NO20032236L - Laktamforbindelse - Google Patents

Laktamforbindelse

Info

Publication number
NO20032236L
NO20032236L NO20032236A NO20032236A NO20032236L NO 20032236 L NO20032236 L NO 20032236L NO 20032236 A NO20032236 A NO 20032236A NO 20032236 A NO20032236 A NO 20032236A NO 20032236 L NO20032236 L NO 20032236L
Authority
NO
Norway
Prior art keywords
lactam compound
lactam
compound
Prior art date
Application number
NO20032236A
Other languages
English (en)
Other versions
NO324324B1 (no
NO20032236D0 (no
Inventor
James Edmund Audia
Varghese John
Lee H Latimer
Stacey Leigh Mcdaniel
Jeffrey Scott Nissen
Eugene D Thorsett
Jay S Tung
Original Assignee
Elan Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Pharm Inc filed Critical Elan Pharm Inc
Publication of NO20032236D0 publication Critical patent/NO20032236D0/no
Publication of NO20032236L publication Critical patent/NO20032236L/no
Publication of NO324324B1 publication Critical patent/NO324324B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicinal Preparation (AREA)
NO20032236A 2000-11-17 2003-05-16 Laktamforbindelse samt farmasoytisk sammensetning inneholdende denne NO324324B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24955200P 2000-11-17 2000-11-17
PCT/US2001/027799 WO2002047671A2 (en) 2000-11-17 2001-11-05 Lactam compound to inhibit beta-amyloid peptide release or synthesis

Publications (3)

Publication Number Publication Date
NO20032236D0 NO20032236D0 (no) 2003-05-16
NO20032236L true NO20032236L (no) 2003-07-10
NO324324B1 NO324324B1 (no) 2007-09-24

Family

ID=22943982

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20032236A NO324324B1 (no) 2000-11-17 2003-05-16 Laktamforbindelse samt farmasoytisk sammensetning inneholdende denne

Country Status (34)

