NO20032236L - Laktamforbindelse - Google Patents

Laktamforbindelse

Info

Publication number
NO20032236L
NO20032236L NO20032236A NO20032236A NO20032236L NO 20032236 L NO20032236 L NO 20032236L NO 20032236 A NO20032236 A NO 20032236A NO 20032236 A NO20032236 A NO 20032236A NO 20032236 L NO20032236 L NO 20032236L
Authority
NO
Norway
Prior art keywords
lactam compound
lactam
compound
Prior art date
Application number
NO20032236A
Other languages
English (en)
Other versions
NO324324B1 (no
NO20032236D0 (no
Inventor
James Edmund Audia
Varghese John
Lee H Latimer
Stacey Leigh Mcdaniel
Jeffrey Scott Nissen
Eugene D Thorsett
Jay S Tung
Original Assignee
Elan Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Pharm Inc filed Critical Elan Pharm Inc
Publication of NO20032236D0 publication Critical patent/NO20032236D0/no
Publication of NO20032236L publication Critical patent/NO20032236L/no
Publication of NO324324B1 publication Critical patent/NO324324B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Hydrogenated Pyridines (AREA)
NO20032236A 2000-11-17 2003-05-16 Laktamforbindelse samt farmasoytisk sammensetning inneholdende denne NO324324B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24955200P 2000-11-17 2000-11-17
PCT/US2001/027799 WO2002047671A2 (en) 2000-11-17 2001-11-05 Lactam compound to inhibit beta-amyloid peptide release or synthesis

Publications (3)

Publication Number Publication Date
NO20032236D0 NO20032236D0 (no) 2003-05-16
NO20032236L true NO20032236L (no) 2003-07-10
NO324324B1 NO324324B1 (no) 2007-09-24

Family

ID=22943982

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20032236A NO324324B1 (no) 2000-11-17 2003-05-16 Laktamforbindelse samt farmasoytisk sammensetning inneholdende denne

Country Status (34)

Country Link
US (1) US20050261495A1 (no)
EP (1) EP1341531B1 (no)
JP (1) JP4116437B2 (no)
KR (1) KR100819679B1 (no)
CN (1) CN1486184A (no)
AR (1) AR035927A1 (no)
AU (2) AU2002243192B2 (no)
BR (1) BR0115427A (no)
CA (1) CA2427227C (no)
CY (1) CY1106366T1 (no)
CZ (1) CZ20031351A3 (no)
DE (1) DE60126132T2 (no)
DK (1) DK1341531T3 (no)
DZ (1) DZ3453A1 (no)
EA (1) EA005954B1 (no)
EC (1) ECSP034600A (no)
ES (1) ES2278804T3 (no)
HK (1) HK1059731A1 (no)
HR (1) HRP20030383B1 (no)
HU (1) HU228117B1 (no)
IL (2) IL155960A0 (no)
MX (1) MXPA03004292A (no)
MY (1) MY134559A (no)
NO (1) NO324324B1 (no)
NZ (1) NZ525854A (no)
PE (1) PE20020802A1 (no)
PL (1) PL212199B1 (no)
PT (1) PT1341531E (no)
SI (1) SI1341531T1 (no)
SK (1) SK288065B6 (no)
TW (1) TWI305204B (no)
UA (1) UA74849C2 (no)
WO (1) WO2002047671A2 (no)
ZA (1) ZA200303789B (no)

Families Citing this family (43)

