HUP0400766A2 - Vírusellenes hatású imidazopiridin- és imidazopirimidin-származékok, ezeket tartalmazó készítmények és előállításuk - Google Patents

Vírusellenes hatású imidazopiridin- és imidazopirimidin-származékok, ezeket tartalmazó készítmények és előállításuk

Info

Publication number
HUP0400766A2
HUP0400766A2 HU0400766A HUP0400766A HUP0400766A2 HU P0400766 A2 HUP0400766 A2 HU P0400766A2 HU 0400766 A HU0400766 A HU 0400766A HU P0400766 A HUP0400766 A HU P0400766A HU P0400766 A2 HUP0400766 A2 HU P0400766A2
Authority
HU
Hungary
Prior art keywords
group
general formula
imidazopyrimidine
imidazopyridine
antiviral
Prior art date
Application number
HU0400766A
Other languages
English (en)
Hungarian (hu)
Inventor
Rita L. Civiello
Keith D. Combrink
Hatice Belgin Gulgeze
Nicholas A. Meanwell
Ny Sin
Brian Lee Venables
Xiangdong Wang
Kuo Long Yu
Original Assignee
Bristol-Myers Squibb Co.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Co. filed Critical Bristol-Myers Squibb Co.
Publication of HUP0400766A2 publication Critical patent/HUP0400766A2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HU0400766A 2000-06-13 2001-05-08 Vírusellenes hatású imidazopiridin- és imidazopirimidin-származékok, ezeket tartalmazó készítmények és előállításuk HUP0400766A2 (hu)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21144700P 2000-06-13 2000-06-13
US26336301P 2001-01-22 2001-01-22
PCT/US2001/014775 WO2001095910A1 (en) 2000-06-13 2001-05-08 Imidazopyridine and imidazopyrimidine antiviral agents

Publications (1)

Publication Number Publication Date
HUP0400766A2 true HUP0400766A2 (hu) 2004-07-28

Family

ID=26906145

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0400766A HUP0400766A2 (hu) 2000-06-13 2001-05-08 Vírusellenes hatású imidazopiridin- és imidazopirimidin-származékok, ezeket tartalmazó készítmények és előállításuk

Country Status (20)

Country Link
US (1) US6489338B2 (enExample)
EP (1) EP1311268A4 (enExample)
JP (1) JP2004503501A (enExample)
KR (1) KR20030008151A (enExample)
CN (1) CN1436079A (enExample)
AR (1) AR029128A1 (enExample)
AU (2) AU2001272906B2 (enExample)
BR (1) BR0111569A (enExample)
CA (1) CA2412327A1 (enExample)
CZ (1) CZ20024078A3 (enExample)
HU (1) HUP0400766A2 (enExample)
IL (1) IL152889A0 (enExample)
MX (1) MXPA02012204A (enExample)
NO (1) NO20025977L (enExample)
NZ (1) NZ523566A (enExample)
PE (1) PE20011348A1 (enExample)
PL (1) PL360290A1 (enExample)
RU (1) RU2003100828A (enExample)
UY (1) UY26758A1 (enExample)
WO (1) WO2001095910A1 (enExample)