Country Link
US (1) US20050261495A1 (no)
EP (1) EP1341531B1 (no)
JP (1) JP4116437B2 (no)
KR (1) KR100819679B1 (no)
CN (1) CN1486184A (no)
AR (1) AR035927A1 (no)
AU (2) AU4319202A (no)
BR (1) BR0115427A (no)
CA (1) CA2427227C (no)
CY (1) CY1106366T1 (no)
CZ (1) CZ20031351A3 (no)
DE (1) DE60126132T2 (no)
DK (1) DK1341531T3 (no)
DZ (1) DZ3453A1 (no)
EA (1) EA005954B1 (no)
EC (1) ECSP034600A (no)
ES (1) ES2278804T3 (no)
HK (1) HK1059731A1 (no)
HR (1) HRP20030383B1 (no)
HU (1) HU228117B1 (no)
IL (2) IL155960A0 (no)
MX (1) MXPA03004292A (no)
MY (1) MY134559A (no)
NO (1) NO324324B1 (no)
NZ (1) NZ525854A (no)
PE (1) PE20020802A1 (no)
PL (1) PL212199B1 (no)
PT (1) PT1341531E (no)
SI (1) SI1341531T1 (no)
SK (1) SK288065B6 (no)
TW (1) TWI305204B (no)
UA (1) UA74849C2 (no)
WO (1) WO2002047671A2 (no)
ZA (1) ZA200303789B (no)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7468365B2 (en) 2000-11-17 2008-12-23 Eli Lilly And Company Lactam compound
UA74849C2 (en) * 2000-11-17 2006-02-15 Lilly Co Eli Lactam
US8114886B2 (en) 2005-04-08 2012-02-14 Daiichi Sankyo Company, Limited Pyridylmethylsulfone derivative
ATE550019T1 (de) 2005-05-17 2012-04-15 Merck Sharp & Dohme Cis-4-ä(4-chlorophenyl)sulfonylü-4-(2,5- difluorophenyl)cyclohexanepropansäure zur behandlug von krebs
US8258302B2 (en) * 2006-01-31 2012-09-04 Api Corporation Method for producing benzazepinone
JP2010518064A (ja) 2007-02-12 2010-05-27 メルク・シャープ・エンド・ドーム・コーポレイション Ａｄおよび関連状態の治療のためのピペラジン誘導体
CA2693959A1 (en) * 2007-07-16 2009-01-22 Wyeth Inhibitors of beta amyloid production
EA017286B1 (ru) 2007-08-14 2012-11-30 Эли Лилли Энд Компани Ингибиторы гамма-секретазы
TW200920362A (en) 2007-09-11 2009-05-16 Daiichi Sankyo Co Ltd Alkylsulfone derivatives
PT2222636E (pt) 2007-12-21 2013-07-16 Ligand Pharm Inc Moduladores seletivos de recetores de andrógeno (sarms) e suas utilizações
EP2291181B9 (en) 2008-04-18 2013-09-11 University College Dublin National University Of Ireland, Dublin Captodiamine for the treatment of depression symptoms
US8691825B2 (en) 2009-04-01 2014-04-08 Merck Sharp & Dohme Corp. Inhibitors of AKT activity
CN104945382B (zh) 2009-10-14 2020-02-07 默沙东公司 提高p53活性的取代的哌啶和其用途
WO2011163330A1 (en) 2010-06-24 2011-12-29 Merck Sharp & Dohme Corp. Novel heterocyclic compounds as erk inhibitors
WO2012018754A2 (en) 2010-08-02 2012-02-09 Merck Sharp & Dohme Corp. RNA INTERFERENCE MEDIATED INHIBITION OF CATENIN (CADHERIN-ASSOCIATED PROTEIN), BETA 1 (CTNNB1) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
US9029341B2 (en) 2010-08-17 2015-05-12 Sirna Therapeutics, Inc. RNA interference mediated inhibition of hepatitis B virus (HBV) gene expression using short interfering nucleic acid (siNA)
EP2613782B1 (en) 2010-09-01 2016-11-02 Merck Sharp & Dohme Corp. Indazole derivatives useful as erk inhibitors
US9242981B2 (en) 2010-09-16 2016-01-26 Merck Sharp & Dohme Corp. Fused pyrazole derivatives as novel ERK inhibitors
WO2012040444A2 (en) * 2010-09-24 2012-03-29 Bristol-Myers Squibb Company Treatment of patients with incipient alzheimer's disease
US9260471B2 (en) 2010-10-29 2016-02-16 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using short interfering nucleic acids (siNA)
WO2012087772A1 (en) 2010-12-21 2012-06-28 Schering Corporation Indazole derivatives useful as erk inhibitors
EP2770987B1 (en) 2011-10-27 2018-04-04 Merck Sharp & Dohme Corp. Novel compounds that are erk inhibitors
CN102690231B (zh) * 2012-04-11 2014-07-09 南京友杰医药科技有限公司 治疗阿尔茨海默病潜在药物司马西特的合成方法
EP3453762B1 (en) 2012-05-02 2021-04-21 Sirna Therapeutics, Inc. Short interfering nucleic acid (sina) compositions
JP2015527398A (ja) 2012-09-07 2015-09-17 マサチューセッツ アイ アンド イヤー インファーマリー 聴覚喪失治療
MX2015004041A (es) 2012-09-28 2015-07-06 Merck Sharp & Dohme Compuestos novedosos que son inhibidores de erk.
WO2014085216A1 (en) 2012-11-28 2014-06-05 Merck Sharp & Dohme Corp. Compositions and methods for treating cancer
CA2895504A1 (en) 2012-12-20 2014-06-26 Merck Sharp & Dohme Corp. Substituted imidazopyridines as hdm2 inhibitors
EP2951180B1 (en) 2013-01-30 2018-05-02 Merck Sharp & Dohme Corp. 2,6,7,8 substituted purines as hdm2 inhibitors
JP6319912B2 (ja) 2013-04-19 2018-05-09 国立大学法人 岡山大学 アミロイドβ蛋白質により誘発される認知障害の治療剤およびアルツハイマー病治療薬、ならびにこれらに関連する治療方法および病態解析方法
EP3041938A1 (en) 2013-09-03 2016-07-13 Moderna Therapeutics, Inc. Circular polynucleotides
EP3613418A1 (en) 2014-01-17 2020-02-26 Ligand Pharmaceuticals, Inc. Methods and compositions for modulating hormone levels
US11370823B2 (en) 2014-10-29 2022-06-28 Massachusetts Eye And Ear Infirmary Efficient delivery of therapeutic molecules to cells of the inner ear
JP6840774B2 (ja) 2016-05-16 2021-03-10 ザ ジェネラル ホスピタル コーポレイション 肺上皮エンジニアリングにおけるヒト気道幹細胞
WO2019094311A1 (en) 2017-11-08 2019-05-16 Merck Sharp & Dohme Corp. Prmt5 inhibitors
WO2019148067A1 (en) 2018-01-26 2019-08-01 Massachusetts Eye And Ear Infirmary Treatment of hearing loss
US11981701B2 (en) 2018-08-07 2024-05-14 Merck Sharp & Dohme Llc PRMT5 inhibitors
EP3833668A4 (en) 2018-08-07 2022-05-11 Merck Sharp & Dohme Corp. PRMT5 INHIBITORS
JP2023507634A (ja) 2019-12-17 2023-02-24 メルク・シャープ・アンド・ドーム・エルエルシー Ｐｒｍｔ５阻害剤
US20240116945A1 (en) 2022-09-02 2024-04-11 Merck Sharp & Dohme Llc Exatecan-derived topoisomerase-1 inhibitors pharmaceutical compositions, and uses thereof
WO2024091437A1 (en) 2022-10-25 2024-05-02 Merck Sharp & Dohme Llc Exatecan-derived adc linker-payloads, pharmaceutical compositions, and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3812952B2 (ja) * 1996-12-23 2006-08-23 エラン ファーマシューティカルズ，インコーポレイテッド シクロアルキル、ラクタム、ラクトンおよびその関連化合物およびその医薬組成物、並びに該化合物を用いたβ−アミロイドペプチドの放出および／またはその合成を阻害する方法
AU4707999A (en) * 1998-06-22 2000-01-10 Elan Pharmaceuticals, Inc. Compounds for inhibiting beta-amyloid peptide release and/or its synthesis
WO2001034571A1 (en) * 1999-11-09 2001-05-17 Eli Lilly And Company β-AMINOACID COMPOUNDS USEFUL FOR INHIBITING β-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS
UA77165C2 (en) * 2000-11-17 2006-11-15 Lilly Co Eli (n)-((s)-2-hydroxy-3-methyl-butyryl)-1-(l-alaninyl)-(s)-1-amino-3-methyl-4,5,6,7-tetrahydro-2h-3-benzazepin-2-one dihydrate, processes for manufacturing and pharmaceutical composition
ATE405577T1 (de) * 2000-11-17 2008-09-15 Lilly Co Eli Lactam dipeptid und dessen verwendung zur inhibierung der beta-amyloid peptid frisetzung
UA74849C2 (en) * 2000-11-17 2006-02-15 Lilly Co Eli Lactam

