DZ3453A1 - Compose lactame - Google Patents
Compose lactameInfo
- Publication number
- DZ3453A1 DZ3453A1 DZ013453A DZ013453A DZ3453A1 DZ 3453 A1 DZ3453 A1 DZ 3453A1 DZ 013453 A DZ013453 A DZ 013453A DZ 013453 A DZ013453 A DZ 013453A DZ 3453 A1 DZ3453 A1 DZ 3453A1
- Authority
- DZ
- Algeria
- Prior art keywords
- lactame
- compound
- lactame compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24955200P | 2000-11-17 | 2000-11-17 | |
PCT/US2001/027799 WO2002047671A2 (fr) | 2000-11-17 | 2001-11-05 | Composé de lactam |
Publications (1)
Publication Number | Publication Date |
---|---|
DZ3453A1 true DZ3453A1 (fr) | 2002-06-20 |
Family
ID=22943982
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DZ013453A DZ3453A1 (fr) | 2000-11-17 | 2001-11-05 | Compose lactame |
Country Status (34)
Country | Link |
---|---|
US (1) | US20050261495A1 (fr) |
EP (1) | EP1341531B1 (fr) |
JP (1) | JP4116437B2 (fr) |
KR (1) | KR100819679B1 (fr) |
CN (1) | CN1486184A (fr) |
AR (1) | AR035927A1 (fr) |
AU (2) | AU2002243192B2 (fr) |
BR (1) | BR0115427A (fr) |
CA (1) | CA2427227C (fr) |
CY (1) | CY1106366T1 (fr) |
CZ (1) | CZ20031351A3 (fr) |
DE (1) | DE60126132T2 (fr) |
DK (1) | DK1341531T3 (fr) |
DZ (1) | DZ3453A1 (fr) |
EA (1) | EA005954B1 (fr) |
EC (1) | ECSP034600A (fr) |
ES (1) | ES2278804T3 (fr) |
HK (1) | HK1059731A1 (fr) |
HR (1) | HRP20030383B1 (fr) |
HU (1) | HU228117B1 (fr) |
IL (2) | IL155960A0 (fr) |
MX (1) | MXPA03004292A (fr) |
MY (1) | MY134559A (fr) |
NO (1) | NO324324B1 (fr) |
NZ (1) | NZ525854A (fr) |
PE (1) | PE20020802A1 (fr) |
PL (1) | PL212199B1 (fr) |
PT (1) | PT1341531E (fr) |
SI (1) | SI1341531T1 (fr) |
SK (1) | SK288065B6 (fr) |
TW (1) | TWI305204B (fr) |
UA (1) | UA74849C2 (fr) |
WO (1) | WO2002047671A2 (fr) |
ZA (1) | ZA200303789B (fr) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA74849C2 (en) * | 2000-11-17 | 2006-02-15 | Lilly Co Eli | Lactam |
US7468365B2 (en) | 2000-11-17 | 2008-12-23 | Eli Lilly And Company | Lactam compound |
WO2006109729A1 (fr) | 2005-04-08 | 2006-10-19 | Daiichi Sankyo Company, Limited | Dérivé de pyridylméthylsulfone |
US8362075B2 (en) | 2005-05-17 | 2013-01-29 | Merck Sharp & Dohme Corp. | Cyclohexyl sulphones for treatment of cancer |
EP1985615A4 (fr) * | 2006-01-31 | 2011-12-14 | Api Corp | Procédé de production de benzazépinone |
EP2121633A2 (fr) | 2007-02-12 | 2009-11-25 | Merck & Co., Inc. | Dérivés de pipérazine pour le traitement de la maladie d'alzheimer et des conditions apparentées |
CL2008002060A1 (es) * | 2007-07-16 | 2008-11-21 | Wyeth Corp | Compuestos derivados de sulfonamida, inhibidores de la produccion de beta amiloide; metodo de preparacion; composicion farmaceutica; kit farmaceutico; y uso en el tratamiento de enfermedades tales como alzheimer, angiopatia amiloide, sindrome de down, entre otras. |
