CN1599623B - 免疫刺激物向病毒样颗粒内的包装:制备方法与用途 - Google Patents
免疫刺激物向病毒样颗粒内的包装:制备方法与用途 Download PDFInfo
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- CN1599623B CN1599623B CN028179358A CN02817935A CN1599623B CN 1599623 B CN1599623 B CN 1599623B CN 028179358 A CN028179358 A CN 028179358A CN 02817935 A CN02817935 A CN 02817935A CN 1599623 B CN1599623 B CN 1599623B
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31899401P | 2001-09-14 | 2001-09-14 | |
| US60/318,994 | 2001-09-14 | ||
| US37414502P | 2002-04-22 | 2002-04-22 | |
| US60/374,145 | 2002-04-22 | ||
| PCT/IB2002/004132 WO2003024481A2 (en) | 2001-09-14 | 2002-09-16 | Packaging of immunostimulatory substances into virus-like particles: method of preparation and use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1599623A CN1599623A (zh) | 2005-03-23 |
| CN1599623B true CN1599623B (zh) | 2011-05-11 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN028179358A Expired - Lifetime CN1599623B (zh) | 2001-09-14 | 2002-09-16 | 免疫刺激物向病毒样颗粒内的包装:制备方法与用途 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US20030099668A1 (https=) |
| EP (2) | EP2196217A1 (https=) |
| JP (2) | JP4516748B2 (https=) |
| CN (1) | CN1599623B (https=) |
| AT (1) | ATE447967T1 (https=) |
| AU (2) | AU2002339224B2 (https=) |
| CA (1) | CA2492826C (https=) |
| CY (1) | CY1110585T1 (https=) |
| DE (1) | DE60234375D1 (https=) |
| DK (1) | DK1450856T3 (https=) |
| ES (1) | ES2335979T3 (https=) |
| WO (1) | WO2003024481A2 (https=) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107428813A (zh) * | 2014-12-31 | 2017-12-01 | 查克美特制药公司 | 组合肿瘤免疫疗法 |
| US12084655B2 (en) | 2018-04-09 | 2024-09-10 | Checkmate Pharmaceuticals | Packaging oligonucleotides into virus-like particles |
| US12246031B2 (en) | 2018-02-13 | 2025-03-11 | Checkmate Pharmaceuticals, Inc. | Compositions and methods for tumor immunotherapy |
Families Citing this family (208)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6572862B1 (en) * | 1989-11-08 | 2003-06-03 | Baylor College Of Medicine | Methods and reagents to detect and characterize Norwalk and related viruses |
| US20030232055A1 (en) * | 2000-07-31 | 2003-12-18 | Ruslan Medzhitov | Innate immune system-directed vaccines |
| US20030175287A1 (en) * | 2001-01-03 | 2003-09-18 | Yale University | Innate immune system-directed vaccines |
| US7264810B2 (en) * | 2001-01-19 | 2007-09-04 | Cytos Biotechnology Ag | Molecular antigen array |
| DE60234375D1 (de) | 2001-09-14 | 2009-12-24 | Cytos Biotechnology Ag | VERPACKUNG VON IMMUNSTIMULIERENDEM CpG IN VIRUSÄHNLICHEN PARTIKELN: HERSTELLUNGSVERFAHREN UND VERWENDUNG |
| CA2492823A1 (en) * | 2001-09-14 | 2003-03-27 | Cytos Biotechnology Ag | In vivo activation of antigen presenting cells for enhancement of immune responses induced by virus like particles |
| US7682618B2 (en) * | 2001-11-07 | 2010-03-23 | The United States Of America As Represented By The Secretary Of The Army | Generation of virus-like particles and use as panfilovirus vaccine |
| AU2002346424A1 (en) * | 2001-11-19 | 2003-06-10 | Becton, Dickinson And Company | Pharmaceutical compositions in particulate form |
| KR101092043B1 (ko) | 2002-04-22 | 2011-12-12 | 바이오니취 라이프 사이언시즈 인코포레이티드 | 올리고뉴클레오티드 조성물 및 면역 반응 조절시 이의 용도 |
| JP2006507800A (ja) | 2002-06-07 | 2006-03-09 | ラージ・スケール・バイオロジー・コーポレイション | 可撓性ワクチンアセンブリおよびワクチン送達プラットフォーム |
| BR0311995A (pt) * | 2002-06-20 | 2005-04-05 | Cytos Biotechnology Ag | Partìculas semelhantes a vìrus empacotadas para o uso como adjuvantes: método de preparação e uso |
| CA2490866A1 (en) * | 2002-06-26 | 2004-01-08 | Advanced Bionutrition Corporation | Viruses and virus-like particles for multiple antigen and target display |
| US7138252B2 (en) | 2002-07-17 | 2006-11-21 | Cytos Biotechnology Ag | Molecular antigen arrays |
| ATE441429T1 (de) * | 2002-07-19 | 2009-09-15 | Cytos Biotechnology Ag | Ghrelin-träger-konjugate |
| EP2338510A1 (en) * | 2002-07-19 | 2011-06-29 | Novartis Pharma AG | Vaccine compositions containing amyloid beta1-6 antigen arrays |
| CA2497798A1 (en) * | 2002-09-03 | 2004-04-22 | Large Scale Biology Corporation | Production of peptides in plants as viral coat protein fusions |
| CA2500661A1 (en) | 2002-10-01 | 2004-04-15 | Chiron Corporation | Anti-cancer and anti-infectious disease compositions and methods for using same |
| HUE031886T2 (en) | 2002-10-11 | 2017-08-28 | Glaxosmithkline Biologicals Sa | Polypeptide vaccines for extensive protection against hypervirulent meningococcal lines |
| CN1753687A (zh) | 2002-10-29 | 2006-03-29 | 科勒制药集团股份有限公司 | Cpg寡核苷酸在治疗丙型肝炎病毒感染中的应用 |
| CA2502015A1 (en) | 2002-12-11 | 2004-06-24 | Coley Pharmaceutical Group, Inc. | 5' cpg nucleic acids and methods of use |
| EP2172213B1 (en) | 2003-01-30 | 2013-04-03 | Novartis AG | Injectable vaccines against multiple meningococcal serogroups |
| AU2004224761A1 (en) | 2003-03-26 | 2004-10-07 | Cytos Biotechnology Ag | HIV-peptide-carrier-conjugates |
| US20060210588A1 (en) * | 2003-03-26 | 2006-09-21 | Cytos Biotechnology Ag | Hiv-peptide-carrier-conjugates |
| US7537767B2 (en) | 2003-03-26 | 2009-05-26 | Cytis Biotechnology Ag | Melan-A- carrier conjugates |
| EP1623229A2 (en) * | 2003-05-15 | 2006-02-08 | Cytos Biotechnology AG | Selection of b cells with specificity of interest: method of preparation and use |
| KR100872472B1 (ko) * | 2003-05-15 | 2008-12-05 | 도꾸리쯔교세이호징 가가꾸 기쥬쯔 신꼬 기꼬 | 면역자극제 |
| RU2375076C2 (ru) * | 2003-07-10 | 2009-12-10 | Цитос Биотехнологи Аг | Укомплектованные вирусоподобные частицы |
| US20060182793A1 (en) * | 2003-07-22 | 2006-08-17 | Cytos Biotechnology Ag | Cpg-packaged liposomes |
| US7320795B2 (en) * | 2003-07-30 | 2008-01-22 | Vaccine Research Institute Of San Diego | Rodent hepatitis B virus core proteins as vaccine platforms and methods of use thereof |
| US7144712B2 (en) * | 2003-07-30 | 2006-12-05 | Vaccine Research Institute Of San Diego | Human hepatitis B virus core proteins as vaccine platforms and methods of use thereof |
