CN1620413B - 还原型辅酶q10的稳定方法和组合物 - Google Patents

还原型辅酶q10的稳定方法和组合物 Download PDF

Info

Publication number
CN1620413B
CN1620413B CN038024462A CN03802446A CN1620413B CN 1620413 B CN1620413 B CN 1620413B CN 038024462 A CN038024462 A CN 038024462A CN 03802446 A CN03802446 A CN 03802446A CN 1620413 B CN1620413 B CN 1620413B
Authority
CN
China
Prior art keywords
oil
composition
coenzyme
reduced coenzyme
weight
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CN038024462A
Other languages
English (en)
Chinese (zh)
Other versions
CN1620413A (zh
Inventor
上田恭义
植田尚宏
大野直生
北村志郎
藤井健志
细江和典
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kanegafuchi Chemical Industry Co Ltd
Original Assignee
Kanegafuchi Chemical Industry Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kanegafuchi Chemical Industry Co Ltd filed Critical Kanegafuchi Chemical Industry Co Ltd
Publication of CN1620413A publication Critical patent/CN1620413A/zh
Application granted granted Critical
Publication of CN1620413B publication Critical patent/CN1620413B/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/347—Phenols
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS OR COOKING OILS
    • A23D9/00—Other edible oils or fats, e.g. shortenings or cooking oils
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS OR COOKING OILS
    • A23D9/00—Other edible oils or fats, e.g. shortenings or cooking oils
    • A23D9/007—Other edible oils or fats, e.g. shortenings or cooking oils characterised by ingredients other than fatty acid triglycerides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/105—Aliphatic or alicyclic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35—Ketones, e.g. benzophenone
    • A61K8/355—Quinones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/925—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of animal origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/34—Separation; Purification; Stabilisation; Use of additives
    • C07C41/46—Use of additives, e.g. for stabilisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/52—Stabilizers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Birds (AREA)
  • Emergency Medicine (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Mycology (AREA)
  • Animal Husbandry (AREA)
  • Dermatology (AREA)
  • Nutrition Science (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Cosmetics (AREA)
CN038024462A 2002-01-18 2003-01-20 还原型辅酶q10的稳定方法和组合物 Expired - Lifetime CN1620413B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2002009737 2002-01-18
JP9737/2002 2002-01-18
JP296802/2002 2002-10-09
JP2002296802 2002-10-09
PCT/JP2003/000394 WO2003062182A1 (fr) 2002-01-18 2003-01-20 Procede de stabilisation d'une coenzyme q10 reduite et composition associee

Publications (2)

Publication Number Publication Date
CN1620413A CN1620413A (zh) 2005-05-25
CN1620413B true CN1620413B (zh) 2012-02-08

Family

ID=27615660

Family Applications (1)

Application Number Title Priority Date Filing Date
CN038024462A Expired - Lifetime CN1620413B (zh) 2002-01-18 2003-01-20 还原型辅酶q10的稳定方法和组合物

Country Status (11)

