ES331427A1 - Procedure for the preparation of new condensed heterociclic compounds. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Process for the preparation of new condensed hoterocyclic compounds, of the general formula I ** (See formula) ** in which R1 and R2 each represent hydrogen atoms, lower alkyl or alkoxy groups or halogen atoms, R3 means a hydrogen atom or a lower alkyl group, R 4 and R 5 each represent lower alkyl, hydroxyalkyl or benzylic groups, of which one may be substituted in the phenyl nucleus by a total of at most two of the following groups: lower alkyl and/or alkoxy, hydroxyl, halogen , or by the methylenedioxyl group, or R4 and R5, together with the adjacent nitrogen atom, mean the piperidinic, 1-pyrrolidinyl, morpholinic, 4-methyl-1-piperazinyl, tetrahydroisoquinolin-1-yl or tetrahydroisoindolin-2-yl radical and n is 1, 2 or 3, and its acid addition salts, quaternary salts and N-oxides thereof, characterized in reacting a reactable ester of a compound of the general formula II ** (See formula) ** in which R1, R2, R3 and n have the meaning set forth in formula I, with a compound of general formula III ** (See formula) ** in which R4 and R5, independently of one another, or together with the adjacent nitrogen atom, have the meaning set forth in formula I, in the presence of an acid-accepting agent, and, if desired, by transforming the obtained compound, of the general formula I, into a salt with an inorganic or organic acid, in a quaternary ammonium salt or in the N-oxide. (Machine-translation by Google Translate, not legally binding)