DK3417073T3 - Genetiske markører til transplantation af humane, hjerteventrikulære progenitorceller - Google Patents
Genetiske markører til transplantation af humane, hjerteventrikulære progenitorceller Download PDFInfo
- Publication number
- DK3417073T3 DK3417073T3 DK17708364.9T DK17708364T DK3417073T3 DK 3417073 T3 DK3417073 T3 DK 3417073T3 DK 17708364 T DK17708364 T DK 17708364T DK 3417073 T3 DK3417073 T3 DK 3417073T3
- Authority
- DK
- Denmark
- Prior art keywords
- transplantation
- progenitor cells
- genetic markers
- human cardiac
- cardiac ventricular
- Prior art date
Links
- 230000000747 cardiac effect Effects 0.000 title 1
- 230000002068 genetic effect Effects 0.000 title 1
- 210000000130 stem cell Anatomy 0.000 title 1
- 238000002054 transplantation Methods 0.000 title 1
- 230000002861 ventricular Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/34—Muscles; Smooth muscle cells; Heart; Cardiac stem cells; Myoblasts; Myocytes; Cardiomyocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0657—Cardiomyocytes; Heart cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/415—Wnt; Frizzeled
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/42—Notch; Delta; Jagged; Serrate
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Cardiology (AREA)
- Developmental Biology & Embryology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Rheumatology (AREA)
- Virology (AREA)
- Vascular Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662297217P | 2016-02-19 | 2016-02-19 | |
| PCT/US2017/017952 WO2017172086A1 (en) | 2016-02-19 | 2017-02-15 | Genetic markers for engraftment of human cardiac ventricular progenitor cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3417073T3 true DK3417073T3 (da) | 2023-10-30 |
Family
ID=58192373
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK17708364.9T DK3417073T3 (da) | 2016-02-19 | 2017-02-15 | Genetiske markører til transplantation af humane, hjerteventrikulære progenitorceller |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US10612094B2 (da) |
| EP (2) | EP3417073B1 (da) |
| JP (2) | JP7097814B2 (da) |
| DK (1) | DK3417073T3 (da) |
| FI (1) | FI3417073T3 (da) |
| PT (1) | PT3417073T (da) |
| WO (1) | WO2017172086A1 (da) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011140441A2 (en) | 2010-05-06 | 2011-11-10 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
| CA2949834A1 (en) | 2014-05-28 | 2015-12-03 | James Macormack Wells | Methods and systems for converting precursor cells into gastric tissues through directed differentiation |
| US10596200B2 (en) | 2014-08-22 | 2020-03-24 | Procella Therapeutics Ab | Use of LIFR or FGFR3 as a cell surface marker for isolating human cardiac ventricular progenitor cells |
| JP6738808B2 (ja) | 2014-08-22 | 2020-08-12 | プロセラ セラピューティクス アーベー | ヒト心室前駆体細胞を単離するための細胞表面マーカーとしてのＪａｇｇｅｄ１／Ｆｒｉｚｚｌｅｄ４の使用 |
| JP6804438B2 (ja) | 2014-10-17 | 2020-12-23 | チルドレンズ ホスピタル メディカル センター | 多能性幹細胞を使用するヒト小腸のｉｎ ｖｉｖｏモデル、並びにそれを作製、及び使用する方法 |
| FI3417073T3 (fi) | 2016-02-19 | 2023-11-01 | Procella Therapeutics Ab | Geenimarkkereita humaanien sydämen kammion progenitorisolujen siirtämiselle |
| CA3016641A1 (en) | 2016-05-05 | 2017-11-09 | Children's Hospital Medical Center | Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same |
