JP2004503501A - イミダゾピリジンおよびイミダゾピリミジン抗ウイルス剤 - Google Patents

イミダゾピリジンおよびイミダゾピリミジン抗ウイルス剤 Download PDF

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Publication number
JP2004503501A
JP2004503501A JP2002510088A JP2002510088A JP2004503501A JP 2004503501 A JP2004503501 A JP 2004503501A JP 2002510088 A JP2002510088 A JP 2002510088A JP 2002510088 A JP2002510088 A JP 2002510088A JP 2004503501 A JP2004503501 A JP 2004503501A
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JP
Japan
Prior art keywords
embedded image
nmr
compound
mmol
alkyl
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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JP2002510088A
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English (en)
Japanese (ja)
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JP2004503501A5 (enExample
Inventor
クオ−ロン・ユ
リタ・エル・シビエロ
キース・ディ・コムブリンク
ハティス・ベルジン・ガルゲーズ
ニ・シン
シャンドン・ワン
ニコラス・エイ・ミーンウェル
ブライアン・リー・ベナブルズ
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of JP2004503501A publication Critical patent/JP2004503501A/ja
Publication of JP2004503501A5 publication Critical patent/JP2004503501A5/ja
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2002510088A 2000-06-13 2001-05-08 イミダゾピリジンおよびイミダゾピリミジン抗ウイルス剤 Withdrawn JP2004503501A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21144700P 2000-06-13 2000-06-13
US26336301P 2001-01-22 2001-01-22
PCT/US2001/014775 WO2001095910A1 (en) 2000-06-13 2001-05-08 Imidazopyridine and imidazopyrimidine antiviral agents

Publications (2)

Publication Number Publication Date
JP2004503501A true JP2004503501A (ja) 2004-02-05
JP2004503501A5 JP2004503501A5 (enExample) 2006-06-01

Family

ID=26906145

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002510088A Withdrawn JP2004503501A (ja) 2000-06-13 2001-05-08 イミダゾピリジンおよびイミダゾピリミジン抗ウイルス剤

Country Status (20)

Country Link
US (1) US6489338B2 (enExample)
EP (1) EP1311268A4 (enExample)
JP (1) JP2004503501A (enExample)
KR (1) KR20030008151A (enExample)
CN (1) CN1436079A (enExample)
AR (1) AR029128A1 (enExample)
AU (2) AU2001272906B2 (enExample)
BR (1) BR0111569A (enExample)
CA (1) CA2412327A1 (enExample)
CZ (1) CZ20024078A3 (enExample)
HU (1) HUP0400766A2 (enExample)
IL (1) IL152889A0 (enExample)
MX (1) MXPA02012204A (enExample)
NO (1) NO20025977L (enExample)
NZ (1) NZ523566A (enExample)
PE (1) PE20011348A1 (enExample)
PL (1) PL360290A1 (enExample)
RU (1) RU2003100828A (enExample)
UY (1) UY26758A1 (enExample)
WO (1) WO2001095910A1 (enExample)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008546738A (ja) * 2005-06-20 2008-12-25 テイボテク・フアーマシユーチカルズ・リミテツド 呼吸器シンシチウムウイルスに活性をもつ、１−（２−アミノ−３−（置換アルキル）−３ｈ−ベンズイミダゾイルメチル）−３−置換−１，３−ジヒドロ−ベンゾイミダゾル−２−オン
JP2013545785A (ja) * 2010-12-16 2013-12-26 ヤンセン・アールアンドデイ・アイルランド ベンゾイミダゾール呼吸合胞体ウイルス阻害剤
JP2015519381A (ja) * 2012-06-11 2015-07-09 ユーシービー バイオファルマ エスピーアールエル Ｔｎｆ−アルファ調節ベンゾイミダゾール
JP2015519386A (ja) * 2012-06-15 2015-07-09 ヤンセン・アールアンドデイ・アイルランド Ｒｓウイルス抗ウイルス薬としての、複素環によって置換された新規１，３−ジヒドロ−２ｈ−ベンゾイミダゾル−２−オン誘導体
JP2016145236A (ja) * 2010-12-16 2016-08-12 ヤンセン・サイエンシズ・アイルランド・ユーシー 呼吸合胞体ウイルスの抗ウイルス剤としてのインドール
JP2023500213A (ja) * 2019-10-30 2023-01-05 ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー ３－ニトロ－ｎ－（２，２，２－トリフルオロエチル）－４－ピリジンアミンの合成
JP2023500214A (ja) * 2019-10-30 2023-01-05 ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー ３－（｛５－クロロ－１－［３－（メチルスルホニル）プロピル］－１Ｈ－インドール－２イル｝メチル）－１－（２，２，２－トリフルオロエチル）－１，３－ジヒドロ－２Ｈ－イミダゾ［４，５－ｃ］ピリジン－２－オンの合成

Families Citing this family (38)

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US6774134B2 (en) * 2000-12-20 2004-08-10 Bristol-Myers Squibb Company Heterocyclic substituted 2-methyl-benzimidazole antiviral agents
US6919331B2 (en) * 2001-12-10 2005-07-19 Bristol-Myers Squibb Company Substituted 2-methyl-benzimidazole respiratory syncytial virus antiviral agents
WO2003049688A2 (en) * 2001-12-10 2003-06-19 Bristol-Myers Squibb Company Bis hydrochloride monohydrate salt of rsv fusion inhibitor
WO2004043913A2 (en) * 2002-11-08 2004-05-27 Trimeris, Inc. Hetero-substituted benzimidazole compounds and antiviral uses thereof
CN1852711A (zh) * 2003-08-05 2006-10-25 3M创新有限公司 使用免疫响应调节化合物的传染病预防
US7323567B2 (en) 2003-10-30 2008-01-29 Boehringer Ingelheim (Canada) Ltd. RSV polymerase inhibitors
NZ551468A (en) 2003-12-24 2010-05-28 Biota Scient Management Polycyclic agents for the treatment of respiratory syncytial virus infections
GB0406279D0 (en) * 2004-03-19 2004-04-21 Arrow Therapeutics Ltd Therapeutic compounds
GB0406282D0 (en) * 2004-03-19 2004-04-21 Arrow Therapeutics Ltd Therapeutic compounds
BRPI0513811A (pt) * 2004-07-27 2008-07-15 Gilead Sciences Inc imidazo [4,5-d] pirimidinas, seus usos e processos de preparação
RU2441866C2 (ru) 2005-06-20 2012-02-10 Тиботек Фармасьютикалз Лтд 2-замещенные бензимидазолы
RU2419613C2 (ru) 2005-06-20 2011-05-27 Тиботек Фармасьютикалз Лтд Гетероциклиламиноалкилзамещенные бензимидазолы
TWI423972B (zh) 2006-09-28 2014-01-21 Biota Scient Management 治療呼吸系融合細胞病毒感染之多環劑
WO2009084544A1 (ja) * 2007-12-27 2009-07-09 Idemitsu Kosan Co., Ltd. 含窒素複素環誘導体及びそれを用いた有機エレクトロルミネッセンス素子
US20100278835A1 (en) 2009-03-10 2010-11-04 Astrazeneca Uk Limited Novel compounds 660
RU2407738C1 (ru) * 2009-07-03 2010-12-27 Общество с ограниченной ответственностью "Интеллектуальный Диалог" Противовирусный активный компонент, фармацевтическая композиция, лекарственное средство, способ лечения вирусных заболеваний
TWI508968B (zh) 2010-02-08 2015-11-21 Biota Scient Management 用於治療呼吸道融合性病毒感染的化合物
JPWO2011115150A1 (ja) * 2010-03-18 2013-07-04 興和株式会社 ベンゾチアジン化合物の製造方法
US8796303B2 (en) 2010-11-26 2014-08-05 Biota Scientific Management Pty Ltd. Imidazo[2,1-G][1,7]naphthyridines for treating respiratory syncytial virus infections
TWI541241B (zh) * 2010-12-16 2016-07-11 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之咪唑并吡啶類
