JPS5581813A - Composition containing coenzyme q10 and its perparation - Google Patents
Composition containing coenzyme q10 and its perparationInfo
- Publication number
- JPS5581813A JPS5581813A JP15460978A JP15460978A JPS5581813A JP S5581813 A JPS5581813 A JP S5581813A JP 15460978 A JP15460978 A JP 15460978A JP 15460978 A JP15460978 A JP 15460978A JP S5581813 A JPS5581813 A JP S5581813A
- Authority
- JP
- Japan
- Prior art keywords
- coenzyme
- surfactant
- neutral oil
- dissolved
- soft capsules
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: Coenzyme Q10 that is useful as a medicine is dissolved in a neutral oil in the presence of a surfactant, thus producing said composition for filling soft capsules with long-term stability and high handleability.
CONSTITUTION: Coenzyme Q10 is mixed with a neutral oil as soybean or corn oil and a surfactant as sorbitan monolaurate and dissolved in them, wherein heating the mixture over 70°C results in remarkably increased stability of the solution. The amount of the neutral oil used is over 5 times that of the coenzyme Q10 employed, preferably 10W20 times and that of the surfactant is 0.01W2, preferably 0.05W1 time. The resulting composition is a stable solution so that it precipitates no crystals even when stored for a long time and can be filled in soft capsules because of its high flowability. Coenzyme Q10 concerns itself with the electron transport system in vivo and shows outstandingly pharmaceutical effects on various kinds of diseases.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15460978A JPS6339566B2 (en) | 1978-12-16 | 1978-12-16 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15460978A JPS6339566B2 (en) | 1978-12-16 | 1978-12-16 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5581813A true JPS5581813A (en) | 1980-06-20 |
JPS6339566B2 JPS6339566B2 (en) | 1988-08-05 |
Family
ID=15587913
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP15460978A Expired JPS6339566B2 (en) | 1978-12-16 | 1978-12-16 |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS6339566B2 (en) |
Cited By (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5877810A (en) * | 1981-11-01 | 1983-05-11 | Furointo Sangyo Kk | Oral drug composition containing polyglycerol unsaturated fatty acid ester |
JPS6267019A (en) * | 1985-09-18 | 1987-03-26 | Nisshin Kagaku Kk | Self-emulsifiable soft capsule agent |
US4827062A (en) * | 1985-03-28 | 1989-05-02 | Eisai Co., Ltd. | Composition containing ubidecarenone with absorption promoted |
US5258179A (en) * | 1989-10-27 | 1993-11-02 | Nestec S.A. | Protection of a food, cosmetic or pharmaceutical product against oxidation |
EP0617957A1 (en) * | 1993-03-30 | 1994-10-05 | INVERNI DELLA BEFFA FARMACEUTICI S.r.l. | Oral formulations of ubidecarenone in form of capsules |
WO2003007907A1 (en) * | 2001-07-12 | 2003-01-30 | Aquanova German Solubilisate Technologies (Agt) Gmbh | Water-free ubichinon concentrate |
WO2003062182A1 (en) * | 2002-01-18 | 2003-07-31 | Kaneka Corporation | Method for stabilizing reduced coenzyme q10 and composition therefor |
JPWO2003007928A1 (en) * | 2001-07-17 | 2004-11-04 | 出光興産株式会社 | Poultry for ascites prevention agent |
JP2005047851A (en) * | 2003-07-29 | 2005-02-24 | Nisshin Pharma Inc | Ubidecarenone-containing composition |
US7220429B2 (en) * | 1999-03-29 | 2007-05-22 | Soft Gel Technologies, Inc. | Coenzyme Q10 formulation and process methodology for soft gel capsules manufacturing |
US7273622B2 (en) * | 2000-06-22 | 2007-09-25 | Soft Gel Technologies, Inc. | Super absorption Coenzyme Q10 |
JP2008005813A (en) * | 2006-06-30 | 2008-01-17 | Ezaki Glico Co Ltd | Coenzyme q10-containing chocolate |
WO2008002121A3 (en) * | 2006-06-28 | 2008-09-18 | Hovid Berhad | A self-emulsifying composition for poorly bioavailable drugs |
US7713523B2 (en) | 2003-09-29 | 2010-05-11 | Soft Gel Technologies, Inc. | Solubilized CoQ-10 and carnitine |
