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JPS5581813A - Composition containing coenzyme q10 and its perparation - Google Patents

Composition containing coenzyme q10 and its perparation

Info

Publication number
JPS5581813A
JPS5581813A JP15460978A JP15460978A JPS5581813A JP S5581813 A JPS5581813 A JP S5581813A JP 15460978 A JP15460978 A JP 15460978A JP 15460978 A JP15460978 A JP 15460978A JP S5581813 A JPS5581813 A JP S5581813A
Authority
JP
Japan
Prior art keywords
coenzyme
surfactant
neutral oil
dissolved
soft capsules
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP15460978A
Other versions
JPS6339566B2 (en
Inventor
Hiroshi Seo
Original Assignee
Nisshin Flour Milling Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nisshin Flour Milling Co Ltd filed Critical Nisshin Flour Milling Co Ltd
Priority to JP15460978A priority Critical patent/JPS6339566B2/ja
Publication of JPS5581813A publication Critical patent/JPS5581813A/en
Publication of JPS6339566B2 publication Critical patent/JPS6339566B2/ja
Application status is Expired legal-status Critical

Links

Abstract

PURPOSE: Coenzyme Q10 that is useful as a medicine is dissolved in a neutral oil in the presence of a surfactant, thus producing said composition for filling soft capsules with long-term stability and high handleability.
CONSTITUTION: Coenzyme Q10 is mixed with a neutral oil as soybean or corn oil and a surfactant as sorbitan monolaurate and dissolved in them, wherein heating the mixture over 70°C results in remarkably increased stability of the solution. The amount of the neutral oil used is over 5 times that of the coenzyme Q10 employed, preferably 10W20 times and that of the surfactant is 0.01W2, preferably 0.05W1 time. The resulting composition is a stable solution so that it precipitates no crystals even when stored for a long time and can be filled in soft capsules because of its high flowability. Coenzyme Q10 concerns itself with the electron transport system in vivo and shows outstandingly pharmaceutical effects on various kinds of diseases.
COPYRIGHT: (C)1980,JPO&Japio
JP15460978A 1978-12-16 1978-12-16 Expired JPS6339566B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP15460978A JPS6339566B2 (en) 1978-12-16 1978-12-16

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15460978A JPS6339566B2 (en) 1978-12-16 1978-12-16

Publications (2)

Publication Number Publication Date
JPS5581813A true JPS5581813A (en) 1980-06-20
JPS6339566B2 JPS6339566B2 (en) 1988-08-05

Family

ID=15587913

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15460978A Expired JPS6339566B2 (en) 1978-12-16 1978-12-16

Country Status (1)

Country Link
JP (1) JPS6339566B2 (en)

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5877810A (en) * 1981-11-01 1983-05-11 Furointo Sangyo Kk Oral drug composition containing polyglycerol unsaturated fatty acid ester
JPS6267019A (en) * 1985-09-18 1987-03-26 Nisshin Kagaku Kk Self-emulsifiable soft capsule agent
US4827062A (en) * 1985-03-28 1989-05-02 Eisai Co., Ltd. Composition containing ubidecarenone with absorption promoted
US5258179A (en) * 1989-10-27 1993-11-02 Nestec S.A. Protection of a food, cosmetic or pharmaceutical product against oxidation
EP0617957A1 (en) * 1993-03-30 1994-10-05 INVERNI DELLA BEFFA FARMACEUTICI S.r.l. Oral formulations of ubidecarenone in form of capsules
WO2003007907A1 (en) * 2001-07-12 2003-01-30 Aquanova German Solubilisate Technologies (Agt) Gmbh Water-free ubichinon concentrate
WO2003062182A1 (en) * 2002-01-18 2003-07-31 Kaneka Corporation Method for stabilizing reduced coenzyme q10 and composition therefor
JPWO2003007928A1 (en) * 2001-07-17 2004-11-04 出光興産株式会社 Poultry for ascites prevention agent
JP2005047851A (en) * 2003-07-29 2005-02-24 Nisshin Pharma Inc Ubidecarenone-containing composition
US7220429B2 (en) * 1999-03-29 2007-05-22 Soft Gel Technologies, Inc. Coenzyme Q10 formulation and process methodology for soft gel capsules manufacturing
US7273622B2 (en) * 2000-06-22 2007-09-25 Soft Gel Technologies, Inc. Super absorption Coenzyme Q10
JP2008005813A (en) * 2006-06-30 2008-01-17 Ezaki Glico Co Ltd Coenzyme q10-containing chocolate
WO2008002121A3 (en) * 2006-06-28 2008-09-18 Hovid Berhad A self-emulsifying composition for poorly bioavailable drugs
US7713523B2 (en) 2003-09-29 2010-05-11 Soft Gel Technologies, Inc. Solubilized CoQ-10 and carnitine
US8758743B2 (en) * 2003-01-17 2014-06-24 Taiyo Kagaku Co., Ltd. Compositions containing coenzyme Q10
US8865032B2 (en) 2003-09-29 2014-10-21 Soft Gel Technologies, Inc. Method of making a soft gel capsule comprising CoQ-10 solubilized in a monoterpene
US8932585B2 (en) 2003-09-29 2015-01-13 Soft Gel Technologies, Inc. Solubilized CoQ-10

