AR029128A1 - Agentes antivirales de imidazopiridina e imidazopirimidina - Google Patents
Agentes antivirales de imidazopiridina e imidazopirimidinaInfo
- Publication number
- AR029128A1 AR029128A1 ARP010102772A ARP010102772A AR029128A1 AR 029128 A1 AR029128 A1 AR 029128A1 AR P010102772 A ARP010102772 A AR P010102772A AR P010102772 A ARP010102772 A AR P010102772A AR 029128 A1 AR029128 A1 AR 029128A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- cycloalkenyl
- cycloalkyl
- alkynyl
- alkenyl
- Prior art date
Links
- 239000003443 antiviral agent Substances 0.000 title abstract 2
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 10
- 125000003118 aryl group Chemical group 0.000 abstract 9
- 125000005843 halogen group Chemical group 0.000 abstract 7
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 6
- 125000003342 alkenyl group Chemical group 0.000 abstract 6
- 125000000304 alkynyl group Chemical group 0.000 abstract 6
- 241000725643 Respiratory syncytial virus Species 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 3
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 229910052760 oxygen Inorganic materials 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 229910052717 sulfur Inorganic materials 0.000 abstract 3
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 abstract 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 2
- YBYIRNPNPLQARY-UHFFFAOYSA-N 1H-indene Natural products C1=CC=C2CC=CC2=C1 YBYIRNPNPLQARY-UHFFFAOYSA-N 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 2
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 abstract 2
- 125000002178 anthracenyl group Chemical group C1(=CC=CC2=CC3=CC=CC=C3C=C12)* 0.000 abstract 2
- 125000003828 azulenyl group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000003983 fluorenyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3CC12)* 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 125000003454 indenyl group Chemical group C1(C=CC2=CC=CC=C12)* 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 229960000329 ribavirin Drugs 0.000 abstract 2
- HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 abstract 2
- 229940036185 synagis Drugs 0.000 abstract 2
- 125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 abstract 1
- 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 abstract 1
- 206010061598 Immunodeficiency Diseases 0.000 abstract 1
- 108060003951 Immunoglobulin Proteins 0.000 abstract 1
- 206010024971 Lower respiratory tract infections Diseases 0.000 abstract 1
- 206010035664 Pneumonia Diseases 0.000 abstract 1
- 206010061603 Respiratory syncytial virus infection Diseases 0.000 abstract 1
- 208000036142 Viral infection Diseases 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 239000000443 aerosol Substances 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 206010006451 bronchitis Diseases 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000006165 cyclic alkyl group Chemical group 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 102000018358 immunoglobulin Human genes 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000006574 non-aromatic ring group Chemical group 0.000 abstract 1
- 239000002777 nucleoside Substances 0.000 abstract 1
- 150000003833 nucleoside derivatives Chemical class 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21144700P | 2000-06-13 | 2000-06-13 | |
| US26336301P | 2001-01-22 | 2001-01-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR029128A1 true AR029128A1 (es) | 2003-06-04 |
Family
