KR100819679B1 - 베타-아밀로이드 펩티드 방출 또는 합성을 억제하는 락탐화합물 - Google Patents

베타-아밀로이드 펩티드 방출 또는 합성을 억제하는 락탐화합물 Download PDF

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Publication number
KR100819679B1
KR100819679B1 KR1020037006721A KR20037006721A KR100819679B1 KR 100819679 B1 KR100819679 B1 KR 100819679B1 KR 1020037006721 A KR1020037006721 A KR 1020037006721A KR 20037006721 A KR20037006721 A KR 20037006721A KR 100819679 B1 KR100819679 B1 KR 100819679B1
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South Korea
Prior art keywords
methyl
amino
tetrahydro
reaction
formula
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Expired - Fee Related
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English (en)
Korean (ko)
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KR20030051846A (ko
Inventor
제임스 에드문드 아우디아
바기즈 존
리 에이치. 라티머
스테이시 레이 맥다니엘
제프리 스코트 니센
유진 디. 토르세트
제이 에스. 텅
Original Assignee
일라이 릴리 앤드 캄파니
엘란 파마슈티칼스, 인크.
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Publication of KR20030051846A publication Critical patent/KR20030051846A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicinal Preparation (AREA)
KR1020037006721A 2000-11-17 2001-11-05 베타-아밀로이드 펩티드 방출 또는 합성을 억제하는 락탐화합물 Expired - Fee Related KR100819679B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24955200P 2000-11-17 2000-11-17
US60/249,552 2000-11-17
PCT/US2001/027799 WO2002047671A2 (en) 2000-11-17 2001-11-05 Lactam compound to inhibit beta-amyloid peptide release or synthesis

Publications (2)

Publication Number Publication Date
KR20030051846A KR20030051846A (ko) 2003-06-25
KR100819679B1 true KR100819679B1 (ko) 2008-04-04

Family

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KR1020037006721A Expired - Fee Related KR100819679B1 (ko) 2000-11-17 2001-11-05 베타-아밀로이드 펩티드 방출 또는 합성을 억제하는 락탐화합물

Country Status (33)

Country Link
US (1) US20050261495A1 (https=)
EP (1) EP1341531B1 (https=)
JP (1) JP4116437B2 (https=)
KR (1) KR100819679B1 (https=)
CN (1) CN1486184A (https=)
AR (1) AR035927A1 (https=)
AU (2) AU4319202A (https=)
BR (1) BR0115427A (https=)
CA (1) CA2427227C (https=)
CY (1) CY1106366T1 (https=)
CZ (1) CZ20031351A3 (https=)
DE (1) DE60126132T2 (https=)
DK (1) DK1341531T3 (https=)
DZ (1) DZ3453A1 (https=)
EA (1) EA005954B1 (https=)
EC (1) ECSP034600A (https=)
ES (1) ES2278804T3 (https=)
HR (1) HRP20030383B1 (https=)
HU (1) HU228117B1 (https=)
IL (2) IL155960A0 (https=)
MX (1) MXPA03004292A (https=)
MY (1) MY134559A (https=)
NO (1) NO324324B1 (https=)
NZ (1) NZ525854A (https=)
PE (1) PE20020802A1 (https=)
PL (1) PL212199B1 (https=)
PT (1) PT1341531E (https=)
SI (1) SI1341531T1 (https=)
SK (1) SK288065B6 (https=)
TW (1) TWI305204B (https=)
UA (1) UA74849C2 (https=)
WO (1) WO2002047671A2 (https=)
ZA (1) ZA200303789B (https=)

