CN1436079A - 咪唑并吡啶和咪唑并嘧啶抗病毒剂 - Google Patents

咪唑并吡啶和咪唑并嘧啶抗病毒剂 Download PDF

Info

Publication number
CN1436079A
CN1436079A CN01811136A CN01811136A CN1436079A CN 1436079 A CN1436079 A CN 1436079A CN 01811136 A CN01811136 A CN 01811136A CN 01811136 A CN01811136 A CN 01811136A CN 1436079 A CN1436079 A CN 1436079A
Authority
CN
China
Prior art keywords
compound
nmr
mmol
alkyl
cycloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN01811136A
Other languages
English (en)
Chinese (zh)
Inventor
游国龙
R·L·茨维洛
K·D·科姆布林克
H·B·古尔格泽
N·辛
王向东
N·A·梅恩维尔
B·L·维纳布勒斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of CN1436079A publication Critical patent/CN1436079A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN01811136A 2000-06-13 2001-05-08 咪唑并吡啶和咪唑并嘧啶抗病毒剂 Pending CN1436079A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US21144700P 2000-06-13 2000-06-13
US60/211,447 2000-06-13
US26336301P 2001-01-22 2001-01-22
US60/263,363 2001-01-22

Publications (1)

Publication Number Publication Date
CN1436079A true CN1436079A (zh) 2003-08-13

Family

ID=26906145

Family Applications (1)

Application Number Title Priority Date Filing Date
CN01811136A Pending CN1436079A (zh) 2000-06-13 2001-05-08 咪唑并吡啶和咪唑并嘧啶抗病毒剂

Country Status (20)

Country Link
US (1) US6489338B2 (enExample)
EP (1) EP1311268A4 (enExample)
JP (1) JP2004503501A (enExample)
KR (1) KR20030008151A (enExample)
CN (1) CN1436079A (enExample)
AR (1) AR029128A1 (enExample)
AU (2) AU7290601A (enExample)
BR (1) BR0111569A (enExample)
CA (1) CA2412327A1 (enExample)
CZ (1) CZ20024078A3 (enExample)
HU (1) HUP0400766A2 (enExample)
IL (1) IL152889A0 (enExample)
MX (1) MXPA02012204A (enExample)
NO (1) NO20025977L (enExample)
NZ (1) NZ523566A (enExample)
PE (1) PE20011348A1 (enExample)
PL (1) PL360290A1 (enExample)
RU (1) RU2003100828A (enExample)
UY (1) UY26758A1 (enExample)
WO (1) WO2001095910A1 (enExample)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102690262A (zh) * 2011-03-23 2012-09-26 上海市第一人民医院 靶向人La蛋白的先导化合物及其在制备抗乙型肝炎病毒的药物中的用途
CN103313974A (zh) * 2010-12-16 2013-09-18 爱尔兰詹森研发公司 苯并咪唑呼吸道合胞病毒抑制剂
CN103347875A (zh) * 2010-12-16 2013-10-09 爱尔兰詹森研发公司 作为呼吸道合胞病毒抗病毒剂的吲哚类
CN104470916A (zh) * 2012-06-15 2015-03-25 爱尔兰詹森研发公司 新颖的作为呼吸道合胞病毒抗病毒剂的被苯并咪唑取代的1,3-二氢-2h-苯并咪唑-2-酮衍生物
CN104507916A (zh) * 2012-06-15 2015-04-08 爱尔兰詹森研发公司 作为呼吸道合胞病毒抗病毒剂的被苯并咪唑取代的4-取代的1,3-二氢-2h-苯并咪唑-2-酮衍生物
CN104540817A (zh) * 2012-06-15 2015-04-22 爱尔兰詹森研发公司 作为呼吸道合胞病毒抗病毒剂的用杂环取代的1,3-二氢-2h-苯并咪唑-2-酮衍生物
CN105683190A (zh) * 2013-10-29 2016-06-15 美迪维尔公司 基于喹唑啉的呼吸道合胞病毒抑制剂
CN108349940A (zh) * 2015-10-14 2018-07-31 淄博百极常生制药有限公司 布鲁顿酪氨酸激酶抑制剂
CN114630820A (zh) * 2019-10-30 2022-06-14 杨森科学爱尔兰无限公司 3-硝基-n-(2,2,2-三氟乙基)-4-吡啶胺的合成
WO2023143520A1 (en) * 2022-01-28 2023-08-03 Insilico Medicine Ip Limited Ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp1) inhibitors and uses thereof
CN116589399A (zh) * 2023-05-29 2023-08-15 济南大学 一种3-甲氧基-2-硝基吡啶的制备方法
CN117586250A (zh) * 2022-08-11 2024-02-23 潍坊汇韬化工有限公司 一种人类呼吸道合胞病毒抑制剂中间体的制备方法