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US6919331B2 (en) * 2001-12-10 2005-07-19 Bristol-Myers Squibb Company Substituted 2-methyl-benzimidazole respiratory syncytial virus antiviral agents
WO2004043913A2 (en) * 2002-11-08 2004-05-27 Trimeris, Inc. Hetero-substituted benzimidazole compounds and antiviral uses thereof
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US7323567B2 (en) 2003-10-30 2008-01-29 Boehringer Ingelheim (Canada) Ltd. RSV polymerase inhibitors
JP5384793B2 (ja) 2003-12-24 2014-01-08 バイオウタ サイエンティフィック マネジメント プロプライエタリー リミテッド 呼吸器合胞体ウイルス感染の処置のための多環式薬剤
GB0406279D0 (en) * 2004-03-19 2004-04-21 Arrow Therapeutics Ltd Therapeutic compounds
GB0406282D0 (en) * 2004-03-19 2004-04-21 Arrow Therapeutics Ltd Therapeutic compounds
CA2574220C (en) * 2004-07-27 2014-09-16 Gilead Sciences, Inc. Imidazo[4,5-d]pyrimidines, their uses and methods of preparation
RU2441866C2 (ru) 2005-06-20 2012-02-10 Тиботек Фармасьютикалз Лтд 2-замещенные бензимидазолы
CN101203506B (zh) 2005-06-20 2012-02-22 泰博特克药品有限公司 杂环基氨基烷基取代的苯并咪唑
AU2006260969B2 (en) * 2005-06-20 2011-11-17 Janssen Sciences Ireland Uc 1- ( 2-amino-3- (substituted alkyl)-3H-benzimidazolylmethyl) -3-substituted-1,3-dihydro-benzoimidazol-2-ones with activity on respiratory syncytial virus
TWI423972B (zh) 2006-09-28 2014-01-21 Biota Scient Management 治療呼吸系融合細胞病毒感染之多環劑
WO2009084544A1 (ja) * 2007-12-27 2009-07-09 Idemitsu Kosan Co., Ltd. 含窒素複素環誘導体及びそれを用いた有機エレクトロルミネッセンス素子
US20100278835A1 (en) 2009-03-10 2010-11-04 Astrazeneca Uk Limited Novel compounds 660
RU2407738C1 (ru) * 2009-07-03 2010-12-27 Общество с ограниченной ответственностью "Интеллектуальный Диалог" Противовирусный активный компонент, фармацевтическая композиция, лекарственное средство, способ лечения вирусных заболеваний
TWI508968B (zh) 2010-02-08 2015-11-21 Biota Scient Management 用於治療呼吸道融合性病毒感染的化合物
WO2011115150A1 (ja) * 2010-03-18 2011-09-22 興和株式会社 ベンゾチアジン化合物の製造方法
US8796303B2 (en) 2010-11-26 2014-08-05 Biota Scientific Management Pty Ltd. Imidazo[2,1-G][1,7]naphthyridines for treating respiratory syncytial virus infections
TWI527814B (zh) * 2010-12-16 2016-04-01 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之氮雜苯并咪唑類
TWI541241B (zh) * 2010-12-16 2016-07-11 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之咪唑并吡啶類
TWI530495B (zh) 2010-12-16 2016-04-21 健生科學愛爾蘭無限公司 苯并咪唑呼吸道融合病毒抑制劑
TWI501967B (zh) * 2010-12-16 2015-10-01 Janssen R&D Ireland 作為呼吸道融合病毒抗病毒劑之氮雜吲哚類
TWI515187B (zh) 2010-12-16 2016-01-01 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之吲哚類
CN102690262B (zh) * 2011-03-23 2014-05-28 上海市第一人民医院 靶向人La蛋白的先导化合物及其在制备抗乙型肝炎病毒的药物中的用途
TR201807207T4 (tr) * 2012-06-11 2018-06-21 Ucb Biopharma Sprl Tnf-alfa modüle edici benzimidazol bileşikleri.
US20150158862A1 (en) * 2012-06-15 2015-06-11 Janssen R&D Ireland 1,3-dihydro-2h-benzimidazol-2-one derivatives substituted with heterocycles as respiratory syncytial virus antiviral agents
CA2873920C (en) * 2012-06-15 2021-07-20 Janssen R&D Ireland 1,3-dihydro-2h-benzimidazol-2-one derivatives substituted with heterocycles as respiratory syncytial virus antiviral agents
US20150175608A1 (en) * 2012-06-15 2015-06-25 Janssen R&D Ireland Novel 4-substituted 1,3-dihydro-2h-benzimidazol-2-one derivatives substituted with benzimidazoles as respiratory syncytial virus antiviral agents
CA2873921A1 (en) * 2012-06-15 2013-12-19 Janssen R&D Ireland 1,3-dihydro-2h-benzimidazol-2-one derivatives substituted with benzimidazoles as respiratory syncytial virus antiviral agents
PT2909195T (pt) * 2012-10-16 2017-09-13 Janssen Sciences Ireland Uc Compostos antivirais de vsr
JP2016145155A (ja) * 2013-04-30 2016-08-12 日本農薬株式会社 フタルアミド誘導体及び該誘導体を含有する農園芸用殺虫剤並びにその使用方法
KR20160075766A (ko) * 2013-10-29 2016-06-29 메디비르 아베 퀴나졸린계 호흡기 세포융합 바이러스 억제제
WO2015065336A1 (en) * 2013-10-29 2015-05-07 Medivir Ab Respiratory syncytial virus inhibitors
CN108349940B (zh) * 2015-10-14 2021-08-13 淄博百极常生制药有限公司 布鲁顿酪氨酸激酶抑制剂
WO2019046364A1 (en) * 2017-08-29 2019-03-07 Emory University INHIBITORS OF SYNCYTIAL RESPIRATORY VIRUS (RSV) REPLICATION AND USES THEREOF
MX2022005257A (es) * 2019-10-30 2022-06-09 Janssen Sciences Ireland Unlimited Co Sintesis de 3-({5-cloro-1-[3-(metilsulfonil)propil]-1h-indol-2-il} metil)-1-(2,2,2-trifluoroetil)-1,3-dihidro-2h-imidazo[4,5-c]pirid in-2-ona.
AU2020372712A1 (en) 2019-10-30 2022-06-16 Janssen Sciences Ireland Unlimited Company Synthesis of 3-nitro-N-(2,2,2-trifluoroethyl)-4-pyridinamine
US12145933B2 (en) 2020-06-11 2024-11-19 Janssen Sciences Ireland Unlimited Company Hemi (L)-tartrate forms of 3-({5-chloro-1-[3-(methylsulfonyl)propyl]-1H-indol-2-yl}methyl)-1-(2,2,2-trifluoroethy)-1,3-dihydro-2H-imidazo[4,5-C]pyridin-2-one and pharmaceutical compositions comprising the same
WO2022184606A1 (en) * 2021-03-01 2022-09-09 Janssen Sciences Ireland Unlimited Company Synthesis of rilematovir
JP2025502943A (ja) * 2022-01-28 2025-01-30 インシリコ メディシン アイピー リミテッド エクトヌクレオチドピロホスファターゼ－ホスホジエステラーゼ１（ｅｎｐｐ１）阻害剤およびその使用
WO2025026383A1 (en) * 2023-08-02 2025-02-06 Insilico Medicine Ip Limited Crytsalline forms of ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp1) inhibitors and uses thereof

