AU775637B2 - Macrolide antiinfective agents - Google Patents

Macrolide antiinfective agents Download PDF

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Publication number
AU775637B2
AU775637B2 AU44578/00A AU4457800A AU775637B2 AU 775637 B2 AU775637 B2 AU 775637B2 AU 44578/00 A AU44578/00 A AU 44578/00A AU 4457800 A AU4457800 A AU 4457800A AU 775637 B2 AU775637 B2 AU 775637B2
Authority
AU
Australia
Prior art keywords
substituted
unsubstituted
compound
alkyl
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU44578/00A
Other languages
English (en)
Other versions
AU4457800A (en
Inventor
Daniel T.W. Chu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kosan Biosciences Inc
Original Assignee
Kosan Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kosan Biosciences Inc filed Critical Kosan Biosciences Inc
Publication of AU4457800A publication Critical patent/AU4457800A/en
Application granted granted Critical
Publication of AU775637B2 publication Critical patent/AU775637B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23B—PRESERVATION OF FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES; CHEMICAL RIPENING OF FRUIT OR VEGETABLES
    • A23B2/00—Preservation of foods or foodstuffs, in general
    • A23B2/70—Preservation of foods or foodstuffs, in general by treatment with chemicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Food Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU44578/00A 1999-04-16 2000-04-14 Macrolide antiinfective agents Ceased AU775637B2 (en)

Applications Claiming Priority (15)

Application Number Priority Date Filing Date Title
USNOTGIVEN 1999-01-29
US12972999P 1999-04-16 1999-04-16
US60/129729 1999-04-16
US14017599P 1999-06-18 1999-06-18
US60/140175 1999-06-18
US17215499P 1999-12-17 1999-12-17
US17215999P 1999-12-17 1999-12-17
US60/172159 1999-12-17
US60/172154 1999-12-17
US17380499P 1999-12-30 1999-12-30
US17380599P 1999-12-30 1999-12-30
US60/173805 1999-12-30
US60/173804 1999-12-30
PCT/US2000/009915 WO2000063225A2 (en) 1999-04-16 2000-04-14 Macrolide antiinfective agents
US09/550,045 US6395710B1 (en) 1999-04-16 2000-04-14 Macrolide antiinfective agents

Publications (2)

Publication Number Publication Date
AU4457800A AU4457800A (en) 2000-11-02
AU775637B2 true AU775637B2 (en) 2004-08-12

Family

ID=27568857

Family Applications (2)

Application Number Title Priority Date Filing Date
AU44578/00A Ceased AU775637B2 (en) 1999-04-16 2000-04-14 Macrolide antiinfective agents
AU42379/00A Ceased AU773678B2 (en) 1999-04-16 2000-04-14 Macrolide antiinfective agents

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU42379/00A Ceased AU773678B2 (en) 1999-04-16 2000-04-14 Macrolide antiinfective agents

Country Status (16)

Country Link
US (3) US6395710B1 (enExample)
EP (1) EP1171446B1 (enExample)
JP (1) JP2003523938A (enExample)
KR (2) KR20020007374A (enExample)
CN (1) CN1241931C (enExample)
AT (1) ATE340183T1 (enExample)
AU (2) AU775637B2 (enExample)
BR (1) BR0010680A (enExample)
CA (1) CA2369816A1 (enExample)
DE (1) DE60030847T2 (enExample)
ES (1) ES2272273T3 (enExample)
ID (1) ID30547A (enExample)
IL (2) IL145777A0 (enExample)
MX (1) MXPA01010524A (enExample)
NZ (1) NZ515027A (enExample)
WO (2) WO2000063225A2 (enExample)