Also Published As

Publication number Publication date
CZ20031351A3 (cs) 2003-11-12
EA200300580A1 (ru) 2003-10-30
CY1106366T1 (el) 2011-10-12
MXPA03004292A (es) 2004-02-12
PE20020802A1 (es) 2002-09-10
IL155960A (en) 2009-06-15
SK5592003A3 (en) 2003-12-02
WO2002047671A2 (en) 2002-06-20
HRP20030383B1 (en) 2007-12-31
HU228117B1 (en) 2012-11-28
ES2278804T3 (es) 2007-08-16
TWI305204B (en) 2009-01-11
HK1059731A1 (en) 2004-07-16
NO324324B1 (no) 2007-09-24
PL212199B1 (pl) 2012-08-31
EP1341531B1 (en) 2007-01-17
DE60126132D1 (de) 2007-03-08
NZ525854A (en) 2004-06-25
SI1341531T1 (sl) 2007-06-30
KR20030051846A (ko) 2003-06-25
IL155960A0 (en) 2003-12-23
CA2427227C (en) 2010-08-17
UA74849C2 (en) 2006-02-15
DZ3453A1 (fr) 2002-06-20
JP2004517090A (ja) 2004-06-10
PL362688A1 (en) 2004-11-02
HUP0301842A3 (en) 2010-03-29
ECSP034600A (es) 2003-06-25
EA005954B1 (ru) 2005-08-25
AU4319202A (en) 2002-06-24
PT1341531E (pt) 2007-04-30
DE60126132T2 (de) 2007-10-18
AR035927A1 (es) 2004-07-28
NO20032236D0 (no) 2003-05-16
AU2002243192B2 (en) 2006-07-20
US20050261495A1 (en) 2005-11-24
DK1341531T3 (da) 2007-05-14
HRP20030383A2 (en) 2005-10-31
HUP0301842A2 (hu) 2003-09-29
CN1486184A (zh) 2004-03-31
BR0115427A (pt) 2003-10-07
KR100819679B1 (ko) 2008-04-04
WO2002047671A3 (en) 2003-03-06
SK288065B6 (sk) 2013-04-03
EP1341531A2 (en) 2003-09-10
CA2427227A1 (en) 2002-06-20
MY134559A (en) 2007-12-31
ZA200303789B (en) 2004-08-16
JP4116437B2 (ja) 2008-07-09

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Legal Events

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MM1K Lapsed by not paying the annual fees