CN1486184A - 抑制β-淀粉状蛋白肽释放或合成的内酰胺化合物 - Google Patents

抑制β-淀粉状蛋白肽释放或合成的内酰胺化合物 Download PDF

Info

Publication number
CN1486184A
CN1486184A CNA018221009A CN01822100A CN1486184A CN 1486184 A CN1486184 A CN 1486184A CN A018221009 A CNA018221009 A CN A018221009A CN 01822100 A CN01822100 A CN 01822100A CN 1486184 A CN1486184 A CN 1486184A
Authority
CN
China
Prior art keywords
methyl
amino
reaction
tetrahydro
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA018221009A
Other languages
English (en)
Chinese (zh)
Inventor
J��E���µ���
J·E·奥蒂亚
V·约翰
��Ĭ����
L·H·拉蒂默
S·L·麦克丹尼尔
�������ɭ
J·S·尼森
ж�
E·D·托尔塞特
J·S·董
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Elan Pharmaceuticals LLC
Eli Lilly and Co
Original Assignee
Elan Pharmaceuticals LLC
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Pharmaceuticals LLC, Eli Lilly and Co filed Critical Elan Pharmaceuticals LLC
Publication of CN1486184A publication Critical patent/CN1486184A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicinal Preparation (AREA)
CNA018221009A 2000-11-17 2001-11-05 抑制β-淀粉状蛋白肽释放或合成的内酰胺化合物 Pending CN1486184A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24955200P 2000-11-17 2000-11-17
US60/249,552 2000-11-17

Publications (1)

Publication Number Publication Date
CN1486184A true CN1486184A (zh) 2004-03-31

Family

ID=22943982

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA018221009A Pending CN1486184A (zh) 2000-11-17 2001-11-05 抑制β-淀粉状蛋白肽释放或合成的内酰胺化合物

Country Status (33)

Country Link
US (1) US20050261495A1 (https=)
EP (1) EP1341531B1 (https=)
JP (1) JP4116437B2 (https=)
KR (1) KR100819679B1 (https=)
CN (1) CN1486184A (https=)
AR (1) AR035927A1 (https=)
AU (2) AU4319202A (https=)
BR (1) BR0115427A (https=)
CA (1) CA2427227C (https=)
CY (1) CY1106366T1 (https=)
CZ (1) CZ20031351A3 (https=)
DE (1) DE60126132T2 (https=)
DK (1) DK1341531T3 (https=)
DZ (1) DZ3453A1 (https=)
EA (1) EA005954B1 (https=)
EC (1) ECSP034600A (https=)
ES (1) ES2278804T3 (https=)
HR (1) HRP20030383B1 (https=)
HU (1) HU228117B1 (https=)
IL (2) IL155960A0 (https=)
MX (1) MXPA03004292A (https=)
MY (1) MY134559A (https=)
NO (1) NO324324B1 (https=)
NZ (1) NZ525854A (https=)
PE (1) PE20020802A1 (https=)
PL (1) PL212199B1 (https=)
PT (1) PT1341531E (https=)
SI (1) SI1341531T1 (https=)
SK (1) SK288065B6 (https=)
TW (1) TWI305204B (https=)
UA (1) UA74849C2 (https=)
WO (1) WO2002047671A2 (https=)
ZA (1) ZA200303789B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102690231A (zh) * 2012-04-11 2012-09-26 南京友杰医药科技有限公司 治疗阿尔茨海默病潜在药物司马西特的合成方法

