CS202550B2 - Method of preparing novel derivatives of 1-/benzazolylalkyl/piperidine - Google Patents

Method of preparing novel derivatives of 1-/benzazolylalkyl/piperidine Download PDF

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Publication number
CS202550B2
CS202550B2 CS764688A CS468876A CS202550B2 CS 202550 B2 CS202550 B2 CS 202550B2 CS 764688 A CS764688 A CS 764688A CS 468876 A CS468876 A CS 468876A CS 202550 B2 CS202550 B2 CS 202550B2
Authority
CS
Czechoslovakia
Prior art keywords
parts
formula
dihydro
hydrogen
methyl
Prior art date
Application number
CS764688A
Other languages
Czech (cs)
English (en)
Inventor
Jan Vandenberk
Ludo E J Kennis
Der Aa Marcel Van
Heertum Albert Van
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/687,139 external-priority patent/US4066772A/en
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of CS202550B2 publication Critical patent/CS202550B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Otolaryngology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CS764688A 1975-07-21 1976-07-16 Method of preparing novel derivatives of 1-/benzazolylalkyl/piperidine CS202550B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US59779375A 1975-07-21 1975-07-21
US05/687,139 US4066772A (en) 1975-07-21 1976-05-17 1,3-Dihydro-1-[3-(1-piperidinyl)propyl]-2H-benzimidazol-2-ones and related compounds
KR7601697A KR810000334B1 (ko) 1975-07-21 1976-07-12 1-(벤즈 아조릴알킬) 피페리딘 유도체의 제조방법

Publications (1)

Publication Number Publication Date
CS202550B2 true CS202550B2 (en) 1981-01-30

Family

ID=27348142

Family Applications (1)

Application Number Title Priority Date Filing Date
CS764688A CS202550B2 (en) 1975-07-21 1976-07-16 Method of preparing novel derivatives of 1-/benzazolylalkyl/piperidine

Country Status (25)

Country Link
JP (1) JPS5217475A (is")
AT (1) AT364358B (is")
AU (1) AU511027B2 (is")
BG (1) BG26526A3 (is")
CA (1) CA1085852A (is")
CH (1) CH623820A5 (is")
CS (1) CS202550B2 (is")
DE (1) DE2632870A1 (is")
DK (1) DK154950C (is")
ES (3) ES449740A1 (is")
FI (1) FI62667C (is")
GB (1) GB1542514A (is")
HK (1) HK14180A (is")
IE (1) IE43496B1 (is")
IT (1) IT1062614B (is")
KE (1) KE3215A (is")
LU (1) LU75354A1 (is")
MY (1) MY8100017A (is")
NL (1) NL187442C (is")
NZ (1) NZ181256A (is")
PH (1) PH13710A (is")
PT (1) PT65387B (is")
RO (1) RO70566A (is")
SE (2) SE426490B (is")
YU (1) YU39969B (is")

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4501749A (en) * 1983-10-31 1985-02-26 Merck & Co., Inc. Peripherally selective dopamine antagonists in the treatment of ocular hypertension
JPS6248684A (ja) * 1985-08-26 1987-03-03 Sumitomo Chem Co Ltd 新規なヨ−ドブチロフエノン誘導体およびその製造法
JPS62251313A (ja) * 1986-04-25 1987-11-02 信越ポリマー株式会社 結束装置
US6355659B1 (en) 1994-07-29 2002-03-12 Laboratorios Del Dr. Esteve, S.A. 4-(4-Chlorophenyl)-1236-tetrahydro-1(1H-124-triazol-1-yl)butty)pyrideine and salts thereof; pharmaceutical compositions and method of treating psychoses utilizing same
FR2723091B1 (fr) * 1994-07-29 1996-11-08 Esteve Labor Dr Tetrahydropyridine-(6,4-hydroxypiperidine) alkylazoles
RU2192848C1 (ru) * 2001-10-30 2002-11-20 Закрытое акционерное общество "ВЕРОФАРМ" Противорвотное средство
PA8603801A1 (es) 2003-05-27 2004-12-16 Janssen Pharmaceutica Nv Derivados de la quinazolina
RU2268047C2 (ru) * 2003-12-15 2006-01-20 Закрытое акционерное общество "Фармацевтическое предприятие "Оболенское" Лекарственная форма, обладающая противорвотным действием, и способ ее изготовления
DE602004012891T2 (de) 2003-12-18 2009-04-09 Janssen Pharmaceutica N.V. Pyrido- und pyrimidopyrimidinderivate als anti-proliferative mittel
NI200700147A (es) 2004-12-08 2019-05-10 Janssen Pharmaceutica Nv Derivados de quinazolina inhibidores de cinasas dirigidos a multip
MX2009000456A (es) 2006-07-13 2009-01-27 Janssen Pharmaceutica Nv Derivados de quinazolina mtki.
EP1997805A1 (en) * 2007-06-01 2008-12-03 Commissariat à l'Energie Atomique Compounds with antiparasitic activity, applications thereof to the treatment of infectious diseases caused by apicomplexans
JP5536647B2 (ja) 2007-07-27 2014-07-02 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ピロロピリミジン
TWI448289B (zh) 2007-08-31 2014-08-11 Purdue Pharma Lp 經取代之喹啉型哌啶化合物及其用途
US9090618B2 (en) 2012-12-27 2015-07-28 Purdue Pharma L.P. Substituted benzimidazole-type piperidine compounds and uses thereof
BR112018016032B1 (pt) * 2016-02-04 2024-03-05 Cindome Pharma, Inc Compostos, composição farmacêutica e uso dos mesmos para melhorar um distúrbio
US11364226B2 (en) 2017-06-30 2022-06-21 Cinrx Pharma, Llc Deuterated domperidone compositions, methods, and preparation