| EP1651258B1 (en) * | 2003-07-30 | 2014-03-19 | Vaccine Research Institute of San Diego | Hepatitis virus core proteins as vaccine platforms and methods of use thereof |
| GB0323103D0 (en) | 2003-10-02 | 2003-11-05 | Chiron Srl | De-acetylated saccharides |
| NZ546430A (en) | 2003-10-02 | 2009-04-30 | Novartis Vaccines & Diagnostic | Liquid vaccines for multiple meningococcal serogroups |
| CA2547511A1 (en) * | 2003-12-01 | 2005-07-28 | Dow Global Technolgies Inc. | Recombinant icosahedral virus like particle production in pseudomonads |
| CA2553594A1 (en) * | 2004-01-20 | 2005-07-28 | Cytos Biotechnology Ag | Particle-induced ghrelin immune response |
| JP3976742B2 (ja) | 2004-02-27 | 2007-09-19 | 江守商事株式会社 | インターフェロンアルファを誘導する免疫刺激オリゴヌクレオチド |
| JP5600375B2 (ja) | 2004-03-09 | 2014-10-01 | ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド | インフルエンザウイルスワクチン |
| GB0500787D0 (en) | 2005-01-14 | 2005-02-23 | Chiron Srl | Integration of meningococcal conjugate vaccination |
| NZ550533A (en) | 2004-04-30 | 2010-02-26 | Novartis Vaccines & Diagnostic | Meningococcal conjugate vaccination comprising N. meningitidis and diphtheria toxin |
| GB0409745D0 (en) | 2004-04-30 | 2004-06-09 | Chiron Srl | Compositions including unconjugated carrier proteins |
| GB0410866D0 (en) | 2004-05-14 | 2004-06-16 | Chiron Srl | Haemophilius influenzae |
| EP2848692B1 (en) | 2004-05-21 | 2017-08-16 | Novartis Vaccines and Diagnostics, Inc. | Alphavirus vectors for influenza virus vaccines |
| EP1773303A2 (en) * | 2004-05-25 | 2007-04-18 | Chimeracore, Inc. | Self-assembling nanoparticle drug delivery system |
| JP2008508320A (ja) | 2004-07-29 | 2008-03-21 | カイロン コーポレイション | Streptococcusagalactiaeのようなグラム陽性細菌に対する免疫原性組成物 |
| EP1784210A2 (en) * | 2004-08-04 | 2007-05-16 | Cytos Biotechnology AG | Carrier conjugates of gnrh-peptides |
| AU2005279303B2 (en) * | 2004-09-03 | 2011-10-27 | Consejo Superior De Investigaciones Cientificas | Nucleic acid sequences encoding proteins capable of associating into a virus-like particle |
| MX2007003171A (es) * | 2004-09-21 | 2007-05-23 | Cytos Biotechnology Ag | Particulas tipo virus que comprenden una proteina de fusion de la proteina de cubierta de ap205 y un polipeptido antigenico. |
| NZ554388A (en) * | 2004-10-05 | 2010-01-29 | Cytos Biotechnology Ag | VLP-Antigen conjugates and their uses as vaccines |
| US7959928B2 (en) | 2004-10-05 | 2011-06-14 | Cytos Biotechnology Ag | VLP-antigen conjugates and their uses as vaccines |
| GB0424092D0 (en) | 2004-10-29 | 2004-12-01 | Chiron Srl | Immunogenic bacterial vesicles with outer membrane proteins |
| WO2007001448A2 (en) | 2004-11-04 | 2007-01-04 | Massachusetts Institute Of Technology | Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals |
| WO2006063974A2 (en) * | 2004-12-13 | 2006-06-22 | Cytos Biotechnology Ag | Il-15 antigen arrays and uses thereof |
| US8420102B2 (en) * | 2006-03-07 | 2013-04-16 | Vaxinnate Corporation | Compositions that include hemagglutinin |
| WO2006083706A2 (en) * | 2005-01-31 | 2006-08-10 | Vaxinnate Corporation | Method to identify polypeptide toll-like receptor (tlr) ligands |
| GB0502095D0 (en) | 2005-02-01 | 2005-03-09 | Chiron Srl | Conjugation of streptococcal capsular saccharides |
| JP2008530245A (ja) | 2005-02-18 | 2008-08-07 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス, インコーポレイテッド | 尿路病原性菌株由来の抗原 |
| SI1858920T1 (sl) | 2005-02-18 | 2016-07-29 | Glaxosmithkline Biologicals S.A. | Proteini in nukleinske kisline iz escherichia coli, povezane z meningitisom/sepso |
| ZA200707413B (en) | 2005-03-18 | 2009-01-28 | Cytos Biotechnology Ag | Cat allergen fusion proteins and uses thereof |
| LT5414B (lt) * | 2005-04-13 | 2007-04-25 | Biotechnologijos Institutas | Monokloninių antikūnų gavimo būdas, hibridomos, gautos šiuo būdu ir rekombinantinės chimerinės į virusus panašios dalelės su įterptais kitų baltymų fragmentais kaip imunogenai hibridomų gavimui šiuo būdu |
| CA2605808A1 (en) * | 2005-04-25 | 2006-11-02 | 3M Innovative Properties Company | Immunostimulatory compositions |
| EP1736538A1 (en) | 2005-06-21 | 2006-12-27 | Cytos Biotechnology AG | Process for the preparative purification of virus-like-particles (VLPs) |
| ES2310062B1 (es) | 2005-07-15 | 2009-11-13 | Bionostra, S.L. | Particulas pseudovirales vacias quimericas derivadas del virus causante de la enfermedad de la bursitis infecciosa (ibdv), procedimiento de obtencion y aplicaciones. |
| NZ566971A (en) | 2005-09-28 | 2011-06-30 | Cytos Biotechnology Ag | Vaccine containing a virus like particle linked with an interleukin-1 molecule |
| CA2626253A1 (en) | 2005-10-18 | 2007-04-26 | Novartis Vaccines And Diagnostics, Inc. | Mucosal and systemic immunizations with alphavirus replicon particles |
| ES2514316T3 (es) | 2005-11-22 | 2014-10-28 | Novartis Vaccines And Diagnostics, Inc. | Partículas similares a virus (VLPs) de Norovirus y Sapovirus |
| GB0524066D0 (en) | 2005-11-25 | 2006-01-04 | Chiron Srl | 741 ii |
| CA2636139A1 (en) | 2005-12-14 | 2007-06-21 | Cytos Biotechnology Ag | Immunostimulatory nucleic acid packaged particles for the treatment of hypersensitivity |
| WO2007070682A2 (en) * | 2005-12-15 | 2007-06-21 | Massachusetts Institute Of Technology | System for screening particles |
| ES2536426T3 (es) | 2006-03-23 | 2015-05-25 | Novartis Ag | Compuestos de imidazoquinoxalina como inmunomoduladores |
| CA2648099C (en) * | 2006-03-31 | 2012-05-29 | The Brigham And Women's Hospital, Inc | System for targeted delivery of therapeutic agents |
| JP5630998B2 (ja) | 2006-05-15 | 2014-11-26 | マサチューセッツ インスティテュート オブ テクノロジー | 機能的粒子のためのポリマー |
| WO2007137117A2 (en) * | 2006-05-17 | 2007-11-29 | Massachusetts Institute Of Technology | Aptamer-directed drug delivery |
| US8541559B2 (en) | 2006-06-12 | 2013-09-24 | Cytos Biotechnology Ag | Process for producing aggregated oligonucleotides |
| AU2013204383B2 (en) * | 2006-06-12 | 2016-09-22 | Kuros Us Llc | Processes for packaging oligonucleotides into virus-like particles of RNA bacteriophages |