US8758743B2 (en) * | 2003-01-17 | 2014-06-24 | Taiyo Kagaku Co., Ltd. | Compositions containing coenzyme Q10 |
US8865032B2 (en) | 2003-09-29 | 2014-10-21 | Soft Gel Technologies, Inc. | Method of making a soft gel capsule comprising CoQ-10 solubilized in a monoterpene |
US8932585B2 (en) | 2003-09-29 | 2015-01-13 | Soft Gel Technologies, Inc. | Solubilized CoQ-10 |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0236472U (en) * | 1988-08-31 | 1990-03-09 |
-
1978
- 1978-12-16 JP JP15460978A patent/JPS6339566B2/ja not_active Expired
Cited By (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5877810A (en) * | 1981-11-01 | 1983-05-11 | Furointo Sangyo Kk | Oral drug composition containing polyglycerol unsaturated fatty acid ester |
JPS6230965B2 (en) * | 1981-11-01 | 1987-07-06 | Furointo Sangyo Kk | |
US4827062A (en) * | 1985-03-28 | 1989-05-02 | Eisai Co., Ltd. | Composition containing ubidecarenone with absorption promoted |
JPS6267019A (en) * | 1985-09-18 | 1987-03-26 | Nisshin Kagaku Kk | Self-emulsifiable soft capsule agent |
US5258179A (en) * | 1989-10-27 | 1993-11-02 | Nestec S.A. | Protection of a food, cosmetic or pharmaceutical product against oxidation |
US5443842A (en) * | 1993-03-30 | 1995-08-22 | Inverni Della Beffa Farmaceutici S.R.L. | Oral formulations of ubidecarenone in form of capsules |
EP0617957A1 (en) * | 1993-03-30 | 1994-10-05 | INVERNI DELLA BEFFA FARMACEUTICI S.r.l. | Oral formulations of ubidecarenone in form of capsules |
US7220429B2 (en) * | 1999-03-29 | 2007-05-22 | Soft Gel Technologies, Inc. | Coenzyme Q10 formulation and process methodology for soft gel capsules manufacturing |
US7273622B2 (en) * | 2000-06-22 | 2007-09-25 | Soft Gel Technologies, Inc. | Super absorption Coenzyme Q10 |
WO2003007907A1 (en) * | 2001-07-12 | 2003-01-30 | Aquanova German Solubilisate Technologies (Agt) Gmbh | Water-free ubichinon concentrate |
US7094804B2 (en) | 2001-07-12 | 2006-08-22 | Aquanova German Solubilisate Technologies | Water free ubiquinone concentrate |
JP4503286B2 (en) * | 2001-07-17 | 2010-07-14 | 出光興産株式会社 | Poultry for ascites prevention agent |
JPWO2003007928A1 (en) * | 2001-07-17 | 2004-11-04 | 出光興産株式会社 | Poultry for ascites prevention agent |
JP2010189437A (en) * | 2002-01-18 | 2010-09-02 | Kaneka Corp | Method for stabilizing reduced coenzyme q10 and composition |
US8562975B2 (en) | 2002-01-18 | 2013-10-22 | Kaneka Corporation | Method for stabilizing reduced coenzyme Q10 and composition therefor |
WO2003062182A1 (en) * | 2002-01-18 | 2003-07-31 | Kaneka Corporation | Method for stabilizing reduced coenzyme q10 and composition therefor |
US8758743B2 (en) * | 2003-01-17 | 2014-06-24 | Taiyo Kagaku Co., Ltd. | Compositions containing coenzyme Q10 |
JP2005047851A (en) * | 2003-07-29 | 2005-02-24 | Nisshin Pharma Inc | Ubidecarenone-containing composition |
US7713523B2 (en) | 2003-09-29 | 2010-05-11 | Soft Gel Technologies, Inc. | Solubilized CoQ-10 and carnitine |
US10166192B2 (en) | 2003-09-29 | 2019-01-01 | Soft Gel Technologies, Inc. | Solubilized CoQ-10 |
US10166193B2 (en) | 2003-09-29 | 2019-01-01 | Soft Gel Technologies, Inc. | Method of making a soft gel capsule comprising CoQ-10 solubilized in a monoterpene |
US8865032B2 (en) | 2003-09-29 | 2014-10-21 | Soft Gel Technologies, Inc. | Method of making a soft gel capsule comprising CoQ-10 solubilized in a monoterpene |
US8932584B2 (en) | 2003-09-29 | 2015-01-13 | Soft Gel Technologies, Inc. | Solubilized CoQ-10 |
US8932585B2 (en) | 2003-09-29 | 2015-01-13 | Soft Gel Technologies, Inc. | Solubilized CoQ-10 |
WO2008002121A3 (en) * | 2006-06-28 | 2008-09-18 | Hovid Berhad | A self-emulsifying composition for poorly bioavailable drugs |
JP2008005813A (en) * | 2006-06-30 | 2008-01-17 | Ezaki Glico Co Ltd | Coenzyme q10-containing chocolate |
Also Published As
Publication number | Publication date |
---|---|
JPS6339566B2 (en) | 1988-08-05 |
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