KR100710605B1 - 매크롤라이드 항감염제 - Google Patents

매크롤라이드 항감염제 Download PDF

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Publication number
KR100710605B1
KR100710605B1 KR1020017013150A KR20017013150A KR100710605B1 KR 100710605 B1 KR100710605 B1 KR 100710605B1 KR 1020017013150 A KR1020017013150 A KR 1020017013150A KR 20017013150 A KR20017013150 A KR 20017013150A KR 100710605 B1 KR100710605 B1 KR 100710605B1
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South Korea
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compound
formula
methyl
added
mmol
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Expired - Fee Related
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KR1020017013150A
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English (en)
Korean (ko)
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KR20020007372A (ko
Inventor
추다니엘티.더블류.
애슐리게리더블류.
Original Assignee
코산 바이오사이언시즈, 인코포레이티드
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Publication of KR20020007372A publication Critical patent/KR20020007372A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23B—PRESERVATION OF FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES; CHEMICAL RIPENING OF FRUIT OR VEGETABLES
    • A23B2/00—Preservation of foods or foodstuffs, in general
    • A23B2/70—Preservation of foods or foodstuffs, in general by treatment with chemicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020017013150A 1999-04-16 2000-04-14 매크롤라이드 항감염제 Expired - Fee Related KR100710605B1 (ko)

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
US12972999P 1999-04-16 1999-04-16
US60/129,729 1999-04-16
US14017599P 1999-06-18 1999-06-18
US60/140,175 1999-06-18
US17215499P 1999-12-17 1999-12-17
US17215999P 1999-12-17 1999-12-17
US60/172,159 1999-12-17
US60/172,154 1999-12-17
US17380499P 1999-12-30 1999-12-30
US17380599P 1999-12-30 1999-12-30
US60/173,805 1999-12-30
US60/173,804 1999-12-30
US09/550,045 2000-04-14
US09/550,045 US6395710B1 (en) 1999-04-16 2000-04-14 Macrolide antiinfective agents

Publications (2)

Publication Number Publication Date
KR20020007372A KR20020007372A (ko) 2002-01-26
KR100710605B1 true KR100710605B1 (ko) 2007-04-24

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020017013150A Expired - Fee Related KR100710605B1 (ko) 1999-04-16 2000-04-14 매크롤라이드 항감염제
KR1020017013225A Withdrawn KR20020007374A (ko) 1999-04-16 2000-04-14 매크롤라이드 항감염제

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020017013225A Withdrawn KR20020007374A (ko) 1999-04-16 2000-04-14 매크롤라이드 항감염제

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US (3) US6395710B1 (enExample)
EP (1) EP1171446B1 (enExample)
JP (1) JP2003523938A (enExample)
KR (2) KR100710605B1 (enExample)
CN (1) CN1241931C (enExample)
AT (1) ATE340183T1 (enExample)
AU (2) AU773678B2 (enExample)
BR (1) BR0010680A (enExample)
CA (1) CA2369816A1 (enExample)
DE (1) DE60030847T2 (enExample)
ES (1) ES2272273T3 (enExample)
ID (1) ID30547A (enExample)
IL (2) IL145777A0 (enExample)
MX (1) MXPA01010524A (enExample)
NZ (1) NZ515027A (enExample)
WO (2) WO2000063224A2 (enExample)

