CR20140566A - 7h-pirrolo[2,3-d]pirimidinas 4-(amino-substituidas) novedosas como inhibidores de lrrk2 - Google Patents

7h-pirrolo[2,3-d]pirimidinas 4-(amino-substituidas) novedosas como inhibidores de lrrk2

Info

Publication number
CR20140566A
CR20140566A CR20140566A CR20140566A CR20140566A CR 20140566 A CR20140566 A CR 20140566A CR 20140566 A CR20140566 A CR 20140566A CR 20140566 A CR20140566 A CR 20140566A CR 20140566 A CR20140566 A CR 20140566A
Authority
CR
Costa Rica
Prior art keywords
lrrk2
pyrimidins
pirrolo
novelty
substitutes
Prior art date
Application number
CR20140566A
Other languages
English (en)
Spanish (es)
Inventor
Paul Galatsis
Matthew Merrill Hayward
Jaclyn Henderson
Bethany Lyn Kormos
Ravi G Kurumbail
Antonia Friederike Stepan
Patrick Robert Verhoest
Travis T Wager
Lei Zhang
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49029142&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CR20140566(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer filed Critical Pfizer
Publication of CR20140566A publication Critical patent/CR20140566A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CR20140566A 2012-06-29 2014-12-08 7h-pirrolo[2,3-d]pirimidinas 4-(amino-substituidas) novedosas como inhibidores de lrrk2 CR20140566A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261666299P 2012-06-29 2012-06-29
US201361820828P 2013-05-08 2013-05-08
PCT/IB2013/055039 WO2014001973A1 (en) 2012-06-29 2013-06-19 NOVEL 4-(SUBSTITUTED-AMINO)-7H-PYRROLO[2,3-d]PYRIMIDINES AS LRRK2 INHIBITORS

Publications (1)

Publication Number Publication Date
CR20140566A true CR20140566A (es) 2015-01-09

Family

ID=49029142

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20140566A CR20140566A (es) 2012-06-29 2014-12-08 7h-pirrolo[2,3-d]pirimidinas 4-(amino-substituidas) novedosas como inhibidores de lrrk2

Country Status (31)

Country Link
US (2) US9156845B2 (OSRAM)
EP (2) EP3255049A1 (OSRAM)
JP (3) JP6189948B2 (OSRAM)
KR (1) KR20150027267A (OSRAM)
CN (2) CN105732639A (OSRAM)
AP (1) AP3902A (OSRAM)
AR (1) AR091628A1 (OSRAM)
AU (1) AU2013282869B2 (OSRAM)
BR (1) BR112014032913A2 (OSRAM)
CA (1) CA2878054C (OSRAM)
CL (1) CL2014003566A1 (OSRAM)
CO (1) CO7160063A2 (OSRAM)
CR (1) CR20140566A (OSRAM)
DO (1) DOP2014000303A (OSRAM)
EA (1) EA025186B1 (OSRAM)
ES (1) ES2637245T3 (OSRAM)
GE (1) GEP201706620B (OSRAM)
GT (1) GT201400301A (OSRAM)
IL (1) IL236294A (OSRAM)
MD (1) MD20140130A2 (OSRAM)
MX (1) MX2014015769A (OSRAM)
NI (1) NI201400151A (OSRAM)
NZ (1) NZ702571A (OSRAM)
PE (1) PE20150153A1 (OSRAM)
PH (1) PH12014502886A1 (OSRAM)
SG (1) SG11201408044QA (OSRAM)
TN (1) TN2014000537A1 (OSRAM)
TW (1) TWI482774B (OSRAM)
UY (1) UY34883A (OSRAM)
WO (1) WO2014001973A1 (OSRAM)
ZA (1) ZA201409136B (OSRAM)

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KR101990739B1 (ko) * 2018-07-24 2019-06-19 재단법인 대구경북첨단의료산업진흥재단 혈액 뇌관문을 통과할 수 있는 화합물을 유효성분으로 함유하는 뇌암의 예방 또는 치료용 약학적 조성물
WO2020040591A1 (ko) * 2018-08-23 2020-02-27 재단법인 대구경북첨단의료산업진흥재단 Lrrk 키나아제 저해제를 유효성분으로 함유하는 피리미딘 유도체의 신규용도
KR101992059B1 (ko) * 2018-08-23 2019-06-21 재단법인 대구경북첨단의료산업진흥재단 혈액 뇌관문을 통과할 수 있는 화합물을 유효성분으로 함유하는 뇌암의 예방 또는 치료용 약학적 조성물
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