Country Link
US (1) US8562975B2 (https=)
EP (1) EP1475363B1 (https=)
JP (2) JP4572073B2 (https=)
KR (1) KR100895912B1 (https=)
CN (1) CN1620413B (https=)
AU (1) AU2003201924B2 (https=)
CA (1) CA2473700C (https=)
DK (1) DK1475363T3 (https=)
RU (1) RU2304573C2 (https=)
TW (1) TW200302056A (https=)
WO (1) WO2003062182A1 (https=)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3742602B2 (ja) * 2001-05-09 2006-02-08 株式会社カネカ 還元型補酵素ｑの安定な溶液
WO2004064543A1 (ja) * 2003-01-17 2004-08-05 Taiyo Kagaku Co., Ltd. コエンザイムq10含有組成物
JP4567945B2 (ja) * 2003-01-17 2010-10-27 太陽化学株式会社 ユビデカレノン製剤
CN100534968C (zh) * 2003-09-10 2009-09-02 株式会社钟化 稳定性优异的还原型辅酶q10 结晶及含有还原型辅酶q10结晶的组合物
ES2809302T3 (es) 2004-01-22 2021-03-03 Univ Miami Formulaciones de coenzima Q10 para tratar tumores sólidos mediante administración intravenosa
US7708990B2 (en) 2004-03-23 2010-05-04 Kaneka Corporation Coenzyme Q compositions persisting in blood
EP1728506A1 (en) * 2004-03-23 2006-12-06 Kaneka Corporation Coenzyme q composition with long-term persistence in blood
US20060051462A1 (en) * 2004-09-03 2006-03-09 Wang Jimmy X Self emulsifying compositions for delivering lipophilic coenzyme Q10 and other dietary ingredients
US8961958B2 (en) 2004-11-16 2015-02-24 Bioavailability, Inc High concentration self-microemulsifying coenzyme Q10 preparations for nutritional use
US20060147542A1 (en) * 2004-12-24 2006-07-06 Tadao Ono Solid preparation containing reduced coenzyme Q10 and method for producing the same
US8067217B2 (en) * 2004-12-28 2011-11-29 Kaneka Corporation Method for preserving reduced coenzyme Q10
JP5053544B2 (ja) * 2004-12-28 2012-10-17 株式会社カネカ 還元型補酵素ｑ１０の保存方法
WO2006134970A1 (ja) * 2005-06-15 2006-12-21 Kaneka Corporation コエンザイムｑ１０含有水溶性組成物及びその製法
US8506956B2 (en) 2005-10-31 2013-08-13 Kaneka Corporation Method for stabilizing reduced coenzyme Q10
JP5015548B2 (ja) * 2005-10-31 2012-08-29 株式会社カネカ 還元型補酵素ｑ１０を安定化するための方法
CA2633807A1 (en) * 2005-12-23 2007-06-28 Miv Therapeutics Inc. Compositions formulated for solvent-regulated drug release
SG10201601998PA (en) 2006-03-31 2016-04-28 Suntory Holdings Ltd Jp Compositions containing lignan-class compounds
JP5140585B2 (ja) * 2006-06-22 2013-02-06 株式会社カネカ 還元型補酵素ｑ１０含有組成物およびその製造方法
KR100786884B1 (ko) * 2006-06-27 2007-12-20 영진약품공업주식회사 코엔자임 ｑ１０ 함유 수용성 조성물
US20080152636A1 (en) * 2006-09-08 2008-06-26 Kaneka Corporation Composition containing reduced coenzyme Q10 and lysolecithin
US20080145411A1 (en) * 2006-10-06 2008-06-19 Kaneka Corporation Composition of high absorbability for oral administration comprising oxidized coenzyme q10
CA2680825C (en) 2007-03-22 2013-10-29 Cytotech Labs, Llc Topical formulations having enhanced bioavailability
US20100092560A1 (en) * 2007-04-16 2010-04-15 Kaneka Corporation Reduced coenzyme q10-containing particulate composition and method for producing the same
JP5244790B2 (ja) * 2007-04-16 2013-07-24 株式会社カネカ 還元型補酵素ｑ１０含有粒子状組成物及びその製造方法
KR100871050B1 (ko) * 2007-05-14 2008-12-01 다윈이십일주식회사 코엔자임큐텐을 함유한 미세캡슐의 제조방법
EP2186789B1 (en) 2007-08-22 2013-12-25 Kaneka Corporation Method of producing reduced coenzyme q10 and method of stabilizing the same
WO2009025372A1 (ja) * 2007-08-23 2009-02-26 Kaneka Corporation 還元型補酵素ｑ１０含有組成物及びその安定化方法
JP2009100735A (ja) * 2007-10-03 2009-05-14 Nisshin Oillio Group Ltd 食用油脂組成物
US9284625B2 (en) * 2007-11-20 2016-03-15 Nalco Company Use of polyols as scale control reagents in the mining processes
JP2009149584A (ja) * 2007-12-21 2009-07-09 Kaneka Corp 還元型補酵素ｑ１０含有粒子状組成物及びその製造方法
DK200800040U3 (da) 2008-03-06 2009-06-26 Pharma Nord Aps Lægemiddel og kosttilskud med indhold af stabiliseret ubiquinol i beskyttende pakning.
AU2009233785B2 (en) 2008-04-11 2015-08-20 Berg Llc Methods and use of inducing apoptosis in cancer cells
CA2736907C (en) * 2008-10-03 2018-06-05 E.I. Du Pont De Nemours And Company Improved perhydrolases for enzymatic peracid generation
CN101514148B (zh) * 2009-03-27 2015-05-13 玉溪健坤生物药业有限公司 一种还原型辅酶q10的制备方法
AU2010247800A1 (en) 2009-05-11 2011-12-15 Berg Llc Methods for the diagnosis of metabolic disorders using epimetabolic shifters, multidimensional intracellular molecules, or environmental influencers
WO2011045934A1 (ja) * 2009-10-16 2011-04-21 株式会社カネカ 還元型補酵素ｑ１０の製造方法、安定化方法及びそれを含有する組成物
CN102057991B (zh) * 2009-12-31 2013-11-06 山东三星玉米产业科技有限公司 一种富含辅酶q10的玉米油及其生产方法
CN105168135A (zh) 2010-03-12 2015-12-23 博格有限责任公司 辅酶Q10(CoQ10)的静脉内制剂及其使用方法
CA2832324C (en) 2011-04-04 2022-03-15 Berg Llc Methods of treating central nervous system tumors
US10973763B2 (en) 2011-06-17 2021-04-13 Berg Llc Inhalable pharmaceutical compositions
CN102754829A (zh) * 2012-07-03 2012-10-31 广东仙乐制药有限公司 一种含辅酶q10的保健组合物、胶囊制剂及制备方法
JP5722299B2 (ja) * 2012-12-07 2015-05-20 バイオアバイラビリティ，インク． 栄養学的に使用するための高濃度自己マイクロエマルジョン化コエンザイムｑ１０調製物
JP5999765B2 (ja) * 2012-12-07 2016-09-28 バイオアバイラビリティ，インク． 栄養学的に使用するための高濃度自己マイクロエマルジョン化コエンザイムｑ１０調製物
SG10201903112WA (en) 2013-04-08 2019-05-30 Berg Llc Treatment of cancer using coenzyme q10 combination therapies
CN103211217A (zh) * 2013-04-25 2013-07-24 福建永生活力生物工程有限公司 一种增强免疫力功能的保健软胶囊及其制备方法
WO2014188861A1 (ja) 2013-05-20 2014-11-27 ユーハ味覚糖株式会社 ユビキノール高含有ゲル状組成物
KR102370843B1 (ko) 2013-09-04 2022-03-04 버그 엘엘씨 코엔자임 q10의 연속주입에 의한 암치료 방법
CN103859395B (zh) * 2014-01-24 2015-08-26 天津科技大学 一种高吸收率的辅酶q10的自乳化释药体系及其制备方法及应用
WO2016038150A1 (en) * 2014-09-10 2016-03-17 Pharma Nord Aps Ubidecarenone composition
WO2017087576A1 (en) 2015-11-16 2017-05-26 Berg Llc Methods of treatment of temozolomide-resistant glioma using coenzyme q10
CN105831767A (zh) * 2016-03-24 2016-08-10 袁洪 用于增强免疫力和抗疲劳的组合物及其制备方法和应用
CN112888321A (zh) * 2018-10-26 2021-06-01 三得利控股株式会社 含有还原型辅酶q10的口服用组合物、其制造方法、变色抑制方法及变色抑制剂
IT201900006573A1 (it) * 2019-05-06 2020-11-06 Gricar Chemical S R L Composizione liquida per la veicolazione di sostanze a bassa solubilità e bio-accessibilità enterica
WO2020255411A1 (ja) * 2019-06-21 2020-12-24 株式会社ベリタス ラブダン型ジテルペンを含有する経口投与用安定化製剤およびその製造方法
DE102019218244A1 (de) * 2019-11-26 2021-05-27 Beiersdorf Ag Wirkstoffkombinationen aus Ubichinol und einem oder mehreren Emulgatoren aus der Gruppe der Phosphate und Sulfate sowie kosmetische oder dermatologische Zubereitungen, solche Wirkstoffkombinationen enthaltend

