HK1059731A1 - Lactam compound to inhibit beta-amyloid peptide release or synthesis - Google Patents

Lactam compound to inhibit beta-amyloid peptide release or synthesis

Info

Publication number
HK1059731A1
HK1059731A1 HK04101245A HK04101245A HK1059731A1 HK 1059731 A1 HK1059731 A1 HK 1059731A1 HK 04101245 A HK04101245 A HK 04101245A HK 04101245 A HK04101245 A HK 04101245A HK 1059731 A1 HK1059731 A1 HK 1059731A1
Authority
HK
Hong Kong
Prior art keywords
synthesis
amyloid peptide
lactam compound
peptide release
inhibit beta
Prior art date
Application number
HK04101245A
Other languages
English (en)
Inventor
James Edmund Audia
Varghese John
Lee H Latimer
Stacey Leigh Mcdaniel
Jeffrey Scott Nissen
Eugene D Thorsett
Jay S Tung
Original Assignee
Lilly Co Eli
Elan Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli, Elan Pharm Inc filed Critical Lilly Co Eli
Publication of HK1059731A1 publication Critical patent/HK1059731A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Hydrogenated Pyridines (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
HK04101245A 2000-11-17 2004-02-20 Lactam compound to inhibit beta-amyloid peptide release or synthesis HK1059731A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24955200P 2000-11-17 2000-11-17
PCT/US2001/027799 WO2002047671A2 (en) 2000-11-17 2001-11-05 Lactam compound to inhibit beta-amyloid peptide release or synthesis

Publications (1)

Publication Number Publication Date
HK1059731A1 true HK1059731A1 (en) 2004-07-16

Family

ID=22943982

Family Applications (1)

Application Number Title Priority Date Filing Date
HK04101245A HK1059731A1 (en) 2000-11-17 2004-02-20 Lactam compound to inhibit beta-amyloid peptide release or synthesis

Country Status (34)

Country Link
US (1) US20050261495A1 (xx)
EP (1) EP1341531B1 (xx)
JP (1) JP4116437B2 (xx)
KR (1) KR100819679B1 (xx)
CN (1) CN1486184A (xx)
AR (1) AR035927A1 (xx)
AU (2) AU2002243192B2 (xx)
BR (1) BR0115427A (xx)
CA (1) CA2427227C (xx)
CY (1) CY1106366T1 (xx)
CZ (1) CZ20031351A3 (xx)
DE (1) DE60126132T2 (xx)
DK (1) DK1341531T3 (xx)
DZ (1) DZ3453A1 (xx)
EA (1) EA005954B1 (xx)
EC (1) ECSP034600A (xx)
ES (1) ES2278804T3 (xx)
HK (1) HK1059731A1 (xx)
HR (1) HRP20030383B1 (xx)
HU (1) HU228117B1 (xx)
IL (2) IL155960A0 (xx)
MX (1) MXPA03004292A (xx)
MY (1) MY134559A (xx)
NO (1) NO324324B1 (xx)
NZ (1) NZ525854A (xx)
PE (1) PE20020802A1 (xx)
PL (1) PL212199B1 (xx)
PT (1) PT1341531E (xx)
SI (1) SI1341531T1 (xx)
SK (1) SK288065B6 (xx)
TW (1) TWI305204B (xx)
UA (1) UA74849C2 (xx)
WO (1) WO2002047671A2 (xx)
ZA (1) ZA200303789B (xx)

Families Citing this family (41)

