CN111565798B - 食道组织和/或类器官组合物及其制备方法 - Google Patents

食道组织和/或类器官组合物及其制备方法 Download PDF

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CN111565798B
CN111565798B CN201880077247.XA CN201880077247A CN111565798B CN 111565798 B CN111565798 B CN 111565798B CN 201880077247 A CN201880077247 A CN 201880077247A CN 111565798 B CN111565798 B CN 111565798B
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sox2
esophageal
foregut
cells
heo
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CN111565798A (zh
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J·M·威尔斯
S·特里斯诺
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Cincinnati Childrens Hospital Medical Center
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0679—Cells of the gastro-intestinal tract
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • A—HUMAN NECESSITIES
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    • A01K2207/00—Modified animals
    • A01K2207/30—Animals modified by surgical methods
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    • A01K2227/10—Mammal
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    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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CN201880077247.XA 2017-10-10 2018-10-05 食道组织和/或类器官组合物及其制备方法 Active CN111565798B (zh)

Applications Claiming Priority (3)

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US201762570182P 2017-10-10 2017-10-10
US62/570,182 2017-10-10
PCT/US2018/054635 WO2019074793A1 (en) 2017-10-10 2018-10-05 OESOPHAGIAN TISSUE COMPOSITIONS AND / OR ORGANOIDS AND METHODS OF MAKING SAME

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CN111565798A CN111565798A (zh) 2020-08-21
CN111565798B true CN111565798B (zh) 2025-06-24

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US (1) US12297457B2 (https=)
EP (1) EP3694603B1 (https=)
JP (2) JP2020536529A (https=)
CN (1) CN111565798B (https=)
CA (1) CA3077442A1 (https=)
WO (1) WO2019074793A1 (https=)

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EP3548507A4 (en) 2016-12-05 2020-07-15 Children's Hospital Medical Center COLON ORGANOIDS AND PROCESSES FOR THE PREPARATION AND USE THEREOF
JP7248586B2 (ja) 2017-04-14 2023-03-29 チルドレンズ ホスピタル メディカル センター 複数ドナー幹細胞組成物およびそれを作製する方法
EP3694603B1 (en) 2017-10-10 2026-04-08 Children's Hospital Medical Center Esophageal tissue and/or organoid compositions and methods of making same
EP3727394A4 (en) 2017-12-21 2021-09-08 Children's Hospital Medical Center DIGITALIZED HUMAN ORGANOIDS AND METHOD OF USING THEREOF
EP4678727A3 (en) * 2018-07-26 2026-03-11 Children's Hospital Medical Center Hepato-biliary-pancreatic tissues and methods of making same
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US12600943B2 (en) 2019-02-01 2026-04-14 The University Of Hong Kong Innervated organoid compositions and methods of making same
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AU2020283048A1 (en) 2019-05-31 2021-12-23 Children's Hospital Medical Center Shaped organoid compositions and methods of making same
CN111471643B (zh) * 2020-04-09 2020-12-29 创芯国际生物科技(广州)有限公司 一种通用型上呼吸道粘膜类器官的培养基及培养方法
CN113943755B (zh) * 2020-07-15 2023-09-12 四川大学华西医院 构建原位原发食管癌动物模型的方法
WO2022066772A1 (en) * 2020-09-25 2022-03-31 Children´S Hospital Medical Center Raft cultures and methods of making thereof
KR20240120263A (ko) 2023-01-31 2024-08-07 재단법인대구경북과학기술원 식도 오가노이드의 제조방법 및 이의 용도
WO2024259353A2 (en) * 2023-06-16 2024-12-19 The Board Of Trustees Of The Leland Stanford Junior University Methods of generating esophagus basal cells from pluripotent stem cells
WO2025072803A1 (en) 2023-09-29 2025-04-03 Children's Hospital Medical Center Ntrk2 signaling-mediated alveolar capillary injury and repair
CN117491641B (zh) * 2023-10-30 2025-03-11 重庆医科大学 K1c13泪液浓度检测试剂在妊娠泪液鉴别试剂制备中的应用
CN117286108B (zh) * 2023-11-24 2024-03-01 领因生物科技(上海)有限公司 一种乳腺癌类器官专用培养基及培养方法
CN118755748B (zh) * 2024-09-05 2025-01-14 珠海麦得发生物科技股份有限公司 木糖转运蛋白在生产p34hb中的应用

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