PL2326735T3 - Zmiany genetyczne w dehydrogenazie izocytrynianowej i innych genach w glejaku złośliwym - Google Patents
Zmiany genetyczne w dehydrogenazie izocytrynianowej i innych genach w glejaku złośliwymInfo
- Publication number
- PL2326735T3 PL2326735T3 PL09792198T PL09792198T PL2326735T3 PL 2326735 T3 PL2326735 T3 PL 2326735T3 PL 09792198 T PL09792198 T PL 09792198T PL 09792198 T PL09792198 T PL 09792198T PL 2326735 T3 PL2326735 T3 PL 2326735T3
- Authority
- PL
- Poland
- Prior art keywords
- genes
- genetic alterations
- malignant glioma
- isocitrate dehydrogenase
- isocitrate
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
- G16B40/20—Supervised data analysis
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9373908P | 2008-09-03 | 2008-09-03 | |
| US11039708P | 2008-10-31 | 2008-10-31 | |
| US16273709P | 2009-03-24 | 2009-03-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2326735T3 true PL2326735T3 (pl) | 2017-04-28 |
Family
ID=41228200
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL12188429T PL2546365T3 (pl) | 2008-09-03 | 2009-09-03 | Zmiany genetyczne w dehydrogenazie izocytrynianowej i innych genach w glejaku złośliwym |
| PL09792198T PL2326735T3 (pl) | 2008-09-03 | 2009-09-03 | Zmiany genetyczne w dehydrogenazie izocytrynianowej i innych genach w glejaku złośliwym |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL12188429T PL2546365T3 (pl) | 2008-09-03 | 2009-09-03 | Zmiany genetyczne w dehydrogenazie izocytrynianowej i innych genach w glejaku złośliwym |
Country Status (11)
| Country | Link |
|---|---|
| US (7) | US8685660B2 (pl) |
| EP (4) | EP2607498B1 (pl) |
| JP (3) | JP5421374B2 (pl) |
| CN (1) | CN102177251B (pl) |
| AU (1) | AU2009288004B2 (pl) |
| CA (1) | CA2736125C (pl) |
| DK (2) | DK2326735T3 (pl) |
| ES (3) | ES2755139T3 (pl) |
| MX (3) | MX359574B (pl) |
| PL (2) | PL2546365T3 (pl) |
| WO (1) | WO2010028099A1 (pl) |
Families Citing this family (71)
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| JP5421374B2 (ja) | 2008-09-03 | 2014-02-19 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 悪性神経膠腫におけるイソクエン酸デヒドロゲナーゼ遺伝子および他の遺伝子の遺伝子変化 |
| CN102985557B (zh) * | 2009-03-13 | 2018-06-15 | 安吉奥斯医药品有限公司 | 用于细胞增殖相关病症的方法和组合物 |
| EP2253716A1 (en) | 2009-05-15 | 2010-11-24 | Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts | Diagnostic methods for the prognosis of a brain tumor |
| EP2448582B1 (en) | 2009-06-29 | 2017-04-19 | Agios Pharmaceuticals, Inc. | Quinoline-8-sulfonamide derivatives having an anticancer activity |
| US8642271B2 (en) * | 2009-08-27 | 2014-02-04 | Case Western Reserve University | Aberrant methylation of C6Orf150 DNA sequences in human colorectal cancer |
| EP3461912B1 (en) | 2009-09-09 | 2022-07-13 | The General Hospital Corporation | Use of microvesicles in analyzing nucleic acid profiles |
| EP2475989A4 (en) | 2009-09-09 | 2013-02-27 | Gen Hospital Corp | USE OF MICROVESICLES IN THE ANALYSIS OF KRAS MUTATIONS |
| ES2594402T3 (es) | 2009-10-21 | 2016-12-20 | Agios Pharmaceuticals, Inc. | Métodos y composiciones para trastornos relacionados con la proliferación celular |
| EP2525790B1 (en) | 2009-10-21 | 2020-05-27 | Agios Pharmaceuticals, Inc. | Methods and compositions for cell-proliferation-related disorders |
| EP2330218A1 (en) * | 2009-12-07 | 2011-06-08 | Europath Biosciences, S.L. | EGFR and PTEN gene alterations predicts survival in patients with brain tumors |
| AU2011278998B2 (en) * | 2010-07-16 | 2016-06-09 | Les Laboratoires Servier | Therapeutically active compositions and their method of use |