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US7468365B2 (en) 2000-11-17 2008-12-23 Eli Lilly And Company Lactam compound
UA74849C2 (en) * 2000-11-17 2006-02-15 Lilly Co Eli Lactam
AU2006234441B2 (en) 2005-04-08 2011-07-07 Daiichi Sankyo Company, Limited Pyridylmethylsulfone derivative
EP1888050B1 (en) 2005-05-17 2012-03-21 Merck Sharp & Dohme Ltd. cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid for the treatment of cancer
JP5198877B2 (ja) 2006-01-31 2013-05-15 株式会社エーピーアイ コーポレーション ベンゾアゼピノン類の製造方法
JP2010518064A (ja) 2007-02-12 2010-05-27 メルク・シャープ・エンド・ドーム・コーポレイション Ａｄおよび関連状態の治療のためのピペラジン誘導体
US20090023801A1 (en) * 2007-07-16 2009-01-22 Wyeth Inhibitors of beta amyloid production
WO2009023453A1 (en) 2007-08-14 2009-02-19 Eli Lilly And Company Azepine derivatives as gamma-secretase inhibitors
TW200920362A (en) 2007-09-11 2009-05-16 Daiichi Sankyo Co Ltd Alkylsulfone derivatives
CN104188971B (zh) 2007-12-21 2017-05-03 配体药物公司 选择性雄激素受体调节剂(sarm)及其应用
EP2291181B9 (en) 2008-04-18 2013-09-11 University College Dublin National University Of Ireland, Dublin Captodiamine for the treatment of depression symptoms
WO2010114780A1 (en) 2009-04-01 2010-10-07 Merck Sharp & Dohme Corp. Inhibitors of akt activity
MX2012004377A (es) 2009-10-14 2012-06-01 Merck Sharp & Dohme Piperidinas sustituidas que aumentan la actividad de p53 y sus usos.
EP2584903B1 (en) 2010-06-24 2018-10-24 Merck Sharp & Dohme Corp. Novel heterocyclic compounds as erk inhibitors
US8518907B2 (en) 2010-08-02 2013-08-27 Merck Sharp & Dohme Corp. RNA interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (CTNNB1) gene expression using short interfering nucleic acid (siNA)
EP3587574B1 (en) 2010-08-17 2022-03-16 Sirna Therapeutics, Inc. Rna interference mediated inhibition of hepatitis b virus (hbv) gene expression using short interfering nucleic acid (sina)
EP2613782B1 (en) 2010-09-01 2016-11-02 Merck Sharp & Dohme Corp. Indazole derivatives useful as erk inhibitors
WO2012036997A1 (en) 2010-09-16 2012-03-22 Schering Corporation Fused pyrazole derivatives as novel erk inhibitors
WO2012040444A2 (en) * 2010-09-24 2012-03-29 Bristol-Myers Squibb Company Treatment of patients with incipient alzheimer's disease
US9260471B2 (en) 2010-10-29 2016-02-16 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using short interfering nucleic acids (siNA)
US9351965B2 (en) 2010-12-21 2016-05-31 Merck Sharp & Dohme Corp. Indazole derivatives useful as ERK inhibitors
WO2013063214A1 (en) 2011-10-27 2013-05-02 Merck Sharp & Dohme Corp. Novel compounds that are erk inhibitors
CN102690231B (zh) * 2012-04-11 2014-07-09 南京友杰医药科技有限公司 治疗阿尔茨海默病潜在药物司马西特的合成方法
EP3919620A1 (en) 2012-05-02 2021-12-08 Sirna Therapeutics, Inc. Short interfering nucleic acid (sina) compositions
CA2883896C (en) 2012-09-07 2023-03-07 Massachusetts Eye & Ear Infirmary Treating hearing loss
MX2015004041A (es) 2012-09-28 2015-07-06 Merck Sharp & Dohme Compuestos novedosos que son inhibidores de erk.
CA2892361A1 (en) 2012-11-28 2014-06-05 Merck Sharp & Dohme Corp. Use of a wee1 inhibitor for treating a cancer characterized by low pkmyt1 expression levels
ES2707305T3 (es) 2012-12-20 2019-04-03 Merck Sharp & Dohme Imidazopiridinas sustituidas como inhibidores de HDM2
WO2014120748A1 (en) 2013-01-30 2014-08-07 Merck Sharp & Dohme Corp. 2,6,7,8 substituted purines as hdm2 inhibitors
US20160067306A1 (en) 2013-04-19 2016-03-10 National University Corporation Hokkaido University Treatment agent for cognitive impairment induced by amyloid beta-protein, therapeutic agent for alzheimer's disease, and treatment method and pathological analysis method related to these
EP3041938A1 (en) 2013-09-03 2016-07-13 Moderna Therapeutics, Inc. Circular polynucleotides
WO2015108988A2 (en) 2014-01-17 2015-07-23 Ligand Pharmaceuticals, Inc. Methods and compositions for modulating hormone levels
WO2016069906A1 (en) 2014-10-29 2016-05-06 Massachusetts Eye And Ear Infirmary Efficient delivery of therapeutic molecules to cells of the inner ear
AU2017268078B2 (en) 2016-05-16 2023-03-02 The General Hospital Corporation Human airway stem cells in lung epithelial engineering
WO2019094311A1 (en) 2017-11-08 2019-05-16 Merck Sharp & Dohme Corp. Prmt5 inhibitors
WO2019148067A1 (en) 2018-01-26 2019-08-01 Massachusetts Eye And Ear Infirmary Treatment of hearing loss
US11981701B2 (en) 2018-08-07 2024-05-14 Merck Sharp & Dohme Llc PRMT5 inhibitors
WO2020033282A1 (en) 2018-08-07 2020-02-13 Merck Sharp & Dohme Corp. Prmt5 inhibitors
MX2022007535A (es) 2019-12-17 2022-09-23 Merck Sharp & Dohme Llc Inhibidores de prmt5.
WO2024049931A1 (en) 2022-09-02 2024-03-07 Merck Sharp & Dohme Llc Exatecan-derived topoisomerase-1 inhibitors pharmaceutical compositions, and uses thereof
WO2024091437A1 (en) 2022-10-25 2024-05-02 Merck Sharp & Dohme Llc Exatecan-derived adc linker-payloads, pharmaceutical compositions, and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20000069654A (ko) * 1996-12-23 2000-11-25 엘란 파마슈티칼스, 인크. 시클로알킬, 락탐, 락톤 및 관련 화합물, 그의 약제학적 조성물및 그를 사용한 β-아밀로이드 펩티드의 방출 및(또는) 합성억제 방법
WO1999067219A1 (en) * 1998-06-22 1999-12-29 Elan Pharmaceuticals, Inc. Compounds for inhibiting beta-amyloid peptide release and/or its synthesis
JP2003513958A (ja) * 1999-11-09 2003-04-15 イーライ・リリー・アンド・カンパニー β−アミロイドペプチド放出および／またはその合成を阻害するために有用なβ−アミノ酸化合物
UA77165C2 (en) * 2000-11-17 2006-11-15 Lilly Co Eli (n)-((s)-2-hydroxy-3-methyl-butyryl)-1-(l-alaninyl)-(s)-1-amino-3-methyl-4,5,6,7-tetrahydro-2h-3-benzazepin-2-one dihydrate, processes for manufacturing and pharmaceutical composition
UA74849C2 (en) * 2000-11-17 2006-02-15 Lilly Co Eli Lactam
ES2311561T3 (es) * 2000-11-17 2009-02-16 Eli Lilly And Company Dipeptido de lactama y su uso en la inhibicion de la liberacion del peptido beta amiloide.