| WO2007150030A2 (en) * | 2006-06-23 | 2007-12-27 | Massachusetts Institute Of Technology | Microfluidic synthesis of organic nanoparticles |
| EP2586790A3 (en) | 2006-08-16 | 2013-08-14 | Novartis AG | Immunogens from uropathogenic Escherichia coli |
| US8586728B2 (en) * | 2006-12-12 | 2013-11-19 | Cytos Biotechnology Ag | Oligonucleotides containing high concentrations of guanine monomers |
| WO2008071774A1 (en) * | 2006-12-14 | 2008-06-19 | Cytos Biotechnology Ag | Purification process for coat protein of rna bacteriophages |
| EP2134830A2 (en) * | 2007-02-09 | 2009-12-23 | Massachusetts Institute of Technology | Oscillating cell culture bioreactor |
| JP2010523595A (ja) * | 2007-04-04 | 2010-07-15 | マサチューセッツ インスティテュート オブ テクノロジー | ポリ(アミノ酸)ターゲッティング部分 |
| CN101784655A (zh) * | 2007-04-27 | 2010-07-21 | 菲尼克斯股份有限公司 | 可溶性重组二十面体病毒样颗粒的改良生成和体内装配 |
| GB0713880D0 (en) | 2007-07-17 | 2007-08-29 | Novartis Ag | Conjugate purification |
| GB0714963D0 (en) | 2007-08-01 | 2007-09-12 | Novartis Ag | Compositions comprising antigens |
| KR101621837B1 (ko) | 2007-09-12 | 2016-05-17 | 노파르티스 아게 | Gas57 돌연변이 항원 및 gas57 항체 |
| JP2011500569A (ja) | 2007-10-12 | 2011-01-06 | マサチューセッツ インスティテュート オブ テクノロジー | ワクチンナノテクノロジー |
| US20110014231A1 (en) * | 2007-11-05 | 2011-01-20 | Mor Research Applications Ltd | Anti-measles cancer immunotherapy |
| GB0818453D0 (en) | 2008-10-08 | 2008-11-12 | Novartis Ag | Fermentation processes for cultivating streptococci and purification processes for obtaining cps therefrom |
| EP2537857B1 (en) | 2007-12-21 | 2017-01-18 | GlaxoSmithKline Biologicals SA | Mutant forms of streptolysin O |
| CN102356089B (zh) | 2008-02-21 | 2014-02-19 | 诺华股份有限公司 | 脑膜炎球菌fHBP多肽 |
| CN101559224B (zh) * | 2008-04-18 | 2012-07-11 | 北京生物制品研究所 | 脊髓灰质炎疫苗 |
| AU2009236585B2 (en) | 2008-04-18 | 2013-03-07 | Vaxinnate Corporation | Deletion mutants of flagellin and methods of use |
| NO339169B1 (no) * | 2008-04-24 | 2016-11-14 | Chemoforma Ltd | Funksjonelt fiskefôr omfattende peptidoglykan og nukleotider |
| GB0808780D0 (en) * | 2008-05-15 | 2008-06-18 | Big Dna Ltd | Fish vaccines |
| ES2569907T3 (es) | 2008-06-27 | 2016-05-13 | Zoetis Services Llc | Composiciones adyuvantes novedosas |
| US9296790B2 (en) | 2008-10-03 | 2016-03-29 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods and compositions for protein delivery |
| US8343498B2 (en) | 2008-10-12 | 2013-01-01 | Massachusetts Institute Of Technology | Adjuvant incorporation in immunonanotherapeutics |
| US8277812B2 (en) | 2008-10-12 | 2012-10-02 | Massachusetts Institute Of Technology | Immunonanotherapeutics that provide IgG humoral response without T-cell antigen |
| US8343497B2 (en) | 2008-10-12 | 2013-01-01 | The Brigham And Women's Hospital, Inc. | Targeting of antigen presenting cells with immunonanotherapeutics |
| US8591905B2 (en) | 2008-10-12 | 2013-11-26 | The Brigham And Women's Hospital, Inc. | Nicotine immunonanotherapeutics |
| SI2759306T1 (sl) * | 2008-12-09 | 2016-05-31 | Coley Pharmaceutical Group, Inc. | Imunostimulacijski oligonukleotidi |
| BRPI0922561A2 (pt) | 2008-12-09 | 2020-08-11 | Pfizer Vaccines Llc | vacina de peptídeo de ch3 da ige. |
| CN103897045A (zh) | 2009-01-12 | 2014-07-02 | 诺华股份有限公司 | 抗革兰氏阳性细菌疫苗中的Cna_B结构域 |
| US8568732B2 (en) | 2009-03-06 | 2013-10-29 | Novartis Ag | Chlamydia antigens |
| EP3263128A3 (en) | 2009-04-14 | 2018-01-24 | GlaxoSmithKline Biologicals S.A. | Compositions for immunising against staphylococcus aureus |
| WO2010122164A1 (en) | 2009-04-23 | 2010-10-28 | Cytos Biotechnology Ag | VIRUS-LIKE PARTICLES OF BACTERIOPHAGE φCB5 |
| NZ596058A (en) * | 2009-04-30 | 2013-08-30 | Cytos Biotechnology Ag | Influenza hemagglutinin compositions and uses thereof |
| US10988511B2 (en) | 2009-07-07 | 2021-04-27 | Glaxosmithkline Biologicals Sa | Conserved Escherichia bacterial IG-like domain (group 1) protein (ORF405) immunogens |
| AU2010272243A1 (en) | 2009-07-16 | 2012-03-08 | Novartis Ag | Detoxified Escherichia coli immunogens |
| JP2013500326A (ja) | 2009-07-30 | 2013-01-07 | ファイザー バクシーンズ エルエルシー | 抗原性タウペプチドおよびその使用 |
| CN102596240B (zh) | 2009-08-27 | 2015-02-04 | 诺华股份有限公司 | 包括脑膜炎球菌fHBP序列的杂交多肽 |
| WO2011027257A2 (en) | 2009-09-03 | 2011-03-10 | Pfizer Vaccines Llc | Pcsk9 vaccine |
| BR112012009014B8 (pt) | 2009-09-30 | 2022-10-04 | Novartis Ag | Processo para preparar conjugado de polissacarídeo capsular de s. aureus tipo 5 ou tipo 8 e molécula de transporte crm197, conjugado e composição imunogênica |
| GB0918392D0 (en) | 2009-10-20 | 2009-12-02 | Novartis Ag | Diagnostic and therapeutic methods |
| CA2779816A1 (en) | 2009-10-27 | 2011-05-05 | Novartis Ag | Modified meningococcal fhbp polypeptides |
| GB0919690D0 (en) | 2009-11-10 | 2009-12-23 | Guy S And St Thomas S Nhs Foun | compositions for immunising against staphylococcus aureus |
| WO2011080595A2 (en) | 2009-12-30 | 2011-07-07 | Novartis Ag | Polysaccharide immunogens conjugated to e. coli carrier proteins |
| TWI378144B (en) * | 2010-02-09 | 2012-12-01 | Univ Nat Pingtung Sci & Tech | Recombinant plasmic containing multicopy cpg motifs and transformant thereof for applying on dna adjuvant in avian vaccines |
| GB201003333D0 (en) | 2010-02-26 | 2010-04-14 | Novartis Ag | Immunogenic proteins and compositions |
| US8840902B2 (en) * | 2010-03-16 | 2014-09-23 | Biontech Ag | Tumor vaccination involving a humoral immune response against self-proteins |
| GB201005625D0 (en) | 2010-04-01 | 2010-05-19 | Novartis Ag | Immunogenic proteins and compositions |
| EP2558069A1 (en) | 2010-04-13 | 2013-02-20 | Novartis AG | Benzonapthyridine compositions and uses thereof |
| KR20130121699A (ko) | 2010-05-28 | 2013-11-06 | 테트리스 온라인, 인코포레이티드 | 상호작용 혼성 비동기 컴퓨터 게임 기반구조 |
| EP2575868A1 (en) | 2010-06-07 | 2013-04-10 | Pfizer Vaccines LLC | Ige ch3 peptide vaccine |
| GB201009861D0 (en) | 2010-06-11 | 2010-07-21 | Novartis Ag | OMV vaccines |
| US9192661B2 (en) | 2010-07-06 | 2015-11-24 | Novartis Ag | Delivery of self-replicating RNA using biodegradable polymer particles |
| US9549901B2 (en) | 2010-09-03 | 2017-01-24 | The Brigham And Women's Hospital, Inc. | Lipid-polymer hybrid particles |