ID=26906145
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP010102772A AR029128A1 (es) | 2000-06-13 | 2001-06-12 | Agentes antivirales de imidazopiridina e imidazopirimidina |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6489338B2 (enExample) |
| EP (1) | EP1311268A4 (enExample) |
| JP (1) | JP2004503501A (enExample) |
| KR (1) | KR20030008151A (enExample) |
| CN (1) | CN1436079A (enExample) |
| AR (1) | AR029128A1 (enExample) |
| AU (2) | AU7290601A (enExample) |
| BR (1) | BR0111569A (enExample) |
| CA (1) | CA2412327A1 (enExample) |
| CZ (1) | CZ20024078A3 (enExample) |
| HU (1) | HUP0400766A2 (enExample) |
| IL (1) | IL152889A0 (enExample) |
| MX (1) | MXPA02012204A (enExample) |
| NO (1) | NO20025977L (enExample) |
| NZ (1) | NZ523566A (enExample) |
| PE (1) | PE20011348A1 (enExample) |
| PL (1) | PL360290A1 (enExample) |
| RU (1) | RU2003100828A (enExample) |
| UY (1) | UY26758A1 (enExample) |
| WO (1) | WO2001095910A1 (enExample) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6774134B2 (en) * | 2000-12-20 | 2004-08-10 | Bristol-Myers Squibb Company | Heterocyclic substituted 2-methyl-benzimidazole antiviral agents |
| PL369432A1 (en) | 2001-12-10 | 2005-04-18 | Bristol-Myers Squibb Company | Bis hydrochloride monohydrate salt of rsv fusion inhibitor |
| US6919331B2 (en) * | 2001-12-10 | 2005-07-19 | Bristol-Myers Squibb Company | Substituted 2-methyl-benzimidazole respiratory syncytial virus antiviral agents |
| AU2003294249A1 (en) * | 2002-11-08 | 2004-06-03 | Trimeris, Inc. | Hetero-substituted benzimidazole compounds and antiviral uses thereof |
| WO2005016275A2 (en) * | 2003-08-05 | 2005-02-24 | 3M Innovative Properties Company | Formulations containing an immune response modifier |
| JP4537407B2 (ja) | 2003-10-30 | 2010-09-01 | ベーリンガー インゲルハイム （カナダ） リミテッド | Ｒｓｖポリメラーゼインヒビター |
| EP1697377B1 (en) | 2003-12-24 | 2011-01-26 | Biota Scientific Management Pty. Ltd. | Polycyclic agents for the treatment of respiratory syncytial virus infections |
| GB0406282D0 (en) * | 2004-03-19 | 2004-04-21 | Arrow Therapeutics Ltd | Therapeutic compounds |
| GB0406279D0 (en) * | 2004-03-19 | 2004-04-21 | Arrow Therapeutics Ltd | Therapeutic compounds |
| WO2006033703A1 (en) * | 2004-07-27 | 2006-03-30 | Gilead Sciences, Inc. | Imidazo[4,5-d]pyrimidines, their uses and methods of preparation |
| US7884215B2 (en) | 2005-06-20 | 2011-02-08 | Bonfanti Jean-Francois | 2-substituted benzimidazoles |
| US8178694B2 (en) | 2005-06-20 | 2012-05-15 | Tibotec Pharmaceuticals Ltd. | Heterocyclylaminoalkyl substituted benzimidazoles |
| EP1896473B1 (en) | 2005-06-20 | 2011-10-19 | Tibotec Pharmaceuticals | 1-[[2-amino-3-(substituted alkyl)-3h-benzimidazolyl]methyl]-3-subtituted-1,3-dihydro-benzoimidazol-2-ones as inhibitors of respiratory syncytial virus replication |
| TWI423972B (zh) | 2006-09-28 | 2014-01-21 | Biota Scient Management | 治療呼吸系融合細胞病毒感染之多環劑 |
| WO2009084544A1 (ja) * | 2007-12-27 | 2009-07-09 | Idemitsu Kosan Co., Ltd. | 含窒素複素環誘導体及びそれを用いた有機エレクトロルミネッセンス素子 |
| US20100278835A1 (en) | 2009-03-10 | 2010-11-04 | Astrazeneca Uk Limited | Novel compounds 660 |
| RU2407738C1 (ru) * | 2009-07-03 | 2010-12-27 | Общество с ограниченной ответственностью "Интеллектуальный Диалог" | Противовирусный активный компонент, фармацевтическая композиция, лекарственное средство, способ лечения вирусных заболеваний |
| TWI508968B (zh) | 2010-02-08 | 2015-11-21 | Biota Scient Management | 用於治療呼吸道融合性病毒感染的化合物 |
| JPWO2011115150A1 (ja) * | 2010-03-18 | 2013-07-04 | 興和株式会社 | ベンゾチアジン化合物の製造方法 |