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UA74849C2 (en) * 2000-11-17 2006-02-15 Lilly Co Eli Lactam
US7468365B2 (en) 2000-11-17 2008-12-23 Eli Lilly And Company Lactam compound
ES2413705T3 (es) 2005-04-08 2013-07-17 Daiichi Sankyo Company, Limited Derivado de piridilmetilsulfona
EP1888050B1 (en) 2005-05-17 2012-03-21 Merck Sharp & Dohme Ltd. cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid for the treatment of cancer
WO2007088878A1 (ja) 2006-01-31 2007-08-09 Api Corporation ベンゾアゼピノン類の製造方法
JP2010518064A (ja) 2007-02-12 2010-05-27 メルク・シャープ・エンド・ドーム・コーポレイション Ａｄおよび関連状態の治療のためのピペラジン誘導体
CL2008002060A1 (es) * 2007-07-16 2008-11-21 Wyeth Corp Compuestos derivados de sulfonamida, inhibidores de la produccion de beta amiloide; metodo de preparacion; composicion farmaceutica; kit farmaceutico; y uso en el tratamiento de enfermedades tales como alzheimer, angiopatia amiloide, sindrome de down, entre otras.
EA017286B1 (ru) 2007-08-14 2012-11-30 Эли Лилли Энд Компани Ингибиторы гамма-секретазы
TW200920362A (en) 2007-09-11 2009-05-16 Daiichi Sankyo Co Ltd Alkylsulfone derivatives
MX2010006972A (es) 2007-12-21 2010-08-26 Ligand Pharm Inc Moduladores selectivos de receptores de andrógenos (sarm) y usos de los mismos.
WO2009128057A2 (en) 2008-04-18 2009-10-22 UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN et al Psycho-pharmaceuticals
US8691825B2 (en) 2009-04-01 2014-04-08 Merck Sharp & Dohme Corp. Inhibitors of AKT activity
CN104945382B (zh) 2009-10-14 2020-02-07 默沙东公司 提高p53活性的取代的哌啶和其用途
EP2584903B1 (en) 2010-06-24 2018-10-24 Merck Sharp & Dohme Corp. Novel heterocyclic compounds as erk inhibitors
JP6043285B2 (ja) 2010-08-02 2016-12-14 サーナ・セラピューティクス・インコーポレイテッドＳｉｒｎａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． 低分子干渉核酸（ｓｉＮＡ）を用いたカテニン（カドヘリン結合型タンパク質）β１（ＣＴＮＮＢ１）遺伝子発現のＲＮＡ干渉媒介性阻害
LT2606134T (lt) 2010-08-17 2019-07-25 Sirna Therapeutics, Inc. Hepatito b viruso (hbv) geno raiškos slopinimas, tarpininkaujant rnr interferencijai naudojant mažą interferuojančią nukleorūgštį (sina)
EP2613782B1 (en) 2010-09-01 2016-11-02 Merck Sharp & Dohme Corp. Indazole derivatives useful as erk inhibitors
US9242981B2 (en) 2010-09-16 2016-01-26 Merck Sharp & Dohme Corp. Fused pyrazole derivatives as novel ERK inhibitors
WO2012040444A2 (en) * 2010-09-24 2012-03-29 Bristol-Myers Squibb Company Treatment of patients with incipient alzheimer's disease
DK2632472T3 (en) 2010-10-29 2018-03-19 Sirna Therapeutics Inc RNA INTERFERENCE-MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERRING NUCLEIC ACIDS (SINA)
US9351965B2 (en) 2010-12-21 2016-05-31 Merck Sharp & Dohme Corp. Indazole derivatives useful as ERK inhibitors
US9023865B2 (en) 2011-10-27 2015-05-05 Merck Sharp & Dohme Corp. Compounds that are ERK inhibitors
CN102690231B (zh) * 2012-04-11 2014-07-09 南京友杰医药科技有限公司 治疗阿尔茨海默病潜在药物司马西特的合成方法
EP3919620A1 (en) 2012-05-02 2021-12-08 Sirna Therapeutics, Inc. Short interfering nucleic acid (sina) compositions
CA2883896C (en) 2012-09-07 2023-03-07 Massachusetts Eye & Ear Infirmary Treating hearing loss
EP2900241B1 (en) 2012-09-28 2018-08-08 Merck Sharp & Dohme Corp. Novel compounds that are erk inhibitors
PT2925888T (pt) 2012-11-28 2017-12-13 Merck Sharp & Dohme Composições e métodos para tratamento do cancro
AU2013361694B2 (en) 2012-12-20 2017-10-26 Merck Sharp & Dohme Corp. Substituted imidazopyridines as HDM2 inhibitors
WO2014120748A1 (en) 2013-01-30 2014-08-07 Merck Sharp & Dohme Corp. 2,6,7,8 substituted purines as hdm2 inhibitors
US20160067306A1 (en) 2013-04-19 2016-03-10 National University Corporation Hokkaido University Treatment agent for cognitive impairment induced by amyloid beta-protein, therapeutic agent for alzheimer's disease, and treatment method and pathological analysis method related to these
EP3041938A1 (en) 2013-09-03 2016-07-13 Moderna Therapeutics, Inc. Circular polynucleotides
WO2015108988A2 (en) 2014-01-17 2015-07-23 Ligand Pharmaceuticals, Inc. Methods and compositions for modulating hormone levels
EP3212773B1 (en) 2014-10-29 2021-09-15 Massachusetts Eye and Ear Infirmary Efficient delivery of therapeutic molecules to cells of the inner ear
CA3024424A1 (en) 2016-05-16 2017-11-23 The General Hospital Corporation Human airway stem cells in lung epithelial engineering
WO2018071283A1 (en) 2016-10-12 2018-04-19 Merck Sharp & Dohme Corp. Kdm5 inhibitors
US10947234B2 (en) 2017-11-08 2021-03-16 Merck Sharp & Dohme Corp. PRMT5 inhibitors
EP3743057A4 (en) 2018-01-26 2021-11-17 Massachusetts Eye & Ear Infirmary TREATMENT OF HEARING LOSS
EP3833667B1 (en) 2018-08-07 2024-03-13 Merck Sharp & Dohme LLC Prmt5 inhibitors
EP3833668A4 (en) 2018-08-07 2022-05-11 Merck Sharp & Dohme Corp. PRMT5 INHIBITORS
CA3160153A1 (en) 2019-12-17 2021-06-24 Michelle Machacek Prmt5 inhibitors
TW202423928A (zh) 2022-09-02 2024-06-16 美商默沙東有限責任公司 源自依克沙替康(exatecan)之拓樸異構酶-1抑制劑醫藥組合物及其用途
US20240208987A1 (en) 2022-10-25 2024-06-27 Merck Sharp & Dohme Llc Exatecan-derived adc linker-payloads, pharmaceutical compositions, and uses thereof
US20240207425A1 (en) 2022-12-14 2024-06-27 Merck Sharp & Dohme Llc Auristatin linker-payloads, pharmaceutical compositions, and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ335583A (en) * 1996-12-23 2001-03-30 Lilly Co Eli Cycloalkyl, lactam, lactone and analogs, and pharmaceutical compositions
EP1089977A1 (en) * 1998-06-22 2001-04-11 Elan Pharmaceuticals, Inc. Compounds for inhibiting beta-amyloid peptide release and/or its synthesis
AU1569501A (en) * 1999-11-09 2001-06-06 Eli Lilly And Company Beta-aminoacid compounds useful for inhibiting beta-amyloid peptide release and/or its synthesis
UA74849C2 (en) * 2000-11-17 2006-02-15 Lilly Co Eli Lactam
UA77165C2 (en) * 2000-11-17 2006-11-15 Lilly Co Eli (n)-((s)-2-hydroxy-3-methyl-butyryl)-1-(l-alaninyl)-(s)-1-amino-3-methyl-4,5,6,7-tetrahydro-2h-3-benzazepin-2-one dihydrate, processes for manufacturing and pharmaceutical composition
AU2002224322A1 (en) * 2000-11-17 2002-05-27 Eli Lilly And Company Lactam dipeptide and its use in inhibiting beta-amyloid peptiderelease

