MX2011002409A - Alteraciones geneticas en isocitrato-deshidrogenasa y otros genes en glioma maligno. - Google Patents

Alteraciones geneticas en isocitrato-deshidrogenasa y otros genes en glioma maligno.

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Publication number
MX2011002409A
MX2011002409A MX2011002409A MX2011002409A MX2011002409A MX 2011002409 A MX2011002409 A MX 2011002409A MX 2011002409 A MX2011002409 A MX 2011002409A MX 2011002409 A MX2011002409 A MX 2011002409A MX 2011002409 A MX2011002409 A MX 2011002409A
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Prior art keywords
isocitrate dehydrogenase
genes
genetic alterations
malignant glioma
mutations
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MX2011002409A
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English (en)
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Hai Yan
Bert Vogelstein
Kenneth W Kinzler
D Williams Parsons
Xiaosong Zhang
Jimmy Chang-Ho Lin
Rebecca J Leary
Philipp Angenendt
Nickolas Papadopoulos
Victor Velculescu
Giovanni Parmigiani
Rachel Karchin
Sian Jones
Darell Bigner
Chien-Tsun Kuan
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Univ Johns Hopkins
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Publication of MX2011002409A publication Critical patent/MX2011002409A/es

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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • C12Q2600/00—Oligonucleotides characterized by their use
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/20—Supervised data analysis

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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
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Abstract

Se encontraron mutaciones del residuo R132 de isocitrato-deshidrogenasa 1 (IDH1) en la mayoría de los astrocitomas Grado II y III y oligodendrogliomas así como en glioblastomas que se desarrollan de estas lesiones de menor grado. Estos tumores sin mutaciones en IDH1 tienen frecuentemente mutaciones en el residuo R172 análogo del gen de IDH2 cercanamente relacionado. Estos hallazgos tienen implicaciones importantes para la patogénesis y diagnosis de gliomas malignos.
MX2011002409A 2008-09-03 2009-09-03 Alteraciones geneticas en isocitrato-deshidrogenasa y otros genes en glioma maligno. MX2011002409A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US9373908P 2008-09-03 2008-09-03
US11039708P 2008-10-31 2008-10-31
US16273709P 2009-03-24 2009-03-24
PCT/US2009/055803 WO2010028099A1 (en) 2008-09-03 2009-09-03 Genetic alterations in isocitrate dehydrogenase and other genes in malignant glioma

Publications (1)

Publication Number Publication Date
MX2011002409A true MX2011002409A (es) 2011-09-06

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ID=41228200

Family Applications (3)

Application Number Title Priority Date Filing Date
MX2011002409A MX2011002409A (es) 2008-09-03 2009-09-03 Alteraciones geneticas en isocitrato-deshidrogenasa y otros genes en glioma maligno.
MX2015015733A MX359574B (es) 2008-09-03 2009-09-03 Alteraciones geneticas en isocitrato-deshidrogenasa y otros genes en glioma maligno.
MX2012012788A MX343226B (es) 2008-09-03 2009-09-03 Alteraciones geneticas en isocitrato-deshidrogenasa y otros genes en glioma maligno.

Family Applications After (2)

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MX2015015733A MX359574B (es) 2008-09-03 2009-09-03 Alteraciones geneticas en isocitrato-deshidrogenasa y otros genes en glioma maligno.
MX2012012788A MX343226B (es) 2008-09-03 2009-09-03 Alteraciones geneticas en isocitrato-deshidrogenasa y otros genes en glioma maligno.

Country Status (11)

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US (7) US8685660B2 (es)
EP (4) EP2546365B1 (es)
JP (3) JP5421374B2 (es)
CN (1) CN102177251B (es)
AU (1) AU2009288004B2 (es)
CA (1) CA2736125C (es)
DK (2) DK2546365T3 (es)
ES (3) ES2608310T3 (es)
MX (3) MX2011002409A (es)
PL (2) PL2546365T3 (es)
WO (1) WO2010028099A1 (es)

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ES2608310T3 (es) 2017-04-07
JP2014110786A (ja) 2014-06-19
EP2546365A1 (en) 2013-01-16
CA2736125A1 (en) 2010-03-11
US10894987B2 (en) 2021-01-19
JP5421374B2 (ja) 2014-02-19
WO2010028099A1 (en) 2010-03-11
DK2326735T3 (en) 2017-01-16
EP2607498A1 (en) 2013-06-26
EP3266879B1 (en) 2019-07-03
US20180282821A1 (en) 2018-10-04
PL2326735T3 (pl) 2017-04-28
CN102177251A (zh) 2011-09-07
US9353418B2 (en) 2016-05-31
US20190106752A1 (en) 2019-04-11
ES2609414T3 (es) 2017-04-20
US20170081730A1 (en) 2017-03-23
DK2546365T3 (en) 2017-01-16
AU2009288004B2 (en) 2015-02-05
JP2016129517A (ja) 2016-07-21
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