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AP1060A (en) * 1998-01-02 2002-04-23 Pfizer Prod Inc Novel erythromycin derivatives.
AP2001002222A0 (en) 1999-01-27 2001-09-30 Pfizer Prod Inc Ketolide antibiotics.
US6451768B1 (en) 1999-04-16 2002-09-17 Kosan Biosciences, Inc. Macrolide antiinfective agents
US6590083B1 (en) * 1999-04-16 2003-07-08 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
TR200401847T4 (tr) 2000-06-30 2004-09-21 Pfizer Products Inc. Makrolit antibiyotikler.
US6472372B1 (en) 2000-12-06 2002-10-29 Ortho-Mcneil Pharmaceuticals, Inc. 6-O-Carbamoyl ketolide antibacterials
DK1373290T3 (da) * 2001-03-21 2014-12-01 Dow Agrosciences Llc Pesticidale spinosynderivater
CN1589277A (zh) 2001-09-17 2005-03-02 奥索-麦克尼尔药品公司 6－o－氨基甲酸酯－11,12－内酯－酮内酯抗菌剂
AU2002346475A1 (en) 2001-12-05 2003-06-23 Ortho-Mcneil Pharmaceutical, Inc. 6-o-acyl ketolide derivatives of erythromycine useful as antibacterials
US8063021B2 (en) * 2002-01-17 2011-11-22 Kosan Biosciences Incorporated Ketolide anti-infective compounds
DK1483251T3 (da) 2002-03-12 2010-04-12 Bristol Myers Squibb Co C3-cyano-epothilon-derivater
US20040014691A1 (en) * 2002-04-25 2004-01-22 Searle Xenia Beebe 9-Oxime macrolide antibacterials
US20040009932A1 (en) * 2002-04-26 2004-01-15 Kathleen Phelan Antibacterial compounds with activity against penicillin-resistant streptococcus pneumoniae
WO2003102010A1 (en) 2002-05-31 2003-12-11 Janssen Pharmaceutica N.V. 3-descladinosyl-6-o-carbamoyl and 6-o-carbonoyl macrolide antibacterial agents
US7427493B2 (en) 2002-06-28 2008-09-23 Kosan Biosciences Incorporated Recombinant genes for polyketide modifying enzymes
WO2004019879A2 (en) * 2002-08-29 2004-03-11 Kosan Biosciences, Inc. Motilide compounds
EP1638549A4 (en) 2003-03-10 2011-06-15 Optimer Pharmaceuticals Inc NEW ANTIBACTERIAL AGENTS
US7407941B2 (en) * 2003-08-26 2008-08-05 Pfizer, Inc. N-desmethyl-N-substituted-11-deoxyerythromycin compounds
US20050113319A1 (en) * 2003-08-26 2005-05-26 Christopher Carreras 11-Deoxy-6,9-ether erythromycin compounds
WO2005067919A1 (en) * 2003-12-24 2005-07-28 Enanta Pharmaceuticals, Inc. 11-csubsituted erythromycin derivatives
EP2233493A1 (en) * 2004-12-21 2010-09-29 Pfizer Products Inc. Macrolides
US7595300B2 (en) 2005-12-13 2009-09-29 Kosan Biosciences Incorporated 7-quinolyl ketolide antibacterial agents
CA2703475A1 (en) * 2007-10-25 2009-04-30 Cempra Pharmaceuticals, Inc. Process for the preparation of macrolide antibacterial agents
JP5769972B2 (ja) * 2008-02-08 2015-08-26 バジリア ファルマスーチカ アーゲーＢａｓｉｌｅａ Ｐｈａｒｍａｃｅｕｔｉｃａ ＡＧ Ｐｄｅ阻害により仲介される疾患を処置するためのマクロライド
US8796232B2 (en) * 2008-10-24 2014-08-05 Cempra Pharmaceuticals, Inc. Methods for treating resistant diseases using triazole containing macrolides
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
JP5914335B2 (ja) 2009-09-10 2016-05-11 センプラ ファーマシューティカルズ，インコーポレイテッド マラリア、結核、及びｍａｃ病の治療方法
CN103080122A (zh) 2010-03-22 2013-05-01 森普拉制药公司 大环内脂的结晶形式及其用途
WO2011146829A1 (en) 2010-05-20 2011-11-24 Cempra Pharmaceuticals, Inc. Processes for preparing macrolides and ketolides and intermediates therefor
US8796474B1 (en) 2010-08-23 2014-08-05 Rutgers, The State University Of New Jersey Macrolide compounds and methods and intermediates useful for their preparation
JP6042334B2 (ja) 2010-09-10 2016-12-14 センプラ ファーマシューティカルズ，インコーポレイテッド 疾患治療のための水素結合形成フルオロケトライド
US9206214B2 (en) * 2011-03-01 2015-12-08 Wockhardt Ltd. Process for preparation of ketolide intermediates
CN104470527B (zh) 2012-03-27 2019-05-28 森普拉制药公司 用于施用大环内酯抗生素的肠胃外制剂
CN102718816B (zh) * 2012-07-11 2014-11-05 山东大学 4''-O-(反式-β-芳基烯丙酰胺)氨基甲酰基阿奇霉素衍生物
RU2015138796A (ru) 2013-03-14 2017-04-19 Семпра Фармасьютикалс, Инк. Способы и составы для лечения респираторных заболеваний
WO2014145210A1 (en) 2013-03-15 2014-09-18 Cempra Pharmaceuticals, Inc. Convergent processes for preparing macrolide antibacterial agents
WO2021236859A1 (en) * 2020-05-22 2021-11-25 Merck Sharp & Dohme Corp. Synthesis of fluorinated nucleotides

