BR0010680A - Agentes antiinfecciosos de macrolìdeo - Google Patents

Agentes antiinfecciosos de macrolìdeo

Info

Publication number
BR0010680A
BR0010680A BR0010680-1A BR0010680A BR0010680A BR 0010680 A BR0010680 A BR 0010680A BR 0010680 A BR0010680 A BR 0010680A BR 0010680 A BR0010680 A BR 0010680A
Authority
BR
Brazil
Prior art keywords
substituted
unsubstituted
alkyl
amino
methylene
Prior art date
Application number
BR0010680-1A
Other languages
English (en)
Portuguese (pt)
Inventor
Daniel T W Chu
Gary W Ashley
Original Assignee
Kosan Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kosan Biosciences Inc filed Critical Kosan Biosciences Inc
Publication of BR0010680A publication Critical patent/BR0010680A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23B—PRESERVATION OF FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES; CHEMICAL RIPENING OF FRUIT OR VEGETABLES
    • A23B2/00—Preservation of foods or foodstuffs, in general
    • A23B2/70—Preservation of foods or foodstuffs, in general by treatment with chemicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
BR0010680-1A 1999-04-16 2000-04-14 Agentes antiinfecciosos de macrolìdeo BR0010680A (pt)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US12972999P 1999-04-16 1999-04-16
US14017599P 1999-06-18 1999-06-18
US17215499P 1999-12-17 1999-12-17
US17215999P 1999-12-17 1999-12-17
US17380499P 1999-12-30 1999-12-30
US17380599P 1999-12-30 1999-12-30
PCT/US2000/009914 WO2000063224A2 (en) 1999-04-16 2000-04-14 Macrolide antiinfective agents
US09/550,045 US6395710B1 (en) 1999-04-16 2000-04-14 Macrolide antiinfective agents

Publications (1)

Publication Number Publication Date
BR0010680A true BR0010680A (pt) 2002-02-19

Family

ID=27568857

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0010680-1A BR0010680A (pt) 1999-04-16 2000-04-14 Agentes antiinfecciosos de macrolìdeo

Country Status (16)

Country Link
US (3) US6395710B1 (enExample)
EP (1) EP1171446B1 (enExample)
JP (1) JP2003523938A (enExample)
KR (2) KR20020007374A (enExample)
CN (1) CN1241931C (enExample)
AT (1) ATE340183T1 (enExample)
AU (2) AU775637B2 (enExample)
BR (1) BR0010680A (enExample)
CA (1) CA2369816A1 (enExample)
DE (1) DE60030847T2 (enExample)
ES (1) ES2272273T3 (enExample)
ID (1) ID30547A (enExample)
IL (2) IL145777A0 (enExample)
MX (1) MXPA01010524A (enExample)
NZ (1) NZ515027A (enExample)
WO (2) WO2000063225A2 (enExample)

Families Citing this family (37)

