GB830709A - Improvements in or relating to piperidine-carboxamide derivatives - Google Patents
Improvements in or relating to piperidine-carboxamide derivativesInfo
- Publication number
- GB830709A GB830709A GB3551857A GB3551857A GB830709A GB 830709 A GB830709 A GB 830709A GB 3551857 A GB3551857 A GB 3551857A GB 3551857 A GB3551857 A GB 3551857A GB 830709 A GB830709 A GB 830709A
- Authority
- GB
- United Kingdom
- Prior art keywords
- general formula
- compound
- radical
- nrr1
- piperidinecarboxamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
The invention comprises compounds of the general formula <FORM:0830709/IV (b)/1> and their pharmaceutically acceptable non-toxic acid addition and quaternary ammonium salts (wherein Alk is a lower alkylene radical, X is a hydrogen or halogen atom, and NRR1 is an amino, lower alkylamino, lower alkenylamino, lower hydroxy-alkylamino, lower dialkylamino or lower dialkenylamino radical), and the preparation thereof by condensing a compound of the general formula <FORM:0830709/IV (b)/2> with at least one equivalent of a compound of the general formula <FORM:0830709/IV (b)/3> (wherein one of the symbols Y and Z represents a hydrogen atom and the other a halogen-Alk group, and A is either NRR1 or a lower alkoxy radical) in the presence of at least one additional equivalent of base, followed in the case where A is a lower alkoxy radical by transamination with a compound of the general formula HNRR1. The term "lower" is used to describe radicals containing not more than six carbon atoms. 4 - (N,N - dimethyl)piperidinecarboxamide is made by hydrogenating over a platinum oxide catalyst 4 - (N,N - dimethyl)pyridinecarboxamide, which is made by reacting dimethylamine with methyl isonicotinate in a bomb. 4 - (N,N - diethyl)piperidinecarboxamide is similarly made.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US62228356A | 1956-11-15 | 1956-11-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB830709A true GB830709A (en) | 1960-03-16 |
Family
ID=24493619
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB3551857A Expired GB830709A (en) | 1956-11-15 | 1957-11-14 | Improvements in or relating to piperidine-carboxamide derivatives |
Country Status (6)
Country | Link |
---|---|
BE (1) | BE562299A (en) |
CH (1) | CH366043A (en) |
DE (1) | DE1089386B (en) |
FR (1) | FR1231657A (en) |
GB (1) | GB830709A (en) |
NL (1) | NL99690C (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992020658A1 (en) * | 1991-05-17 | 1992-11-26 | Novo Nordisk A/S | Novel heterocyclic carboxylic acids |
WO1996031498A1 (en) * | 1995-04-07 | 1996-10-10 | Novo Nordisk A/S | Novel heterocyclic compounds |
US5795888A (en) * | 1994-01-04 | 1998-08-18 | Novo Nordisk A/S | N-substituted azaheterocyclic carboxlic acids and esters thereof |
US6166009A (en) * | 1994-01-04 | 2000-12-26 | Novo Nordisk A/S | N-substituted azaheterocyclic carboxylic acids and esters thereof |
US6613791B1 (en) | 1994-01-04 | 2003-09-02 | Novo Nordisk A/S | N-substituted azaheterocyclic carboxylic acids and their use |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE560750A (en) * | 1957-07-26 | |||
FR1216268A (en) * | 1958-04-24 | 1960-04-25 | Rhone Poulenc Sa | New phenothiazine derivatives with a piperidine chain substituted by an amide function and their preparation |
US3155652A (en) * | 1958-09-04 | 1964-11-03 | Searle & Co | 2-acyl-10-carbamoylpiperidinoalkylphenothiazines and process |
US3063996A (en) * | 1959-03-02 | 1962-11-13 | Smith Kline French Lab | Substituted piperidinylalkyl phenothiazines |
US3225037A (en) * | 1959-03-30 | 1965-12-21 | Sterling Drug Inc | 10-[(amino- and acylamino-1-piperidyl) lower-alkyl]-phenothiazines |
US3055891A (en) * | 1960-03-21 | 1962-09-25 | Searle & Co | N-(aminoalkylcarbamoylpiperidinoalkyl)phenothiazines |
US3112308A (en) * | 1961-11-20 | 1963-11-26 | Searle & Co | Substituted 10-(4-carbalkoxy-4-phenylpiperidinoalkyl) phenothiazines |
BE786583A (en) * | 1971-07-21 | 1973-01-22 | Rhone Poulenc Sa | NEW PHENOTHIAZINE DERIVATIVES, THEIR PREPARATION AND THE COMPOSITIONS CONTAINING THEM |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB716227A (en) * | 1951-02-16 | 1954-09-29 | Rhone Poulenc Sa | New phenthiazine derivatives and processes for their production |
CH302073A (en) * | 1951-02-16 | 1954-09-30 | Rhone Poulenc Chemicals | Process for the preparation of a novel derivative of phenothiazine. |
NL87657C (en) * | 1953-04-10 |
-
0
- BE BE562299D patent/BE562299A/xx unknown
- NL NL99690D patent/NL99690C/xx active
-
1957
- 1957-11-08 DE DES55817A patent/DE1089386B/en active Pending
- 1957-11-14 GB GB3551857A patent/GB830709A/en not_active Expired
- 1957-11-14 CH CH5266557A patent/CH366043A/en unknown
- 1957-11-14 FR FR751601A patent/FR1231657A/en not_active Expired
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992020658A1 (en) * | 1991-05-17 | 1992-11-26 | Novo Nordisk A/S | Novel heterocyclic carboxylic acids |
US5348965A (en) * | 1991-05-17 | 1994-09-20 | Novo Nordisk A/S | N-substituted azaheterocyclic carboxylic acids |
US5795888A (en) * | 1994-01-04 | 1998-08-18 | Novo Nordisk A/S | N-substituted azaheterocyclic carboxlic acids and esters thereof |
US6166009A (en) * | 1994-01-04 | 2000-12-26 | Novo Nordisk A/S | N-substituted azaheterocyclic carboxylic acids and esters thereof |
US6613791B1 (en) | 1994-01-04 | 2003-09-02 | Novo Nordisk A/S | N-substituted azaheterocyclic carboxylic acids and their use |
WO1996031498A1 (en) * | 1995-04-07 | 1996-10-10 | Novo Nordisk A/S | Novel heterocyclic compounds |
US5874428A (en) * | 1995-04-07 | 1999-02-23 | Novo Nordisk Als | N-substituted aza-heterocyclic carboxylic acids and esters thereof |
Also Published As
Publication number | Publication date |
---|---|
BE562299A (en) | |
NL99690C (en) | |
CH366043A (en) | 1962-12-15 |
DE1089386B (en) | 1960-09-22 |
FR1231657A (en) | 1960-09-30 |
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