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7468365B2 (en) 2000-11-17 2008-12-23 Eli Lilly And Company Lactam compound
UA74849C2 (en) * 2000-11-17 2006-02-15 Lilly Co Eli Lactam
AU2006234441B2 (en) 2005-04-08 2011-07-07 Daiichi Sankyo Company, Limited Pyridylmethylsulfone derivative
ES2382814T3 (es) 2005-05-17 2012-06-13 Merck Sharp & Dohme Ltd. Ácido cis-4-[(4-clorofenil)sulfonil]-4-(2,5-difluorofenil)ciclohexanopropanoico para el tratamiento del cáncer
JP5198877B2 (ja) 2006-01-31 2013-05-15 株式会社エーピーアイ コーポレーション ベンゾアゼピノン類の製造方法
CA2676715A1 (en) 2007-02-12 2008-08-21 Merck & Co., Inc. Piperazine derivatives for treatment of ad and related conditions
JP2010533723A (ja) * 2007-07-16 2010-10-28 ワイス・エルエルシー βアミロイド生成の阻害剤
JP5385904B2 (ja) 2007-08-14 2014-01-08 イーライ リリー アンド カンパニー γ−セクレターゼ阻害剤
TW200920362A (en) 2007-09-11 2009-05-16 Daiichi Sankyo Co Ltd Alkylsulfone derivatives
EP2222636B1 (en) 2007-12-21 2013-04-10 Ligand Pharmaceuticals Inc. Selective androgen receptor modulators (sarms) and uses thereof
EP2291181B9 (en) 2008-04-18 2013-09-11 University College Dublin National University Of Ireland, Dublin Captodiamine for the treatment of depression symptoms
WO2010114780A1 (en) 2009-04-01 2010-10-07 Merck Sharp & Dohme Corp. Inhibitors of akt activity
PE20121172A1 (es) 2009-10-14 2012-09-05 Merck Sharp & Dohme Piperidinas sustituidas con actividad en la hdm2
WO2011163330A1 (en) 2010-06-24 2011-12-29 Merck Sharp & Dohme Corp. Novel heterocyclic compounds as erk inhibitors
EP3330377A1 (en) 2010-08-02 2018-06-06 Sirna Therapeutics, Inc. Rna interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (ctnnb1) gene expression using short interfering nucleic acid (sina)
US9029341B2 (en) 2010-08-17 2015-05-12 Sirna Therapeutics, Inc. RNA interference mediated inhibition of hepatitis B virus (HBV) gene expression using short interfering nucleic acid (siNA)
EP2613782B1 (en) 2010-09-01 2016-11-02 Merck Sharp & Dohme Corp. Indazole derivatives useful as erk inhibitors
US9242981B2 (en) 2010-09-16 2016-01-26 Merck Sharp & Dohme Corp. Fused pyrazole derivatives as novel ERK inhibitors
WO2012040444A2 (en) * 2010-09-24 2012-03-29 Bristol-Myers Squibb Company Treatment of patients with incipient alzheimer's disease
WO2012058210A1 (en) 2010-10-29 2012-05-03 Merck Sharp & Dohme Corp. RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACIDS (siNA)
WO2012087772A1 (en) 2010-12-21 2012-06-28 Schering Corporation Indazole derivatives useful as erk inhibitors
EP2770987B1 (en) 2011-10-27 2018-04-04 Merck Sharp & Dohme Corp. Novel compounds that are erk inhibitors
US20150299696A1 (en) 2012-05-02 2015-10-22 Sirna Therapeutics, Inc. SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS
US20150209406A1 (en) 2012-09-07 2015-07-30 Massachusetts Eye And Ear Infirmary Methods and compositions for regenerating hair cells and/or supporting cells
US20150209367A1 (en) 2012-09-07 2015-07-30 Massachusetts Eye & Ear Infirmary Treating Hearing Loss
RU2660429C2 (ru) 2012-09-28 2018-07-06 Мерк Шарп И Доум Корп. Новые соединения, которые являются ингибиторами erk
RS56680B1 (sr) 2012-11-28 2018-03-30 Merck Sharp & Dohme Kompozicije i postupci za lečenje kancera
KR102196882B1 (ko) 2012-12-20 2020-12-30 머크 샤프 앤드 돔 코포레이션 Hdm2 억제제로서의 치환된 이미다조피리딘