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AP1060A (en) * 1998-01-02 2002-04-23 Pfizer Prod Inc Novel erythromycin derivatives.
CZ20012675A3 (cs) 1999-01-27 2002-04-17 Pfizer Products Inc. Ketolidová antibiotika
US6451768B1 (en) 1999-04-16 2002-09-17 Kosan Biosciences, Inc. Macrolide antiinfective agents
US6590083B1 (en) * 1999-04-16 2003-07-08 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
ES2222966T3 (es) 2000-06-30 2005-02-16 Pfizer Products Inc. Macrolidos antibioticos.
US6472372B1 (en) 2000-12-06 2002-10-29 Ortho-Mcneil Pharmaceuticals, Inc. 6-O-Carbamoyl ketolide antibacterials
IL157974A0 (en) * 2001-03-21 2004-03-28 Dow Agrosciences Llc Pesticidal macrolides
CA2460947A1 (en) 2001-09-17 2003-03-27 Ortho-Mcneil Pharmaceutical, Inc. 6-o-carbamate-11,12-lacto-ketolide antimicrobials
RU2004117082A (ru) 2001-12-05 2005-04-10 Орто-Макнейл Фармасьютикал, Инк. (Us) Кетолидные 6-0-ацил-производные эритромицина в качестве антибактериальных средств
US8063021B2 (en) * 2002-01-17 2011-11-22 Kosan Biosciences Incorporated Ketolide anti-infective compounds
ATE452896T1 (de) 2002-03-12 2010-01-15 Bristol Myers Squibb Co C3-cyanoepothilonderivate
US20040014691A1 (en) * 2002-04-25 2004-01-22 Searle Xenia Beebe 9-Oxime macrolide antibacterials
US20040009932A1 (en) * 2002-04-26 2004-01-15 Kathleen Phelan Antibacterial compounds with activity against penicillin-resistant streptococcus pneumoniae
CA2487918A1 (en) 2002-05-31 2003-12-11 Janssen Pharmaceutica N.V. 3-descladinosyl-6-o-carbamoyl and 6-o-carbonoyl macrolide antibacterial agents
US7427493B2 (en) 2002-06-28 2008-09-23 Kosan Biosciences Incorporated Recombinant genes for polyketide modifying enzymes
DK1532131T3 (da) * 2002-08-29 2009-02-09 Pfizer Motilid-forbindelser
US7601695B2 (en) * 2003-03-10 2009-10-13 Optimer Pharmaceuticals, Inc. Antibacterial agents
US20050113319A1 (en) * 2003-08-26 2005-05-26 Christopher Carreras 11-Deoxy-6,9-ether erythromycin compounds
US7407941B2 (en) * 2003-08-26 2008-08-05 Pfizer, Inc. N-desmethyl-N-substituted-11-deoxyerythromycin compounds
WO2005067919A1 (en) * 2003-12-24 2005-07-28 Enanta Pharmaceuticals, Inc. 11-csubsituted erythromycin derivatives
PL1836211T3 (pl) * 2004-12-21 2010-07-30 Pfizer Prod Inc Makrolidy
US7595300B2 (en) 2005-12-13 2009-09-29 Kosan Biosciences Incorporated 7-quinolyl ketolide antibacterial agents
EP2214484A4 (en) 2007-10-25 2013-01-02 Cempra Pharmaceuticals Inc PROCESS FOR PREPARING ANTIBACTERIAL MAKROLIDE AGENTS
KR101589960B1 (ko) * 2008-02-08 2016-01-29 바실리어 파마슈티카 아게 Ｐｄｅ 억제를 통해 중재되는 질환의 치료를 위한 마크로라이드
CN102245195B (zh) * 2008-10-24 2016-01-13 森普拉制药公司 使用含三唑的大环内酯的生物防御
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
JP5914335B2 (ja) 2009-09-10 2016-05-11 センプラ ファーマシューティカルズ，インコーポレイテッド マラリア、結核、及びｍａｃ病の治療方法
EP3009442B1 (en) 2010-03-22 2019-06-19 Cempra Pharmaceuticals, Inc. Crystalline forms of a macrolide, and uses therefor
CA2799937A1 (en) 2010-05-20 2011-11-24 Cempra Pharmaceuticals, Inc. Processes for preparing macrolides and ketolides and intermediates therefor
US8796474B1 (en) 2010-08-23 2014-08-05 Rutgers, The State University Of New Jersey Macrolide compounds and methods and intermediates useful for their preparation
WO2012034058A1 (en) 2010-09-10 2012-03-15 Cempra Pharmaceuticals, Inc. Hydrogen bond forming fluoro ketolides for treating diseases
KR101567658B1 (ko) * 2011-03-01 2015-11-09 욱크하르트 리미티드 케톨리드 중간체의 제조 방법
CA2868262A1 (en) 2012-03-27 2013-10-03 Cempra Pharmaceuticals, Inc. Parenteral formulations for administering macrolide antibiotics
CN102718816B (zh) * 2012-07-11 2014-11-05 山东大学 4''-O-(反式-β-芳基烯丙酰胺)氨基甲酰基阿奇霉素衍生物
HK1217665A1 (zh) 2013-03-14 2017-01-20 森普拉制药公司 用於治療呼吸道疾病的方法及其製劑
HK1218864A1 (zh) 2013-03-15 2017-03-17 森普拉制药公司 用於制备大环内酯抗菌剂的收敛方法
US20230174567A1 (en) * 2020-05-22 2023-06-08 Merck Sharp & Dohme Llc Synthesis of fluorinated nucleotides

