JP4116437B2 - β−アミロイドペプチドの放出および／または合成を阻害するラクタム化合物 - Google Patents

β−アミロイドペプチドの放出および／または合成を阻害するラクタム化合物 Download PDF

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JP4116437B2
JP4116437B2 JP2002549245A JP2002549245A JP4116437B2 JP 4116437 B2 JP4116437 B2 JP 4116437B2 JP 2002549245 A JP2002549245 A JP 2002549245A JP 2002549245 A JP2002549245 A JP 2002549245A JP 4116437 B2 JP4116437 B2 JP 4116437B2
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methyl
tetrahydro
amino
reaction
formula
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JP2004517090A (ja
JP2004517090A5 (https=
Inventor
ジェイムズ・エドモンド・オーディア
バーゲス・ジョン
リー・エイチ・ラティマー
ステイシー・リー・マクダニエル
ジェフリー・スコット・ニッセン
ユージーン・ディ・ソーセット
ジェイ・エス・トゥン
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イーライ リリー アンド カンパニー
エラン ファーマシューティカルズ，インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicinal Preparation (AREA)
JP2002549245A 2000-11-17 2001-11-05 β−アミロイドペプチドの放出および／または合成を阻害するラクタム化合物 Expired - Fee Related JP4116437B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24955200P 2000-11-17 2000-11-17
PCT/US2001/027799 WO2002047671A2 (en) 2000-11-17 2001-11-05 Lactam compound to inhibit beta-amyloid peptide release or synthesis

Publications (3)

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JP2004517090A JP2004517090A (ja) 2004-06-10
JP2004517090A5 JP2004517090A5 (https=) 2006-08-17
JP4116437B2 true JP4116437B2 (ja) 2008-07-09

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JP2002549245A Expired - Fee Related JP4116437B2 (ja) 2000-11-17 2001-11-05 β−アミロイドペプチドの放出および／または合成を阻害するラクタム化合物

Country Status (33)

Country Link
US (1) US20050261495A1 (https=)
EP (1) EP1341531B1 (https=)
JP (1) JP4116437B2 (https=)
KR (1) KR100819679B1 (https=)
CN (1) CN1486184A (https=)
AR (1) AR035927A1 (https=)
AU (2) AU4319202A (https=)
BR (1) BR0115427A (https=)
CA (1) CA2427227C (https=)
CY (1) CY1106366T1 (https=)
CZ (1) CZ20031351A3 (https=)
DE (1) DE60126132T2 (https=)
DK (1) DK1341531T3 (https=)
DZ (1) DZ3453A1 (https=)
EA (1) EA005954B1 (https=)
EC (1) ECSP034600A (https=)
ES (1) ES2278804T3 (https=)
HR (1) HRP20030383B1 (https=)
HU (1) HU228117B1 (https=)
IL (2) IL155960A0 (https=)
MX (1) MXPA03004292A (https=)
MY (1) MY134559A (https=)
NO (1) NO324324B1 (https=)
NZ (1) NZ525854A (https=)
PE (1) PE20020802A1 (https=)
PL (1) PL212199B1 (https=)
PT (1) PT1341531E (https=)
SI (1) SI1341531T1 (https=)
SK (1) SK288065B6 (https=)
TW (1) TWI305204B (https=)
UA (1) UA74849C2 (https=)
WO (1) WO2002047671A2 (https=)
ZA (1) ZA200303789B (https=)

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WO2009128057A2 (en) 2008-04-18 2009-10-22 UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN et al Psycho-pharmaceuticals
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EP2654748B1 (en) 2010-12-21 2016-07-27 Merck Sharp & Dohme Corp. Indazole derivatives useful as erk inhibitors
EP2770987B1 (en) 2011-10-27 2018-04-04 Merck Sharp & Dohme Corp. Novel compounds that are erk inhibitors
CN102690231B (zh) * 2012-04-11 2014-07-09 南京友杰医药科技有限公司 治疗阿尔茨海默病潜在药物司马西特的合成方法
WO2013165816A2 (en) 2012-05-02 2013-11-07 Merck Sharp & Dohme Corp. SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS
CA2884309A1 (en) 2012-09-07 2014-03-13 Massachusetts Eye And Ear Infirmary Methods and compositions for regenerating hair cells and/or supporting cells from differentiated cochlear cells or differentiated utricular cells by modulation of notch and cmyc activity
CA2883896C (en) 2012-09-07 2023-03-07 Massachusetts Eye & Ear Infirmary Treating hearing loss
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US12595248B2 (en) 2019-12-17 2026-04-07 Merck Sharp & Dohme Llc PRMT5 inhibitors
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Also Published As

Publication number Publication date
EP1341531A2 (en) 2003-09-10
ES2278804T3 (es) 2007-08-16
DE60126132D1 (de) 2007-03-08
CA2427227C (en) 2010-08-17
AR035927A1 (es) 2004-07-28
HRP20030383B1 (hr) 2007-12-31
AU2002243192B2 (en) 2006-07-20
DE60126132T2 (de) 2007-10-18
ECSP034600A (es) 2003-06-25
EP1341531B1 (en) 2007-01-17
HK1059731A1 (en) 2004-07-16
PL362688A1 (en) 2004-11-02
MXPA03004292A (es) 2004-02-12
WO2002047671A3 (en) 2003-03-06
HU228117B1 (en) 2012-11-28
IL155960A0 (en) 2003-12-23
HRP20030383A2 (en) 2005-10-31
TWI305204B (en) 2009-01-11
KR100819679B1 (ko) 2008-04-04
HUP0301842A2 (hu) 2003-09-29
DZ3453A1 (fr) 2002-06-20
BR0115427A (pt) 2003-10-07
NO20032236L (no) 2003-07-10
EA200300580A1 (ru) 2003-10-30
NO20032236D0 (no) 2003-05-16
ZA200303789B (en) 2004-08-16
CN1486184A (zh) 2004-03-31
CA2427227A1 (en) 2002-06-20
SI1341531T1 (sl) 2007-06-30
SK288065B6 (sk) 2013-04-03
PE20020802A1 (es) 2002-09-10
EA005954B1 (ru) 2005-08-25
IL155960A (en) 2009-06-15
KR20030051846A (ko) 2003-06-25
UA74849C2 (en) 2006-02-15
SK5592003A3 (en) 2003-12-02
AU4319202A (en) 2002-06-24
CY1106366T1 (el) 2011-10-12
MY134559A (en) 2007-12-31
JP2004517090A (ja) 2004-06-10
US20050261495A1 (en) 2005-11-24
PL212199B1 (pl) 2012-08-31
NZ525854A (en) 2004-06-25
WO2002047671A2 (en) 2002-06-20
CZ20031351A3 (cs) 2003-11-12
NO324324B1 (no) 2007-09-24
DK1341531T3 (da) 2007-05-14
HUP0301842A3 (en) 2010-03-29
PT1341531E (pt) 2007-04-30

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