| GB201101665D0 (en) | 2011-01-31 | 2011-03-16 | Novartis Ag | Immunogenic compositions |
| WO2012072769A1 (en) | 2010-12-01 | 2012-06-07 | Novartis Ag | Pneumococcal rrgb epitopes and clade combinations |
| CA2860331A1 (en) | 2010-12-24 | 2012-06-28 | Novartis Ag | Compounds |
| EP2471926A3 (en) | 2010-12-30 | 2012-07-11 | Intervet International BV | Immunostimulatory oligodeoxynucleotides |
| US9238679B2 (en) | 2011-02-11 | 2016-01-19 | The Trustees Of The University Of Pennslyvania | Nucleic acid molecule encoding hepatitis B virus core protein and surface antigen protein and vaccine comprising the same |
| EA032364B1 (ru) * | 2011-02-11 | 2019-05-31 | Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания | Молекула нуклеиновой кислоты, кодирующая коровый белок вируса гепатита в, и вакцина, содержащая указанную молекулу |
| WO2012131504A1 (en) | 2011-03-02 | 2012-10-04 | Pfizer Inc. | Pcsk9 vaccine |
| JPWO2012157408A1 (ja) | 2011-05-13 | 2014-07-31 | Lsipファンド運営合同会社 | 細胞傷害性t細胞誘導剤 |
| PL2714908T3 (pl) * | 2011-05-26 | 2018-07-31 | Intervet International B.V. | Oligodeoksynukleotydy immunostymulacyjne |
| MX346596B (es) * | 2011-05-26 | 2017-03-23 | Intervet Int Bv | Oligodesoxinucleotidos inmunoestimuladores. |
| EP2729165B1 (en) | 2011-07-06 | 2017-11-08 | GlaxoSmithKline Biologicals SA | Immunogenic combination compositions and uses thereof |
| CA2841047A1 (en) | 2011-07-06 | 2013-01-10 | Novartis Ag | Immunogenic compositions and uses thereof |
| DK2734544T3 (da) * | 2011-07-18 | 2021-03-15 | Us Health | Fremgangsmåder og sammensætninger til hæmning af polyomavirus-associeret patologi |
| GB201114923D0 (en) | 2011-08-30 | 2011-10-12 | Novartis Ag | Immunogenic proteins and compositions |
| EP2755994A2 (en) | 2011-09-14 | 2014-07-23 | Novartis AG | Escherichia coli vaccine combination |
| WO2013084071A2 (en) | 2011-12-08 | 2013-06-13 | Novartis Ag | Clostridium difficile toxin-based vaccine |
| EP2798059B1 (en) | 2011-12-21 | 2021-09-29 | Apse, Llc | Process for purifying vlps with capsids resistant to hydrolases |
| CN104011080B (zh) | 2011-12-22 | 2017-10-20 | 弗·哈夫曼-拉罗切有限公司 | 用于真核细胞的全长抗体展示系统及其用途 |
| WO2013108272A2 (en) | 2012-01-20 | 2013-07-25 | International Centre For Genetic Engineering And Biotechnology | Blood stage malaria vaccine |
| WO2013124473A1 (en) | 2012-02-24 | 2013-08-29 | Novartis Ag | Pilus proteins and compositions |
| AU2013240248B2 (en) | 2012-03-26 | 2018-12-20 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Delivery of packaged RNA to mammalian cells |
| RU2727476C2 (ru) | 2012-04-26 | 2020-07-21 | Новартис Аг | Антигены и антигенные композиции |
| US10279026B2 (en) | 2012-04-26 | 2019-05-07 | Glaxosmithkline Biologicals Sa | Antigens and antigen combinations |
| RU2014151567A (ru) | 2012-05-22 | 2016-07-10 | Новартис Аг | Конъюгат менингококка серогруппы х |
| US20150140068A1 (en) | 2012-07-06 | 2015-05-21 | Novartis Ag | Immunogenic compositions and uses thereof |
| US8932598B2 (en) | 2012-08-28 | 2015-01-13 | Vaxinnate Corporation | Fusion proteins and methods of use |
| TR201808684T4 (tr) | 2012-10-02 | 2018-07-23 | Glaxosmithkline Biologicals Sa | Lineer olmayan sakarit konjügatları. |
| RU2015106791A (ru) | 2012-10-03 | 2016-11-20 | Глэксосмитиклайн Байолоджикалз Са | Иммуногенные композиции |
| CA2936092A1 (en) | 2013-01-23 | 2014-07-31 | The Board Of Trustees Of The Leland Stanford Junior University | Stabilized hepatitis b core polypeptide |
| US11576958B2 (en) | 2013-02-07 | 2023-02-14 | Children's Medical Center Corporation | Protein antigens that provide protection against pneumococcal colonization and/or disease |
| US10130691B2 (en) | 2013-03-15 | 2018-11-20 | Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center | Compositions and methods for treating fungal and bacterial pathogens |
| CA2942654A1 (en) * | 2013-03-15 | 2014-09-18 | Bullet Biotechnology, Inc. | Specific multivalent virus-like particle vaccines and uses thereof |
| EP3010494B1 (en) | 2013-06-19 | 2018-08-15 | Apse Llc | Method using capsids resistant to hydrolases |
| EP3024936B1 (en) | 2013-07-25 | 2019-09-04 | Exicure, Inc. | Spherical nucleic acid-based constructs as immunostimulatory agents for prophylactic and therapeutic use |
| WO2015024992A2 (en) * | 2013-08-22 | 2015-02-26 | Cytos Biotechnology Ag | Treatment of asthma |
| UA130246C2 (uk) | 2013-09-19 | 2025-12-31 | Зоетіс Сервісіз Ллс | Ад'ювант на основі олії |
| CN106232807A (zh) | 2013-12-16 | 2016-12-14 | 美利坚合众国, 由健康及人类服务部部长代表 | 通过使用vlp复制子投递ii类mhc抗原的癌症免疫疗法 |
| WO2015123291A1 (en) | 2014-02-11 | 2015-08-20 | The Usa, As Represented By The Secretary, Dept. Of Health And Human Services | Pcsk9 vaccine and methods of using the same |
| TR201908550T4 (tr) | 2014-06-04 | 2019-07-22 | Exicure Inc | Profilaktik veya terapötik uygulamalar için lipozomal sferik nükleik asitler tarafından immün modülatörlerin çok değerlikli teslimi. |
| US11213593B2 (en) | 2014-11-21 | 2022-01-04 | Northwestern University | Sequence-specific cellular uptake of spherical nucleic acid nanoparticle conjugates |
| WO2016112921A1 (en) | 2015-01-15 | 2016-07-21 | University Of Copenhagen | Virus-like particle with efficient epitope display |
| CN115317600A (zh) | 2015-01-16 | 2022-11-11 | 硕腾服务有限责任公司 | 口蹄疫疫苗 |
| EP3368068B1 (en) | 2015-10-30 | 2020-11-18 | University of Copenhagen | Virus like particle with efficient epitope display |
| WO2017173334A1 (en) | 2016-04-01 | 2017-10-05 | Checkmate Pharmaceuticals, Inc. | Fc receptor-mediated drug delivery |
| WO2017184655A1 (en) * | 2016-04-18 | 2017-10-26 | University Of Florida Research Foundaiton, Inc. | Stable poliovirus variants and uses thereof |
| BR112018071965A2 (pt) | 2016-04-27 | 2019-03-06 | Benchmark Animal Health Ltd | tratamento da dermatite atópica canina |
| WO2017186808A1 (en) | 2016-04-27 | 2017-11-02 | Allergy Therapeutics (Uk) Limited | Treatment of peanut allergy |
| WO2018039629A2 (en) | 2016-08-25 | 2018-03-01 | Northwestern University | Micellar spherical nucleic acids from thermoresponsive, traceless templates |
| BE1025162B9 (fr) | 2016-12-06 | 2019-01-07 | Glaxosmithkline Biologicals Sa | Procede de purification pour les polysaccharides capsulaires |
| US10434171B2 (en) | 2016-12-23 | 2019-10-08 | United States of America as Represented by Secretary of Agriculture | Microfluidized Mycobacterium avium fragments as an adjuvant and carrier for mucosal vaccine delivery |
| US11018610B2 (en) | 2017-01-27 | 2021-05-25 | Franklin Electric Co., Inc. | Motor drive system and method |
| US11696954B2 (en) | 2017-04-28 | 2023-07-11 | Exicure Operating Company | Synthesis of spherical nucleic acids using lipophilic moieties |
| US12459965B2 (en) | 2017-10-09 | 2025-11-04 | Compass Pathfinder Limited | Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use |
| GB2571696B (en) | 2017-10-09 | 2020-05-27 | Compass Pathways Ltd | Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced |
| WO2019173438A1 (en) | 2018-03-06 | 2019-09-12 | Stc. Unm | Compositions and methods for reducing serum triglycerides |
| JP7366057B2 (ja) | 2018-04-19 | 2023-10-20 | チェックメイト ファーマシューティカルズ, インコーポレイテッド | 合成rig-i様受容体アゴニスト |
| US20220111040A1 (en) * | 2018-08-07 | 2022-04-14 | Institute Of Biophyscis, Chinese Academy Of Sciences | Method for activating cd4+t cell |
| JP7623282B2 (ja) | 2018-12-20 | 2025-01-28 | サイバ アクチェンゲゼルシャフト | 融合によって修飾されたcmvのウイルス様粒子 |
| US12377112B2 (en) | 2019-04-17 | 2025-08-05 | Compass Pathfinder Limited | Methods of treating neurocognitive disorders, chronic pain and reducing inflammation |
| WO2021016509A1 (en) * | 2019-07-24 | 2021-01-28 | Unm Rainforest Innovations | Malaria immunogen and methods for using same |
| JP7707161B2 (ja) * | 2019-10-23 | 2025-07-14 | チェックメイト ファーマシューティカルズ, インコーポレイテッド | 合成rig-i様受容体アゴニスト |
| CN111166727A (zh) * | 2019-11-15 | 2020-05-19 | 河南省生物工程技术研究中心 | 一种肿瘤免疫治疗复合物及其制备方法和用途 |
| CN110862435B (zh) * | 2019-12-05 | 2021-09-24 | 中国农业大学 | 非洲猪瘟ctl表位多肽及其应用 |
| CN111214663B (zh) * | 2020-03-06 | 2022-03-15 | 中国人民解放军军事科学院军事医学研究院 | Tmed2在作为埃博拉病毒病治疗靶点中的应用 |
| CN111253494B (zh) * | 2020-03-10 | 2022-04-26 | 天康制药(苏州)有限公司 | 猪口蹄疫病毒和猪轮状病毒的融合蛋白、类病毒颗粒和疫苗及制备方法 |
| CN111281973A (zh) * | 2020-03-31 | 2020-06-16 | 清华大学 | 含有trpv2激动剂的疫苗佐剂及其用途 |
| CU20200028A7 (es) * | 2020-04-20 | 2021-11-04 | Ct Ingenieria Genetica Biotecnologia | Nucleoproteína viral y formulaciones que la contienen |
| WO2021252450A1 (en) * | 2020-06-08 | 2021-12-16 | Adaptive Phage Therapeutics, Inc. | Phage display vaccine for covid-19 using a novel peptide sequence |
| MX2022015860A (es) | 2020-06-12 | 2023-01-24 | Glaxosmithkline Biologicals Sa | Inmunizacion bacteriana que utiliza una vacuna con nanoparticulas. |
| WO2021260131A1 (en) | 2020-06-25 | 2021-12-30 | Saiba AG | Virus-like particles of cmv modified by fusion |
| CN113136372B (zh) * | 2021-05-28 | 2023-08-01 | 广西大学 | 一种重组噬菌体的构建方法 |
| US12121574B2 (en) * | 2021-09-28 | 2024-10-22 | Unm Rainforest Innovations | Malaria immunogen and methods for using same |
| WO2023111826A1 (en) | 2021-12-14 | 2023-06-22 | Glaxosmithkline Biologicals Sa | Bacterial immunization using qbeta hairpin nanoparticle constructs |
| WO2023168023A1 (en) | 2022-03-04 | 2023-09-07 | Reset Pharmaceuticals, Inc. | Co-crystals or salts comprising psilocin |
| CA3266002A1 (en) | 2022-08-30 | 2024-03-07 | Saiba Animal Health Ag | Veterinary compositions of modified virus-like particles of cmv and ngf antigens |
| EP4581044A1 (en) | 2022-08-31 | 2025-07-09 | Unm Rainforest Innovations | Compositions targeting apoptosis-associated speck-like protein with caspase activation and recruitment domain (asc) and methods of use |
| AU2023358546A1 (en) * | 2022-10-14 | 2025-05-29 | Longhorn Vaccines And Diagnostics, Llc | Vaccines and antibodies for the treatment and prevention of microbial infections |
| WO2024091589A1 (en) * | 2022-10-28 | 2024-05-02 | Unm Rainforest Innovations | Malaria immunogen and methods for using same |
| WO2024164006A2 (en) * | 2023-02-03 | 2024-08-08 | The Regents Of The University Of California | Self-amplifying rna form of a constitutively-active sting protein for enhancing t-cell response to antigenpresenting cells |
| US20250281584A1 (en) | 2024-03-04 | 2025-09-11 | Boehringer Ingelheim Vetmedica Gmbh | Active vaccination for the treatment of ngf-related disorders |
| WO2025186317A1 (en) | 2024-03-06 | 2025-09-12 | Elanco Us Inc. | Veterinary compositions of modified virus-like particles of cmv and canine il-1beta mutein antigens |
| WO2025242657A1 (en) | 2024-05-21 | 2025-11-27 | Shape Biopharmaceuticals Ag | Lipopeptide building blocks and aggregates |
Family Cites Families (131)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2034118A1 (en) | 1970-07-09 | 1972-01-13 | Seinfeld, Hugo, Brendel, Walter, Prof Dr . 8000 München | Xenogenic nucleic acids for enhancing antigenicity - of peptides and proteins |
| US4722840A (en) | 1984-09-12 | 1988-02-02 | Chiron Corporation | Hybrid particle immunogens |
| FR2581394B1 (fr) | 1985-05-02 | 1988-08-05 | Grp Genie Genetique | Particules ayant les proprietes immunogenes de l'antigene hbs et portant un site antigenique etranger aux epitopes portes par l'antigene hbs, vecteurs et cellules animales pour la production de telles particules et compositions contenant de telles particules pour la production de vaccins mixtes |
| US5374426A (en) | 1986-09-03 | 1994-12-20 | University Of Saskatchewan | Rotavirus nucleocapsid protein VP6 in vaccine compositions |
| US4918166A (en) | 1987-04-10 | 1990-04-17 | Oxford Gene Systems Limited | Particulate hybrid HIV antigens |
| US5057540A (en) * | 1987-05-29 | 1991-10-15 | Cambridge Biotech Corporation | Saponin adjuvant |
| GB8913737D0 (en) | 1989-06-15 | 1989-08-02 | Univ Birmingham | A novel anti-allergy treatment |
| NZ235315A (en) | 1989-09-19 | 1991-09-25 | Wellcome Found | Chimaeric hepadnavirus core antigen proteins and their construction |
| DE69120146T2 (de) | 1990-01-12 | 1996-12-12 | Cell Genesys Inc | Erzeugung xenogener antikörper |