TWI501967B (zh) * 2010-12-16 2015-10-01 Janssen R&D Ireland 作為呼吸道融合病毒抗病毒劑之氮雜吲哚類
TWI527814B (zh) * 2010-12-16 2016-04-01 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之氮雜苯并咪唑類
CN102690262B (zh) * 2011-03-23 2014-05-28 上海市第一人民医院 靶向人La蛋白的先导化合物及其在制备抗乙型肝炎病毒的药物中的用途
EA201590023A1 (ru) * 2012-06-15 2015-05-29 ЯНССЕН Ар ЭНД Ди АЙРЛЭНД Новые 4-замещенные производные 1,3-дигидро-2h-бензимидазол-2-она, замещенные бензимидазолами, в качестве противовирусных средств против респираторного синцитиального вируса
WO2013186334A1 (en) * 2012-06-15 2013-12-19 Janssen R&D Ireland 1,3-dihydro-2h-benzimidazol-2-one derivatives substituted with benzimidazoles as respiratory syncytial virus antiviral agents
JP2015519387A (ja) * 2012-06-15 2015-07-09 ヤンセン・アールアンドデイ・アイルランド Ｒｓウイルス抗ウイルス薬としての、複素環によって置換された新規４−置換１，３−ジヒドロ−２ｈ−ベンゾイミダゾル−２−オン誘導体
MY172021A (en) * 2012-10-16 2019-11-12 Janssen Sciences Ireland Uc Rsv antiviral compounds
JP2016145155A (ja) * 2013-04-30 2016-08-12 日本農薬株式会社 フタルアミド誘導体及び該誘導体を含有する農園芸用殺虫剤並びにその使用方法
WO2015065336A1 (en) * 2013-10-29 2015-05-07 Medivir Ab Respiratory syncytial virus inhibitors
AU2013404035B2 (en) * 2013-10-29 2017-04-20 Medivir Ab Quinazoline based respiratory syncytial virus inhibitors
EP3414234B1 (en) * 2015-10-14 2022-06-29 Zibo Biopolar Changsheng Pharmaceutical Co. Ltd. Bruton's tyrosine kinase inhibitors
WO2019046364A1 (en) * 2017-08-29 2019-03-07 Emory University INHIBITORS OF SYNCYTIAL RESPIRATORY VIRUS (RSV) REPLICATION AND USES THEREOF
EP4165034A1 (en) 2020-06-11 2023-04-19 Janssen Sciences Ireland Unlimited Company Hemi (l)-tartrate forms of 3-({5-chloro-1-[3-(methylsulfonyl)propyl]-1h-indol-2 yl} methyl)-1-(2,2,2-trifluoroethyl)-1,3-dihydro-2h-imidazo[4,5-c]pyridin-2-one and pharmaceutical compositions comprising the same
WO2022184606A1 (en) * 2021-03-01 2022-09-09 Janssen Sciences Ireland Unlimited Company Synthesis of rilematovir
IL313821A (en) * 2022-01-28 2024-08-01 Insilico Medicine Ip Ltd Ectonucleotide pyrophosphatase-phosphodiesterase 1 (ENPP1) inhibitors and their uses
CN117586250A (zh) * 2022-08-11 2024-02-23 潍坊汇韬化工有限公司 一种人类呼吸道合胞病毒抑制剂中间体的制备方法
CN116589399A (zh) * 2023-05-29 2023-08-15 济南大学 一种3-甲氧基-2-硝基吡啶的制备方法
CN121969621A (zh) * 2023-08-02 2026-05-01 英矽智能科技知识产权有限公司 外核苷酸焦磷酸酶-磷酸二酯酶1 (enpp1)抑制剂的结晶形式及其用途