| WO2012031008A2 (en) | 2010-08-31 | 2012-03-08 | The General Hospital Corporation | Cancer-related biological materials in microvesicles |
| US20140147839A1 (en) * | 2010-10-15 | 2014-05-29 | The General Hospital Corporation | Microvesicle-based assays |
| US9695400B2 (en) | 2010-10-22 | 2017-07-04 | Duke University | Homozygous and heterozygous IDH1 gene-defective human astrocytoma cell lines |
| US9074221B2 (en) | 2010-10-25 | 2015-07-07 | Duke University | Homozygous and heterozygous IDH1 gene-defective cell lines derived from human colorectal cells |
| CA2817111C (en) | 2010-11-10 | 2019-03-05 | Exosome Diagnostics, Inc. | Method for isolation of nucleic acid containing particles and extraction of nucleic acids therefrom |
| AU2012242847B2 (en) | 2011-04-15 | 2017-01-19 | The Johns Hopkins University | Safe sequencing system |
| HUE039269T2 (hu) | 2011-05-03 | 2018-12-28 | Agios Pharmaceuticals Inc | Piruvát-kináz aktivátorok terápiában történõ alkalmazásra |
| CA2834610A1 (en) * | 2011-06-06 | 2012-12-13 | Merck Sharp & Dohme Corp. | Rna interference mediated inhibition of isocitrate dehydrogenase (idh1) gene expression |
| CN102827170A (zh) | 2011-06-17 | 2012-12-19 | 安吉奥斯医药品有限公司 | 治疗活性组合物和它们的使用方法 |
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| WO2012176651A1 (ja) * | 2011-06-22 | 2012-12-27 | 国立大学法人 京都大学 | 新規抗腫瘍剤及び新規抗腫瘍剤のスクリーニング方法 |
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| AU2013207191B2 (en) * | 2012-01-05 | 2017-10-26 | Deutsches Krebsforschungszentrum Stiftung Des Offentlichen Rechts | Means and methods for treating or diagnosing IDH1 R132H mutant-positive cancers |
| NZ627096A (en) | 2012-01-06 | 2017-02-24 | Agios Pharmaceuticals Inc | Triazinyl compounds and their methods of use |
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| CN102732633B (zh) * | 2012-07-06 | 2014-02-26 | 广州好芝生物科技有限公司 | 人idh基因突变的检测引物和试剂盒 |
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| EP3019480B1 (en) | 2013-07-11 | 2020-05-06 | Agios Pharmaceuticals, Inc. | 2,4- or 4,6-diaminopyrimidine compounds as idh2 mutants inhibitors for the treatment of cancer |
| US9579324B2 (en) | 2013-07-11 | 2017-02-28 | Agios Pharmaceuticals, Inc | Therapeutically active compounds and their methods of use |
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| US20150031627A1 (en) | 2013-07-25 | 2015-01-29 | Agios Pharmaceuticals, Inc | Therapeutically active compounds and their methods of use |
| CN103451314A (zh) * | 2013-09-30 | 2013-12-18 | 南京艾迪康医学检验所有限公司 | 检测idh1、idh2基因多态突变位点的引物、方法和试剂盒 |
| EP3099776A4 (en) * | 2014-01-28 | 2017-10-04 | Duke University | Mutatations define clinical subgroups of gliomas |
| AU2015229214B2 (en) | 2014-03-14 | 2019-07-11 | Les Laboratoires Servier | Pharmaceutical compositions of therapeutically active compounds |
| SG11201701220PA (en) | 2014-08-25 | 2017-03-30 | Univ Duke | Methods for rapid and sensitive detection of hotspot mutations |
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| WO2019173712A1 (en) * | 2018-03-09 | 2019-09-12 | Duke University | Addressing treatments for glioblastoma |
| CN108384857A (zh) * | 2018-05-04 | 2018-08-10 | 良培基因生物科技（武汉）有限公司 | ddPCR技术检测IDH1 R132H基因变异的引物、试剂盒及检测方法 |
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| CN108588194A (zh) * | 2018-05-28 | 2018-09-28 | 北京诺禾致源科技股份有限公司 | 利用高通量测序数据检测肿瘤突变负荷的方法及装置 |
| US10980788B2 (en) | 2018-06-08 | 2021-04-20 | Agios Pharmaceuticals, Inc. | Therapy for treating malignancies |
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| TW202043256A (zh) | 2019-01-10 | 2020-12-01 | 美商健生生物科技公司 | 前列腺新抗原及其用途 |