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US4324794A (en) 1980-08-26 1982-04-13 Research Triangle Institute Inhibition of respiratory syncytial virus-induced cell fusion by amidino compounds
NO155805C (no) 1981-02-06 1987-06-10 Ucb Sa Analogifremgangsmaate for fremstilling av terapeutisk virksomme 2-(4-(difenylmethyl)-1-piperazinyl)-eddiksyrer og deres amider og ikke-toksiske salter.
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BR9908522A (pt) 1998-01-29 2001-10-02 Viropharma Inc Composto, pró-droga, intermediário para a preparação de um composto, composição farmacêutica, processos para tratar e prevenir infecção por pneumovìrus, para tratar células em cultura, para tratar materiais biológicos, e, para preparar um composto
EP1098644A1 (en) 1998-07-20 2001-05-16 Bristol-Myers Squibb Company Substituted benzimidazole antiviral agents
HUP0201789A3 (en) 1999-06-28 2003-12-29 Janssen Pharmaceutica Nv Respiratory syncytial virus replication inhibitors

Also Published As

Publication number Publication date
JP2004503501A (ja) 2004-02-05
CA2412327A1 (en) 2001-12-20
AU2001272906B2 (en) 2004-08-26
EP1311268A4 (en) 2004-06-30
US6489338B2 (en) 2002-12-03
US20020016309A1 (en) 2002-02-07
NO20025977D0 (no) 2002-12-12
NO20025977L (no) 2003-01-29
RU2003100828A (ru) 2004-06-27
UY26758A1 (es) 2002-01-31
EP1311268A1 (en) 2003-05-21
CZ20024078A3 (cs) 2003-08-13
AR029128A1 (es) 2003-06-04
AU7290601A (en) 2001-12-24
PE20011348A1 (es) 2002-02-07
IL152889A0 (en) 2003-06-24
PL360290A1 (en) 2004-09-06
BR0111569A (pt) 2003-04-29
CN1436079A (zh) 2003-08-13
NZ523566A (en) 2004-08-27
MXPA02012204A (es) 2003-10-15
WO2001095910A1 (en) 2001-12-20
KR20030008151A (ko) 2003-01-24

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