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US4324794A (en) 1980-08-26 1982-04-13 Research Triangle Institute Inhibition of respiratory syncytial virus-induced cell fusion by amidino compounds
FI75816C (fi) 1981-02-06 1988-08-08 Ucb Sa Foerfarande foer framstaellning av terapeutiskt aktiv 2-/4-(difenylmetyl)-1-piperazinyl/-aettiksyror eller dess amid.
US5256668A (en) 1993-03-17 1993-10-26 American Home Products Corporation Aminopyrimidine derivatives as antiviral agents for respiratory syncytial virus
CA2197393A1 (en) 1996-02-13 1997-08-14 Yakov Gluzman (Deceased) Triazine containing anionic compounds useful as antiviral agents
WO1999038508A1 (en) 1998-01-29 1999-08-05 Viropharma Incorporated Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases
EP1098644A1 (en) 1998-07-20 2001-05-16 Bristol-Myers Squibb Company Substituted benzimidazole antiviral agents
ES2215670T3 (es) 1999-06-28 2004-10-16 Janssen Pharmaceutica N.V. Inhibidores de la replicacion del virus sincitial respiratorio.

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008546738A (ja) * 2005-06-20 2008-12-25 テイボテク・フアーマシユーチカルズ・リミテツド 呼吸器シンシチウムウイルスに活性をもつ、１−（２−アミノ−３−（置換アルキル）−３ｈ−ベンズイミダゾイルメチル）−３−置換−１，３−ジヒドロ−ベンゾイミダゾル−２−オン
JP2013545785A (ja) * 2010-12-16 2013-12-26 ヤンセン・アールアンドデイ・アイルランド ベンゾイミダゾール呼吸合胞体ウイルス阻害剤
JP2016145236A (ja) * 2010-12-16 2016-08-12 ヤンセン・サイエンシズ・アイルランド・ユーシー 呼吸合胞体ウイルスの抗ウイルス剤としてのインドール
JP2015519381A (ja) * 2012-06-11 2015-07-09 ユーシービー バイオファルマ エスピーアールエル Ｔｎｆ−アルファ調節ベンゾイミダゾール
JP2015519386A (ja) * 2012-06-15 2015-07-09 ヤンセン・アールアンドデイ・アイルランド Ｒｓウイルス抗ウイルス薬としての、複素環によって置換された新規１，３−ジヒドロ−２ｈ−ベンゾイミダゾル−２−オン誘導体
JP2023500213A (ja) * 2019-10-30 2023-01-05 ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー ３－ニトロ－ｎ－（２，２，２－トリフルオロエチル）－４－ピリジンアミンの合成
JP2023500214A (ja) * 2019-10-30 2023-01-05 ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー ３－（｛５－クロロ－１－［３－（メチルスルホニル）プロピル］－１Ｈ－インドール－２イル｝メチル）－１－（２，２，２－トリフルオロエチル）－１，３－ジヒドロ－２Ｈ－イミダゾ［４，５－ｃ］ピリジン－２－オンの合成

Also Published As

Publication number Publication date
KR20030008151A (ko) 2003-01-24
NO20025977L (no) 2003-01-29
WO2001095910A1 (en) 2001-12-20
UY26758A1 (es) 2002-01-31
MXPA02012204A (es) 2003-10-15
IL152889A0 (en) 2003-06-24
AU2001272906B2 (en) 2004-08-26
RU2003100828A (ru) 2004-06-27
US20020016309A1 (en) 2002-02-07
CA2412327A1 (en) 2001-12-20
CN1436079A (zh) 2003-08-13
AU7290601A (en) 2001-12-24
HUP0400766A2 (hu) 2004-07-28
BR0111569A (pt) 2003-04-29
US6489338B2 (en) 2002-12-03
EP1311268A4 (en) 2004-06-30
AR029128A1 (es) 2003-06-04
PL360290A1 (en) 2004-09-06
PE20011348A1 (es) 2002-02-07
NZ523566A (en) 2004-08-27
CZ20024078A3 (cs) 2003-08-13
NO20025977D0 (no) 2002-12-12
EP1311268A1 (en) 2003-05-21

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