US8188069B2 (en) | 2007-08-14 | 2012-05-29 | Eli Lilly And Company | Azepine derivatives as gamma-secretase inhibitors |
TW200920362A (en) | 2007-09-11 | 2009-05-16 | Daiichi Sankyo Co Ltd | Alkylsulfone derivatives |
PT2222636E (pt) | 2007-12-21 | 2013-07-16 | Ligand Pharm Inc | Moduladores seletivos de recetores de andrógeno (sarms) e suas utilizações |
WO2009128057A2 (fr) | 2008-04-18 | 2009-10-22 | UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN et al | Produits psycho-pharmaceutiques |
WO2010114780A1 (fr) | 2009-04-01 | 2010-10-07 | Merck Sharp & Dohme Corp. | Inhibiteurs de l'activité akt |
NZ599343A (en) | 2009-10-14 | 2014-05-30 | Merck Sharp & Dohme | Substituted piperidines that increase p53 activity and the uses thereof |
WO2011163330A1 (fr) | 2010-06-24 | 2011-12-29 | Merck Sharp & Dohme Corp. | Nouveaux composés hétérocycliques utilisés comme inhibiteurs de erk |
US8518907B2 (en) | 2010-08-02 | 2013-08-27 | Merck Sharp & Dohme Corp. | RNA interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (CTNNB1) gene expression using short interfering nucleic acid (siNA) |
RU2624045C2 (ru) | 2010-08-17 | 2017-06-30 | Сирна Терапьютикс,Инк | ОПОСРЕДУЕМОЕ РНК-ИНТЕРФЕРЕНЦИЕЙ ИНГИБИРОВАНИЕ ЭКСПРЕССИИ ГЕНОВ ВИРУСА ГЕПАТИТА B (HBV) С ПРИМЕНЕНИЕМ МАЛОЙ ИНТЕРФЕРИРУЮЩЕЙ НУКЛЕИНОВОЙ КИСЛОТЫ (миНК) |
WO2012030685A2 (fr) | 2010-09-01 | 2012-03-08 | Schering Corporation | Dérivés d'indazole utilisables en tant qu'inhibiteurs de la voie erk |
WO2012036997A1 (fr) | 2010-09-16 | 2012-03-22 | Schering Corporation | Dérivés condensés de pyrazole utilisés comme nouveaux inhibiteurs erk |
WO2012040444A2 (fr) * | 2010-09-24 | 2012-03-29 | Bristol-Myers Squibb Company | Traitement de patients présentant un début de maladie d'alzheimer |
WO2012058210A1 (fr) | 2010-10-29 | 2012-05-03 | Merck Sharp & Dohme Corp. | INHIBITION FACILITÉE PAR L'INTERFÉRENCE D'ARN DE L'EXPRESSION D'UN GÈNE AU MOYEN D'ACIDES NUCLÉIQUES INTERFÉRENTS COURTS (siNA) |
EP2654748B1 (fr) | 2010-12-21 | 2016-07-27 | Merck Sharp & Dohme Corp. | Dérivés d'indazole utiles en tant qu'inhibiteurs de erk |
WO2013063214A1 (fr) | 2011-10-27 | 2013-05-02 | Merck Sharp & Dohme Corp. | Nouveaux composés qui sont des inhibiteurs d'erk |
CN102690231B (zh) * | 2012-04-11 | 2014-07-09 | 南京友杰医药科技有限公司 | 治疗阿尔茨海默病潜在药物司马西特的合成方法 |
EP3358013B1 (fr) | 2012-05-02 | 2020-06-24 | Sirna Therapeutics, Inc. | Compositions d'acide nucléique interférent court (sina) |
EP3970725A1 (fr) | 2012-09-07 | 2022-03-23 | Massachusetts Eye & Ear Infirmary | Un inhibiteur de la gamma-sécrétase pour le traitement de la perte auditive |
US9233979B2 (en) | 2012-09-28 | 2016-01-12 | Merck Sharp & Dohme Corp. | Compounds that are ERK inhibitors |
PT2925888T (pt) | 2012-11-28 | 2017-12-13 | Merck Sharp & Dohme | Composições e métodos para tratamento do cancro |
CA2895504A1 (fr) | 2012-12-20 | 2014-06-26 | Merck Sharp & Dohme Corp. | Imidazopyridines substituees en tant qu'inhibiteurs de hdm2 |
WO2014120748A1 (fr) | 2013-01-30 | 2014-08-07 | Merck Sharp & Dohme Corp. | Purines 2,6,7,8-substituées utilisées en tant qu'inhibiteurs de hdm2 |
WO2014171434A1 (fr) | 2013-04-19 | 2014-10-23 | 国立大学法人岡山大学 | Agent de traitement des troubles cognitifs, basé sur la protéine bêta-amyloïde, agent thérapeutique contre la maladie d'alzheimer et procédé de traitement et procédé d'analyse pathologique correspondants |
US20160194368A1 (en) | 2013-09-03 | 2016-07-07 | Moderna Therapeutics, Inc. | Circular polynucleotides |
EP3613418A1 (fr) | 2014-01-17 | 2020-02-26 | Ligand Pharmaceuticals, Inc. | Procédés et compositions de modulation des niveaux d'hormones |
US11370823B2 (en) | 2014-10-29 | 2022-06-28 | Massachusetts Eye And Ear Infirmary | Efficient delivery of therapeutic molecules to cells of the inner ear |
EP3458076A4 (fr) | 2016-05-16 | 2020-01-22 | The General Hospital Corporation | Cellules souches de voies respiratoires humaines en ingénierie épithéliale pulmonaire |
US10947234B2 (en) | 2017-11-08 | 2021-03-16 | Merck Sharp & Dohme Corp. | PRMT5 inhibitors |
US11590152B2 (en) | 2018-01-26 | 2023-02-28 | Massachusetts Eye And Ear Infirmary | Treatment of hearing loss |
WO2020033282A1 (fr) | 2018-08-07 | 2020-02-13 | Merck Sharp & Dohme Corp. | Inhibiteurs de prmt5 |
EP3833667B1 (fr) | 2018-08-07 | 2024-03-13 | Merck Sharp & Dohme LLC | Inhibiteurs de prmt5 |
KR20220123229A (ko) | 2019-12-17 | 2022-09-06 | 머크 샤프 앤드 돔 엘엘씨 | Prmt5 억제제 |
US20240116945A1 (en) | 2022-09-02 | 2024-04-11 | Merck Sharp & Dohme Llc | Exatecan-derived topoisomerase-1 inhibitors pharmaceutical compositions, and uses thereof |
WO2024091437A1 (fr) | 2022-10-25 | 2024-05-02 | Merck Sharp & Dohme Llc | Charges utiles de lieur adc dérivées d'exatécan, compositions pharmaceutiques et leurs utilisations |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20000069654A (ko) * | 1996-12-23 | 2000-11-25 | 엘란 파마슈티칼스, 인크. | 시클로알킬, 락탐, 락톤 및 관련 화합물, 그의 약제학적 조성물및 그를 사용한 β-아밀로이드 펩티드의 방출 및(또는) 합성억제 방법 |
JP2002518481A (ja) * | 1998-06-22 | 2002-06-25 | エラン ファーマシューティカルズ,インコーポレイテッド | β−アミロイドペプチドの放出および/またはその合成を阻害するための化合物 |
EP1230220A1 (fr) * | 1999-11-09 | 2002-08-14 | Eli Lilly And Company | COMPOSES CONTENANT DES $g(b)-ACIDES AMINES UTILES POUR INHIBER LA LIBERATION ET/OU LA SYNTHESE DU PEPTIDE $g(b)-AMYLOIDE |
UA74849C2 (en) * | 2000-11-17 | 2006-02-15 | Lilly Co Eli | Lactam |
UA77165C2 (en) * | 2000-11-17 | 2006-11-15 | Lilly Co Eli | (n)-((s)-2-hydroxy-3-methyl-butyryl)-1-(l-alaninyl)-(s)-1-amino-3-methyl-4,5,6,7-tetrahydro-2h-3-benzazepin-2-one dihydrate, processes for manufacturing and pharmaceutical composition |
ATE405577T1 (de) * | 2000-11-17 | 2008-09-15 | Lilly Co Eli | Lactam dipeptid und dessen verwendung zur inhibierung der beta-amyloid peptid frisetzung |
-
2001
- 2001-05-11 UA UA2003054408A patent/UA74849C2/uk unknown
- 2001-11-05 SI SI200130701T patent/SI1341531T1/sl unknown
- 2001-11-05 CA CA2427227A patent/CA2427227C/fr not_active Expired - Fee Related
- 2001-11-05 US US10/416,771 patent/US20050261495A1/en not_active Abandoned
- 2001-11-05 CN CNA018221009A patent/CN1486184A/zh active Pending
- 2001-11-05 WO PCT/US2001/027799 patent/WO2002047671A2/fr active IP Right Grant
- 2001-11-05 HU HU0301842A patent/HU228117B1/hu not_active IP Right Cessation
- 2001-11-05 DK DK01989070T patent/DK1341531T3/da active
- 2001-11-05 EA EA200300580A patent/EA005954B1/ru not_active IP Right Cessation
- 2001-11-05 BR BR0115427-3A patent/BR0115427A/pt not_active IP Right Cessation
- 2001-11-05 CZ CZ20031351A patent/CZ20031351A3/cs unknown
- 2001-11-05 ES ES01989070T patent/ES2278804T3/es not_active Expired - Lifetime
- 2001-11-05 NZ NZ525854A patent/NZ525854A/en not_active IP Right Cessation
- 2001-11-05 KR KR1020037006721A patent/KR100819679B1/ko not_active IP Right Cessation
- 2001-11-05 EP EP01989070A patent/EP1341531B1/fr not_active Expired - Lifetime
- 2001-11-05 AU AU2002243192A patent/AU2002243192B2/en not_active Ceased
- 2001-11-05 IL IL15596001A patent/IL155960A0/xx unknown
- 2001-11-05 JP JP2002549245A patent/JP4116437B2/ja not_active Expired - Fee Related
- 2001-11-05 PT PT01989070T patent/PT1341531E/pt unknown
- 2001-11-05 DE DE60126132T patent/DE60126132T2/de not_active Expired - Lifetime
- 2001-11-05 SK SK559-2003A patent/SK288065B6/sk not_active IP Right Cessation
- 2001-11-05 PL PL362688A patent/PL212199B1/pl unknown
- 2001-11-05 MX MXPA03004292A patent/MXPA03004292A/es active IP Right Grant
- 2001-11-05 AU AU4319202A patent/AU4319202A/xx active Pending
- 2001-11-05 DZ DZ013453A patent/DZ3453A1/fr active
- 2001-11-12 TW TW090128005A patent/TWI305204B/zh not_active IP Right Cessation
- 2001-11-14 AR ARP010105312A patent/AR035927A1/es not_active Application Discontinuation
- 2001-11-15 MY MYPI20015236A patent/MY134559A/en unknown
- 2001-11-16 PE PE2001001142A patent/PE20020802A1/es not_active Application Discontinuation
-
2003
- 2003-05-13 EC EC2003004600A patent/ECSP034600A/es unknown
- 2003-05-14 HR HR20030383A patent/HRP20030383B1/xx not_active IP Right Cessation
- 2003-05-15 IL IL155960A patent/IL155960A/en not_active IP Right Cessation
- 2003-05-15 ZA ZA200303789A patent/ZA200303789B/en unknown
- 2003-05-16 NO NO20032236A patent/NO324324B1/no not_active IP Right Cessation
-
2004
- 2004-02-20 HK HK04101245A patent/HK1059731A1/xx not_active IP Right Cessation
-
2007
- 2007-03-09 CY CY20071100331T patent/CY1106366T1/el unknown
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