Also Published As

Publication number Publication date
EA200300580A1 (ru) 2003-10-30
NO324324B1 (no) 2007-09-24
CA2427227A1 (en) 2002-06-20
PE20020802A1 (es) 2002-09-10
HU228117B1 (en) 2012-11-28
HUP0301842A2 (hu) 2003-09-29
CZ20031351A3 (cs) 2003-11-12
ZA200303789B (en) 2004-08-16
CY1106366T1 (el) 2011-10-12
PT1341531E (pt) 2007-04-30
SK288065B6 (sk) 2013-04-03
DZ3453A1 (fr) 2002-06-20
JP4116437B2 (ja) 2008-07-09
WO2002047671A2 (en) 2002-06-20
PL212199B1 (pl) 2012-08-31
DE60126132D1 (de) 2007-03-08
AU2002243192B2 (en) 2006-07-20
EP1341531B1 (en) 2007-01-17
HRP20030383B1 (en) 2007-12-31
CN1486184A (zh) 2004-03-31
IL155960A (en) 2009-06-15
ECSP034600A (es) 2003-06-25
KR20030051846A (ko) 2003-06-25
HRP20030383A2 (en) 2005-10-31
EP1341531A2 (en) 2003-09-10
SI1341531T1 (sl) 2007-06-30
AU4319202A (en) 2002-06-24
PL362688A1 (en) 2004-11-02
NZ525854A (en) 2004-06-25
KR100819679B1 (ko) 2008-04-04
MXPA03004292A (es) 2004-02-12
MY134559A (en) 2007-12-31
DK1341531T3 (da) 2007-05-14
CA2427227C (en) 2010-08-17
DE60126132T2 (de) 2007-10-18
SK5592003A3 (en) 2003-12-02
US20050261495A1 (en) 2005-11-24
IL155960A0 (en) 2003-12-23
NO20032236D0 (no) 2003-05-16
UA74849C2 (en) 2006-02-15
EA005954B1 (ru) 2005-08-25
WO2002047671A3 (en) 2003-03-06
HK1059731A1 (en) 2004-07-16
HUP0301842A3 (en) 2010-03-29
BR0115427A (pt) 2003-10-07
TWI305204B (en) 2009-01-11
AR035927A1 (es) 2004-07-28
JP2004517090A (ja) 2004-06-10
ES2278804T3 (es) 2007-08-16

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Legal Events

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