AU2002224322A1 - Lactam dipeptide and its use in inhibiting beta-amyloid peptiderelease - Google Patents
Lactam dipeptide and its use in inhibiting beta-amyloid peptidereleaseInfo
- Publication number
- AU2002224322A1 AU2002224322A1 AU2002224322A AU2432202A AU2002224322A1 AU 2002224322 A1 AU2002224322 A1 AU 2002224322A1 AU 2002224322 A AU2002224322 A AU 2002224322A AU 2432202 A AU2432202 A AU 2432202A AU 2002224322 A1 AU2002224322 A1 AU 2002224322A1
- Authority
- AU
- Australia
- Prior art keywords
- peptiderelease
- dipeptide
- amyloid
- lactam
- inhibiting beta
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
The present invention provides crystalline (N)-((S)-2-hydroxy-3-methyl-butyryl-1-(L-alaninyl)-(S)-1-amino-3-methyl-4,5,6,7-tetrahydro-2H-3-benzazepin-2-one anhydrate, compositions thereof, and methods for using the same, processes for making the same, and processes for making intermediate thereof.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24965500P | 2000-11-17 | 2000-11-17 | |
US60/249,655 | 2000-11-17 | ||
PCT/US2001/027796 WO2002040508A2 (en) | 2000-11-17 | 2001-11-02 | Lactam dipeptide and its use in inhibiting beta-amyloid peptide release |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2002224322A1 true AU2002224322A1 (en) | 2002-05-27 |
Family
ID=22944432
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2002224322A Abandoned AU2002224322A1 (en) | 2000-11-17 | 2001-11-02 | Lactam dipeptide and its use in inhibiting beta-amyloid peptiderelease |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP1345955B1 (en) |
JP (1) | JP2005538031A (en) |
AT (1) | ATE405577T1 (en) |
AU (1) | AU2002224322A1 (en) |
CA (1) | CA2425558C (en) |
DE (1) | DE60135489D1 (en) |
ES (1) | ES2311561T3 (en) |
WO (1) | WO2002040508A2 (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA74849C2 (en) * | 2000-11-17 | 2006-02-15 | Lilly Co Eli | Lactam |
US7468365B2 (en) | 2000-11-17 | 2008-12-23 | Eli Lilly And Company | Lactam compound |
BRPI0513837B1 (en) | 2004-07-27 | 2021-10-13 | The Regents Of The University Of California | GENETICLY MODIFIED SACCHAROMYCES CEREVISIAE HOST CELL; COMPOSITION COMPRISING THE SAME AND METHOD TO INCREASE THE PRODUCTION OF ISOPRENOIDS |
ES2413705T3 (en) | 2005-04-08 | 2013-07-17 | Daiichi Sankyo Company, Limited | Pyridylmethylsulfone derivative |
WO2007088878A1 (en) * | 2006-01-31 | 2007-08-09 | Api Corporation | Method for producing benzazepinone |
TW200920362A (en) | 2007-09-11 | 2009-05-16 | Daiichi Sankyo Co Ltd | Alkylsulfone derivatives |
CN102690231B (en) * | 2012-04-11 | 2014-07-09 | 南京友杰医药科技有限公司 | Method for synthesizing potential drug of Semagacestat for treating Alzheimer disease |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5294615A (en) * | 1993-04-29 | 1994-03-15 | Abbott Laboratories | Terazosin polymorph and pharmaceutical composition |
AU749658C (en) * | 1996-12-23 | 2004-04-29 | Elan Pharmaceuticals, Inc. | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds |
ES2198940T3 (en) * | 1998-08-07 | 2004-02-01 | Smithkline Beecham Plc | PROCEDURE FOR THE PREPARATION OF A NON-CRYSTAL ANHYDRA FORM OF PAROXETINE HYDROCLORIDE. |
-
2001
- 2001-11-02 AT AT01996549T patent/ATE405577T1/en not_active IP Right Cessation
- 2001-11-02 AU AU2002224322A patent/AU2002224322A1/en not_active Abandoned
- 2001-11-02 ES ES01996549T patent/ES2311561T3/en not_active Expired - Lifetime
- 2001-11-02 EP EP01996549A patent/EP1345955B1/en not_active Expired - Lifetime
- 2001-11-02 CA CA2425558A patent/CA2425558C/en not_active Expired - Fee Related
- 2001-11-02 WO PCT/US2001/027796 patent/WO2002040508A2/en active Search and Examination
- 2001-11-02 DE DE60135489T patent/DE60135489D1/en not_active Expired - Lifetime
- 2001-11-02 JP JP2002543516A patent/JP2005538031A/en not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
DE60135489D1 (en) | 2008-10-02 |
WO2002040508A2 (en) | 2002-05-23 |
ES2311561T3 (en) | 2009-02-16 |
CA2425558C (en) | 2012-01-03 |
EP1345955B1 (en) | 2008-08-20 |
CA2425558A1 (en) | 2002-05-23 |
JP2005538031A (en) | 2005-12-15 |
EP1345955A2 (en) | 2003-09-24 |
ATE405577T1 (en) | 2008-09-15 |
WO2002040508A3 (en) | 2003-03-27 |
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