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6774134B2 (en) * 2000-12-20 2004-08-10 Bristol-Myers Squibb Company Heterocyclic substituted 2-methyl-benzimidazole antiviral agents
US6919331B2 (en) * 2001-12-10 2005-07-19 Bristol-Myers Squibb Company Substituted 2-methyl-benzimidazole respiratory syncytial virus antiviral agents
US6737428B2 (en) 2001-12-10 2004-05-18 Bristol-Myers Squibb Company BIS hydrochloride monohydrate salt of RSV fusion inhibitor
US20040166137A1 (en) * 2002-11-08 2004-08-26 Lackey John William Hetero-substituted benzimidazole compounds and antiviral uses thereof
JP2007501252A (ja) * 2003-08-05 2007-01-25 スリーエム イノベイティブ プロパティズ カンパニー 免疫応答調整剤を含有する製剤
WO2005042530A1 (en) 2003-10-30 2005-05-12 Boehringer Ingelheim (Canada) Ltd. Rsv polymerase inhibitors
CA2551178C (en) * 2003-12-24 2012-11-06 Biota Scientific Management Pty Ltd Polycyclic agents for the treatment of respiratory syncytial virus infections
GB0406282D0 (en) * 2004-03-19 2004-04-21 Arrow Therapeutics Ltd Therapeutic compounds
GB0406279D0 (en) * 2004-03-19 2004-04-21 Arrow Therapeutics Ltd Therapeutic compounds
CN101027303A (zh) 2004-07-27 2007-08-29 吉里德科学公司 咪唑并[4，5－d]嘧啶类、其应用和制备方法
MX2007016311A (es) 2005-06-20 2008-03-07 Tibotec Pharm Ltd Bencimidazoles sustituidos con heterociclilaminoalquilo.
AU2006260969B2 (en) * 2005-06-20 2011-11-17 Janssen Sciences Ireland Uc 1- ( 2-amino-3- (substituted alkyl)-3H-benzimidazolylmethyl) -3-substituted-1,3-dihydro-benzoimidazol-2-ones with activity on respiratory syncytial virus
PL1896450T3 (pl) 2005-06-20 2013-01-31 Janssen Sciences Ireland Uc 2-podstawione benzimidazole
TWI423972B (zh) 2006-09-28 2014-01-21 Biota Scient Management 治療呼吸系融合細胞病毒感染之多環劑
WO2009084544A1 (ja) * 2007-12-27 2009-07-09 Idemitsu Kosan Co., Ltd. 含窒素複素環誘導体及びそれを用いた有機エレクトロルミネッセンス素子
US20100278835A1 (en) 2009-03-10 2010-11-04 Astrazeneca Uk Limited Novel compounds 660
RU2407738C1 (ru) * 2009-07-03 2010-12-27 Общество с ограниченной ответственностью "Интеллектуальный Диалог" Противовирусный активный компонент, фармацевтическая композиция, лекарственное средство, способ лечения вирусных заболеваний
TWI508968B (zh) 2010-02-08 2015-11-21 Biota Scient Management 用於治療呼吸道融合性病毒感染的化合物
WO2011115150A1 (ja) * 2010-03-18 2011-09-22 興和株式会社 ベンゾチアジン化合物の製造方法
US8796303B2 (en) 2010-11-26 2014-08-05 Biota Scientific Management Pty Ltd. Imidazo[2,1-G][1,7]naphthyridines for treating respiratory syncytial virus infections
TWI541241B (zh) 2010-12-16 2016-07-11 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之咪唑并吡啶類
TWI501967B (zh) 2010-12-16 2015-10-01 Janssen R&D Ireland 作為呼吸道融合病毒抗病毒劑之氮雜吲哚類
TWI527814B (zh) * 2010-12-16 2016-04-01 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之氮雜苯并咪唑類
CA2874303C (en) * 2012-06-11 2020-10-13 Ucb Biopharma Sprl Tnf -alpha modulating benz imidazoles
JP2015519387A (ja) * 2012-06-15 2015-07-09 ヤンセン・アールアンドデイ・アイルランド Ｒｓウイルス抗ウイルス薬としての、複素環によって置換された新規４−置換１，３−ジヒドロ−２ｈ−ベンゾイミダゾル−２−オン誘導体
AU2013334001B2 (en) * 2012-10-16 2017-07-20 Janssen Sciences Ireland Uc RSV antiviral compounds
JP2016145155A (ja) * 2013-04-30 2016-08-12 日本農薬株式会社 フタルアミド誘導体及び該誘導体を含有する農園芸用殺虫剤並びにその使用方法
WO2015065336A1 (en) * 2013-10-29 2015-05-07 Medivir Ab Respiratory syncytial virus inhibitors
WO2019046364A1 (en) * 2017-08-29 2019-03-07 Emory University INHIBITORS OF SYNCYTIAL RESPIRATORY VIRUS (RSV) REPLICATION AND USES THEREOF
PH12022551042A1 (en) * 2019-10-30 2023-05-29 Janssen Sciences Ireland Unlimited Co Synthesis of 3-({5-chloro-1-[3-(methylsulfonyl)propyl]-1h-indol-2 yl} methyl)-1-(2,2,2-trifluoroethyl)-1,3-dihydro-2h-imidazo[4,5-c]pyridin-2-one
JP2023528969A (ja) 2020-06-11 2023-07-06 ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー ３－（｛５－クロロ－１－［３－（メチルスルホニル）プロピル］－１Ｈ－インドール－２ イル｝メチル）－１－（２，２，２－トリフルオロエチル）－１，３－ジヒドロ－２Ｈ－イミダゾ［４，５－ｃ］ピリジン－２－オンのヘミ（Ｌ）－酒石酸塩形態及びそれを含む医薬組成物
WO2022184606A1 (en) * 2021-03-01 2022-09-09 Janssen Sciences Ireland Unlimited Company Synthesis of rilematovir
CN121969621A (zh) * 2023-08-02 2026-05-01 英矽智能科技知识产权有限公司 外核苷酸焦磷酸酶-磷酸二酯酶1 (enpp1)抑制剂的结晶形式及其用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4324794A (en) 1980-08-26 1982-04-13 Research Triangle Institute Inhibition of respiratory syncytial virus-induced cell fusion by amidino compounds
NO155805C (no) 1981-02-06 1987-06-10 Ucb Sa Analogifremgangsmaate for fremstilling av terapeutisk virksomme 2-(4-(difenylmethyl)-1-piperazinyl)-eddiksyrer og deres amider og ikke-toksiske salter.
US5256668A (en) 1993-03-17 1993-10-26 American Home Products Corporation Aminopyrimidine derivatives as antiviral agents for respiratory syncytial virus
ZA971185B (en) 1996-02-13 1998-08-12 American Cyanamid Co Triazine containing compounds useful as antiviral agents
CN1289248A (zh) 1998-01-29 2001-03-28 维洛药品公司 治疗或预防肺病毒感染及有关疾病的化合物、组合物和方法
JP2002521334A (ja) 1998-07-20 2002-07-16 ブリストルーマイヤーズ スクイブ カンパニー 置換ベンズイミダゾール抗ウィルス剤
JP2003503403A (ja) 1999-06-28 2003-01-28 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 呼吸合胞体ウイルス複製阻害剤

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107417683A (zh) * 2010-12-16 2017-12-01 爱尔兰詹森科学公司 苯并咪唑呼吸道合胞病毒抑制剂
CN103313974A (zh) * 2010-12-16 2013-09-18 爱尔兰詹森研发公司 苯并咪唑呼吸道合胞病毒抑制剂
CN103347875A (zh) * 2010-12-16 2013-10-09 爱尔兰詹森研发公司 作为呼吸道合胞病毒抗病毒剂的吲哚类
CN103347875B (zh) * 2010-12-16 2016-03-30 爱尔兰詹森科学公司 作为呼吸道合胞病毒抗病毒剂的吲哚类
CN102690262B (zh) * 2011-03-23 2014-05-28 上海市第一人民医院 靶向人La蛋白的先导化合物及其在制备抗乙型肝炎病毒的药物中的用途
CN103860538A (zh) * 2011-03-23 2014-06-18 上海市第一人民医院 靶向人La蛋白的先导化合物及其在制备抗乙型肝炎病毒的药物中的用途
CN103893173A (zh) * 2011-03-23 2014-07-02 上海市第一人民医院 靶向人La蛋白的先导化合物及其在制备抗乙型肝炎病毒的药物中的用途
CN102690262A (zh) * 2011-03-23 2012-09-26 上海市第一人民医院 靶向人La蛋白的先导化合物及其在制备抗乙型肝炎病毒的药物中的用途
CN104470916A (zh) * 2012-06-15 2015-03-25 爱尔兰詹森研发公司 新颖的作为呼吸道合胞病毒抗病毒剂的被苯并咪唑取代的1,3-二氢-2h-苯并咪唑-2-酮衍生物
CN104507916A (zh) * 2012-06-15 2015-04-08 爱尔兰詹森研发公司 作为呼吸道合胞病毒抗病毒剂的被苯并咪唑取代的4-取代的1,3-二氢-2h-苯并咪唑-2-酮衍生物
CN104540817A (zh) * 2012-06-15 2015-04-22 爱尔兰詹森研发公司 作为呼吸道合胞病毒抗病毒剂的用杂环取代的1,3-二氢-2h-苯并咪唑-2-酮衍生物
CN104540817B (zh) * 2012-06-15 2017-03-01 爱尔兰詹森科学公司 作为呼吸道合胞病毒抗病毒剂的用杂环取代的1，3‑二氢‑2h‑苯并咪唑‑2‑酮衍生物
CN105683190A (zh) * 2013-10-29 2016-06-15 美迪维尔公司 基于喹唑啉的呼吸道合胞病毒抑制剂
CN108349940A (zh) * 2015-10-14 2018-07-31 淄博百极常生制药有限公司 布鲁顿酪氨酸激酶抑制剂
CN108349940B (zh) * 2015-10-14 2021-08-13 淄博百极常生制药有限公司 布鲁顿酪氨酸激酶抑制剂
CN114630820A (zh) * 2019-10-30 2022-06-14 杨森科学爱尔兰无限公司 3-硝基-n-(2,2,2-三氟乙基)-4-吡啶胺的合成
CN114630820B (zh) * 2019-10-30 2023-10-31 杨森科学爱尔兰无限公司 3-硝基-n-(2,2,2-三氟乙基)-4-吡啶胺的合成
WO2023143520A1 (en) * 2022-01-28 2023-08-03 Insilico Medicine Ip Limited Ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp1) inhibitors and uses thereof
CN117586250A (zh) * 2022-08-11 2024-02-23 潍坊汇韬化工有限公司 一种人类呼吸道合胞病毒抑制剂中间体的制备方法
CN116589399A (zh) * 2023-05-29 2023-08-15 济南大学 一种3-甲氧基-2-硝基吡啶的制备方法

