositions |
US4904673A (en) * | 1988-01-14 | 1990-02-27 | Dr. Karl Thomae, Gmbh | Agent for treating bradycardia and bradyarrhythmia |
WO2005021505A1 (en) * | 2003-09-03 | 2005-03-10 | Galapagos Nv | The claimed invention relates to novel 4-piperidinecarboxamide and the use thereof for the preparation of medicaments against 5-ht2a receptor-related disorders |
US7867992B2 (en) | 2004-07-21 | 2011-01-11 | Aicuris Gmbh & Co. Kg | Substituted quinolones |
US7977349B2 (en) | 2006-02-09 | 2011-07-12 | Aicuris Gmbh & Co. Kg | Substituted quinolones III |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
GB992732A (en) | 1-arylalkyl-4-(n-arylalkanamido)piperidines and related compounds and method for their preparation | |
GB929739A (en) | N-substituted azaspiranes | |
GB932487A (en) | Piperidine derivatives | |
GB861561A (en) | N-substituted piperidines | |
US2343198A (en) | Nu-alkamine substituted derivatives of phthalimide | |
ES400963A1 (en) | 3-benzylpyridines | |
BG60267B2 (en) | Process for the preparation of amidoxime derivatives | |
GB834290A (en) | Substituted piperidines | |
KR870002090A (en) | Method for preparing 1- (2-oxyamino carbonylphenylsulfonyl) -3-heteroaryl-urea | |
GB1122249A (en) | Novel diazo compounds and diazotype copying material | |
US2742472A (en) | Spasmolytic pipergzjnes | |
ES453582A2 (en) | Tetrahydropyridine and piperidine derivatives and processes for the preparation thereof | |
ES406098A1 (en) | Substituted 2,6-dinitroanilines and herbicidal compositions containing them | |
US2566376A (en) | Beta-tertiary aminoethanol ethers of diaryl pyridyl carbinols | |
GB986199A (en) | New 1-(alkoxyphenylalkyl)-2-imidazolinones, -2-imidazolidinones and -2-pyrimidinonesand their manufacture | |
ES387506A1 (en) | Certain 4 - amino - 2-(5-nitro-2-thienyl) quinazolines and the intermediate 4 - chloro-(5 - nitro-2-thienyl)quinazolines therefor | |
GB933504A (en) | New piperidine derivatives and methods for preparing the same | |
ES394761A1 (en) | 2-amino-1,5-benzodiazocine derivatives | |
ES331427A1 (en) | Procedure for the preparation of new condensed heterociclic compounds. (Machine-translation by Google Translate, not legally binding) | |
GB1066468A (en) | Diazotype copying material containing substituted 2,3-hydroxy-naphthoic acid amides | |
GB888664A (en) | Improvements in or relating to acylamidophenol derivatives | |
ES261831A1 (en) | Amido-diamines and triamines | |
GB977810A (en) | Alkynylamine derivatives | |
GB793852A (en) | Manufacture of new 3-amino-indanes | |
ES313956A1 (en) | Procedure for obtaining heterociclic piperidinic compounds. (Machine-translation by Google Translate, not legally binding) |