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5581813A (en) * 1978-12-16 1980-06-20 Nisshin Flour Milling Co Ltd Composition containing coenzyme q10 and its perparation
DE3224619A1 (de) * 1981-07-14 1983-05-19 Freund Industrial Co., Ltd., Tokyo Orale pharmazeutische zusammensetzung
IT1265312B1 (it) * 1993-12-21 1996-10-31 Indena Spa Formulazioni contenenti carotenoidi e procarotenoidi associati a polifenoli nella prevenzione dei danni da abnorme produzione di
FR2714600B1 (fr) * 1993-12-30 1996-02-09 Oreal Composition protectrice, nutritive et/ou raffermissante pour le traitement simultané des couches superficielles et profondes de la peau, son utilisation.
JP3889481B2 (ja) * 1996-08-16 2007-03-07 株式会社カネカ 医薬組成物
JP3926888B2 (ja) * 1997-05-27 2007-06-06 株式会社カネカ コレステロール低下剤
IT1304406B1 (it) 1998-10-21 2001-03-19 Danital Italia S R L Preparazione per la veicolazione di principi attivi basata su acidigrassi polinsaturi del gruppo omega 3.
US6835408B2 (en) * 1998-11-13 2004-12-28 The Nisshin Oillio Group, Ltd. Oil or fat composition
JP4733246B2 (ja) 1998-11-13 2011-07-27 日清オイリオグループ株式会社 油脂組成物
US8753675B1 (en) 2000-01-20 2014-06-17 Raj K. Chopra Reduced form of Coenzyme Q in high bioavailability stable dosage forms and related applications
US6441050B1 (en) 2000-08-29 2002-08-27 Raj K. Chopra Palatable oral coenzyme Q liquid
US6300377B1 (en) * 2001-02-22 2001-10-09 Raj K. Chopra Coenzyme Q products exhibiting high dissolution qualities
JP3742602B2 (ja) 2001-05-09 2006-02-08 株式会社カネカ 還元型補酵素ｑの安定な溶液
JP4170657B2 (ja) 2001-07-13 2008-10-22 株式会社カネカ 還元型補酵素ｑ１０の結晶化法
TWI235146B (en) * 2001-07-16 2005-07-01 Kaneka Corp Method of stabilizing reduced coenzyme q10 and method of acidic crystallization
JP4170656B2 (ja) 2001-07-30 2008-10-22 株式会社カネカ 還元型補酵素ｑ１０結晶の製造方法
TWI329510B (en) * 2001-10-10 2010-09-01 Kaneka Corp Method of stabilizing reduced coenzyme q10
JP3822479B2 (ja) * 2001-10-10 2006-09-20 株式会社カネカ 還元型補酵素ｑ水溶液の安定化組成
JP3892881B2 (ja) * 2001-10-10 2007-03-14 株式会社カネカ 還元型補酵素ｑ１０の安定化法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
US 2002/0001660 A1,权利要求.