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Publication number Priority date Publication date Assignee Title
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FR2754821A1 (fr) * 1996-10-23 1998-04-24 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments

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US5523399A (en) * 1991-12-27 1996-06-04 Taisho Pharmaceutical Co., Ltd. 5-O-desosaminylerythronolide derivatives
JP3259429B2 (ja) * 1992-04-22 2002-02-25 大正製薬株式会社 ５−ｏ−デソサミニルエリスロノライドａ誘導体
US5527780A (en) 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
US6066721A (en) 1995-07-06 2000-05-23 Stanford University Method to produce novel polyketides
US5672491A (en) 1993-09-20 1997-09-30 The Leland Stanford Junior University Recombinant production of novel polyketides
FR2718450B1 (fr) * 1994-04-08 1997-01-10 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
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US5141926A (en) * 1990-04-18 1992-08-25 Abbott Laboratories Erythromycin derivatives
FR2754821A1 (fr) * 1996-10-23 1998-04-24 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments

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Title
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Also Published As

Publication number Publication date
WO2000063224A3 (en) 2001-01-18
AU773678B2 (en) 2004-06-03
US6593302B2 (en) 2003-07-15
USRE39836E1 (en) 2007-09-11
KR100710605B1 (ko) 2007-04-24
KR20020007374A (ko) 2002-01-26
DE60030847D1 (de) 2006-11-02
JP2003523938A (ja) 2003-08-12
ID30547A (id) 2001-12-20
IL145777A (en) 2007-02-11
CA2369816A1 (en) 2000-10-26
BR0010680A (pt) 2002-02-19
ATE340183T1 (de) 2006-10-15
EP1171446A2 (en) 2002-01-16
WO2000063224A2 (en) 2000-10-26
NZ515027A (en) 2004-01-30
US6395710B1 (en) 2002-05-28
AU4457800A (en) 2000-11-02
ES2272273T3 (es) 2007-05-01
CN1384838A (zh) 2002-12-11
US20020119938A1 (en) 2002-08-29
IL145777A0 (en) 2002-07-25
MXPA01010524A (es) 2002-03-14
WO2000063225A3 (en) 2001-01-18
KR20020007372A (ko) 2002-01-26
EP1171446B1 (en) 2006-09-20
AU4237900A (en) 2000-11-02
WO2000063225A2 (en) 2000-10-26
DE60030847T2 (de) 2007-04-19
CN1241931C (zh) 2006-02-15

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