CN114761037A - 结合bcma和cd19的嵌合抗原受体及其用途 - Google Patents

结合bcma和cd19的嵌合抗原受体及其用途 Download PDF

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CN114761037A
CN114761037A CN202080082013.1A CN202080082013A CN114761037A CN 114761037 A CN114761037 A CN 114761037A CN 202080082013 A CN202080082013 A CN 202080082013A CN 114761037 A CN114761037 A CN 114761037A
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cells
optionally
nucleic acid
acid sequence
car
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Chinese (zh)
Inventor
A·阿布朱布
J·布兰肯希普
A·邦达扎
J·布罗格顿
D·布
S·德维塔
G·德拉诺夫
B·恩格斯
T·弗莱明
M·R·格林内
A·哈克
B·霍姆伯格
C·洪
L·黄
O·考德拉斯
H·利姆
E·D·普拉蒂科
A·普赖斯
A·索霍尼
A·M·斯泰因
L·特雷纳
C·张
B·W·格兰达
J·W·兰
C·P·吉马良斯
X·朱
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Novartis AG
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Novartis AG
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CN202080082013.1A 2019-11-26 2020-11-25 结合bcma和cd19的嵌合抗原受体及其用途 Pending CN114761037A (zh)

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US201962940509P 2019-11-26 2019-11-26
US62/940,509 2019-11-26
PCT/US2020/062357 WO2021108661A2 (en) 2019-11-26 2020-11-25 Chimeric antigen receptors and uses thereof

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AU (2) AU2020393912B2 (https=)
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Cited By (2)

* Cited by examiner, † Cited by third party
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CN116751310A (zh) * 2023-06-13 2023-09-15 广东省第二人民医院（广东省卫生应急医院） 靶向cd19和gprc5d配体的嵌合抗原受体及其应用
WO2024193562A1 (zh) * 2023-03-21 2024-09-26 苏州沙砾生物科技有限公司 一种修饰的细胞及其用途

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EP2970426B1 (en) 2013-03-15 2019-08-28 Michael C. Milone Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy
UY35468A (es) 2013-03-16 2014-10-31 Novartis Ag Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19
US10287354B2 (en) 2013-12-20 2019-05-14 Novartis Ag Regulatable chimeric antigen receptor
US11028143B2 (en) 2014-01-21 2021-06-08 Novartis Ag Enhanced antigen presenting ability of RNA CAR T cells by co-introduction of costimulatory molecules
AU2015244039B2 (en) * 2014-04-07 2021-10-21 Novartis Ag Treatment of cancer using anti-CD19 chimeric antigen receptor
TWI750110B (zh) 2014-07-21 2021-12-21 瑞士商諾華公司 使用人類化抗-ｂｃｍａ嵌合抗原受體治療癌症
ES2791248T3 (es) 2014-08-19 2020-11-03 Novartis Ag Receptor antigénico quimérico (CAR) anti-CD123 para su uso en el tratamiento del cáncer
MX2017012939A (es) 2015-04-08 2018-05-22 Novartis Ag Terapias cd20, terapias cd22 y terapias de combinacion con una celula que expresa un receptor quimerico de antigeno (car) de cd19.
SG11201708516YA (en) 2015-04-17 2017-11-29 David Maxwell Barrett Methods for improving the efficacy and expansion of chimeric antigen receptor-expressing cells
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