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OA11753A (en) 1999-01-27 2005-07-19 Pfizer Prod Inc Ketolide antibiotics.
US6451768B1 (en) 1999-04-16 2002-09-17 Kosan Biosciences, Inc. Macrolide antiinfective agents
US6590083B1 (en) * 1999-04-16 2003-07-08 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
EP1167376B1 (en) 2000-06-30 2004-07-14 Pfizer Products Inc. Macrolide antibiotics
US6472372B1 (en) 2000-12-06 2002-10-29 Ortho-Mcneil Pharmaceuticals, Inc. 6-O-Carbamoyl ketolide antibacterials
DK1373290T3 (da) * 2001-03-21 2014-12-01 Dow Agrosciences Llc Pesticidale spinosynderivater
JP2005503416A (ja) 2001-09-17 2005-02-03 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド ６−ｏ−カルバメート−１１，１２−ラクト−ケトライド抗菌剤
RU2004117082A (ru) 2001-12-05 2005-04-10 Орто-Макнейл Фармасьютикал, Инк. (Us) Кетолидные 6-0-ацил-производные эритромицина в качестве антибактериальных средств
US8063021B2 (en) * 2002-01-17 2011-11-22 Kosan Biosciences Incorporated Ketolide anti-infective compounds
DK1483251T3 (da) 2002-03-12 2010-04-12 Bristol Myers Squibb Co C3-cyano-epothilon-derivater
US20040014691A1 (en) * 2002-04-25 2004-01-22 Searle Xenia Beebe 9-Oxime macrolide antibacterials
US20040009932A1 (en) * 2002-04-26 2004-01-15 Kathleen Phelan Antibacterial compounds with activity against penicillin-resistant streptococcus pneumoniae
US6825172B2 (en) 2002-05-31 2004-11-30 Janssen Pharmaceutica, Nv 3-descladinosyl-6-O-carbamoyl and 6-O-carbonoyl macrolide antibacterial agents
US7427493B2 (en) 2002-06-28 2008-09-23 Kosan Biosciences Incorporated Recombinant genes for polyketide modifying enzymes
SI1532131T1 (sl) * 2002-08-29 2009-04-30 Pfizer Motilidne spojine
CA2529817C (en) 2003-03-10 2013-02-12 Optimer Pharmaceuticals, Inc. Novel antibacterial agents
US7407941B2 (en) * 2003-08-26 2008-08-05 Pfizer, Inc. N-desmethyl-N-substituted-11-deoxyerythromycin compounds
US20050113319A1 (en) * 2003-08-26 2005-05-26 Christopher Carreras 11-Deoxy-6,9-ether erythromycin compounds
WO2005067919A1 (en) * 2003-12-24 2005-07-28 Enanta Pharmaceuticals, Inc. 11-csubsituted erythromycin derivatives
CA2591746A1 (en) * 2004-12-21 2006-06-29 Pfizer Products Inc. Macrolides
US7595300B2 (en) 2005-12-13 2009-09-29 Kosan Biosciences Incorporated 7-quinolyl ketolide antibacterial agents
AU2008316830B2 (en) * 2007-10-25 2016-03-17 Cempra Pharmaceuticals, Inc. Process for the preparation of macrolide antibacterial agents
PL2247294T3 (pl) * 2008-02-08 2014-09-30 Basilea Pharmaceutica Ag Makrolidy do leczenia chorób przez hamowanie PDE
WO2010048600A1 (en) * 2008-10-24 2010-04-29 Cempra Pharmaceuticals, Inc. Methods for treating resistant diseases using triazole containing macrolides
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
US9480679B2 (en) 2009-09-10 2016-11-01 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and MAC diseases
HRP20160168T1 (hr) 2010-03-22 2016-03-25 Cempra Pharmaceuticals Inc Kristalne forme makrolida i njihova uporaba
EP2571506B1 (en) 2010-05-20 2017-05-10 Cempra Pharmaceuticals, Inc. Processes for preparing macrolides and ketolides and intermediates therefor
US8796474B1 (en) 2010-08-23 2014-08-05 Rutgers, The State University Of New Jersey Macrolide compounds and methods and intermediates useful for their preparation
KR20130120458A (ko) 2010-09-10 2013-11-04 셈프라 파마슈티컬스, 인크. 질환을 치료하기 위한 수소결합 형성 플루오로 케토라이드
WO2012117357A2 (en) * 2011-03-01 2012-09-07 Wockhardt Limited Process for preparation of ketolide intermediates
WO2013148891A1 (en) 2012-03-27 2013-10-03 Cempra Pharmaceuticals, Inc. Parenteral formulations for administering macrolide antibiotics
CN102718816B (zh) * 2012-07-11 2014-11-05 山东大学 4''-O-(反式-β-芳基烯丙酰胺)氨基甲酰基阿奇霉素衍生物
EP2968801B1 (en) 2013-03-14 2018-09-26 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
MX356772B (es) 2013-03-15 2018-06-13 Cempra Pharmaceuticals Inc Procesos convergentes para la preparacion de agentes antibacterianos macrolidos.
EP4153189A1 (en) * 2020-05-22 2023-03-29 Merck Sharp & Dohme LLC Synthesis of fluorinated nucleotides

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미국특허공보 제5750510호

Also Published As

Publication number Publication date
IL145777A (en) 2007-02-11
CA2369816A1 (en) 2000-10-26
WO2000063225A2 (en) 2000-10-26
AU775637B2 (en) 2004-08-12
IL145777A0 (en) 2002-07-25
NZ515027A (en) 2004-01-30
ATE340183T1 (de) 2006-10-15
AU4457800A (en) 2000-11-02
AU4237900A (en) 2000-11-02
EP1171446B1 (en) 2006-09-20
AU773678B2 (en) 2004-06-03
CN1384838A (zh) 2002-12-11
ID30547A (id) 2001-12-20
MXPA01010524A (es) 2002-03-14
DE60030847D1 (de) 2006-11-02
EP1171446A2 (en) 2002-01-16
DE60030847T2 (de) 2007-04-19
WO2000063225A3 (en) 2001-01-18
CN1241931C (zh) 2006-02-15
BR0010680A (pt) 2002-02-19
USRE39836E1 (en) 2007-09-11
JP2003523938A (ja) 2003-08-12
US20020119938A1 (en) 2002-08-29
KR20020007374A (ko) 2002-01-26
KR20020007372A (ko) 2002-01-26
ES2272273T3 (es) 2007-05-01
WO2000063224A2 (en) 2000-10-26
US6593302B2 (en) 2003-07-15
US6395710B1 (en) 2002-05-28
WO2000063224A3 (en) 2001-01-18

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