| US5334394A (en) | 1990-06-22 | 1994-08-02 | The Regents Of The University Of California | Human immunodeficiency virus decoy |
| EP0468520A3 (en) | 1990-07-27 | 1992-07-01 | Mitsui Toatsu Chemicals, Inc. | Immunostimulatory remedies containing palindromic dna sequences |
| EP0563091A1 (en) | 1990-12-20 | 1993-10-06 | SMITHKLINE BEECHAM BIOLOGICALS s.a. | Vaccines based on hepatitis b surface antigen |
| GB9101550D0 (en) | 1991-01-24 | 1991-03-06 | Mastico Robert A | Antigen-presenting chimaeric protein |
| GB9114003D0 (en) * | 1991-06-28 | 1991-08-14 | Mastico Robert A | Chimaeric protein |
| GB9213601D0 (en) * | 1992-06-26 | 1992-08-12 | Mastico Robert A | Protein based delivery system |
| ATE162198T1 (de) | 1992-07-27 | 1998-01-15 | Hybridon Inc | Oligonukleotid alkylphosphonothiate |
| FR2695563B1 (fr) | 1992-09-11 | 1994-12-02 | Pasteur Institut | Microparticules portant des antigènes et leur utilisation pour l'induction de réponses humorales ou cellulaires. |
| JP3814290B2 (ja) | 1993-12-09 | 2006-08-23 | エスクナー,ハインリッヒ | 抗原用のアジュバントおよびその製法ならびに用途 |
| WO1995026204A1 (en) | 1994-03-25 | 1995-10-05 | Isis Pharmaceuticals, Inc. | Immune stimulation by phosphorothioate oligonucleotide analogs |
| US6727230B1 (en) * | 1994-03-25 | 2004-04-27 | Coley Pharmaceutical Group, Inc. | Immune stimulation by phosphorothioate oligonucleotide analogs |
| FR2722506B1 (fr) | 1994-07-13 | 1996-08-14 | Rhone Poulenc Rorer Sa | Composition contenant des acides nucleiques, preparation et utilisations |
| EP1167379A3 (en) | 1994-07-15 | 2004-09-08 | University Of Iowa Research Foundation | Immunomodulatory oligonucleotides |
| US20030050263A1 (en) | 1994-07-15 | 2003-03-13 | The University Of Iowa Research Foundation | Methods and products for treating HIV infection |
| US20030026782A1 (en) | 1995-02-07 | 2003-02-06 | Arthur M. Krieg | Immunomodulatory oligonucleotides |
| US6429199B1 (en) * | 1994-07-15 | 2002-08-06 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules for activating dendritic cells |
| US6207646B1 (en) * | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US6239116B1 (en) * | 1994-07-15 | 2001-05-29 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US5935821A (en) * | 1995-01-17 | 1999-08-10 | Board Of Trustees Of The University Of Kentucky | Polynucleotides related to monoclonal antibody 1A7 and use for the treatment of melanoma and small cell carcinoma |
| CN1185811A (zh) | 1995-03-31 | 1998-06-24 | H·沃尔夫 | 依赖于逆转录病毒样颗粒的抗原呈递系统 |
| US5994315A (en) | 1995-06-07 | 1999-11-30 | East Carolina University | Low adenosine agent, composition, kit and method for treatment of airway disease |
| US5780448A (en) | 1995-11-07 | 1998-07-14 | Ottawa Civic Hospital Loeb Research | DNA-based vaccination of fish |
| ZA9756B (en) | 1996-01-16 | 1997-07-17 | Warner Lambert Co | Process for preparing 4,6-disubstituted pyrido[3,4-d]-pyrimidines |
| PL187439B1 (pl) | 1996-01-23 | 2004-07-30 | Icn Pharmaceuticals | Zastosowanie rybawiryny |
| CA2244946C (en) | 1996-01-30 | 2010-04-13 | The Regents Of The University Of California | Gene expression vectors which generate an antigen specific immune response and methods of using the same |
| GB9621091D0 (en) | 1996-10-09 | 1996-11-27 | Fondation Pour Le Perfectionem | Attenuated microorganisms strains and their uses |
| ATE292980T1 (de) | 1996-10-11 | 2005-04-15 | Univ California | Immunostimulierende oligonucleotidekonjugate |
| EP0855184A1 (en) | 1997-01-23 | 1998-07-29 | Grayson B. Dr. Lipford | Pharmaceutical composition comprising a polynucleotide and an antigen especially for vaccination |
| GB9702021D0 (en) | 1997-01-31 | 1997-03-19 | Imperial College | Medicaments |
| WO1998037919A1 (en) | 1997-02-28 | 1998-09-03 | University Of Iowa Research Foundation | USE OF NUCLEIC ACIDS CONTAINING UNMETHYLATED CpG DINUCLEOTIDE IN THE TREATMENT OF LPS-ASSOCIATED DISORDERS |
| US6406705B1 (en) * | 1997-03-10 | 2002-06-18 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
| DK1005368T3 (da) | 1997-03-10 | 2010-01-04 | Ottawa Hospital Res Inst | Anvendelse af nukleinsyrer, der indeholder ikke-metyleret CpG dinukleotid i kombination med alun som hjælpestoffer |
| WO1998049195A1 (en) | 1997-04-29 | 1998-11-05 | Universiteit Utrecht | Corona virus-like particles as tools for vaccination and therapy |
| AU750702B2 (en) * | 1997-05-01 | 2002-07-25 | Chiron Corporation | Use of virus-like particles as adjuvants |
| EP1003531B1 (en) | 1997-05-20 | 2007-08-22 | Ottawa Health Research Institute | Processes for preparing nucleic acid constructs |
| EP1003850B1 (en) | 1997-06-06 | 2009-05-27 | The Regents of the University of California | Inhibitors of dna immunostimulatory sequence activity |
| ATE377022T1 (de) * | 1997-06-23 | 2007-11-15 | Ludwig Inst Cancer Res | Isolierte decapeptide, die an hla moleküle binden,sowie deren verwendung |
| CA2297786C (en) | 1997-08-05 | 2011-06-14 | Vlaams Interuniversitair Instituut Voor Biotechnologie | New immunoprotective influenza antigen and its use in vaccination |
| US6169175B1 (en) | 1997-08-06 | 2001-01-02 | Centers For Disease Control And Prevention | Preparation and use of recombinant influenza A virus M2 construct vaccines |
| JP4663113B2 (ja) | 1997-09-05 | 2011-03-30 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 抗原刺激顆粒球媒介炎症を予防または軽減するための免疫刺激オリゴヌクレオチドの使用 |
| US5989868A (en) | 1997-09-12 | 1999-11-23 | The Board Of Regents Of The University Of Oklahoma | Fusion protein systems designed to increase soluble cytoplasmic expression of heterologous proteins in esherichia coli |
| US6171591B1 (en) * | 1997-12-08 | 2001-01-09 | Pentamer Pharmaceuticals, Inc. | Recombinant nodavirus compositions and methods |
| CZ302092B6 (cs) | 1998-02-12 | 2010-10-06 | Immune Complex, Corporation | Konjugát upraveného jaderného proteinu hepatitidy B, jeho cástice, inokulum a zpusob indukce protilátek |
| AU760549B2 (en) | 1998-04-03 | 2003-05-15 | University Of Iowa Research Foundation, The | Methods and products for stimulating the immune system using immunotherapeutic oligonucleotides and cytokines |