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0236472U (en) * 1988-08-31 1990-03-09

Cited By (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5877810A (en) * 1981-11-01 1983-05-11 Furointo Sangyo Kk Oral drug composition containing polyglycerol unsaturated fatty acid ester
JPS6230965B2 (en) * 1981-11-01 1987-07-06 Furointo Sangyo Kk
US4827062A (en) * 1985-03-28 1989-05-02 Eisai Co., Ltd. Composition containing ubidecarenone with absorption promoted
JPS6267019A (en) * 1985-09-18 1987-03-26 Nisshin Kagaku Kk Self-emulsifiable soft capsule agent
US5258179A (en) * 1989-10-27 1993-11-02 Nestec S.A. Protection of a food, cosmetic or pharmaceutical product against oxidation
US5443842A (en) * 1993-03-30 1995-08-22 Inverni Della Beffa Farmaceutici S.R.L. Oral formulations of ubidecarenone in form of capsules
EP0617957A1 (en) * 1993-03-30 1994-10-05 INVERNI DELLA BEFFA FARMACEUTICI S.r.l. Oral formulations of ubidecarenone in form of capsules
US7220429B2 (en) * 1999-03-29 2007-05-22 Soft Gel Technologies, Inc. Coenzyme Q10 formulation and process methodology for soft gel capsules manufacturing
US7273622B2 (en) * 2000-06-22 2007-09-25 Soft Gel Technologies, Inc. Super absorption Coenzyme Q10
WO2003007907A1 (en) * 2001-07-12 2003-01-30 Aquanova German Solubilisate Technologies (Agt) Gmbh Water-free ubichinon concentrate
US7094804B2 (en) 2001-07-12 2006-08-22 Aquanova German Solubilisate Technologies Water free ubiquinone concentrate
JP4503286B2 (en) * 2001-07-17 2010-07-14 出光興産株式会社 Poultry for ascites prevention agent
JPWO2003007928A1 (en) * 2001-07-17 2004-11-04 出光興産株式会社 Poultry for ascites prevention agent
JP2010189437A (en) * 2002-01-18 2010-09-02 Kaneka Corp Method for stabilizing reduced coenzyme q10 and composition
US8562975B2 (en) 2002-01-18 2013-10-22 Kaneka Corporation Method for stabilizing reduced coenzyme Q10 and composition therefor
WO2003062182A1 (en) * 2002-01-18 2003-07-31 Kaneka Corporation Method for stabilizing reduced coenzyme q10 and composition therefor
US8758743B2 (en) * 2003-01-17 2014-06-24 Taiyo Kagaku Co., Ltd. Compositions containing coenzyme Q10
JP2005047851A (en) * 2003-07-29 2005-02-24 Nisshin Pharma Inc Ubidecarenone-containing composition
US7713523B2 (en) 2003-09-29 2010-05-11 Soft Gel Technologies, Inc. Solubilized CoQ-10 and carnitine
US10166192B2 (en) 2003-09-29 2019-01-01 Soft Gel Technologies, Inc. Solubilized CoQ-10
US10166193B2 (en) 2003-09-29 2019-01-01 Soft Gel Technologies, Inc. Method of making a soft gel capsule comprising CoQ-10 solubilized in a monoterpene
US8865032B2 (en) 2003-09-29 2014-10-21 Soft Gel Technologies, Inc. Method of making a soft gel capsule comprising CoQ-10 solubilized in a monoterpene
US8932584B2 (en) 2003-09-29 2015-01-13 Soft Gel Technologies, Inc. Solubilized CoQ-10
US8932585B2 (en) 2003-09-29 2015-01-13 Soft Gel Technologies, Inc. Solubilized CoQ-10
WO2008002121A3 (en) * 2006-06-28 2008-09-18 Hovid Berhad A self-emulsifying composition for poorly bioavailable drugs
JP2008005813A (en) * 2006-06-30 2008-01-17 Ezaki Glico Co Ltd Coenzyme q10-containing chocolate

Also Published As

Publication number Publication date
JPS6339566B2 (en) 1988-08-05

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