CO7160063A2 - 7h-pirrolo[2,3-d] pirimidinas 4 - (amino-substituidas) novedosas como inhibidores de lrrk2 - Google Patents

7h-pirrolo[2,3-d] pirimidinas 4 - (amino-substituidas) novedosas como inhibidores de lrrk2

Info

Publication number
CO7160063A2
CO7160063A2 CO14278415A CO14278415A CO7160063A2 CO 7160063 A2 CO7160063 A2 CO 7160063A2 CO 14278415 A CO14278415 A CO 14278415A CO 14278415 A CO14278415 A CO 14278415A CO 7160063 A2 CO7160063 A2 CO 7160063A2
Authority
CO
Colombia
Prior art keywords
lrrk2
disease
pyrimidines
pyrrolo
inhibitors
Prior art date
Application number
CO14278415A
Other languages
English (en)
Inventor
Paul Galatsis
Matthew Merrill Hayward
Jaclyn Henderson
Bethany Lyn Kormos
Ravi Kurumbail
Antonia Friederike Stepan
Patrick Robert Verhoest
Travis T Wager
Lei Zhang
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49029142&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO7160063(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer filed Critical Pfizer
Publication of CO7160063A2 publication Critical patent/CO7160063A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente invención proporciona derivados novedosos de 7 H- p irro lo[2,3- d]pirimidina 4,5- disubstituida de la fórmu la I, y las sales farmacéuticamente aceptables de los mismos en donde R1 , R2 , R3 , R4 y R5 son como se definieron en la especificación. La invención también está dirigida a composiciones farmacéuticas que comprenden los compuestos de la fórmula I y a l uso de los compuestos en el tratamiento de enfermedad es asociadas con LRRK2, tales como enfermedades neurodegenerativas que incluyen enfermedad de Parkinson o enfermedad de Alzheimer, cáncer, enfermedad de Crohn o lepra
CO14278415A 2012-06-29 2014-12-18 7h-pirrolo[2,3-d] pirimidinas 4 - (amino-substituidas) novedosas como inhibidores de lrrk2 CO7160063A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261666299P 2012-06-29 2012-06-29
US201361820828P 2013-05-08 2013-05-08

Publications (1)

Publication Number Publication Date
CO7160063A2 true CO7160063A2 (es) 2015-01-15

Family

ID=49029142

Family Applications (1)

Application Number Title Priority Date Filing Date
CO14278415A CO7160063A2 (es) 2012-06-29 2014-12-18 7h-pirrolo[2,3-d] pirimidinas 4 - (amino-substituidas) novedosas como inhibidores de lrrk2

Country Status (32)

Country Link
US (2) US9156845B2 (es)
EP (2) EP2867236B1 (es)
JP (3) JP6189948B2 (es)
KR (1) KR20150027267A (es)
CN (2) CN104395315B (es)
AP (1) AP3902A (es)
AR (1) AR091628A1 (es)
AU (1) AU2013282869B2 (es)
BR (1) BR112014032913A2 (es)
CA (1) CA2878054C (es)
CL (1) CL2014003566A1 (es)
CO (1) CO7160063A2 (es)
CR (1) CR20140566A (es)
DO (1) DOP2014000303A (es)
EA (1) EA025186B1 (es)
ES (1) ES2637245T3 (es)
GE (1) GEP201706620B (es)
GT (1) GT201400301A (es)
HK (1) HK1204619A1 (es)
IL (1) IL236294A (es)
MD (1) MD20140130A2 (es)
MX (1) MX2014015769A (es)
NI (1) NI201400151A (es)
NZ (1) NZ702571A (es)
PE (1) PE20150153A1 (es)
PH (1) PH12014502886B1 (es)
SG (1) SG11201408044QA (es)
TN (1) TN2014000537A1 (es)
TW (1) TWI482774B (es)
UY (1) UY34883A (es)
WO (1) WO2014001973A1 (es)
ZA (1) ZA201409136B (es)

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KR101990739B1 (ko) * 2018-07-24 2019-06-19 재단법인 대구경북첨단의료산업진흥재단 혈액 뇌관문을 통과할 수 있는 화합물을 유효성분으로 함유하는 뇌암의 예방 또는 치료용 약학적 조성물
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