Also Published As

Publication number Publication date
KR20040086275A (ko) 2004-10-08
JP4572073B2 (ja) 2010-10-27
KR100895912B1 (ko) 2009-05-07
US20050147598A1 (en) 2005-07-07
TW200302056A (en) 2003-08-01
US8562975B2 (en) 2013-10-22
EP1475363A1 (en) 2004-11-10
TWI358268B (https=) 2012-02-21
JPWO2003062182A1 (ja) 2005-05-19
CA2473700A1 (en) 2003-07-31
JP2010189437A (ja) 2010-09-02
WO2003062182A1 (fr) 2003-07-31
RU2304573C2 (ru) 2007-08-20
CN1620413A (zh) 2005-05-25
RU2004125169A (ru) 2006-01-27
EP1475363A4 (en) 2006-07-19
CA2473700C (en) 2012-07-24
EP1475363B1 (en) 2014-06-18
AU2003201924B2 (en) 2009-09-03
DK1475363T3 (da) 2014-08-25

Similar Documents

Publication Publication Date Title
CN1620413B (zh) 还原型辅酶q10的稳定方法和组合物
CN100352889C (zh) 高氧化稳定性的含有双键有机物的组合物
JP5286086B2 (ja) 還元型補酵素ｑ１０及びリゾレシチンを含有する組成物
JP5334492B2 (ja) 高濃度アスタキサンチン抽出物
JP6523971B2 (ja) 還元型補酵素ｑ１０を含有する組成物
JPH09111237A (ja) ドコサヘキサエン酸類の酸化防止剤
US20100168249A1 (en) Composition containing reduced coenzyme q10, and method for stabilizing the composition
AU2006231967B2 (en) Oil-in-water emulsions containing lignan-class compounds and compositions containing the same
BR112014028180B1 (pt) Emulsão, suplemento dietético, e, uso de uma emulsão
US20250324994A1 (en) Oil suspensions of edible solids, triglycerides with saturated fatty acids, mct oils with antioxidants and solid and semi-solid oil-derivatives for food applications
US20140141076A1 (en) Soft capsule preparation, composition for soft capsule preparation, and method of producing soft capsule preparation
JP2010142205A (ja) 油溶性物質のｏ／ｗ型乳化組成物
US8388950B2 (en) Coenzyme Q10-containing water-soluble composition and process for production thereof
JP5053544B2 (ja) 還元型補酵素ｑ１０の保存方法
JP5103188B2 (ja) 酸化に対して安定な還元型補酵素ｑ１０含有組成物、及び還元型補酵素ｑ１０を安定化する方法
WO2020241374A1 (ja) ビタミンｂ１２類含有組成物

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CX01 Expiry of patent term
CX01 Expiry of patent term

Granted publication date: 20120208