| US8796303B2 (en) | 2010-11-26 | 2014-08-05 | Biota Scientific Management Pty Ltd. | Imidazo[2,1-G][1,7]naphthyridines for treating respiratory syncytial virus infections |
| TWI515187B (zh) | 2010-12-16 | 2016-01-01 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之吲哚類 |
| TWI530495B (zh) | 2010-12-16 | 2016-04-21 | 健生科學愛爾蘭無限公司 | 苯并咪唑呼吸道融合病毒抑制劑 |
| TWI527814B (zh) | 2010-12-16 | 2016-04-01 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之氮雜苯并咪唑類 |
| TWI541241B (zh) * | 2010-12-16 | 2016-07-11 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之咪唑并吡啶類 |
| TWI501967B (zh) | 2010-12-16 | 2015-10-01 | Janssen R&D Ireland | 作為呼吸道融合病毒抗病毒劑之氮雜吲哚類 |
| CN103893173B (zh) * | 2011-03-23 | 2016-02-24 | 上海市第一人民医院 | 靶向人La蛋白的先导化合物及其在制备抗乙型肝炎病毒的药物中的用途 |
| WO2013186229A1 (en) * | 2012-06-11 | 2013-12-19 | Ucb Pharma S.A. | Tnf -alpha modulating benzimidazoles |
| AU2013276518A1 (en) * | 2012-06-15 | 2014-12-04 | Janssen Sciences Ireland Uc | 4 - substituted 1, 3 - dihydro - 2H - benzimidazol - 2 - one derivatives substituted with benzimidazoles as respiratory syncytial virus antiviral agents |
| EA201590021A1 (ru) * | 2012-06-15 | 2015-04-30 | ЯНССЕН Ар ЭНД Ди АЙРЛЭНД | Новые замещенные производные 1,3-дигидро-2h-бензимидазол-2-она, замещенные гетероциклами, в качестве противовирусных средств против респираторного синцитиального вируса |
| KR20150033645A (ko) * | 2012-06-15 | 2015-04-01 | 얀센 알 앤드 디 아일랜드 | 호흡기 합포체 바이러스의 항바이러스제로서의 벤즈이미다졸로 치환된 1,3-디하이드로-2h-벤즈이미다졸-2-온 유도체 |
| KR102092612B1 (ko) * | 2012-06-15 | 2020-03-25 | 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 | 호흡기 합포체 바이러스의 항바이러스제로서의 헤테로사이클로 치환된 1,3-디하이드로-2h-벤즈이미다졸-2-온 유도체 |
| ME02835B (me) * | 2012-10-16 | 2018-01-20 | Janssen Sciences Ireland Uc | Antivirusna rsv jedinjenja |
| JP2016145155A (ja) * | 2013-04-30 | 2016-08-12 | 日本農薬株式会社 | フタルアミド誘導体及び該誘導体を含有する農園芸用殺虫剤並びにその使用方法 |
| RU2016120763A (ru) * | 2013-10-29 | 2017-12-05 | Медивир Аб | Ингибиторы респираторного синцитиального вируса |
| WO2015065336A1 (en) * | 2013-10-29 | 2015-05-07 | Medivir Ab | Respiratory syncytial virus inhibitors |
| US10358446B2 (en) | 2015-10-14 | 2019-07-23 | Zibo Biopolar Changsheng Pharmaceutical Co., Ltd. | Bruton's tyrosine kinase inhibitors |
| WO2019046364A1 (en) * | 2017-08-29 | 2019-03-07 | Emory University | INHIBITORS OF SYNCYTIAL RESPIRATORY VIRUS (RSV) REPLICATION AND USES THEREOF |
| EP4051663B1 (en) * | 2019-10-30 | 2024-02-21 | Janssen Sciences Ireland Unlimited Company | Synthesis of 3-nitro-n-(2,2,2-trifluoroethyl)-4-pyridinamine |
| IL292526A (en) * | 2019-10-30 | 2022-06-01 | Janssen Sciences Ireland Unlimited Co | Synthesis of 3-({5-chloro-1-[3-(methylsulfonyl)propyl]-1h-indol-2-yl}methyl)-1-(2,2,2-trifluoroethyl)-3,1-dihydro- 2h-Imidazo[5,4-c]pyridin-2-one |
| JP2023528969A (ja) | 2020-06-11 | 2023-07-06 | ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー | ３－（｛５－クロロ－１－［３－（メチルスルホニル）プロピル］－１Ｈ－インドール－２ イル｝メチル）－１－（２，２，２－トリフルオロエチル）－１，３－ジヒドロ－２Ｈ－イミダゾ［４，５－ｃ］ピリジン－２－オンのヘミ（Ｌ）－酒石酸塩形態及びそれを含む医薬組成物 |
| WO2022184606A1 (en) * | 2021-03-01 | 2022-09-09 | Janssen Sciences Ireland Unlimited Company | Synthesis of rilematovir |
| EP4469456A4 (en) * | 2022-01-28 | 2025-12-31 | Insilico Medicine Ip Ltd | Ectunocleotide pyrophosphatase-phosphodiesterase 1 (ENPP1) inhibitors and their uses |
| WO2025026383A1 (en) * | 2023-08-02 | 2025-02-06 | Insilico Medicine Ip Limited | Crytsalline forms of ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp1) inhibitors and uses thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4324794A (en) | 1980-08-26 | 1982-04-13 | Research Triangle Institute | Inhibition of respiratory syncytial virus-induced cell fusion by amidino compounds |
| NO155805C (no) | 1981-02-06 | 1987-06-10 | Ucb Sa | Analogifremgangsmaate for fremstilling av terapeutisk virksomme 2-(4-(difenylmethyl)-1-piperazinyl)-eddiksyrer og deres amider og ikke-toksiske salter. |
| US5256668A (en) | 1993-03-17 | 1993-10-26 | American Home Products Corporation | Aminopyrimidine derivatives as antiviral agents for respiratory syncytial virus |
| CA2197393A1 (en) | 1996-02-13 | 1997-08-14 | Yakov Gluzman (Deceased) | Triazine containing anionic compounds useful as antiviral agents |
| AU759772B2 (en) | 1998-01-29 | 2003-05-01 | Viropharma Incorporated | Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases |
| AU741946B2 (en) | 1998-07-20 | 2001-12-13 | Bristol-Myers Squibb Company | Substituted benzimidazole antiviral agents |
| EP1400519B1 (en) | 1999-06-28 | 2007-03-07 | Janssen Pharmaceutica N.V. | Respiratory syncytial virus replication inhibitors |
-
2001
- 2001-04-23 US US09/840,279 patent/US6489338B2/en not_active Expired - Fee Related
- 2001-05-08 EP EP01952114A patent/EP1311268A4/en not_active Withdrawn
- 2001-05-08 JP JP2002510088A patent/JP2004503501A/ja not_active Withdrawn
- 2001-05-08 KR KR1020027016924A patent/KR20030008151A/ko not_active Ceased
- 2001-05-08 PL PL36029001A patent/PL360290A1/xx not_active Application Discontinuation
- 2001-05-08 RU RU2003100828/15A patent/RU2003100828A/ru not_active Application Discontinuation
- 2001-05-08 CN CN01811136A patent/CN1436079A/zh active Pending
- 2001-05-08 MX MXPA02012204A patent/MXPA02012204A/es unknown
- 2001-05-08 NZ NZ523566A patent/NZ523566A/en unknown
- 2001-05-08 WO PCT/US2001/014775 patent/WO2001095910A1/en not_active Ceased
- 2001-05-08 HU HU0400766A patent/HUP0400766A2/hu unknown
- 2001-05-08 BR BR0111569-3A patent/BR0111569A/pt not_active IP Right Cessation
- 2001-05-08 IL IL15288901A patent/IL152889A0/xx unknown
- 2001-05-08 AU AU7290601A patent/AU7290601A/xx active Pending
- 2001-05-08 CZ CZ20024078A patent/CZ20024078A3/cs unknown
- 2001-05-08 CA CA002412327A patent/CA2412327A1/en not_active Abandoned
- 2001-05-08 AU AU2001272906A patent/AU2001272906B2/en not_active Ceased
- 2001-06-11 UY UY26758A patent/UY26758A1/es not_active Application Discontinuation
- 2001-06-12 AR ARP010102772A patent/AR029128A1/es unknown
- 2001-06-13 PE PE2001000559A patent/PE20011348A1/es not_active Application Discontinuation
-
2002
- 2002-12-12 NO NO20025977A patent/NO20025977L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA02012204A (es) | 2003-10-15 |
| CA2412327A1 (en) | 2001-12-20 |
| NZ523566A (en) | 2004-08-27 |
| WO2001095910A1 (en) | 2001-12-20 |
| CZ20024078A3 (cs) | 2003-08-13 |
| US6489338B2 (en) | 2002-12-03 |
| BR0111569A (pt) | 2003-04-29 |
| KR20030008151A (ko) | 2003-01-24 |
| PE20011348A1 (es) | 2002-02-07 |
| PL360290A1 (en) | 2004-09-06 |
| HUP0400766A2 (hu) | 2004-07-28 |
| RU2003100828A (ru) | 2004-06-27 |
| US20020016309A1 (en) | 2002-02-07 |
| EP1311268A1 (en) | 2003-05-21 |
| IL152889A0 (en) | 2003-06-24 |
| JP2004503501A (ja) | 2004-02-05 |
| AU7290601A (en) | 2001-12-24 |
| CN1436079A (zh) | 2003-08-13 |
| AU2001272906B2 (en) | 2004-08-26 |
| EP1311268A4 (en) | 2004-06-30 |
| NO20025977L (no) | 2003-01-29 |
| UY26758A1 (es) | 2002-01-31 |
| NO20025977D0 (no) | 2002-12-12 |
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