CN1630718A - 改进的类异戊二烯生产 - Google Patents

改进的类异戊二烯生产 Download PDF

Info

Publication number
CN1630718A
CN1630718A CNA028113802A CN02811380A CN1630718A CN 1630718 A CN1630718 A CN 1630718A CN A028113802 A CNA028113802 A CN A028113802A CN 02811380 A CN02811380 A CN 02811380A CN 1630718 A CN1630718 A CN 1630718A
Authority
CN
China
Prior art keywords
seq
sequence
pbbr
polypeptide
activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA028113802A
Other languages
English (en)
Chinese (zh)
Inventor
艾伦·贝里
沃纳·布雷策尔
马库斯·许布林
鲁阿尔·洛佩兹-尤利巴里
安妮·F·迈耶
亚历克西·耶利西夫
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DSM IP Assets BV
Original Assignee
DSM IP Assets BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DSM IP Assets BV filed Critical DSM IP Assets BV
Publication of CN1630718A publication Critical patent/CN1630718A/zh
Pending legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0006Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • C12N1/205Bacterial isolates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1022Transferases (2.) transferring aldehyde or ketonic groups (2.2)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1025Acyltransferases (2.3)
    • C12N9/1029Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1085Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/12Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/12Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1229Phosphotransferases with a phosphate group as acceptor (2.7.4)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88Lyases (4.)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90Isomerases (5.)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P23/00Preparation of compounds containing a cyclohexene ring having an unsaturated side chain containing at least ten carbon atoms bound by conjugated double bonds, e.g. carotenes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y101/00Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01034Hydroxymethylglutaryl-CoA reductase (NADPH) (1.1.1.34)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y101/00Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01036Acetoacetyl-CoA reductase (1.1.1.36)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y203/00Acyltransferases (2.3)
    • C12Y203/03Acyl groups converted into alkyl on transfer (2.3.3)
    • C12Y203/0301Hydroxymethylglutaryl-CoA synthase (2.3.3.10)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y207/00Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/01Phosphotransferases with an alcohol group as acceptor (2.7.1)
    • C12Y207/01036Mevalonate kinase (2.7.1.36)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y207/00Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/04Phosphotransferases with a phosphate group as acceptor (2.7.4)
    • C12Y207/04002Phosphomevalonate kinase (2.7.4.2)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y401/00Carbon-carbon lyases (4.1)
    • C12Y401/01Carboxy-lyases (4.1.1)
    • C12Y401/01033Diphosphomevalonate decarboxylase (4.1.1.33), i.e. mevalonate-pyrophosphate decarboxylase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12RINDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00Microorganisms ; Processes using microorganisms
    • C12R2001/01Bacteria or Actinomycetales ; using bacteria or Actinomycetales

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Compounds Of Unknown Constitution (AREA)
CNA028113802A 2001-06-06 2002-06-05 改进的类异戊二烯生产 Pending CN1630718A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29629901P 2001-06-06 2001-06-06
US60/296,299 2001-06-06

Publications (1)

Publication Number Publication Date
CN1630718A true CN1630718A (zh) 2005-06-22

Family

ID=23141440

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA028113802A Pending CN1630718A (zh) 2001-06-06 2002-06-05 改进的类异戊二烯生产

Country Status (11)

Country Link
US (2) US6989257B2 (https=)
EP (1) EP1392824B1 (https=)
JP (1) JP4280627B2 (https=)
KR (1) KR100704072B1 (https=)
CN (1) CN1630718A (https=)
AT (1) ATE405638T1 (https=)
AU (1) AU2002316966B2 (https=)
CA (1) CA2449885A1 (https=)
DE (1) DE60228439D1 (https=)
ES (1) ES2311613T3 (https=)
WO (1) WO2002099095A2 (https=)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102492701A (zh) * 2007-06-21 2012-06-13 日立造船株式会社 编码杜仲的甲羟戊酸途径的酶的基因
CN101484584B (zh) * 2006-05-26 2013-03-27 阿米瑞斯公司 类异戊二烯的生产
US9200296B2 (en) 2006-05-26 2015-12-01 Amyris Inc. Production of isoprenoids
CN105339490A (zh) * 2012-12-20 2016-02-17 帝斯曼知识产权资产管理有限公司 乙酰转移酶及其用于产生类胡萝卜素的用途
CN105331518A (zh) * 2006-05-26 2016-02-17 阿迈瑞斯公司 制造生物有机化合物的设备
CN108285902A (zh) * 2017-11-03 2018-07-17 杭州爱蔻思生物科技有限公司 生产高价值天然产物的工程菌的构造方法
CN109666683A (zh) * 2019-02-27 2019-04-23 昆明理工大学 乙酰辅酶A乙酰转移酶基因RKAcaT2及其应用
CN109715796A (zh) * 2016-03-31 2019-05-03 Jxtg能源株式会社 类胡萝卜素的制造方法
CN109777815A (zh) * 2019-03-28 2019-05-21 昆明理工大学 HMG-CoA合成酶基因RKHMGCS及其应用
CN111304260A (zh) * 2012-06-01 2020-06-19 朗泽科技新西兰有限公司 重组代谢微生物及其用途
CN115003823A (zh) * 2019-12-26 2022-09-02 加利福尼亚大学董事会 用于生产大麻素和其他异戊二烯化化合物的生物合成平台
CN115605589A (zh) * 2020-05-15 2023-01-13 巴斯夫欧洲公司(De) 改进的用于生产类异戊二烯的方法
CN117965414A (zh) * 2024-04-01 2024-05-03 北京微构工场生物技术有限公司 一种重组盐单胞菌及其在生产异戊二烯中的应用

