CN1241931C - 大环内酯抗感染药物 - Google Patents

大环内酯抗感染药物 Download PDF

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Publication number
CN1241931C
CN1241931C CNB008090718A CN00809071A CN1241931C CN 1241931 C CN1241931 C CN 1241931C CN B008090718 A CNB008090718 A CN B008090718A CN 00809071 A CN00809071 A CN 00809071A CN 1241931 C CN1241931 C CN 1241931C
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CN
China
Prior art keywords
compound
unsubstituted
methyl
added
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB008090718A
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English (en)
Chinese (zh)
Other versions
CN1384838A (zh
Inventor
D·T·W·褚
G·W·阿什利
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kosan Biosciences Inc
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Kosan Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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Publication of CN1384838A publication Critical patent/CN1384838A/zh
Application granted granted Critical
Publication of CN1241931C publication Critical patent/CN1241931C/zh
Anticipated expiration legal-status Critical
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23B—PRESERVATION OF FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES; CHEMICAL RIPENING OF FRUIT OR VEGETABLES
    • A23B2/00—Preservation of foods or foodstuffs, in general
    • A23B2/70—Preservation of foods or foodstuffs, in general by treatment with chemicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CNB008090718A 1999-04-16 2000-04-14 大环内酯抗感染药物 Expired - Fee Related CN1241931C (zh)

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
US12972999P 1999-04-16 1999-04-16
US60/129,729 1999-04-16
US14017599P 1999-06-18 1999-06-18
US60/140,175 1999-06-18
US17215499P 1999-12-17 1999-12-17
US17215999P 1999-12-17 1999-12-17
US60/172,159 1999-12-17
US60/172,154 1999-12-17
US17380499P 1999-12-30 1999-12-30
US17380599P 1999-12-30 1999-12-30
US60/173,805 1999-12-30
US60/173,804 1999-12-30
US09/550,045 2000-04-14
US09/550,045 US6395710B1 (en) 1999-04-16 2000-04-14 Macrolide antiinfective agents

Publications (2)

Publication Number Publication Date
CN1384838A CN1384838A (zh) 2002-12-11
CN1241931C true CN1241931C (zh) 2006-02-15

Family

ID=27568857

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB008090718A Expired - Fee Related CN1241931C (zh) 1999-04-16 2000-04-14 大环内酯抗感染药物

Country Status (16)

Country Link
US (3) US6395710B1 (enExample)
EP (1) EP1171446B1 (enExample)
JP (1) JP2003523938A (enExample)
KR (2) KR100710605B1 (enExample)
CN (1) CN1241931C (enExample)
AT (1) ATE340183T1 (enExample)
AU (2) AU773678B2 (enExample)
BR (1) BR0010680A (enExample)
CA (1) CA2369816A1 (enExample)
DE (1) DE60030847T2 (enExample)
ES (1) ES2272273T3 (enExample)
ID (1) ID30547A (enExample)
IL (2) IL145777A0 (enExample)
MX (1) MXPA01010524A (enExample)
NZ (1) NZ515027A (enExample)
WO (2) WO2000063224A2 (enExample)

