PL212199B1 - Związek N-(((S)-2-hydroksy-3-metylobutyrylo)-1-(L-alaninylo))-(S)-1-amino-3-metylo-2,3,4,5-tetrahydro-1H-3-benzoazepin-2-on oraz kompozycja zawierająca ten związek - Google Patents
Związek N-(((S)-2-hydroksy-3-metylobutyrylo)-1-(L-alaninylo))-(S)-1-amino-3-metylo-2,3,4,5-tetrahydro-1H-3-benzoazepin-2-on oraz kompozycja zawierająca ten związekInfo
- Publication number
- PL212199B1 PL212199B1 PL362688A PL36268801A PL212199B1 PL 212199 B1 PL212199 B1 PL 212199B1 PL 362688 A PL362688 A PL 362688A PL 36268801 A PL36268801 A PL 36268801A PL 212199 B1 PL212199 B1 PL 212199B1
- Authority
- PL
- Poland
- Prior art keywords
- methyl
- compound
- benzoazepin
- amino
- tetrahydro
- Prior art date
Links
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Public Health (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24955200P | 2000-11-17 | 2000-11-17 | |
| PCT/US2001/027799 WO2002047671A2 (en) | 2000-11-17 | 2001-11-05 | Lactam compound to inhibit beta-amyloid peptide release or synthesis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL362688A1 PL362688A1 (en) | 2004-11-02 |
| PL212199B1 true PL212199B1 (pl) | 2012-08-31 |
Family
ID=22943982
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL362688A PL212199B1 (pl) | 2000-11-17 | 2001-11-05 | Związek N-(((S)-2-hydroksy-3-metylobutyrylo)-1-(L-alaninylo))-(S)-1-amino-3-metylo-2,3,4,5-tetrahydro-1H-3-benzoazepin-2-on oraz kompozycja zawierająca ten związek |
Country Status (33)
| Country | Link |
|---|---|
| US (1) | US20050261495A1 (https=) |
| EP (1) | EP1341531B1 (https=) |
| JP (1) | JP4116437B2 (https=) |
| KR (1) | KR100819679B1 (https=) |
| CN (1) | CN1486184A (https=) |
| AR (1) | AR035927A1 (https=) |
| AU (2) | AU4319202A (https=) |
| BR (1) | BR0115427A (https=) |
| CA (1) | CA2427227C (https=) |
| CY (1) | CY1106366T1 (https=) |
| CZ (1) | CZ20031351A3 (https=) |
| DE (1) | DE60126132T2 (https=) |
| DK (1) | DK1341531T3 (https=) |
| DZ (1) | DZ3453A1 (https=) |
| EA (1) | EA005954B1 (https=) |
| EC (1) | ECSP034600A (https=) |
| ES (1) | ES2278804T3 (https=) |
| HR (1) | HRP20030383B1 (https=) |
| HU (1) | HU228117B1 (https=) |
| IL (2) | IL155960A0 (https=) |
| MX (1) | MXPA03004292A (https=) |
| MY (1) | MY134559A (https=) |
| NO (1) | NO324324B1 (https=) |
| NZ (1) | NZ525854A (https=) |
| PE (1) | PE20020802A1 (https=) |
| PL (1) | PL212199B1 (https=) |
| PT (1) | PT1341531E (https=) |
| SI (1) | SI1341531T1 (https=) |
| SK (1) | SK288065B6 (https=) |
| TW (1) | TWI305204B (https=) |
| UA (1) | UA74849C2 (https=) |
| WO (1) | WO2002047671A2 (https=) |
| ZA (1) | ZA200303789B (https=) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7468365B2 (en) | 2000-11-17 | 2008-12-23 | Eli Lilly And Company | Lactam compound |
| UA74849C2 (en) * | 2000-11-17 | 2006-02-15 | Lilly Co Eli | Lactam |
| AU2006234441B2 (en) | 2005-04-08 | 2011-07-07 | Daiichi Sankyo Company, Limited | Pyridylmethylsulfone derivative |
| ES2382814T3 (es) | 2005-05-17 | 2012-06-13 | Merck Sharp & Dohme Ltd. | Ácido cis-4-[(4-clorofenil)sulfonil]-4-(2,5-difluorofenil)ciclohexanopropanoico para el tratamiento del cáncer |
| JP5198877B2 (ja) | 2006-01-31 | 2013-05-15 | 株式会社エーピーアイ コーポレーション | ベンゾアゼピノン類の製造方法 |
| CA2676715A1 (en) | 2007-02-12 | 2008-08-21 | Merck & Co., Inc. | Piperazine derivatives for treatment of ad and related conditions |
| JP2010533723A (ja) * | 2007-07-16 | 2010-10-28 | ワイス・エルエルシー | βアミロイド生成の阻害剤 |
| JP5385904B2 (ja) | 2007-08-14 | 2014-01-08 | イーライ リリー アンド カンパニー | γ−セクレターゼ阻害剤 |
| TW200920362A (en) | 2007-09-11 | 2009-05-16 | Daiichi Sankyo Co Ltd | Alkylsulfone derivatives |
| EP2222636B1 (en) | 2007-12-21 | 2013-04-10 | Ligand Pharmaceuticals Inc. | Selective androgen receptor modulators (sarms) and uses thereof |
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| HUP0001232A3 (en) * | 1996-12-23 | 2001-02-28 | Elan Pharmaceuticals Inc San F | Cycloalkyl, lactam, lactone derivatives and their thio analogues inhibiting betha-amyloid peptide release and/or its synthesis and pharmaceutical compositions containing the compounds |
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| JP2003513958A (ja) * | 1999-11-09 | 2003-04-15 | イーライ・リリー・アンド・カンパニー | β−アミロイドペプチド放出および／またはその合成を阻害するために有用なβ−アミノ酸化合物 |
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