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE633495A (is") * 1962-06-13
BE633914A (is") * 1962-06-22
US3629267A (en) * 1968-10-28 1971-12-21 Smith Kline French Lab Benzoheterocyclicalkyl derivatives of 4-(2-keto -1-benzimidazolinyl)-piperidine 4-(2-keto - 1 - benzimidazolinyl) -1 2 3 6 tetrahydropyridine 1 - phenyl - 1 3 8-triazaspiro(4 5)decan - 4 - one and 2 4 9-triazaspiro(5 5)undecan-1 3 5-trione
AU4698672A (en) * 1972-09-22 1972-11-09 Ciba-Geigy Ag Azacycloaliphatic compounds, process for their manufacture and compositions containing them
FR2218100A1 (en) * 1973-02-20 1974-09-13 Janssen Pharmaceutica Nv Neuroleptic tricyclic derivs. - of benzimidazolinones and triazaspiro-4,5-decan-4-ones
US3989707A (en) * 1974-06-21 1976-11-02 Janssen Pharmaceutica N.V. Benzimidazolinone derivatives

Also Published As

Publication number Publication date
ATA534776A (de) 1981-03-15
ES449740A1 (es) 1978-02-16
CA1085852A (en) 1980-09-16
RO70566A (ro) 1982-10-11
JPS5217475A (en) 1977-02-09
DE2632870C2 (is") 1989-02-16
AT364358B (de) 1981-10-12
NL7608023A (nl) 1977-01-25
DK154950C (da) 1989-05-29
ES461630A1 (es) 1978-06-16
DK154950B (da) 1989-01-09
KE3215A (en) 1982-07-09
DK327576A (da) 1977-01-22
SE435621B (sv) 1984-10-08
YU39969B (en) 1985-06-30
SE8008713L (sv) 1980-12-11
FI62667B (fi) 1982-10-29
BG26526A3 (bg) 1979-04-12
YU179476A (en) 1983-01-21
JPS6131109B2 (is") 1986-07-17
AU511027B2 (en) 1980-07-24
MY8100017A (en) 1981-12-31
DE2632870A1 (de) 1977-02-10
FI62667C (fi) 1983-02-10
NZ181256A (en) 1978-04-28
PH13710A (en) 1980-09-09
SE7608265L (sv) 1977-01-22
FI762086A7 (is") 1977-01-22
ES461631A1 (es) 1978-12-01
AU1596476A (en) 1978-01-19
HK14180A (en) 1980-03-28
CH623820A5 (en) 1981-06-30
IT1062614B (it) 1984-10-20
IE43496B1 (en) 1981-03-11
NL187442C (nl) 1991-10-01
GB1542514A (en) 1979-03-21
SE426490B (sv) 1983-01-24
IE43496L (en) 1977-01-21
PT65387A (en) 1976-08-01
NL187442B (nl) 1991-05-01
PT65387B (en) 1978-06-09
LU75354A1 (is") 1977-02-28

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