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US6472372B1 (en) 2000-12-06 2002-10-29 Ortho-Mcneil Pharmaceuticals, Inc. 6-O-Carbamoyl ketolide antibacterials
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RU2004117082A (ru) 2001-12-05 2005-04-10 Орто-Макнейл Фармасьютикал, Инк. (Us) Кетолидные 6-0-ацил-производные эритромицина в качестве антибактериальных средств
US8063021B2 (en) * 2002-01-17 2011-11-22 Kosan Biosciences Incorporated Ketolide anti-infective compounds
DK1483251T3 (da) 2002-03-12 2010-04-12 Bristol Myers Squibb Co C3-cyano-epothilon-derivater
US20040014691A1 (en) * 2002-04-25 2004-01-22 Searle Xenia Beebe 9-Oxime macrolide antibacterials
US20040009932A1 (en) * 2002-04-26 2004-01-15 Kathleen Phelan Antibacterial compounds with activity against penicillin-resistant streptococcus pneumoniae
US6825172B2 (en) 2002-05-31 2004-11-30 Janssen Pharmaceutica, Nv 3-descladinosyl-6-O-carbamoyl and 6-O-carbonoyl macrolide antibacterial agents
US7427493B2 (en) 2002-06-28 2008-09-23 Kosan Biosciences Incorporated Recombinant genes for polyketide modifying enzymes
SI1532131T1 (sl) * 2002-08-29 2009-04-30 Pfizer Motilidne spojine
CA2529817C (en) 2003-03-10 2013-02-12 Optimer Pharmaceuticals, Inc. Novel antibacterial agents
US7407941B2 (en) * 2003-08-26 2008-08-05 Pfizer, Inc. N-desmethyl-N-substituted-11-deoxyerythromycin compounds
US20050113319A1 (en) * 2003-08-26 2005-05-26 Christopher Carreras 11-Deoxy-6,9-ether erythromycin compounds
WO2005067919A1 (en) * 2003-12-24 2005-07-28 Enanta Pharmaceuticals, Inc. 11-csubsituted erythromycin derivatives
CA2591746A1 (en) * 2004-12-21 2006-06-29 Pfizer Products Inc. Macrolides
US7595300B2 (en) 2005-12-13 2009-09-29 Kosan Biosciences Incorporated 7-quinolyl ketolide antibacterial agents
AU2008316830B2 (en) * 2007-10-25 2016-03-17 Cempra Pharmaceuticals, Inc. Process for the preparation of macrolide antibacterial agents
PL2247294T3 (pl) * 2008-02-08 2014-09-30 Basilea Pharmaceutica Ag Makrolidy do leczenia chorób przez hamowanie PDE
WO2010048600A1 (en) * 2008-10-24 2010-04-29 Cempra Pharmaceuticals, Inc. Methods for treating resistant diseases using triazole containing macrolides
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
US9480679B2 (en) 2009-09-10 2016-11-01 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and MAC diseases
HRP20160168T1 (hr) 2010-03-22 2016-03-25 Cempra Pharmaceuticals Inc Kristalne forme makrolida i njihova uporaba
EP2571506B1 (en) 2010-05-20 2017-05-10 Cempra Pharmaceuticals, Inc. Processes for preparing macrolides and ketolides and intermediates therefor
US8796474B1 (en) 2010-08-23 2014-08-05 Rutgers, The State University Of New Jersey Macrolide compounds and methods and intermediates useful for their preparation
KR20130120458A (ko) 2010-09-10 2013-11-04 셈프라 파마슈티컬스, 인크. 질환을 치료하기 위한 수소결합 형성 플루오로 케토라이드
WO2012117357A2 (en) * 2011-03-01 2012-09-07 Wockhardt Limited Process for preparation of ketolide intermediates
WO2013148891A1 (en) 2012-03-27 2013-10-03 Cempra Pharmaceuticals, Inc. Parenteral formulations for administering macrolide antibiotics
CN102718816B (zh) * 2012-07-11 2014-11-05 山东大学 4''-O-(反式-β-芳基烯丙酰胺)氨基甲酰基阿奇霉素衍生物
EP2968801B1 (en) 2013-03-14 2018-09-26 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
MX356772B (es) 2013-03-15 2018-06-13 Cempra Pharmaceuticals Inc Procesos convergentes para la preparacion de agentes antibacterianos macrolidos.
EP4153189A1 (en) * 2020-05-22 2023-03-29 Merck Sharp & Dohme LLC Synthesis of fluorinated nucleotides

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Also Published As

Publication number Publication date
KR100710605B1 (ko) 2007-04-24
IL145777A (en) 2007-02-11
CA2369816A1 (en) 2000-10-26
WO2000063225A2 (en) 2000-10-26
AU775637B2 (en) 2004-08-12
IL145777A0 (en) 2002-07-25
NZ515027A (en) 2004-01-30
ATE340183T1 (de) 2006-10-15
AU4457800A (en) 2000-11-02
AU4237900A (en) 2000-11-02
EP1171446B1 (en) 2006-09-20
AU773678B2 (en) 2004-06-03
CN1384838A (zh) 2002-12-11
ID30547A (id) 2001-12-20
MXPA01010524A (es) 2002-03-14
DE60030847D1 (de) 2006-11-02
EP1171446A2 (en) 2002-01-16
DE60030847T2 (de) 2007-04-19
WO2000063225A3 (en) 2001-01-18
BR0010680A (pt) 2002-02-19
USRE39836E1 (en) 2007-09-11
JP2003523938A (ja) 2003-08-12
US20020119938A1 (en) 2002-08-29
KR20020007374A (ko) 2002-01-26
KR20020007372A (ko) 2002-01-26
ES2272273T3 (es) 2007-05-01
WO2000063224A2 (en) 2000-10-26
US6593302B2 (en) 2003-07-15
US6395710B1 (en) 2002-05-28
WO2000063224A3 (en) 2001-01-18

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Granted publication date: 20060215