Families Citing this family (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001278098A1 (en) 2000-07-31 2002-02-13 Frederick M. Hahn Manipulation of genes of the mevalonate and isoprenoid pathways to create novel traits in transgenic organisms
US7226739B2 (en) 2001-03-02 2007-06-05 Isis Pharmaceuticals, Inc Methods for rapid detection and identification of bioagents in epidemiological and forensic investigations
US7666588B2 (en) 2001-03-02 2010-02-23 Ibis Biosciences, Inc. Methods for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy
US20030027135A1 (en) 2001-03-02 2003-02-06 Ecker David J. Method for rapid detection and identification of bioagents
WO2004060278A2 (en) 2002-12-06 2004-07-22 Isis Pharmaceuticals, Inc. Methods for rapid identification of pathogens in humans and animals
US20040121309A1 (en) 2002-12-06 2004-06-24 Ecker David J. Methods for rapid detection and identification of bioagents in blood, bodily fluids, and bodily tissues
US8073627B2 (en) 2001-06-26 2011-12-06 Ibis Biosciences, Inc. System for indentification of pathogens
US7217510B2 (en) 2001-06-26 2007-05-15 Isis Pharmaceuticals, Inc. Methods for providing bacterial bioagent characterizing information
US7172886B2 (en) 2001-12-06 2007-02-06 The Regents Of The University Of California Biosynthesis of isopentenyl pyrophosphate
US7192751B2 (en) 2001-12-06 2007-03-20 The Regents Of The University Of California Biosynthesis of amorpha-4,11-diene
AU2004206046B2 (en) * 2003-01-21 2009-12-17 Thallion Pharmaceuticals Inc. Farnesyl dibenzodiazepinones, processes for their production and their use as pharmaceuticals
US8057993B2 (en) 2003-04-26 2011-11-15 Ibis Biosciences, Inc. Methods for identification of coronaviruses
US8158354B2 (en) 2003-05-13 2012-04-17 Ibis Biosciences, Inc. Methods for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture
US7964343B2 (en) 2003-05-13 2011-06-21 Ibis Biosciences, Inc. Method for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture
DE602004020218D1 (de) * 2003-06-12 2009-05-07 Dsm Ip Assets Bv Feedback resistante mevalonate kinase
JP4528297B2 (ja) * 2003-07-08 2010-08-18 ディーエスエム アイピー アセッツ ビー.ブイ. コエンザイムq−10の向上した産生
US8546082B2 (en) 2003-09-11 2013-10-01 Ibis Biosciences, Inc. Methods for identification of sepsis-causing bacteria
US8242254B2 (en) 2003-09-11 2012-08-14 Ibis Biosciences, Inc. Compositions for use in identification of bacteria
US8097416B2 (en) 2003-09-11 2012-01-17 Ibis Biosciences, Inc. Methods for identification of sepsis-causing bacteria
WO2005033287A2 (en) * 2003-09-29 2005-04-14 The Regents Of The University Of California Methods for identifying a biosynthetic pathway gene product
US7666592B2 (en) 2004-02-18 2010-02-23 Ibis Biosciences, Inc. Methods for concurrent identification and quantification of an unknown bioagent
CN101023181A (zh) * 2004-05-21 2007-08-22 加利福尼亚大学董事会 提高类异戊二烯化合物的产生的方法
ES2641832T3 (es) 2004-05-24 2017-11-14 Ibis Biosciences, Inc. Espectrometría de masas con filtración de iones selectiva por establecimiento de umbrales digitales
US20050266411A1 (en) 2004-05-25 2005-12-01 Hofstadler Steven A Methods for rapid forensic analysis of mitochondrial DNA
US7811753B2 (en) 2004-07-14 2010-10-12 Ibis Biosciences, Inc. Methods for repairing degraded DNA
US7572609B2 (en) 2004-08-19 2009-08-11 Dsm Ip Assets B.V. Production of isoprenoids
WO2006135400A2 (en) 2004-08-24 2006-12-21 Isis Pharmaceuticals, Inc. Methods for rapid identification of recombinant organisms
EP1824969B1 (en) * 2004-12-14 2011-03-02 DSM IP Assets B.V. Improved mevalonate kinase
EP2308965A1 (en) 2005-02-11 2011-04-13 DSM IP Assets B.V. Fermentative vitamin C production
US20060205040A1 (en) 2005-03-03 2006-09-14 Rangarajan Sampath Compositions for use in identification of adventitious viruses
US8084207B2 (en) 2005-03-03 2011-12-27 Ibis Bioscience, Inc. Compositions for use in identification of papillomavirus
CN103589650A (zh) 2005-03-18 2014-02-19 米克罗比亚公司 产油酵母和真菌中类胡萝卜素的产生
JP2006280297A (ja) * 2005-04-01 2006-10-19 Tosoh Corp ゲラニルゲラニル2リン酸合成酵素及びその遺伝子等
JP2009502137A (ja) 2005-07-21 2009-01-29 アイシス ファーマシューティカルズ インコーポレイティッド 核酸変種の迅速な同定および定量のための方法
EP1934344B1 (en) 2005-09-08 2010-02-24 DSM IP Assets B.V. Novel gene sms 37
WO2007049416A1 (ja) 2005-10-28 2007-05-03 Tosoh Corporation カロテノイド合成微生物の作製方法およびカロテノイドの製造方法
JP5023474B2 (ja) * 2005-10-28 2012-09-12 東ソー株式会社 カロテノイド合成微生物の作製方法およびカロテノイドの製造方法