| KR102203850B1 (ko) * | 2019-04-09 | 2021-01-18 | 사회복지법인 삼성생명공익재단 | 신경교종의 진단 또는 예후 예측용 조성물 및 이에 관한 정보를 제공하는 방법 |
| CN110646557A (zh) * | 2019-10-12 | 2020-01-03 | 北京航空航天大学 | 携带idh基因突变的胶质母细胞瘤患者的尿液代谢标志物及其用途 |
| CN112071365B (zh) * | 2020-09-17 | 2023-09-19 | 北京理工大学 | 基于pten基因状态筛选胶质瘤生物标记物的方法 |
| CN114381522B (zh) * | 2021-12-30 | 2023-09-05 | 南京医科大学 | Nup98基因作为胶质瘤干细胞特异性分子标志物和胶质母细胞瘤治疗及预后靶点的应用 |
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| JPH11116479A (ja) * | 1997-10-10 | 1999-04-27 | Sugen Inc | 脳癌のための組み合わせ化学療法処置 |
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| AU3391200A (en) * | 1999-03-04 | 2000-09-21 | Corixa Corporation | Compositions and methods for breast cancer therapy and diagnosis |
| AU2002252144A1 (en) * | 2001-02-27 | 2002-09-12 | Case Western Reserve University | Novel methods of diagnosis of metastatic colorectal cancer, compositions and methods of screening for modulators of metastatic colorectal cancer |
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| CN102985557B (zh) | 2009-03-13 | 2018-06-15 | 安吉奥斯医药品有限公司 | 用于细胞增殖相关病症的方法和组合物 |
| EP2253716A1 (en) * | 2009-05-15 | 2010-11-24 | Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts | Diagnostic methods for the prognosis of a brain tumor |
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2009
- 2009-09-03 JP JP2011526180A patent/JP5421374B2/ja active Active
- 2009-09-03 ES ES17168866T patent/ES2755139T3/es active Active
- 2009-09-03 PL PL12188429T patent/PL2546365T3/pl unknown
- 2009-09-03 MX MX2015015733A patent/MX359574B/es unknown
- 2009-09-03 CN CN200980138651.4A patent/CN102177251B/zh active Active
- 2009-09-03 AU AU2009288004A patent/AU2009288004B2/en active Active
- 2009-09-03 DK DK09792198.5T patent/DK2326735T3/en active
- 2009-09-03 WO PCT/US2009/055803 patent/WO2010028099A1/en active Application Filing
- 2009-09-03 ES ES09792198.5T patent/ES2609414T3/es active Active
- 2009-09-03 DK DK12188429.0T patent/DK2546365T3/en active
- 2009-09-03 US US13/060,191 patent/US8685660B2/en active Active
- 2009-09-03 EP EP13160496.9A patent/EP2607498B1/en active Active
- 2009-09-03 MX MX2012012788A patent/MX343226B/es unknown
- 2009-09-03 EP EP17168866.6A patent/EP3266879B1/en active Active
- 2009-09-03 EP EP09792198.5A patent/EP2326735B1/en active Active
- 2009-09-03 ES ES12188429.0T patent/ES2608310T3/es active Active
- 2009-09-03 CA CA2736125A patent/CA2736125C/en active Active
- 2009-09-03 EP EP12188429.0A patent/EP2546365B1/en active Active
- 2009-09-03 MX MX2011002409A patent/MX2011002409A/es active IP Right Grant
- 2009-09-03 PL PL09792198T patent/PL2326735T3/pl unknown
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2012
- 2012-03-06 US US13/412,696 patent/US20120202207A1/en not_active Abandoned
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2013
- 2013-11-21 JP JP2013240519A patent/JP6016755B2/ja active Active
- 2013-12-11 US US14/102,730 patent/US9353418B2/en active Active
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2016
- 2016-04-04 JP JP2016074863A patent/JP2016129517A/ja active Pending
- 2016-11-16 US US15/353,002 patent/US10894987B2/en active Active
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2018
- 2018-03-22 US US15/928,811 patent/US10837064B2/en active Active
- 2018-09-17 US US16/132,928 patent/US10704108B2/en active Active
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2020
- 2020-11-06 US US17/091,658 patent/US20210317532A1/en active Pending
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