| US6541438B1 (en) * | 1998-05-01 | 2003-04-01 | The Procter & Gamble Company | Laundry detergent and/or fabric care compositions comprising a modified cellulase |
| US5990085A (en) | 1998-05-04 | 1999-11-23 | Michigan State University | Inhibin-HBc fusion protein |
| JP2002514397A (ja) * | 1998-05-14 | 2002-05-21 | コーリー ファーマシューティカル ゲーエムベーハー | CpGオリゴヌクレオチドを用いる造血調節の方法 |
| CN1168702C (zh) | 1998-06-30 | 2004-09-29 | Om药业 | 酰基-二肽类化合物,其制备方法以及含有前述化合物的药物组合物 |
| JP2002521489A (ja) | 1998-07-27 | 2002-07-16 | ユニバーシティ オブ アイオワ リサーチ ファウンデーション | CpGオリゴヌクレオチドの立体異性体および関連する方法 |
| WO2000008568A1 (en) | 1998-08-04 | 2000-02-17 | Dryken Technologies | Method and system for dynamic data-mining and on-line communication of customized information |
| PT1104306E (pt) | 1998-08-10 | 2006-05-31 | Antigenics Inc | Composicoes de cpg e adjuvantes de saponina e seus metodos |
| US5962636A (en) * | 1998-08-12 | 1999-10-05 | Amgen Canada Inc. | Peptides capable of modulating inflammatory heart disease |
| US6927278B1 (en) * | 1998-09-01 | 2005-08-09 | Trustees Of The University Of Pennsylvania | Peptide scaffolds for transfer of molecules into eukaryotic cells |
| WO2000014217A2 (en) | 1998-09-03 | 2000-03-16 | Coley Pharmaceutical Gmbh | G-motif oligonucleotides and uses thereof |
| DE69929232T2 (de) * | 1998-10-21 | 2006-08-31 | The United States Government As Represented By The Department Of Health And Human Services | Virusähnliche partikel zur induktion von autoantikörpern |
| MXPA01005389A (es) * | 1998-11-30 | 2003-03-27 | Cytos Biotechnology Ag | Presentacion molecular ordenada de antigenos, metodos de preparacion y uso. |
| EP1230257A4 (en) | 1998-12-23 | 2003-08-13 | Thompson Boyce Plant Res | EXPRESSION OF IMMUNOGENIC HEPATITIS B SURFACE ANTIGENS IN TRANSGENIC PLANTS |
| AU2487300A (en) | 1998-12-31 | 2000-07-31 | Chiron Corporation | Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof |
| WO2000046365A1 (en) * | 1999-02-02 | 2000-08-10 | Biocache Pharmaceuticals, Inc. | Advanced antigen presentation platform |
| EP1151124A1 (en) | 1999-02-03 | 2001-11-07 | The Children's Medical Center Corporation | Gene repair involving in vivo excision of targeting dna |
| EP1155038A1 (en) | 1999-02-25 | 2001-11-21 | SMITHKLINE BEECHAM BIOLOGICALS (S.A.), formerly SMITHKLINE BIOLOGICALS (S.A.) | Epitopes or mimotopes derived from the c-epsilon-3 or c-epsilon-4 domains of ige, antagonists thereof, and their therapeutic uses |
| EP1156781B1 (en) * | 1999-02-26 | 2005-06-08 | Chiron Corporation | Microemulsions with adsorbed macromolecules and microparticles |
| WO2000054803A2 (en) | 1999-03-16 | 2000-09-21 | Panacea Pharmaceuticals, Llc | Immunostimulatory nucleic acids and antigens |
| US6977245B2 (en) * | 1999-04-12 | 2005-12-20 | The United States Of America As Represented By The Department Of Health And Human Services | Oligodeoxynucleotide and its use to induce an immune response |
| PT1187629E (pt) | 1999-04-19 | 2005-02-28 | Glaxosmithkline Biolog Sa | Composicao adjuvante que compreende saponina e um oligonucleotido imunoestimulador |
| AU5821000A (en) | 1999-06-29 | 2001-01-31 | Smithkline Beecham Biologicals (Sa) | Vaccine |
| ATE419869T1 (de) | 1999-08-19 | 2009-01-15 | Dynavax Tech Corp | Methode zur modulierung eines immunantwortes mit immunstimulierenden sequencen und zusammensetzungen dafür |
| WO2001016320A1 (en) | 1999-08-30 | 2001-03-08 | Ludwig Institute For Cancer Research | Isolated nona and decapeptides which bind to hla molecules, and the use thereof |
| JP2001151698A (ja) * | 1999-09-10 | 2001-06-05 | Nichiko Pharmaceutical Co Ltd | インフルエンザワクチン |
| NZ517929A (en) * | 1999-09-25 | 2004-02-27 | Univ Iowa Res Found | Immunostimulatory nucleic acids |
| AU783118B2 (en) | 1999-09-27 | 2005-09-29 | Coley Pharmaceutical Gmbh | Methods related to immunostimulatory nucleic acid-induced interferon |
| US6949520B1 (en) * | 1999-09-27 | 2005-09-27 | Coley Pharmaceutical Group, Inc. | Methods related to immunostimulatory nucleic acid-induced interferon |
| PT1221968E (pt) * | 1999-10-13 | 2010-04-16 | Novartis Vaccines & Diagnostic | Processo de obtenção de respostas imunes celulares de proteínas |
| US7223398B1 (en) | 1999-11-15 | 2007-05-29 | Dynavax Technologies Corporation | Immunomodulatory compositions containing an immunostimulatory sequence linked to antigen and methods of use thereof |
| EP1233783B9 (en) * | 1999-11-24 | 2006-03-15 | Chiron Corporation | Hbv/hcv virus-like particle |
| CA2397374A1 (en) | 2000-01-13 | 2001-07-19 | Antigenics Inc. | Innate immunity-stimulating compositions of cpg and saponin and methods thereof |
| US6261326B1 (en) | 2000-01-13 | 2001-07-17 | North Carolina State University | Method for introducing dyes and other chemicals into a textile treatment system |
| US20010044416A1 (en) * | 2000-01-20 | 2001-11-22 | Mccluskie Michael J. | Immunostimulatory nucleic acids for inducing a Th2 immune response |
| AT409085B (de) * | 2000-01-28 | 2002-05-27 | Cistem Biotechnologies Gmbh | Pharmazeutische zusammensetzung zur immunmodulation und herstellung von vakzinen |
| WO2001056603A1 (en) | 2000-02-01 | 2001-08-09 | Tanox, Inc. | Cd40-binding apc-activating molecules |
| US7585847B2 (en) * | 2000-02-03 | 2009-09-08 | Coley Pharmaceutical Group, Inc. | Immunostimulatory nucleic acids for the treatment of asthma and allergy |
| US6756044B1 (en) | 2000-02-09 | 2004-06-29 | Genvec, Inc. | Antigenic complexes and methods |
| JP2003523398A (ja) * | 2000-02-24 | 2003-08-05 | ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ | 樹状細胞のインビボ活性化によるアジュバント治療 |
| DE60122300T2 (de) | 2000-04-07 | 2007-08-30 | The University Of Leeds | Hepatitis b kernprotein fusionsproteine |
| CA2407897A1 (en) | 2000-05-05 | 2001-11-15 | Cytos Biotechnology Ag | Molecular antigen arrays and vaccines |
| AU2001266163B2 (en) | 2000-06-22 | 2006-07-13 | Celltech Pharmaceticals Limited | Modification of hepatitis b core antigen |
| AUPQ912000A0 (en) | 2000-07-31 | 2000-08-24 | Crown In The Right Of The Queensland Department Of Health, The | Improved virus like particles |
| US20030138769A1 (en) | 2000-08-16 | 2003-07-24 | Birkett Ashley J. | Immunogenic HBc chimer particles having enhanced stability |
| ES2260291T3 (es) | 2000-09-28 | 2006-11-01 | Chiron Corporation | Microparticulas para la administracion de acidos nucleicos heterologos. |
| AU2002244337B2 (en) | 2000-10-18 | 2005-08-11 | Glaxosmithkline Biologicals S.A. | Vaccines |
| WO2002053141A2 (en) | 2000-12-14 | 2002-07-11 | Coley Pharmaceutical Group, Inc. | Inhibition of angiogenesis by nucleic acids |
| WO2003031466A2 (en) | 2001-10-05 | 2003-04-17 | Cytos Biotechnology Ag | Angiotensin peptide-carrier conjugates and uses thereof |
| US7128911B2 (en) * | 2001-01-19 | 2006-10-31 | Cytos Biotechnology Ag | Antigen arrays for treatment of bone disease |
| US7264810B2 (en) | 2001-01-19 | 2007-09-04 | Cytos Biotechnology Ag | Molecular antigen array |
| US7094409B2 (en) * | 2001-01-19 | 2006-08-22 | Cytos Biotechnology Ag | Antigen arrays for treatment of allergic eosinophilic diseases |
| US20030050268A1 (en) * | 2001-03-29 | 2003-03-13 | Krieg Arthur M. | Immunostimulatory nucleic acid for treatment of non-allergic inflammatory diseases |
| WO2003040308A2 (en) | 2001-07-27 | 2003-05-15 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Use of sterically stabilized cationic liposomes to efficiently deliver cpg oligonucleotides in vivo |
| AU2002367977B2 (en) | 2001-08-13 | 2008-06-19 | University Of Rochester | Transcutaneous immunization against papillomavirus with papillomavirus virus-like particles |
| DE60234375D1 (de) | 2001-09-14 | 2009-12-24 | Cytos Biotechnology Ag | VERPACKUNG VON IMMUNSTIMULIERENDEM CpG IN VIRUSÄHNLICHEN PARTIKELN: HERSTELLUNGSVERFAHREN UND VERWENDUNG |
| CA2492823A1 (en) * | 2001-09-14 | 2003-03-27 | Cytos Biotechnology Ag | In vivo activation of antigen presenting cells for enhancement of immune responses induced by virus like particles |
| US7115266B2 (en) | 2001-10-05 | 2006-10-03 | Cytos Biotechnology Ag | Angiotensin peptide-carrier conjugates and uses thereof |
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| US20060210588A1 (en) * | 2003-03-26 | 2006-09-21 | Cytos Biotechnology Ag | Hiv-peptide-carrier-conjugates |
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| MX2007003171A (es) * | 2004-09-21 | 2007-05-23 | Cytos Biotechnology Ag | Particulas tipo virus que comprenden una proteina de fusion de la proteina de cubierta de ap205 y un polipeptido antigenico. |
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| NZ566971A (en) | 2005-09-28 | 2011-06-30 | Cytos Biotechnology Ag | Vaccine containing a virus like particle linked with an interleukin-1 molecule |
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-
2002
- 2002-09-16 DE DE60234375T patent/DE60234375D1/de not_active Expired - Lifetime
- 2002-09-16 AU AU2002339224A patent/AU2002339224B2/en not_active Expired
- 2002-09-16 EP EP09014047A patent/EP2196217A1/en not_active Withdrawn
- 2002-09-16 CN CN028179358A patent/CN1599623B/zh not_active Expired - Lifetime
- 2002-09-16 EP EP02777600A patent/EP1450856B1/en not_active Expired - Lifetime
- 2002-09-16 ES ES02777600T patent/ES2335979T3/es not_active Expired - Lifetime
- 2002-09-16 WO PCT/IB2002/004132 patent/WO2003024481A2/en not_active Ceased
- 2002-09-16 CA CA2492826A patent/CA2492826C/en not_active Expired - Lifetime
- 2002-09-16 AT AT02777600T patent/ATE447967T1/de active
- 2002-09-16 DK DK02777600.4T patent/DK1450856T3/da active
- 2002-09-16 US US10/244,065 patent/US20030099668A1/en not_active Abandoned
- 2002-09-16 JP JP2003528575A patent/JP4516748B2/ja not_active Expired - Lifetime
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2009
- 2009-01-09 AU AU2009200115A patent/AU2009200115B2/en not_active Expired
- 2009-04-06 JP JP2009091943A patent/JP4749475B2/ja not_active Expired - Lifetime
-
2010
- 2010-02-04 CY CY20101100114T patent/CY1110585T1/el unknown
-
2011
- 2011-11-10 US US13/294,006 patent/US8691209B2/en not_active Expired - Lifetime
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107428813A (zh) * | 2014-12-31 | 2017-12-01 | 查克美特制药公司 | 组合肿瘤免疫疗法 |
| CN107428813B (zh) * | 2014-12-31 | 2021-08-03 | 查克美特制药公司 | 组合肿瘤免疫疗法 |
| CN113813386A (zh) * | 2014-12-31 | 2021-12-21 | 查克美特制药公司 | 组合肿瘤免疫疗法 |
| US12246031B2 (en) | 2018-02-13 | 2025-03-11 | Checkmate Pharmaceuticals, Inc. | Compositions and methods for tumor immunotherapy |
| US12084655B2 (en) | 2018-04-09 | 2024-09-10 | Checkmate Pharmaceuticals | Packaging oligonucleotides into virus-like particles |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2196217A1 (en) | 2010-06-16 |
| JP2009197001A (ja) | 2009-09-03 |
| JP4516748B2 (ja) | 2010-08-04 |
| CA2492826A1 (en) | 2003-03-27 |
| HK1067058A1 (en) | 2005-04-01 |
| US8691209B2 (en) | 2014-04-08 |
| JP2005517632A (ja) | 2005-06-16 |
| US20150030620A1 (en) | 2015-01-29 |
| JP4749475B2 (ja) | 2011-08-17 |
| US20120301499A1 (en) | 2012-11-29 |
| AU2002339224B2 (en) | 2008-10-09 |
| CY1110585T1 (el) | 2015-04-29 |
| WO2003024481A3 (en) | 2004-06-03 |
| US9950055B2 (en) | 2018-04-24 |
| US20030099668A1 (en) | 2003-05-29 |
| ES2335979T3 (es) | 2010-04-07 |
| DK1450856T3 (da) | 2010-05-31 |
| CA2492826C (en) | 2016-12-13 |
| AU2009200115A1 (en) | 2009-02-05 |
| AU2009200115B2 (en) | 2012-05-03 |
| CN1599623A (zh) | 2005-03-23 |
| EP1450856A2 (en) | 2004-09-01 |
| WO2003024481A2 (en) | 2003-03-27 |
| DE60234375D1 (de) | 2009-12-24 |
| ATE447967T1 (de) | 2009-11-15 |
| EP1450856B1 (en) | 2009-11-11 |
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Effective date of registration: 20210916 Address after: Swiss Shi Lilun Patentee after: Kuros Biosciences Address before: Swiss Shi Lilun Patentee before: CYTOS BIOTECHNOLOGY AG Effective date of registration: 20210916 Address after: Delaware, USA Patentee after: Kuros USA, LLC Address before: Swiss Shi Lilun Patentee before: Kuros Biosciences |
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