JP2007151475A (ja) * 2005-12-06 2007-06-21 Tosoh Corp 新規微生物およびそれを用いたゼアキサンチンの製造方法
JP4887764B2 (ja) * 2005-12-06 2012-02-29 東ソー株式会社 新規微生物およびそれを用いたリコペンの製造法
DE102006001868B4 (de) * 2006-01-13 2012-03-01 Austriamicrosystems Ag Schaltungsanordnung und Verfahren zur Ansteuerung einer elektrischen Last und eine Energieversorgungseinrichtung
WO2007136847A2 (en) * 2006-05-19 2007-11-29 The Regents Of The University Of California Methods for increasing isoprenoid and isoprenoid precursor production by modulating fatty acid levels
AU2012202630B2 (en) * 2006-05-26 2014-01-16 Amyris, Inc. Production of isoprenoids
WO2008008256A2 (en) * 2006-07-07 2008-01-17 The Regents Of The University Of California Methods for enhancing production of isoprenoid compounds by host cells
US9149473B2 (en) 2006-09-14 2015-10-06 Ibis Biosciences, Inc. Targeted whole genome amplification method for identification of pathogens
WO2008042338A2 (en) 2006-09-28 2008-04-10 Microbia, Inc. Production of carotenoids in oleaginous yeast and fungi
EP2126132B1 (en) 2007-02-23 2013-03-20 Ibis Biosciences, Inc. Methods for rapid foresnsic dna analysis
US7531980B2 (en) * 2007-03-02 2009-05-12 Honeywell International Inc. Aircraft cabin pressure controls: duty cycle offset to compensate for asymmetric motor loading in an open-loop motor control system
WO2008151023A2 (en) 2007-06-01 2008-12-11 Ibis Biosciences, Inc. Methods and compositions for multiple displacement amplification of nucleic acids
WO2009005704A1 (en) * 2007-07-03 2009-01-08 The Regents Of The University Of California Methods of increasing isoprenoid or isoprenoid precursor production
AU2008334945C1 (en) 2007-12-13 2013-09-05 Danisco Us Inc. Compositions and methods for producing isoprene
ES2330602B1 (es) * 2008-03-19 2010-09-30 Vitatene, S.A Metodo de produccion de fitoeno y/o fitoflueno, o mezclas de carotenoides con alto contenido en los mismos.
AU2009240505B2 (en) 2008-04-23 2013-09-05 Danisco Us Inc. Isoprene synthase variants for improved microbial production of isoprene
WO2010001078A2 (fr) * 2008-07-04 2010-01-07 Philippe Marliere Production d'alcenes par decarboxylation enzymatique d'acides 3-hydroxy-alcanoïques
US9556456B2 (en) * 2008-09-09 2017-01-31 Battelle Memorial Institute Production of bio-based materials using photobioreactors with binary cultures
US8550694B2 (en) 2008-09-16 2013-10-08 Ibis Biosciences, Inc. Mixing cartridges, mixing stations, and related kits, systems, and methods
US8148163B2 (en) 2008-09-16 2012-04-03 Ibis Biosciences, Inc. Sample processing units, systems, and related methods
WO2010033625A1 (en) 2008-09-16 2010-03-25 Ibis Biosciences, Inc. Microplate handling systems and related computer program products and methods
EP2396803A4 (en) 2009-02-12 2016-10-26 Ibis Biosciences Inc IONIZATION PROBE ASSEMBLIES
AU2010238770A1 (en) 2009-04-23 2011-11-03 Danisco Us Inc. Three-dimensional structure of isoprene synthase and its use thereof for generating variants
US8950604B2 (en) 2009-07-17 2015-02-10 Ibis Biosciences, Inc. Lift and mount apparatus
EP2454000A4 (en) 2009-07-17 2016-08-10 Ibis Biosciences Inc SYSTEMS FOR IDENTIFYING BIOLOGICAL SUBSTANCES
BR112012005899A2 (pt) * 2009-09-15 2015-09-01 Wwcc Ltd Molécula de ácido nucleico que codifica sintase de triterpenoide
EP2488656B1 (en) 2009-10-15 2015-06-03 Ibis Biosciences, Inc. Multiple displacement amplification
EP2336310A1 (en) 2009-12-16 2011-06-22 Isobionics B.V. Valencene synthase
PL2516656T3 (pl) * 2009-12-22 2014-10-31 Global Bioenergies Sposób otrzymywania izoprenolu z mewalonianu z zastosowaniem dekarboksylazy difosfomewalonianu
CN105671108A (zh) 2010-06-02 2016-06-15 沃维公司 甜菊糖苷的重组生产
CN103261410B (zh) 2010-10-19 2018-05-11 环球生物能源公司 通过3-羟基链烷酸的组合酶促转化来产生烯
CA2816306A1 (en) 2010-10-27 2012-05-03 Danisco Us Inc. Isoprene synthase variants for improved production of isoprene
CN108396044A (zh) 2011-08-08 2018-08-14 埃沃尔瓦公司 甜菊醇糖苷类的重组生产
US9163263B2 (en) 2012-05-02 2015-10-20 The Goodyear Tire & Rubber Company Identification of isoprene synthase variants with improved properties for the production of isoprene
WO2014052054A1 (en) * 2012-09-25 2014-04-03 Albert Einstein College Of Medicine Of Yeshiva University Enzymatic platform for the synthesis of isoprenoid precursors and uses thereof
WO2014089436A1 (en) * 2012-12-07 2014-06-12 Ginkgo Bioworks, Inc. Methods and systems for methylotrophic production of organic compounds
