CY1110585T1 - ΣΥΣΚΕΥΑΣΙΑ (ΠΑΚΕΤΑΡΙΣΜΑ) ΑΝΟΣΟΔΙΕΓΕΡΤIΚΩΝ CpG ΕΝΤΟΣ ΟΜΟΙΑΖΟΝΤΩΝ ΜΕ ΙΟ ΣΩΜΑΤΙΩΝ: ΜΕΘΟΔΟΣ ΠΑΡΑΣΚΕΥΗΣ ΚΑΙ ΧΡΗΣΗ - Google Patents

ΣΥΣΚΕΥΑΣΙΑ (ΠΑΚΕΤΑΡΙΣΜΑ) ΑΝΟΣΟΔΙΕΓΕΡΤIΚΩΝ CpG ΕΝΤΟΣ ΟΜΟΙΑΖΟΝΤΩΝ ΜΕ ΙΟ ΣΩΜΑΤΙΩΝ: ΜΕΘΟΔΟΣ ΠΑΡΑΣΚΕΥΗΣ ΚΑΙ ΧΡΗΣΗ

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CY1110585T1
CY1110585T1 CY20101100114T CY101100114T CY1110585T1 CY 1110585 T1 CY1110585 T1 CY 1110585T1 CY 20101100114 T CY20101100114 T CY 20101100114T CY 101100114 T CY101100114 T CY 101100114T CY 1110585 T1 CY1110585 T1 CY 1110585T1
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Cyprus
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vlps
cpg
antigens
cpgs
loaded
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CY20101100114T
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Martin F Bachmann
Tazio Storni
Patrik Maurer
Alain Tissot
Katrin Schwarz
Edwin Meijerink
Gerd Lipowsky
Paul Pumpens
Indulis Cielens
Regina Renhofa
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Cytos Biotechnology Ag
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Publication of CY1110585T1 publication Critical patent/CY1110585T1/el

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Abstract

Η εφεύρεση σχετίζεται με το εύρημα ότι σωμάτια που ομοιάζουν με ιούς (VLPs) μπορούν να φορτωθούν με ανοσοδιεγερτικά υλικά (ουσίες), συγκεκριμένα με DNA ολιγονουκλεοτίδια που περιέχουν μη-μεθυλιωμένες C και G (CpGs). Αυτού του είδους τα CpG- VLPs είναι δραματικά περισσότερο ανοσογόνα απ' ότι τα ελεύθερα (μη-δεσμευμένα) CpG αντίστοιχα τους και επάγουν ενισχυμένες Β και Τ κυτταρικές αποκρίσεις. Η ανοσολογική απόκριση ενάντια σε προαιρετικά συζευγμένα αντιγόνα, που είναι συντηγμένα ή με κάποιο άλλο τρόπο δεσμευμένα στα VLPs, είναι ομοίως ενισχυμένη όπως και η ανοσολογική απόκριση ενάντια στο ίδιο το VLP. Επιπλέον, οι Τ κυτταρικές αποκρίσεις εναντίον τόσο των VLPs όσο και των αντιγόνων κατευθύνονται ειδικά προς αυτές του τύπου Th1. Συνεπώς, τα αντιγόνα που είναι προσδεμένα στα φορτωμένα με CpG VLPs ενδέχεται να είναι σχεδόν ιδανικά εμβόλια για προφυλακτικό ή θεραπευτικό εμβολιασμό εναντίον αλλεργιών, όγκων και άλλων μορίων του εαυτού και χρονίων ιικών ασθενειών.
CY20101100114T 2001-09-14 2010-02-04 ΣΥΣΚΕΥΑΣΙΑ (ΠΑΚΕΤΑΡΙΣΜΑ) ΑΝΟΣΟΔΙΕΓΕΡΤIΚΩΝ CpG ΕΝΤΟΣ ΟΜΟΙΑΖΟΝΤΩΝ ΜΕ ΙΟ ΣΩΜΑΤΙΩΝ: ΜΕΘΟΔΟΣ ΠΑΡΑΣΚΕΥΗΣ ΚΑΙ ΧΡΗΣΗ CY1110585T1 (el)

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DE60234375D1 (de) 2009-12-24
WO2003024481A3 (en) 2004-06-03
AU2009200115A1 (en) 2009-02-05
CA2492826A1 (en) 2003-03-27
US20150030620A1 (en) 2015-01-29
DK1450856T3 (da) 2010-05-31
EP1450856A2 (en) 2004-09-01
EP2196217A1 (en) 2010-06-16
US9950055B2 (en) 2018-04-24
CN1599623A (zh) 2005-03-23
US20120301499A1 (en) 2012-11-29
HK1067058A1 (en) 2005-04-01
US8691209B2 (en) 2014-04-08
JP2005517632A (ja) 2005-06-16
ES2335979T3 (es) 2010-04-07
CN1599623B (zh) 2011-05-11
US20030099668A1 (en) 2003-05-29
CA2492826C (en) 2016-12-13
JP4749475B2 (ja) 2011-08-17
AU2009200115B2 (en) 2012-05-03
EP1450856B1 (en) 2009-11-11
JP2009197001A (ja) 2009-09-03
AU2002339224B2 (en) 2008-10-09
ATE447967T1 (de) 2009-11-15
WO2003024481A2 (en) 2003-03-27

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