WO2014120748A1 (en) 2013-01-30 2014-08-07 Merck Sharp & Dohme Corp. 2,6,7,8 substituted purines as hdm2 inhibitors
JP6319912B2 (ja) 2013-04-19 2018-05-09 国立大学法人 岡山大学 アミロイドβ蛋白質により誘発される認知障害の治療剤およびアルツハイマー病治療薬、ならびにこれらに関連する治療方法および病態解析方法
WO2015034925A1 (en) 2013-09-03 2015-03-12 Moderna Therapeutics, Inc. Circular polynucleotides
US10441567B2 (en) 2014-01-17 2019-10-15 Ligand Pharmaceuticals Incorporated Methods and compositions for modulating hormone levels
US11370823B2 (en) 2014-10-29 2022-06-28 Massachusetts Eye And Ear Infirmary Efficient delivery of therapeutic molecules to cells of the inner ear
JP6840774B2 (ja) 2016-05-16 2021-03-10 ザ ジェネラル ホスピタル コーポレイション 肺上皮エンジニアリングにおけるヒト気道幹細胞
EP3525785B1 (en) 2016-10-12 2025-08-27 Merck Sharp & Dohme LLC Kdm5 inhibitors
EP3706747B1 (en) 2017-11-08 2025-09-03 Merck Sharp & Dohme LLC Prmt5 inhibitors
US10947234B2 (en) 2017-11-08 2021-03-16 Merck Sharp & Dohme Corp. PRMT5 inhibitors
WO2019148067A1 (en) 2018-01-26 2019-08-01 Massachusetts Eye And Ear Infirmary Treatment of hearing loss
US12173026B2 (en) 2018-08-07 2024-12-24 Merck Sharp & Dohme Llc PRMT5 inhibitors
US11981701B2 (en) 2018-08-07 2024-05-14 Merck Sharp & Dohme Llc PRMT5 inhibitors
US12552826B2 (en) 2018-08-07 2026-02-17 Merck Sharp & Dohme Llc PRMT5 inhibitors
EP3833668B1 (en) 2018-08-07 2025-03-19 Merck Sharp & Dohme LLC Prmt5 inhibitors
WO2020214834A1 (en) 2019-04-19 2020-10-22 Ligand Pharmaceuticals Inc. Crystalline forms and methods of producing crystalline forms of a compound
US12441730B2 (en) 2019-12-17 2025-10-14 Merck Sharp & Dohme Llc PRMT5 inhibitors
US12595248B2 (en) 2019-12-17 2026-04-07 Merck Sharp & Dohme Llc PRMT5 inhibitors
BR112022012015A2 (pt) 2019-12-17 2022-08-30 Merck Sharp & Dohme Llc Inibidores de prmt5
WO2021126731A1 (en) 2019-12-17 2021-06-24 Merck Sharp & Dohme Corp. Prmt5 inhibitors
US20240116945A1 (en) 2022-09-02 2024-04-11 Merck Sharp & Dohme Llc Exatecan-derived topoisomerase-1 inhibitors pharmaceutical compositions, and uses thereof
WO2024091437A1 (en) 2022-10-25 2024-05-02 Merck Sharp & Dohme Llc Exatecan-derived adc linker-payloads, pharmaceutical compositions, and uses thereof
GEAP202516798A (en) 2022-12-14 2025-10-27 Merck Sharp & Dohme Llc Auristatin linker-payloads, pharmaceutical compositions, and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0001232A3 (en) * 1996-12-23 2001-02-28 Elan Pharmaceuticals Inc San F Cycloalkyl, lactam, lactone derivatives and their thio analogues inhibiting betha-amyloid peptide release and/or its synthesis and pharmaceutical compositions containing the compounds
JP2002518481A (ja) * 1998-06-22 2002-06-25 エラン ファーマシューティカルズ，インコーポレイテッド β−アミロイドペプチドの放出および／またはその合成を阻害するための化合物
JP2003513958A (ja) * 1999-11-09 2003-04-15 イーライ・リリー・アンド・カンパニー β−アミロイドペプチド放出および／またはその合成を阻害するために有用なβ−アミノ酸化合物
EP1345955B1 (en) * 2000-11-17 2008-08-20 Eli Lilly And Company Lactam dipeptide and its use in inhibiting beta-amyloid peptide release
UA74849C2 (en) * 2000-11-17 2006-02-15 Lilly Co Eli Lactam
UA77165C2 (en) * 2000-11-17 2006-11-15 Lilly Co Eli (n)-((s)-2-hydroxy-3-methyl-butyryl)-1-(l-alaninyl)-(s)-1-amino-3-methyl-4,5,6,7-tetrahydro-2h-3-benzazepin-2-one dihydrate, processes for manufacturing and pharmaceutical composition

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102690231A (zh) * 2012-04-11 2012-09-26 南京友杰医药科技有限公司 治疗阿尔茨海默病潜在药物司马西特的合成方法
CN102690231B (zh) * 2012-04-11 2014-07-09 南京友杰医药科技有限公司 治疗阿尔茨海默病潜在药物司马西特的合成方法

Also Published As

Publication number Publication date
PT1341531E (pt) 2007-04-30
BR0115427A (pt) 2003-10-07
CA2427227C (en) 2010-08-17
ECSP034600A (es) 2003-06-25
HU228117B1 (en) 2012-11-28
KR100819679B1 (ko) 2008-04-04
NZ525854A (en) 2004-06-25
ES2278804T3 (es) 2007-08-16
PL212199B1 (pl) 2012-08-31
EP1341531A2 (en) 2003-09-10
PE20020802A1 (es) 2002-09-10
WO2002047671A2 (en) 2002-06-20
UA74849C2 (en) 2006-02-15
DE60126132T2 (de) 2007-10-18
DZ3453A1 (fr) 2002-06-20
CY1106366T1 (el) 2011-10-12
HRP20030383B1 (hr) 2007-12-31
EA005954B1 (ru) 2005-08-25
SK288065B6 (sk) 2013-04-03
AU4319202A (en) 2002-06-24
MY134559A (en) 2007-12-31
WO2002047671A3 (en) 2003-03-06
NO20032236L (no) 2003-07-10
HK1059731A1 (en) 2004-07-16
DE60126132D1 (de) 2007-03-08
JP2004517090A (ja) 2004-06-10
SK5592003A3 (en) 2003-12-02
DK1341531T3 (da) 2007-05-14
KR20030051846A (ko) 2003-06-25
AR035927A1 (es) 2004-07-28
CZ20031351A3 (cs) 2003-11-12
IL155960A0 (en) 2003-12-23
EA200300580A1 (ru) 2003-10-30
AU2002243192B2 (en) 2006-07-20
SI1341531T1 (sl) 2007-06-30
HUP0301842A3 (en) 2010-03-29
MXPA03004292A (es) 2004-02-12
CA2427227A1 (en) 2002-06-20
HUP0301842A2 (hu) 2003-09-29
US20050261495A1 (en) 2005-11-24
NO324324B1 (no) 2007-09-24
PL362688A1 (en) 2004-11-02
EP1341531B1 (en) 2007-01-17
HRP20030383A2 (en) 2005-10-31
TWI305204B (en) 2009-01-11
NO20032236D0 (no) 2003-05-16
JP4116437B2 (ja) 2008-07-09
ZA200303789B (en) 2004-08-16
IL155960A (en) 2009-06-15

Similar Documents

Publication Publication Date Title
CN1486184A (zh) 抑制β-淀粉状蛋白肽释放或合成的内酰胺化合物
AU2002243192A1 (en) Lactam compound to inhibit beta-amyloid peptide release or synthesis
CN1088456C (zh) 取代的噁唑烷需钙蛋白酶和/或组织蛋白酶b抑制剂
CN1040985C (zh) 苯并氮杂䓬类化合物的制备方法
CN1238779A (zh) 抑制β－淀粉样肽释放和/或其合成的方法和化合物
CN1377268A (zh) 细胞粘合抑制剂
CN1100413A (zh) 诱导产生细胞素的尿烷类和尿素化合物
HUE027482T2 (en) Benzylamine derivatives as inhibitors of plasma kallikrein
CN1575282A (zh) 内酰胺化合物
CN1237978A (zh) N－(芳基/杂芳基)氨基酸衍生物、包括这些衍生物的药用组合物以及用这些化合物抑制β－淀粉样肽释放和或其合成的方法
US7468365B2 (en) Lactam compound
AU2002224321A1 (en) Lactam compound
CN1347419A (zh) 吡咯烷羰基氨基环状二硫化物
CN1130347C (zh) 2,3－亚甲基－氨基酸化合物,它们的制备方法和含有它们的药物组合物
EP1345955B1 (en) Lactam dipeptide and its use in inhibiting beta-amyloid peptide release
US20040077627A1 (en) Lactam compound
HK1059731B (en) Lactam compound to inhibit beta-amyloid peptide release or synthesis
CN1142830A (zh) 作为抗病毒剂的大环二氟斯它酮衍生物
CN1094730A (zh) 肽类化合物
CN85109243A (zh) 一种制备抗高血压的八氢-6-氮杂吲哚二肽衍生物的方法

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication