ATE405577T1 - Lactam dipeptid und dessen verwendung zur inhibierung der beta-amyloid peptid frisetzung - Google Patents

Lactam dipeptid und dessen verwendung zur inhibierung der beta-amyloid peptid frisetzung

Info

Publication number
ATE405577T1
ATE405577T1 AT01996549T AT01996549T ATE405577T1 AT E405577 T1 ATE405577 T1 AT E405577T1 AT 01996549 T AT01996549 T AT 01996549T AT 01996549 T AT01996549 T AT 01996549T AT E405577 T1 ATE405577 T1 AT E405577T1
Authority
AT
Austria
Prior art keywords
dipeptide
lactam
amyloid peptide
peptide release
inhibiting beta
Prior art date
Application number
AT01996549T
Other languages
English (en)
Inventor
Thomas Koenig
David Mitchell
Jeffrey Nissen
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of ATE405577T1 publication Critical patent/ATE405577T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT01996549T 2000-11-17 2001-11-02 Lactam dipeptid und dessen verwendung zur inhibierung der beta-amyloid peptid frisetzung ATE405577T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US24965500P 2000-11-17 2000-11-17

Publications (1)

Publication Number Publication Date
ATE405577T1 true ATE405577T1 (de) 2008-09-15

Family

ID=22944432

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01996549T ATE405577T1 (de) 2000-11-17 2001-11-02 Lactam dipeptid und dessen verwendung zur inhibierung der beta-amyloid peptid frisetzung

Country Status (8)

Country Link
EP (1) EP1345955B1 (de)
JP (1) JP2005538031A (de)
AT (1) ATE405577T1 (de)
AU (1) AU2002224322A1 (de)
CA (1) CA2425558C (de)
DE (1) DE60135489D1 (de)
ES (1) ES2311561T3 (de)
WO (1) WO2002040508A2 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA74849C2 (en) * 2000-11-17 2006-02-15 Lilly Co Eli Lactam
US7468365B2 (en) 2000-11-17 2008-12-23 Eli Lilly And Company Lactam compound
ZA200700753B (en) 2004-07-27 2008-05-28 Univ California Genetically modified host cells use of same for producing isoprenoid compounds
US8114886B2 (en) 2005-04-08 2012-02-14 Daiichi Sankyo Company, Limited Pyridylmethylsulfone derivative
JP5198877B2 (ja) 2006-01-31 2013-05-15 株式会社エーピーアイ コーポレーション ベンゾアゼピノン類の製造方法
TW200920362A (en) 2007-09-11 2009-05-16 Daiichi Sankyo Co Ltd Alkylsulfone derivatives
CN102690231B (zh) * 2012-04-11 2014-07-09 南京友杰医药科技有限公司 治疗阿尔茨海默病潜在药物司马西特的合成方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5294615A (en) * 1993-04-29 1994-03-15 Abbott Laboratories Terazosin polymorph and pharmaceutical composition
ZA9711537B (en) * 1996-12-23 1998-06-25 Athena Neurosciences Inc Eli L Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting ß-amyloid peptide release and/or its synthesis by use of such compounds.
EP1321465A3 (de) * 1998-08-07 2003-09-03 Smithkline Beecham Plc Verfahreen zur Herstellung von einer nicht-kristallinen wasserfreien form von paroxetin hydrochlorid

Also Published As

Publication number Publication date
ES2311561T3 (es) 2009-02-16
EP1345955A2 (de) 2003-09-24
JP2005538031A (ja) 2005-12-15
WO2002040508A3 (en) 2003-03-27
WO2002040508A2 (en) 2002-05-23
EP1345955B1 (de) 2008-08-20
AU2002224322A1 (en) 2002-05-27
CA2425558A1 (en) 2002-05-23
CA2425558C (en) 2012-01-03
DE60135489D1 (de) 2008-10-02

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Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties