SG11201803061UA - Methods of generating human inner ear sensory epithelia and sensory neurons - Google Patents
Methods of generating human inner ear sensory epithelia and sensory neuronsInfo
- Publication number
- SG11201803061UA SG11201803061UA SG11201803061UA SG11201803061UA SG11201803061UA SG 11201803061U A SG11201803061U A SG 11201803061UA SG 11201803061U A SG11201803061U A SG 11201803061UA SG 11201803061U A SG11201803061U A SG 11201803061UA SG 11201803061U A SG11201803061U A SG 11201803061UA
- Authority
- SG
- Singapore
- Prior art keywords
- sensory
- methods
- inner ear
- epithelia
- generating human
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/062—Sensory transducers, e.g. photoreceptors; Sensory neurons, e.g. for hearing, taste, smell, pH, touch, temperature, pain
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/15—Transforming growth factor beta (TGF-β)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/415—Wnt; Frizzeled
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/50—Proteins
- C12N2533/52—Fibronectin; Laminin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0607—Non-embryonic pluripotent stem cells, e.g. MASC
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562244568P | 2015-10-21 | 2015-10-21 | |
| PCT/US2016/058121 WO2017070471A1 (en) | 2015-10-21 | 2016-10-21 | Methods of generating human inner ear sensory epithelia and sensory neurons |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201803061UA true SG11201803061UA (en) | 2018-05-30 |
Family
ID=58557861
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201803061UA SG11201803061UA (en) | 2015-10-21 | 2016-10-21 | Methods of generating human inner ear sensory epithelia and sensory neurons |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20190093072A1 (en) |
| EP (1) | EP3365428A4 (en) |
| JP (1) | JP6979946B2 (en) |
| CN (1) | CN108291197B (en) |
| AU (1) | AU2016341982B2 (en) |
| CA (1) | CA3002162A1 (en) |
| HK (1) | HK1256552A1 (en) |
| SG (1) | SG11201803061UA (en) |
| WO (1) | WO2017070471A1 (en) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9719068B2 (en) | 2010-05-06 | 2017-08-01 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
| AU2015267148B2 (en) | 2014-05-28 | 2021-07-29 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into gastric tissues through directed differentiation |
| EP3207123A1 (en) | 2014-10-17 | 2017-08-23 | Children's Hospital Center D/b/a Cincinnati Children's Hospital Medical Center | In vivo model of human small intestine using pluripotent stem cells and methods of making and using same |
| EP3411048A4 (en) * | 2016-02-05 | 2019-07-31 | Memorial Sloan-Kettering Cancer Center | Methods of differentiating stem cell-derived ectodermal lineage precursors |
| EP3423069A4 (en) * | 2016-03-02 | 2020-04-08 | Frequency Therapeutics, Inc. | Methods for controlled proliferation of vestibular stem cells / generating inner ear hair cells using wnt and tgf-beta inhibition |
| CN116790476A (en) | 2016-05-05 | 2023-09-22 | 儿童医院医疗中心 | Methods for in vitro manufacturing of fundus tissue and compositions related thereto |
| JP7068305B2 (en) | 2016-12-05 | 2022-05-16 | チルドレンズ ホスピタル メディカル センター | Colon organoids and how to make and use them |
| JP7317016B2 (en) | 2017-12-19 | 2023-07-28 | スロゼン オペレーティング， インコーポレイテッド | Anti-LRP5/6 Antibodies and Methods of Use |
| CN111727203B (en) | 2017-12-19 | 2024-04-26 | 瑟罗泽恩奥普瑞汀公司 | WNT-substituted molecules and uses thereof |
| WO2020037326A1 (en) | 2018-08-17 | 2020-02-20 | Frequency Therapeutics, Inc. | Compositions and methods for generating hair cells by downregulating foxo |
| CN109280634B (en) * | 2018-08-31 | 2022-02-18 | 浙江大学 | Method for in vitro isolated culture of inner ear hair cells |
| WO2020206005A1 (en) * | 2019-04-02 | 2020-10-08 | Surrozen, Inc. | Modulation of wnt signaling in auditory disorders |
| JP2023106639A (en) * | 2020-06-09 | 2023-08-02 | 株式会社オトリンク | Method for producing inner ear progenitor cells, method for producing inner ear hair cells, method for assessing drug, and composition for inducing differentiation of inner ear cells |
| CN111643671B (en) * | 2020-06-22 | 2021-07-30 | 南京大学 | Composition for promoting hair cell regeneration and hearing recovery and application thereof |
| CN112608878B (en) * | 2020-12-18 | 2022-06-14 | 复旦大学附属眼耳鼻喉科医院 | In-vitro cochlear micro-organ functional unit and three-dimensional construction method and application thereof |
| WO2023167986A1 (en) * | 2022-03-02 | 2023-09-07 | Lineage Cell Therapeutics, Inc. | Methods and compositions for treating hearing loss |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004159471A (en) * | 2002-11-08 | 2004-06-03 | Fuji Electric Fa Components & Systems Co Ltd | Automatic power factor adjusting arrangement |
| US20060024278A1 (en) * | 2004-01-23 | 2006-02-02 | The General Hospital Corporation | Methods and products related to the production of inner ear hair cells |
| US20060035375A1 (en) * | 2004-08-16 | 2006-02-16 | Head Jonathan F | Method for selectively culturing epithelial or carcinoma cells |
| US20100144641A1 (en) * | 2005-09-12 | 2010-06-10 | Popel Aleksander S | Compositions Having Antiangiogenic Activity and Uses Thereof |
| US7892830B2 (en) | 2007-01-17 | 2011-02-22 | Wisconsin Alumni Research Foundation | Clonal culture of human pluripotent stem cells |
| CA2731821A1 (en) * | 2008-07-25 | 2010-01-28 | Stephen Dalton | Compositions for mesoderm derived isl1+ multipotent cells (imps), epicardial progenitor cells (epcs) and multipotent cxcr4+cd56+ cells (c56cs) and methods of use |
| SG172160A1 (en) * | 2008-12-17 | 2011-07-28 | Scripps Research Inst | Generation and maintenance of stem cells |
| WO2012103012A1 (en) * | 2011-01-24 | 2012-08-02 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for generating inner ear cells in vitro |
| WO2013166488A1 (en) * | 2012-05-04 | 2013-11-07 | Indiana University Research & Technology Corporation | Methods for generating the inner ear and other cranial placode-derived tissues using pluripotent stem cells |
| WO2015134652A1 (en) * | 2014-03-04 | 2015-09-11 | Bahram Valamehr | Improved reprogramming methods and cell culture platforms |
-
2016
- 2016-10-21 CA CA3002162A patent/CA3002162A1/en not_active Abandoned
- 2016-10-21 SG SG11201803061UA patent/SG11201803061UA/en unknown
- 2016-10-21 AU AU2016341982A patent/AU2016341982B2/en active Active
- 2016-10-21 CN CN201680061915.0A patent/CN108291197B/en active Active
- 2016-10-21 JP JP2018520429A patent/JP6979946B2/en active Active
- 2016-10-21 US US15/769,254 patent/US20190093072A1/en not_active Abandoned
- 2016-10-21 EP EP16858294.8A patent/EP3365428A4/en active Pending
- 2016-10-21 WO PCT/US2016/058121 patent/WO2017070471A1/en active Application Filing
-
2018
- 2018-12-06 HK HK18115622.4A patent/HK1256552A1/en unknown
-
2020
- 2020-08-10 US US16/989,554 patent/US20200370007A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| HK1256552A1 (en) | 2019-09-27 |
| EP3365428A4 (en) | 2019-03-20 |
| JP6979946B2 (en) | 2021-12-15 |
| US20200370007A1 (en) | 2020-11-26 |
| AU2016341982B2 (en) | 2022-07-07 |
| US20190093072A1 (en) | 2019-03-28 |
| EP3365428A1 (en) | 2018-08-29 |
| AU2016341982A1 (en) | 2018-05-10 |
| WO2017070471A1 (en) | 2017-04-27 |
| JP2018531031A (en) | 2018-10-25 |
| CN108291197A (en) | 2018-07-17 |
| CN108291197B (en) | 2022-09-16 |
| CA3002162A1 (en) | 2017-04-27 |
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