Also Published As

Publication number Publication date
BR0115427A (pt) 2003-10-07
EA005954B1 (ru) 2005-08-25
HU228117B1 (en) 2012-11-28
PE20020802A1 (es) 2002-09-10
EA200300580A1 (ru) 2003-10-30
DZ3453A1 (fr) 2002-06-20
ES2278804T3 (es) 2007-08-16
HUP0301842A2 (hu) 2003-09-29
NO324324B1 (no) 2007-09-24
IL155960A0 (en) 2003-12-23
PT1341531E (pt) 2007-04-30
ZA200303789B (en) 2004-08-16
CA2427227A1 (en) 2002-06-20
KR20030051846A (ko) 2003-06-25
HUP0301842A3 (en) 2010-03-29
ECSP034600A (es) 2003-06-25
HRP20030383A2 (en) 2005-10-31
SK5592003A3 (en) 2003-12-02
HRP20030383B1 (en) 2007-12-31
US20050261495A1 (en) 2005-11-24
CZ20031351A3 (cs) 2003-11-12
PL212199B1 (pl) 2012-08-31
DK1341531T3 (da) 2007-05-14
NO20032236L (no) 2003-07-10
WO2002047671A2 (en) 2002-06-20
CY1106366T1 (el) 2011-10-12
WO2002047671A3 (en) 2003-03-06
EP1341531B1 (en) 2007-01-17
UA74849C2 (en) 2006-02-15
JP2004517090A (ja) 2004-06-10
IL155960A (en) 2009-06-15
DE60126132D1 (de) 2007-03-08
AU4319202A (en) 2002-06-24
AR035927A1 (es) 2004-07-28
AU2002243192B2 (en) 2006-07-20
DE60126132T2 (de) 2007-10-18
MY134559A (en) 2007-12-31
CA2427227C (en) 2010-08-17
TWI305204B (en) 2009-01-11
MXPA03004292A (es) 2004-02-12
PL362688A1 (en) 2004-11-02
NO20032236D0 (no) 2003-05-16
JP4116437B2 (ja) 2008-07-09
EP1341531A2 (en) 2003-09-10
SK288065B6 (sk) 2013-04-03
NZ525854A (en) 2004-06-25
CN1486184A (zh) 2004-03-31
KR100819679B1 (ko) 2008-04-04
SI1341531T1 (sl) 2007-06-30

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20141105