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JP5198877B2 (ja) 2006-01-31 2013-05-15 株式会社エーピーアイ コーポレーション ベンゾアゼピノン類の製造方法
CA2676715A1 (en) 2007-02-12 2008-08-21 Merck & Co., Inc. Piperazine derivatives for treatment of ad and related conditions
JP2010533723A (ja) * 2007-07-16 2010-10-28 ワイス・エルエルシー βアミロイド生成の阻害剤
JP5385904B2 (ja) 2007-08-14 2014-01-08 イーライ リリー アンド カンパニー γ−セクレターゼ阻害剤
TW200920362A (en) 2007-09-11 2009-05-16 Daiichi Sankyo Co Ltd Alkylsulfone derivatives
EP2222636B1 (en) 2007-12-21 2013-04-10 Ligand Pharmaceuticals Inc. Selective androgen receptor modulators (sarms) and uses thereof
EP2291181B9 (en) 2008-04-18 2013-09-11 University College Dublin National University Of Ireland, Dublin Captodiamine for the treatment of depression symptoms
WO2010114780A1 (en) 2009-04-01 2010-10-07 Merck Sharp & Dohme Corp. Inhibitors of akt activity
PE20121172A1 (es) 2009-10-14 2012-09-05 Merck Sharp & Dohme Piperidinas sustituidas con actividad en la hdm2
WO2011163330A1 (en) 2010-06-24 2011-12-29 Merck Sharp & Dohme Corp. Novel heterocyclic compounds as erk inhibitors
EP3330377A1 (en) 2010-08-02 2018-06-06 Sirna Therapeutics, Inc. Rna interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (ctnnb1) gene expression using short interfering nucleic acid (sina)
US9029341B2 (en) 2010-08-17 2015-05-12 Sirna Therapeutics, Inc. RNA interference mediated inhibition of hepatitis B virus (HBV) gene expression using short interfering nucleic acid (siNA)
EP2613782B1 (en) 2010-09-01 2016-11-02 Merck Sharp & Dohme Corp. Indazole derivatives useful as erk inhibitors
US9242981B2 (en) 2010-09-16 2016-01-26 Merck Sharp & Dohme Corp. Fused pyrazole derivatives as novel ERK inhibitors
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WO2012058210A1 (en) 2010-10-29 2012-05-03 Merck Sharp & Dohme Corp. RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACIDS (siNA)
WO2012087772A1 (en) 2010-12-21 2012-06-28 Schering Corporation Indazole derivatives useful as erk inhibitors
EP2770987B1 (en) 2011-10-27 2018-04-04 Merck Sharp & Dohme Corp. Novel compounds that are erk inhibitors
CN102690231B (zh) * 2012-04-11 2014-07-09 南京友杰医药科技有限公司 治疗阿尔茨海默病潜在药物司马西特的合成方法
US20150299696A1 (en) 2012-05-02 2015-10-22 Sirna Therapeutics, Inc. SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS
US20150209406A1 (en) 2012-09-07 2015-07-30 Massachusetts Eye And Ear Infirmary Methods and compositions for regenerating hair cells and/or supporting cells
US20150209367A1 (en) 2012-09-07 2015-07-30 Massachusetts Eye & Ear Infirmary Treating Hearing Loss
RU2660429C2 (ru) 2012-09-28 2018-07-06 Мерк Шарп И Доум Корп. Новые соединения, которые являются ингибиторами erk
RS56680B1 (sr) 2012-11-28 2018-03-30 Merck Sharp & Dohme Kompozicije i postupci za lečenje kancera
KR102196882B1 (ko) 2012-12-20 2020-12-30 머크 샤프 앤드 돔 코포레이션 Hdm2 억제제로서의 치환된 이미다조피리딘
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EP3525785B1 (en) 2016-10-12 2025-08-27 Merck Sharp & Dohme LLC Kdm5 inhibitors
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EP1345955B1 (en) * 2000-11-17 2008-08-20 Eli Lilly And Company Lactam dipeptide and its use in inhibiting beta-amyloid peptide release
UA74849C2 (en) * 2000-11-17 2006-02-15 Lilly Co Eli Lactam
UA77165C2 (en) * 2000-11-17 2006-11-15 Lilly Co Eli (n)-((s)-2-hydroxy-3-methyl-butyryl)-1-(l-alaninyl)-(s)-1-amino-3-methyl-4,5,6,7-tetrahydro-2h-3-benzazepin-2-one dihydrate, processes for manufacturing and pharmaceutical composition

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Also Published As

Publication number Publication date
PT1341531E (pt) 2007-04-30
BR0115427A (pt) 2003-10-07
CA2427227C (en) 2010-08-17
ECSP034600A (es) 2003-06-25
HU228117B1 (en) 2012-11-28
NZ525854A (en) 2004-06-25
ES2278804T3 (es) 2007-08-16
PL212199B1 (pl) 2012-08-31
EP1341531A2 (en) 2003-09-10
PE20020802A1 (es) 2002-09-10
WO2002047671A2 (en) 2002-06-20
UA74849C2 (en) 2006-02-15
DE60126132T2 (de) 2007-10-18
DZ3453A1 (fr) 2002-06-20
CY1106366T1 (el) 2011-10-12
HRP20030383B1 (hr) 2007-12-31
EA005954B1 (ru) 2005-08-25
SK288065B6 (sk) 2013-04-03
AU4319202A (en) 2002-06-24
MY134559A (en) 2007-12-31
WO2002047671A3 (en) 2003-03-06
NO20032236L (no) 2003-07-10
HK1059731A1 (en) 2004-07-16
DE60126132D1 (de) 2007-03-08
JP2004517090A (ja) 2004-06-10
SK5592003A3 (en) 2003-12-02
DK1341531T3 (da) 2007-05-14
KR20030051846A (ko) 2003-06-25
AR035927A1 (es) 2004-07-28
CZ20031351A3 (cs) 2003-11-12
IL155960A0 (en) 2003-12-23
EA200300580A1 (ru) 2003-10-30
AU2002243192B2 (en) 2006-07-20
SI1341531T1 (sl) 2007-06-30
HUP0301842A3 (en) 2010-03-29
MXPA03004292A (es) 2004-02-12
CA2427227A1 (en) 2002-06-20
HUP0301842A2 (hu) 2003-09-29
US20050261495A1 (en) 2005-11-24
NO324324B1 (no) 2007-09-24
PL362688A1 (en) 2004-11-02
CN1486184A (zh) 2004-03-31
EP1341531B1 (en) 2007-01-17
HRP20030383A2 (en) 2005-10-31
TWI305204B (en) 2009-01-11
NO20032236D0 (no) 2003-05-16
JP4116437B2 (ja) 2008-07-09
ZA200303789B (en) 2004-08-16
IL155960A (en) 2009-06-15

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