SG11201505597SA (en) 2013-02-06 2015-08-28 Evolva Sa Methods for improved production of rebaudioside d and rebaudioside m
CA2900882A1 (en) 2013-02-11 2014-08-14 Evolva Sa Efficient production of steviol glycosides in recombinants hosts
ES2762154T3 (es) * 2013-03-15 2020-05-22 Dsm Ip Assets Bv Uso de nucleasas termófilas para degradar ácidos nucleicos
JP6282813B2 (ja) * 2013-07-16 2018-02-21 住友ゴム工業株式会社 ヒドロキシメチルグルタリルCoAレダクターゼの発現をbZIP型転写因子により調整する方法、bZIP型転写因子をコードする遺伝子が導入されたイソプレノイド産生植物、及び該イソプレノイド産生植物を用いたポリイソプレノイドの製造方法
WO2016008885A1 (en) * 2014-07-14 2016-01-21 Photanol B.V. Biosynthesis of sesquiterpenes in cyanobacteria
AU2015303294A1 (en) 2014-08-11 2017-02-02 Evolva Sa. Production of steviol glycosides in recombinant hosts
AU2015314251A1 (en) 2014-09-09 2017-03-16 Evolva Sa Production of steviol glycosides in recombinant hosts
SG11201705606PA (en) 2015-01-30 2017-08-30 Evolva Sa Production of steviol glycosides in recombinant hosts
CA2979931A1 (en) 2015-03-16 2016-09-22 Dsm Ip Assets B.V. Udp-glycosyltransferases
AU2016307066A1 (en) 2015-08-07 2018-02-08 Evolva Sa Production of steviol glycosides in recombinant hosts
US20170145441A1 (en) * 2015-08-17 2017-05-25 INVISTA North America S.à.r.l. Methods, hosts, and reagents related thereto for production of unsaturated pentahydrocarbons, derivatives and intermediates thereof
JP6940503B2 (ja) * 2015-08-28 2021-09-29 フィトヴェルト グリーンテクノロジーズ ゲーエムベーハー 発酵によるα−イオノン製造の方法
US10982249B2 (en) 2016-04-13 2021-04-20 Evolva Sa Production of steviol glycosides in recombinant hosts
WO2017198682A1 (en) 2016-05-16 2017-11-23 Evolva Sa Production of steviol glycosides in recombinant hosts
US11396669B2 (en) 2016-11-07 2022-07-26 Evolva Sa Production of steviol glycosides in recombinant hosts
US11634733B2 (en) 2017-06-30 2023-04-25 Inv Nylon Chemicals Americas, Llc Methods, materials, synthetic hosts and reagents for the biosynthesis of hydrocarbons and derivatives thereof
US11162115B2 (en) 2017-06-30 2021-11-02 Inv Nylon Chemicals Americas, Llc Methods, synthetic hosts and reagents for the biosynthesis of hydrocarbons
US11505809B2 (en) 2017-09-28 2022-11-22 Inv Nylon Chemicals Americas Llc Organisms and biosynthetic processes for hydrocarbon synthesis
CA3084263A1 (en) 2017-12-07 2019-06-13 Zymergen Inc. Engineered biosynthetic pathways for production of (6e)-8-hydroxygeraniol by fermentation
BR112020012704A8 (pt) 2017-12-21 2022-03-03 Zymergen Inc Nepetalactol oxidorredutases, nepetalactol sintases, e micróbios capazes de produzir nepetalactona
JP6810096B2 (ja) * 2018-05-09 2021-01-06 Eneos株式会社 カロテノイドの製造方法
CN109880745A (zh) * 2019-03-15 2019-06-14 江苏大学 一种利用腌制废水、晒盐卤水分段培养盐藻的方法
JP2023147514A (ja) * 2022-03-30 2023-10-13 株式会社digzyme ポリエーテルジオールの製造方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3891504A (en) * 1970-07-31 1975-06-24 Hoffmann La Roche Process for the manufacture of zeaxanthin
US5015580A (en) 1987-07-29 1991-05-14 Agracetus Particle-mediated transformation of soybean plants and lines
US5328845A (en) 1992-03-27 1994-07-12 Universal Foods Corporation Fungal negative microorganism capable of producing high levels of beta-carotene
US5466599A (en) 1993-04-19 1995-11-14 Universal Foods Corporation Astaxanthin over-producing strains of phaffia rhodozyma
US5985623A (en) 1995-01-24 1999-11-16 Shin-Etsu Bio, Inc. DNA segments and methods for increasing polysaccharide production
ES2216027T3 (es) 1995-06-09 2004-10-16 Dsm Ip Assets B.V. Produccion de carotenoides fermentativos.
ES2200110T3 (es) 1996-12-02 2004-03-01 F. Hoffmann-La Roche Ag Produccion fermentativa de caroteniodes mejorada.
US5935808A (en) 1997-07-29 1999-08-10 Yissum Research And Development Company Of The Hebrew University Of Jerusalem Carotenoid-producing bacterial species and process for production of carotenoids using same
US6208893B1 (en) 1998-01-27 2001-03-27 Genetronics, Inc. Electroporation apparatus with connective electrode template
CA2736981A1 (en) * 1998-04-14 1999-10-21 Kyowa Hakko Bio Co., Ltd. Process for producing isoprenoid compounds by microorganisms
CN1315947A (zh) 1998-07-06 2001-10-03 伊斯曼化学公司 生育酚的制备
JP4579415B2 (ja) * 1998-07-06 2010-11-10 ディーシーブイ・インコーポレイテッド・ドゥーイング・ビジネス・アズ・バイオ−テクニカル・リソーシィズ ビタミン製造方法
ES2156735B1 (es) 1999-06-09 2002-02-16 Antibioticos Sau Procedimiento de produccion de licopeno.
US6133785A (en) 1999-06-30 2000-10-17 Harris Corporation False carrier lock receiver and associated methods for detection

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101484584B (zh) * 2006-05-26 2013-03-27 阿米瑞斯公司 类异戊二烯的生产
US9200296B2 (en) 2006-05-26 2015-12-01 Amyris Inc. Production of isoprenoids
CN105331518A (zh) * 2006-05-26 2016-02-17 阿迈瑞斯公司 制造生物有机化合物的设备
US10106822B2 (en) 2006-05-26 2018-10-23 Amyris, Inc. Production of isoprenoids
CN102492701B (zh) * 2007-06-21 2013-11-06 日立造船株式会社 编码杜仲的甲羟戊酸途径的酶的基因
CN102492701A (zh) * 2007-06-21 2012-06-13 日立造船株式会社 编码杜仲的甲羟戊酸途径的酶的基因
CN111304260A (zh) * 2012-06-01 2020-06-19 朗泽科技新西兰有限公司 重组代谢微生物及其用途
US12286660B2 (en) 2012-06-01 2025-04-29 Lanzatech, Inc. Microbial fermentation for the production of terpenes
CN105339490A (zh) * 2012-12-20 2016-02-17 帝斯曼知识产权资产管理有限公司 乙酰转移酶及其用于产生类胡萝卜素的用途
CN109715796B (zh) * 2016-03-31 2021-04-09 Jxtg能源株式会社 类胡萝卜素的制造方法
CN109715796A (zh) * 2016-03-31 2019-05-03 Jxtg能源株式会社 类胡萝卜素的制造方法
CN108285902A (zh) * 2017-11-03 2018-07-17 杭州爱蔻思生物科技有限公司 生产高价值天然产物的工程菌的构造方法
CN109666683A (zh) * 2019-02-27 2019-04-23 昆明理工大学 乙酰辅酶A乙酰转移酶基因RKAcaT2及其应用
CN109666683B (zh) * 2019-02-27 2021-10-29 昆明理工大学 乙酰辅酶A乙酰转移酶基因RKAcaT2及其应用
CN109777815A (zh) * 2019-03-28 2019-05-21 昆明理工大学 HMG-CoA合成酶基因RKHMGCS及其应用
CN115003823A (zh) * 2019-12-26 2022-09-02 加利福尼亚大学董事会 用于生产大麻素和其他异戊二烯化化合物的生物合成平台
CN115605589A (zh) * 2020-05-15 2023-01-13 巴斯夫欧洲公司(De) 改进的用于生产类异戊二烯的方法
CN117965414A (zh) * 2024-04-01 2024-05-03 北京微构工场生物技术有限公司 一种重组盐单胞菌及其在生产异戊二烯中的应用
CN117965414B (zh) * 2024-04-01 2024-06-14 北京微构工场生物技术有限公司 一种重组盐单胞菌及其在生产异戊二烯中的应用

