GB830709A - Improvements in or relating to piperidine-carboxamide derivatives - Google Patents

Improvements in or relating to piperidine-carboxamide derivatives

Info

Publication number
GB830709A
GB830709A GB3551857A GB3551857A GB830709A GB 830709 A GB830709 A GB 830709A GB 3551857 A GB3551857 A GB 3551857A GB 3551857 A GB3551857 A GB 3551857A GB 830709 A GB830709 A GB 830709A
Authority
GB
United Kingdom
Prior art keywords
general formula
compound
radical
nrr1
piperidinecarboxamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3551857A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Publication of GB830709A publication Critical patent/GB830709A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The invention comprises compounds of the general formula <FORM:0830709/IV (b)/1> and their pharmaceutically acceptable non-toxic acid addition and quaternary ammonium salts (wherein Alk is a lower alkylene radical, X is a hydrogen or halogen atom, and NRR1 is an amino, lower alkylamino, lower alkenylamino, lower hydroxy-alkylamino, lower dialkylamino or lower dialkenylamino radical), and the preparation thereof by condensing a compound of the general formula <FORM:0830709/IV (b)/2> with at least one equivalent of a compound of the general formula <FORM:0830709/IV (b)/3> (wherein one of the symbols Y and Z represents a hydrogen atom and the other a halogen-Alk group, and A is either NRR1 or a lower alkoxy radical) in the presence of at least one additional equivalent of base, followed in the case where A is a lower alkoxy radical by transamination with a compound of the general formula HNRR1. The term "lower" is used to describe radicals containing not more than six carbon atoms. 4 - (N,N - dimethyl)piperidinecarboxamide is made by hydrogenating over a platinum oxide catalyst 4 - (N,N - dimethyl)pyridinecarboxamide, which is made by reacting dimethylamine with methyl isonicotinate in a bomb. 4 - (N,N - diethyl)piperidinecarboxamide is similarly made.
GB3551857A 1956-11-15 1957-11-14 Improvements in or relating to piperidine-carboxamide derivatives Expired GB830709A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US62228356A 1956-11-15 1956-11-15

Publications (1)

Publication Number Publication Date
GB830709A true GB830709A (en) 1960-03-16

Family

ID=24493619

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3551857A Expired GB830709A (en) 1956-11-15 1957-11-14 Improvements in or relating to piperidine-carboxamide derivatives

Country Status (6)

Country Link
BE (1) BE562299A (en)
CH (1) CH366043A (en)
DE (1) DE1089386B (en)
FR (1) FR1231657A (en)
GB (1) GB830709A (en)
NL (1) NL99690C (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992020658A1 (en) * 1991-05-17 1992-11-26 Novo Nordisk A/S Novel heterocyclic carboxylic acids
WO1996031498A1 (en) * 1995-04-07 1996-10-10 Novo Nordisk A/S Novel heterocyclic compounds
US5795888A (en) * 1994-01-04 1998-08-18 Novo Nordisk A/S N-substituted azaheterocyclic carboxlic acids and esters thereof
US6166009A (en) * 1994-01-04 2000-12-26 Novo Nordisk A/S N-substituted azaheterocyclic carboxylic acids and esters thereof
US6613791B1 (en) 1994-01-04 2003-09-02 Novo Nordisk A/S N-substituted azaheterocyclic carboxylic acids and their use

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE560750A (en) * 1957-07-26
FR1216268A (en) * 1958-04-24 1960-04-25 Rhone Poulenc Sa New phenothiazine derivatives with a piperidine chain substituted by an amide function and their preparation
US3155652A (en) * 1958-09-04 1964-11-03 Searle & Co 2-acyl-10-carbamoylpiperidinoalkylphenothiazines and process
US3063996A (en) * 1959-03-02 1962-11-13 Smith Kline French Lab Substituted piperidinylalkyl phenothiazines
US3225037A (en) * 1959-03-30 1965-12-21 Sterling Drug Inc 10-[(amino- and acylamino-1-piperidyl) lower-alkyl]-phenothiazines
US3055891A (en) * 1960-03-21 1962-09-25 Searle & Co N-(aminoalkylcarbamoylpiperidinoalkyl)phenothiazines
US3112308A (en) * 1961-11-20 1963-11-26 Searle & Co Substituted 10-(4-carbalkoxy-4-phenylpiperidinoalkyl) phenothiazines
BE786583A (en) * 1971-07-21 1973-01-22 Rhone Poulenc Sa NEW PHENOTHIAZINE DERIVATIVES, THEIR PREPARATION AND THE COMPOSITIONS CONTAINING THEM

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH298779A (en) * 1951-02-16 1954-05-15 Rhone Poulenc Chemicals Process for the preparation of a novel derivative of phenothiazine.
GB716227A (en) * 1951-02-16 1954-09-29 Rhone Poulenc Sa New phenthiazine derivatives and processes for their production
BE528164A (en) * 1953-04-10

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992020658A1 (en) * 1991-05-17 1992-11-26 Novo Nordisk A/S Novel heterocyclic carboxylic acids
US5348965A (en) * 1991-05-17 1994-09-20 Novo Nordisk A/S N-substituted azaheterocyclic carboxylic acids
US5795888A (en) * 1994-01-04 1998-08-18 Novo Nordisk A/S N-substituted azaheterocyclic carboxlic acids and esters thereof
US6166009A (en) * 1994-01-04 2000-12-26 Novo Nordisk A/S N-substituted azaheterocyclic carboxylic acids and esters thereof
US6613791B1 (en) 1994-01-04 2003-09-02 Novo Nordisk A/S N-substituted azaheterocyclic carboxylic acids and their use
WO1996031498A1 (en) * 1995-04-07 1996-10-10 Novo Nordisk A/S Novel heterocyclic compounds
US5874428A (en) * 1995-04-07 1999-02-23 Novo Nordisk Als N-substituted aza-heterocyclic carboxylic acids and esters thereof

Also Published As

Publication number Publication date
FR1231657A (en) 1960-09-30
DE1089386B (en) 1960-09-22
BE562299A (en)
CH366043A (en) 1962-12-15
NL99690C (en)

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