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IL114589A (en) * 1990-11-21 1999-12-22 Roussel Uclaf Intermediates for the preparation of erythromycin derivatives
US5523399A (en) * 1991-12-27 1996-06-04 Taisho Pharmaceutical Co., Ltd. 5-O-desosaminylerythronolide derivatives
JP3259429B2 (ja) * 1992-04-22 2002-02-25 大正製薬株式会社 ５−ｏ−デソサミニルエリスロノライドａ誘導体
US5527780A (en) 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
US5672491A (en) 1993-09-20 1997-09-30 The Leland Stanford Junior University Recombinant production of novel polyketides
US6066721A (en) 1995-07-06 2000-05-23 Stanford University Method to produce novel polyketides
FR2718450B1 (fr) * 1994-04-08 1997-01-10 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2719587B1 (fr) 1994-05-03 1996-07-12 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
EP1493814A1 (en) 1995-07-06 2005-01-05 The Leland Stanford Junior University Cell-free synthesis of polyketides
FR2739620B1 (fr) * 1995-10-09 1997-12-19 Roussel Uclaf Nouveaux derives de la 5-0-desosaminyl 6-o-methyl erythronolide a, leur procede de preparation et leur application a la preparation de produits biologiquement actifs
US6274715B1 (en) 1995-11-08 2001-08-14 Abbott Laboratories Tricyclic erythromycin derivatives
FR2742757B1 (fr) * 1995-12-22 1998-01-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
US5750510A (en) 1997-04-04 1998-05-12 Abbott Laboratories 3-descladinose-2,3-anhydroerythromycin derivatives
CA2253330C (en) 1996-05-07 2006-07-25 Abbott Laboratories 6-o-substituted erythromycin compounds and method for making same
FR2748746B1 (fr) * 1996-05-14 1998-08-14 Hoechst Marion Roussel Inc Nouveau procede d'isomerisation du radical methyle en 10 de derives de l'erythromycine
SK182498A3 (en) 1996-07-05 2000-05-16 Biotica Tech Ltd Erythromycins and process for their preparation
US6271255B1 (en) 1996-07-05 2001-08-07 Biotica Technology Limited Erythromycins and process for their preparation
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FR2781484B1 (fr) * 1998-07-21 2001-08-10 Hoechst Marion Roussel Inc Nouveaux derives de la 6-deoxy erythromycine, leur procede de preparation et leur application comme medicaments
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Also Published As

Publication number Publication date
US6395710B1 (en) 2002-05-28
KR100710605B1 (ko) 2007-04-24
CN1384838A (zh) 2002-12-11
ATE340183T1 (de) 2006-10-15
EP1171446B1 (en) 2006-09-20
ES2272273T3 (es) 2007-05-01
USRE39836E1 (en) 2007-09-11
WO2000063225A3 (en) 2001-01-18
JP2003523938A (ja) 2003-08-12
WO2000063224A2 (en) 2000-10-26
KR20020007372A (ko) 2002-01-26
AU775637B2 (en) 2004-08-12
CA2369816A1 (en) 2000-10-26
WO2000063224A3 (en) 2001-01-18
US6593302B2 (en) 2003-07-15
MXPA01010524A (es) 2002-03-14
AU4237900A (en) 2000-11-02
WO2000063225A2 (en) 2000-10-26
EP1171446A2 (en) 2002-01-16
IL145777A0 (en) 2002-07-25
AU4457800A (en) 2000-11-02
DE60030847D1 (de) 2006-11-02
AU773678B2 (en) 2004-06-03
US20020119938A1 (en) 2002-08-29
ID30547A (id) 2001-12-20
CN1241931C (zh) 2006-02-15
DE60030847T2 (de) 2007-04-19
IL145777A (en) 2007-02-11
KR20020007374A (ko) 2002-01-26
NZ515027A (en) 2004-01-30

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