Also Published As

Publication number Publication date
US20050266518A1 (en) 2005-12-01
JP4280627B2 (ja) 2009-06-17
EP1392824A2 (en) 2004-03-03
DE60228439D1 (de) 2008-10-02
US6989257B2 (en) 2006-01-24
US20030148416A1 (en) 2003-08-07
AU2002316966B2 (en) 2007-05-17
WO2002099095A2 (en) 2002-12-12
JP2004527265A (ja) 2004-09-09
EP1392824B1 (en) 2008-08-20
KR20040010683A (ko) 2004-01-31
CA2449885A1 (en) 2002-12-12
WO2002099095A3 (en) 2003-12-18
KR100704072B1 (ko) 2007-04-05
ES2311613T3 (es) 2009-02-16
ATE405638T1 (de) 2008-09-15
US7232679B2 (en) 2007-06-19

Similar Documents

Publication Publication Date Title
CN1630718A (zh) 改进的类异戊二烯生产
CN1262648C (zh) 改进的类异戊二烯的生产
EP3230459B1 (en) Recombinant microorganisms exhibiting increased flux through a fermentation pathway
US10000749B2 (en) Valencene synthase polypeptides, encoding nucleic acid molecules and uses thereof
CN1227362C (zh) 生产刺糖噻杀虫剂所用的生物合成基因
CN101044243A (zh) 类异戊二烯的生产方法
CN111849794B (zh) 一种酿酒酵母重组菌及其构建方法和应用
CN1556855A (zh) 3-羟基丙酸及其它有机化合物
CN1961072A (zh) 改良型腈水合酶
CN101080490A (zh) 改进的甲羟戊酸激酶
CN1993377A (zh) 丙氨酸2,3氨基变位酶
CN116113699B (zh) 改造的磷酸烯醇丙酮酸羧化酶及其在提高谷氨酸棒杆菌氨基酸产量中的应用
CN1717493A (zh) 大环内酯化合物的产生方法
CN1266101A (zh) 虾青素合成酶
CN1813065A (zh) 反馈抗性乙酰羟酸合成酶突变体
US20220348974A1 (en) Biotin synthases for efficient production of biotin
EP2141236A1 (en) Process for production of lipstatin and microorganisms therefore
JP2022116107A (ja) スクアレン消費酵素のスクリーニング方法及びスクアレン-ホペン環化酵素
CN109072216B (zh) 变异型四异戊烯基-β-姜黄烯环化酶及龙涎香醇的制备方法
CN1387566A (zh) 环状缩肽合成酶及其基因、以及环状缩肽的大规模生产系统
CN1498270A (zh) 基因已被破坏的酵母
CN1230544C (zh) 磷酸己酮糖异构酶和编码该酶的基因
CN1906291A (zh) 用扩增zwf基因制备L-氨基酸的方法
WO2014102180A1 (en) Propanol production by lactobacillus bacterial hosts
CN1377407A (zh) 生产被官能团修饰的次级代谢产物的转化体和新的生物合成基因

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Open date: 20050622