CN120400338A - 用于评估和治疗癌症的方法和材料 - Google Patents

用于评估和治疗癌症的方法和材料

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Publication number
CN120400338A
CN120400338A CN202510126452.2A CN202510126452A CN120400338A CN 120400338 A CN120400338 A CN 120400338A CN 202510126452 A CN202510126452 A CN 202510126452A CN 120400338 A CN120400338 A CN 120400338A
Authority
CN
China
Prior art keywords
cancer
subject
codons
biomarkers
mutations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202510126452.2A
Other languages
English (en)
Chinese (zh)
Inventor
B·福格斯坦
K·W·金茨勒
J·科恩
N·帕帕多波洛斯
A·M·列侬
C·托马塞蒂
Y·王
G·J·内托
R·卡尔金
C·杜维尔
S·哈纳斯
S·施普林格
A·格罗尔曼
K·迪克曼
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Johns Hopkins University
University of Texas System
Research Foundation of the State University of New York
Original Assignee
Johns Hopkins University
University of Texas System
Research Foundation of the State University of New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johns Hopkins University, University of Texas System, Research Foundation of the State University of New York filed Critical Johns Hopkins University
Publication of CN120400338A publication Critical patent/CN120400338A/zh
Pending legal-status Critical Current

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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/50—Mutagenesis
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    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
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    • C12Q2531/00—Reactions of nucleic acids characterised by
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    • C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/50—Detection characterised by immobilisation to a surface
    • C12Q2565/514—Detection characterised by immobilisation to a surface characterised by the use of the arrayed oligonucleotides as identifier tags, e.g. universal addressable array, anti-tag or tag complement array
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    • C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/60—Detection means characterised by use of a special device
    • C12Q2565/625—Detection means characterised by use of a special device being a nucleic acid test strip device, e.g. dipsticks, strips, tapes, CD plates
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
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    • C12Q2600/00—Oligonucleotides characterized by their use
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/56—Staging of a disease; Further complications associated with the disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/60—Complex ways of combining multiple protein biomarkers for diagnosis

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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN202510126452.2A 2017-08-07 2018-08-07 用于评估和治疗癌症的方法和材料 Pending CN120400338A (zh)

Applications Claiming Priority (16)

Application Number Priority Date Filing Date Title
US201762542164P 2017-08-07 2017-08-07
US201762542144P 2017-08-07 2017-08-07
US201762542167P 2017-08-07 2017-08-07
US62/542,164 2017-08-07
US62/542,167 2017-08-07
US62/542,144 2017-08-07
US201762594245P 2017-12-04 2017-12-04
US62/594,245 2017-12-04
US201862618232P 2018-01-17 2018-01-17
US62/618,232 2018-01-17
US201862628759P 2018-02-09 2018-02-09
US62/628,759 2018-02-09
US201862629870P 2018-02-13 2018-02-13
US62/629,870 2018-02-13
PCT/US2018/045669 WO2019067092A1 (en) 2017-08-07 2018-08-07 METHODS AND SUBSTANCES FOR THE EVALUATION AND TREATMENT OF CANCER
CN201880066039.XA CN111868260B (zh) 2017-08-07 2018-08-07 用于评估和治疗癌症的方法和材料

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US (3) US12195803B2 (https=)
EP (2) EP3665308A1 (https=)
JP (3) JP7232476B2 (https=)
KR (2) KR102775704B1 (https=)
CN (2) CN120400338A (https=)
AU (2) AU2018342007B2 (https=)
BR (1) BR112020002555A2 (https=)
CA (1) CA3072195A1 (https=)
CL (1) CL2020000343A1 (https=)
IL (2) IL319255A (https=)
MX (2) MX2020001575A (https=)
SG (1) SG11202001010UA (https=)
WO (2) WO2019067092A1 (https=)
ZA (1) ZA202000935B (https=)

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