Also Published As

Publication number Publication date
NZ523566A (en) 2004-08-27
PE20011348A1 (es) 2002-02-07
CZ20024078A3 (cs) 2003-08-13
EP1311268A1 (en) 2003-05-21
PL360290A1 (en) 2004-09-06
CA2412327A1 (en) 2001-12-20
BR0111569A (pt) 2003-04-29
WO2001095910A1 (en) 2001-12-20
US6489338B2 (en) 2002-12-03
MXPA02012204A (es) 2003-10-15
NO20025977D0 (no) 2002-12-12
NO20025977L (no) 2003-01-29
AR029128A1 (es) 2003-06-04
IL152889A0 (en) 2003-06-24
JP2004503501A (ja) 2004-02-05
HUP0400766A2 (hu) 2004-07-28
AU7290601A (en) 2001-12-24
AU2001272906B2 (en) 2004-08-26
RU2003100828A (ru) 2004-06-27
KR20030008151A (ko) 2003-01-24
EP1311268A4 (en) 2004-06-30
UY26758A1 (es) 2002-01-31
US20020016309A1 (en) 2002-02-07

Similar Documents

Publication Publication Date Title
CN1045088C (zh) 用作pnp抑制剂的嘌呤和鸟嘌呤化合物
CN1042730C (zh) 吡唑并吡啶化合物的制备方法
CN1344160A (zh) 用作生长激素促分泌剂的杂环芳族化合物
CN1046724C (zh) 吡唑并吡啶化合物、含有它们的药物组合物、及其制法与用途
CN1117569C (zh) 双环纤维蛋白原拮抗剂
CN1179970C (zh) 嘌呤衍生物
CN1293078C (zh) 咪唑并稠合化合物
CN1255403C (zh) 用作磷酸二酯酶抑制剂的β－咔啉衍生物
CN100337626C (zh) 酰化的、杂芳基－稠合的环烯基胺和它们作为药物的用途
CN1280291C (zh) 用作磷酸二酯酶抑制剂的取代的吡咯并吡啶酮衍生物
CN1688577A (zh) 三氮杂螺[5.5]十一烷衍生物及以它为活性成分的药物
HK1039942B (zh) 作为趋化细胞因子受体5调制剂的哌啶
CN1781920A (zh) 多环鸟嘌呤磷酸二酯酶v抑制剂
CN1460105A (zh) 黄嘌呤磷酸二酯酶v抑制剂
CN101035785A (zh) 具有抗菌活性的新化合物
CN1400975A (zh) 嘌呤衍生物
CN1665789A (zh) 二氨基嘧啶酰胺衍生物
CN1088917A (zh) 取代的苄氨基含氮非芳族杂环化合物
CN1441781A (zh) 具有药用活性的哌啶衍生物,尤其可作为趋化因子受体活性的调节剂
CN101039672A (zh) 化合物
CN1503673A (zh) 消炎药
CN1127498C (zh) 吡啶衍生物、制备吡啶衍生物的方法及其中间体
CN1499972A (zh) 用作促肾上腺皮质激素释放因子抑制剂的咪唑基衍生物
CN1859914A (zh) 苯基吡咯烷醚速激肽受体拮抗剂
CN1035255C (zh) 杂三环衍生物

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication