UY26758A1 - Agentes antivirales de imidazopiridina e imidazopirimidina - Google Patents

Agentes antivirales de imidazopiridina e imidazopirimidina

Info

Publication number
UY26758A1
UY26758A1 UY26758A UY26758A UY26758A1 UY 26758 A1 UY26758 A1 UY 26758A1 UY 26758 A UY26758 A UY 26758A UY 26758 A UY26758 A UY 26758A UY 26758 A1 UY26758 A1 UY 26758A1
Authority
UY
Uruguay
Prior art keywords
imidazopirimidine
imidazopiridine
antiviral agents
treatment
compositions
Prior art date
Application number
UY26758A
Other languages
English (en)
Inventor
Nicholas A Meanwell
Kuo-Long Yu
Rita L Civiello
Keith D Combrink
Hatice Belgin Gulgeze
Ny Sin
Xiangdong Wang
Brian L Venables
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of UY26758A1 publication Critical patent/UY26758A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención se refiere a compuestos antivirales, sus métodos de preparación y sus composiciones, y el uso en el tratamiento de infecciones virales. Más particularmente, la invención proporciona derivados de imidazopiridina e imidazopirimidina (Fórmula I) para el tratamiento de la infección por virus sincitial respiratorio.
UY26758A 2000-06-13 2001-06-11 Agentes antivirales de imidazopiridina e imidazopirimidina UY26758A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21144700P 2000-06-13 2000-06-13
US26336301P 2001-01-22 2001-01-22

Publications (1)

Publication Number Publication Date
UY26758A1 true UY26758A1 (es) 2002-01-31

Family

ID=26906145

Family Applications (1)

Application Number Title Priority Date Filing Date
UY26758A UY26758A1 (es) 2000-06-13 2001-06-11 Agentes antivirales de imidazopiridina e imidazopirimidina

Country Status (20)

Country Link
US (1) US6489338B2 (es)
EP (1) EP1311268A4 (es)
JP (1) JP2004503501A (es)
KR (1) KR20030008151A (es)
CN (1) CN1436079A (es)
AR (1) AR029128A1 (es)
AU (2) AU7290601A (es)
BR (1) BR0111569A (es)
CA (1) CA2412327A1 (es)
CZ (1) CZ20024078A3 (es)
HU (1) HUP0400766A2 (es)
IL (1) IL152889A0 (es)
MX (1) MXPA02012204A (es)
NO (1) NO20025977L (es)
NZ (1) NZ523566A (es)
PE (1) PE20011348A1 (es)
PL (1) PL360290A1 (es)
RU (1) RU2003100828A (es)
UY (1) UY26758A1 (es)
WO (1) WO2001095910A1 (es)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6774134B2 (en) * 2000-12-20 2004-08-10 Bristol-Myers Squibb Company Heterocyclic substituted 2-methyl-benzimidazole antiviral agents
US6919331B2 (en) * 2001-12-10 2005-07-19 Bristol-Myers Squibb Company Substituted 2-methyl-benzimidazole respiratory syncytial virus antiviral agents
WO2003049688A2 (en) * 2001-12-10 2003-06-19 Bristol-Myers Squibb Company Bis hydrochloride monohydrate salt of rsv fusion inhibitor
WO2004043913A2 (en) * 2002-11-08 2004-05-27 Trimeris, Inc. Hetero-substituted benzimidazole compounds and antiviral uses thereof
AU2004264330A1 (en) * 2003-08-05 2005-02-24 3M Innovative Properties Company Infection prophylaxis using immune response modifier compounds
JP4537407B2 (ja) 2003-10-30 2010-09-01 ベーリンガー インゲルハイム （カナダ） リミテッド Ｒｓｖポリメラーゼインヒビター
NZ551468A (en) * 2003-12-24 2010-05-28 Biota Scient Management Polycyclic agents for the treatment of respiratory syncytial virus infections
GB0406279D0 (en) * 2004-03-19 2004-04-21 Arrow Therapeutics Ltd Therapeutic compounds
GB0406282D0 (en) * 2004-03-19 2004-04-21 Arrow Therapeutics Ltd Therapeutic compounds
BRPI0513811A (pt) * 2004-07-27 2008-07-15 Gilead Sciences Inc imidazo [4,5-d] pirimidinas, seus usos e processos de preparação
PL1896450T3 (pl) 2005-06-20 2013-01-31 Janssen Sciences Ireland Uc 2-podstawione benzimidazole
WO2006136561A1 (en) 2005-06-20 2006-12-28 Tibotec Pharmaceuticals Ltd 1- ( 2-amino-3- (substituted alkyl)-3h-benzimidazoiylmethyl) -3-subtituted-1,3-dihydro-benzoimidazol-2-ones with activity on respiratory syncytial virus
BRPI0611744B8 (pt) 2005-06-20 2021-05-25 Janssen R & D Ireland benzimidazóis heterociclilaminoalquila substituída, seu processo de preparação e composição farmacêutica
TWI423972B (zh) 2006-09-28 2014-01-21 Biota Scient Management 治療呼吸系融合細胞病毒感染之多環劑
WO2009084544A1 (ja) * 2007-12-27 2009-07-09 Idemitsu Kosan Co., Ltd. 含窒素複素環誘導体及びそれを用いた有機エレクトロルミネッセンス素子
WO2010103306A1 (en) 2009-03-10 2010-09-16 Astrazeneca Uk Limited Benzimidazole derivatives and their use as antivaral agents
TWI508968B (zh) 2010-02-08 2015-11-21 Biota Scient Management 用於治療呼吸道融合性病毒感染的化合物
WO2011115150A1 (ja) * 2010-03-18 2011-09-22 興和株式会社 ベンゾチアジン化合物の製造方法
US8796303B2 (en) 2010-11-26 2014-08-05 Biota Scientific Management Pty Ltd. Imidazo[2,1-G][1,7]naphthyridines for treating respiratory syncytial virus infections
TWI501967B (zh) * 2010-12-16 2015-10-01 Janssen R&D Ireland 作為呼吸道融合病毒抗病毒劑之氮雜吲哚類
TWI541241B (zh) 2010-12-16 2016-07-11 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之咪唑并吡啶類
TWI527814B (zh) * 2010-12-16 2016-04-01 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之氮雜苯并咪唑類
TWI515187B (zh) 2010-12-16 2016-01-01 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之吲哚類
TWI530495B (zh) 2010-12-16 2016-04-21 健生科學愛爾蘭無限公司 苯并咪唑呼吸道融合病毒抑制劑
CN103860538B (zh) * 2011-03-23 2016-03-02 上海市第一人民医院 靶向人La蛋白的先导化合物及其在制备抗乙型肝炎病毒的药物中的用途
JP6359008B2 (ja) * 2012-06-11 2018-07-18 ユーシービー バイオファルマ エスピーアールエル Ｔｎｆ−アルファ調節ベンゾイミダゾール
TWI643850B (zh) * 2012-06-15 2018-12-11 健生科學愛爾蘭無限公司 作為呼吸道融合病毒之抗病毒劑的新穎經雜環取代之１，３－二氫－２ｈ－苯并咪唑－２－酮衍生物
WO2013186335A1 (en) * 2012-06-15 2013-12-19 Janssen R&D Ireland 1,3 -dihydro-2h-benzimidazol-2-one derivatives substituted with heterocycles as respiratory syncytial virus antiviral agents
CN104470916A (zh) * 2012-06-15 2015-03-25 爱尔兰詹森研发公司 新颖的作为呼吸道合胞病毒抗病毒剂的被苯并咪唑取代的1,3-二氢-2h-苯并咪唑-2-酮衍生物
EP2864299A1 (en) * 2012-06-15 2015-04-29 Janssen Sciences Ireland UC 4 - substituted 1, 3 - dihydro - 2h - benzimidazol - 2 - one derivatives substituted with benzimidazoles as respiratory syncytial virus antiviral agents
PT2909195T (pt) * 2012-10-16 2017-09-13 Janssen Sciences Ireland Uc Compostos antivirais de vsr
JP2016145155A (ja) * 2013-04-30 2016-08-12 日本農薬株式会社 フタルアミド誘導体及び該誘導体を含有する農園芸用殺虫剤並びにその使用方法
WO2015065336A1 (en) * 2013-10-29 2015-05-07 Medivir Ab Respiratory syncytial virus inhibitors
KR20160075766A (ko) * 2013-10-29 2016-06-29 메디비르 아베 퀴나졸린계 호흡기 세포융합 바이러스 억제제
US10358446B2 (en) 2015-10-14 2019-07-23 Zibo Biopolar Changsheng Pharmaceutical Co., Ltd. Bruton's tyrosine kinase inhibitors
WO2019046364A1 (en) * 2017-08-29 2019-03-07 Emory University INHIBITORS OF SYNCYTIAL RESPIRATORY VIRUS (RSV) REPLICATION AND USES THEREOF
EP4051663B1 (en) * 2019-10-30 2024-02-21 Janssen Sciences Ireland Unlimited Company Synthesis of 3-nitro-n-(2,2,2-trifluoroethyl)-4-pyridinamine
WO2022184606A1 (en) * 2021-03-01 2022-09-09 Janssen Sciences Ireland Unlimited Company Synthesis of rilematovir
WO2023143520A1 (en) * 2022-01-28 2023-08-03 Insilico Medicine Ip Limited Ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp1) inhibitors and uses thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4324794A (en) 1980-08-26 1982-04-13 Research Triangle Institute Inhibition of respiratory syncytial virus-induced cell fusion by amidino compounds
NO155805C (no) 1981-02-06 1987-06-10 Ucb Sa Analogifremgangsmaate for fremstilling av terapeutisk virksomme 2-(4-(difenylmethyl)-1-piperazinyl)-eddiksyrer og deres amider og ikke-toksiske salter.
US5256668A (en) 1993-03-17 1993-10-26 American Home Products Corporation Aminopyrimidine derivatives as antiviral agents for respiratory syncytial virus
CA2197393A1 (en) 1996-02-13 1997-08-14 Yakov Gluzman (Deceased) Triazine containing anionic compounds useful as antiviral agents
AU759772B2 (en) 1998-01-29 2003-05-01 Viropharma Incorporated Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases
WO2000004900A1 (en) 1998-07-20 2000-02-03 Bristol-Myers Squibb Company Substituted benzimidazole antiviral agents
SK18952001A3 (sk) 1999-06-28 2002-11-06 Janssen Pharmaceutica N. V. Inhibítory replikácie respiračného syncyciálneho vírusu

Also Published As

Publication number Publication date
RU2003100828A (ru) 2004-06-27
NO20025977L (no) 2003-01-29
AU2001272906B2 (en) 2004-08-26
PE20011348A1 (es) 2002-02-07
AU7290601A (en) 2001-12-24
CA2412327A1 (en) 2001-12-20
EP1311268A1 (en) 2003-05-21
JP2004503501A (ja) 2004-02-05
NO20025977D0 (no) 2002-12-12
IL152889A0 (en) 2003-06-24
MXPA02012204A (es) 2003-10-15
US6489338B2 (en) 2002-12-03
BR0111569A (pt) 2003-04-29
EP1311268A4 (en) 2004-06-30
WO2001095910A1 (en) 2001-12-20
KR20030008151A (ko) 2003-01-24
PL360290A1 (en) 2004-09-06
AR029128A1 (es) 2003-06-04
HUP0400766A2 (hu) 2004-07-28
CN1436079A (zh) 2003-08-13
US20020016309A1 (en) 2002-02-07
CZ20024078A3 (cs) 2003-08-13
NZ523566A (en) 2004-08-27

Similar Documents

Publication Publication Date Title
UY26758A1 (es) Agentes antivirales de imidazopiridina e imidazopirimidina
WO2002062290A3 (en) Heterocyclic substituted 2-methyl-benzimidazole antiviral agents
PA8588501A1 (es) Derivados antivirales de nucleósidos
DK1353911T3 (da) Antivirale midler
EP2041159B8 (en) Macrocyclic compounds as antiviral agents
AR034448A1 (es) Uso de derivados de nucleosidos, dichos derivados de nucleosidos para dicho uso, composiciones farmaceuticas que los comprenden y uso de dichas composiciones
WO2003053344A3 (en) Substituted 2-methyl-benzimidazole respiratory syncytial virus antiviral agents
BR0207172A (pt) Pirido-pirimidinas 6-substituìdas
WO2005084192A3 (en) Novel 2’-c-methyl nucleoside derivatives
PE20080179A1 (es) FORMAS CRISTALINAS DE LA SAL MALEATO DE 5-AMINO-3-(2',3'-DI-O-ACETIL-BETA-D-RIBOFURANOSIL)-3H-TIAZOLO[4,5-d]PIRIMIDIN-2-ONA
HN2003000348A (es) Compuestos de benzofurano, composiciones y metodos para tratamiento y profilaxis de infeccion virales de hepatitis c y enfermedades asociadas.
CY1113323T1 (el) Ενωσεις τετραϋδροφουρο[3,4-d]διοξολανιου για χρηση στη θεραπεια ιικων μολυνσεων και καρκινου
MY128458A (en) Antiviral azaindole derivatives
ATE332301T1 (de) Antivirale pyrazolopyridin verbindungen
BR0316771A (pt) Compostos para o tratamento ou a prevenção de infecções por flavivirus, uso de um composto e composição farmacêutica
DE60215157D1 (de) Verwendungen von antiviralen nucleosid-derivaten zur herstellung eines medikaments zur behandlung von hepatitis c infektionen
WO2021262826A3 (en) 1'-cyano nucleoside analogs and uses thereof
ATE254132T1 (de) Antivirale pyrimidin nucleoside derivate
IL172015A (en) Phosphonate grouping shaft compounds, method of preparation and use thereof for the preparation of drugs for the treatment of viral infection
BRPI0408353A (pt) composto, composição farmacêutica, métodos para o tratamento de neoplasias suscetìveis e para o tratamento de infecções virais, e, uso de um composto
BR0100155A (pt) Azabenzimidazóis aril substituìdos e sua utilização no tratamento de hiv e doenças relacionadas com aids
BR0215016A (pt) Piridoquinoxalinas antivirìcas
UY30788A1 (es) Compuestos quimicos
HK1131988A1 (en) Polycyclic agents for the treatment of respiratory syncytial virus infections
BRPI0509667B8 (pt) composto, processo para a preparação de um composto de fórmula (i), medicamento e uso de um composto

Legal Events

Date Code Title Description
109 Application deemed to be withdrawn

Effective date: 20140131