| US10508263B2 (en) | 2016-11-29 | 2019-12-17 | Procella Therapeutics Ab | Methods for isolating human cardiac ventricular progenitor cells |
| WO2018106628A1 (en) | 2016-12-05 | 2018-06-14 | Children's Hospital Medical Center | Colonic organoids and methods of making and using same |
| JP7275109B2 (ja) * | 2017-08-23 | 2023-05-17 | プロセラ セラピューティクス アーベー | ニューロピリン－１（ｎｒｐ１）のヒト心室前駆細胞を単離するための細胞表面マーカーとしての使用 |
| CN110824173B (zh) * | 2019-11-27 | 2022-09-02 | 中国人民解放军陆军军医大学第一附属医院 | 促血管生成因子pdgfc在作为诊断和治疗肝肺综合征的标志物中的应用 |
| KR102331738B1 (ko) * | 2019-12-12 | 2021-11-26 | 전남대학교산학협력단 | 원형 RNA Smoc1를 포함하는 혈관 석회화의 치료 또는 진단용 조성물 |
| WO2023278382A1 (en) | 2021-06-29 | 2023-01-05 | Staffan Holmin | Endoluminal delivery cannula |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| US5561384A (en) | 1995-11-08 | 1996-10-01 | Advanced Micro Devices, Inc. | Input/output driver circuit for isolating with minimal power consumption a peripheral component from a core section |
| US5994619A (en) | 1996-04-01 | 1999-11-30 | University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, As Represented By Its Amherst Campus | Production of chimeric bovine or porcine animals using cultured inner cell mass cells |
| US5945577A (en) | 1997-01-10 | 1999-08-31 | University Of Massachusetts As Represented By Its Amherst Campus | Cloning using donor nuclei from proliferating somatic cells |
| US7166280B2 (en) | 2000-04-06 | 2007-01-23 | Franco Wayne P | Combination growth factor therapy and cell therapy for treatment of acute and chronic heart disease |
| WO2003024462A1 (en) | 2001-09-19 | 2003-03-27 | Henry Ford Health System | Cardiac transplantation of stem cells for the treatment of heart failure |
| US7745113B2 (en) | 2003-01-31 | 2010-06-29 | The Regents Of The University Of California | Use of islet 1 as a marker for isolating or generating stem cells |
| ATE419334T1 (de) | 2005-07-29 | 2009-01-15 | Stiftung Caesar | Verfahren zur isolierung von stammzellen aus ein kissenformiges gewebe der zähne |
| US20080038229A1 (en) | 2006-08-08 | 2008-02-14 | Minguell Jose J | Intracoronary injection of a mixture of autologous bone marrow derived mononuclear cells and autologous bone marrow derived mesenchymal stem cells for utilization and rescue of infarcted myocardium |
| WO2008054819A2 (en) | 2006-11-02 | 2008-05-08 | The General Hospital Corporation | Cardiovascular stem cells, methods for stem cell isolation, and uses thereof |
| KR101240487B1 (ko) | 2006-11-09 | 2013-03-08 | 더 존스 홉킨스 유니버시티 | 성체 포유동물 심근세포의 심장 줄기 세포로의 역분화 |
| US20080182328A1 (en) | 2006-12-19 | 2008-07-31 | The Burnham Institute | Mammalian extraembryonic endoderm cells and methods of isolation |
| EP2222837A2 (en) | 2007-02-09 | 2010-09-01 | The General Hospital Corporation | Methods for the induction of a cell to enter the islet 1+ lineage and a method for the expansion thereof |
| US20100247493A1 (en) | 2007-07-31 | 2010-09-30 | Rust William L | Method for Identifying and Selecting Cardiomyocytes |
| WO2009073618A2 (en) | 2007-11-30 | 2009-06-11 | New York Medical College | Compositions comprising hdac inhibitors and methods of their use in restoring stem cell function and preventing heart failure |
| US8420620B2 (en) | 2008-01-24 | 2013-04-16 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Induced internalization of surface receptors |
| WO2010042856A2 (en) | 2008-10-09 | 2010-04-15 | The General Hospital Corporation | Tissue engineered myocardium and methods of production and uses thereof |
| WO2010144678A2 (en) | 2009-06-10 | 2010-12-16 | The General Hospital Corporation | Generation of vascularized human heart tissue and uses thereof |
| WO2011091945A1 (en) | 2010-01-26 | 2011-08-04 | Université Libre de Bruxelles | Tools for isolating and following cardiovascular progenitor cells |
| WO2011153236A1 (en) | 2010-06-03 | 2011-12-08 | The Board Of Trustees Of The Leland Stanford Junior University | Purified compositions of cardiovascular progenitor cells |
| US20120009158A1 (en) | 2010-06-18 | 2012-01-12 | The General Hospital Corporation | VENTRICULAR INDUCED PLURIPOTENT STEM (ViPS) CELLS FOR GENERATION OF AUTOLOGOUS VENTRICULAR CARDIOMYOCYTES AND USES THEREOF |
| SG186983A1 (en) | 2010-07-09 | 2013-02-28 | Genentech Inc | Anti-neuropilin antibodies and methods of use |
| AU2010100830A4 (en) | 2010-08-03 | 2010-09-16 | Robert Fallshaw | Biased Pin Lock |
| WO2012070014A2 (en) * | 2010-11-26 | 2012-05-31 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Identification of novel cell surface markers for pancreatic progenitor cells and definite endodermal cells |
| JPWO2012074116A1 (ja) * | 2010-12-02 | 2014-05-19 | 独立行政法人理化学研究所 | アロＮＫＴ細胞を用いた免疫療法およびそのためのＴ細胞抗原受容体（ＴＣＲ）遺伝子のα鎖領域が均一なＶα−Ｊαに再構成されている細胞および該細胞由来ＮＫＴ細胞のバンキング |
| AU2012236707B2 (en) | 2011-03-29 | 2017-07-20 | Asterias Biotherapeutics, Inc. | Enriched populations of cardiomyocyte lineage cells from pluripotent stem cells |
| KR101323650B1 (ko) | 2011-05-04 | 2013-11-05 | 연세대학교 산학협력단 | 미분화 전능성 줄기세포의 제거방법 |
| WO2012162741A1 (en) | 2011-06-01 | 2012-12-06 | Monash University | Enrichment of cardiomyocytes |
| US8951798B2 (en) | 2011-10-13 | 2015-02-10 | Wisconsin Alumni Research Foundation | Generation of cardiomyocytes from human pluripotent stem cells |
| US9764063B2 (en) | 2012-03-15 | 2017-09-19 | Iheart Japan Corporation | Method for producing mixed cell population of cardiomyocytes and vascular cells from induced pluripotent stem cell |
| US9234176B2 (en) * | 2012-11-13 | 2016-01-12 | The Board Of Trustees Of The Leland Stanford Junior University | Chemically defined production of cardiomyocytes from pluripotent stem cells |
| US10851412B2 (en) | 2013-03-15 | 2020-12-01 | Fate Therapeutics, Inc. | Cell potency assay for therapeutic potential |
| US20150079626A1 (en) * | 2013-03-19 | 2015-03-19 | Lsip, Llc | Method of obtaining a cell population containing cancer stem cells |
| WO2015058117A1 (en) | 2013-10-18 | 2015-04-23 | Icahn School Of Medicine At Mount Sinai | Directed cardiomyocyte differentiation and ventricular specification of stem cells |
| EP2875819B1 (en) | 2013-11-20 | 2018-09-19 | Miltenyi Biotec GmbH | Compositions of cardiomyocyte subpopulations |
| WO2015081094A1 (en) | 2013-11-27 | 2015-06-04 | University Of Louisville Research Foundation, Inc. | Cardiac progenitor cells and methods of use therefor |
| AU2015217271B2 (en) | 2014-02-12 | 2018-10-25 | Genentech, Inc. | Anti-Jagged1 antibodies and methods of use |
| JP5924750B2 (ja) | 2014-05-01 | 2016-05-25 | ｉＨｅａｒｔ Ｊａｐａｎ株式会社 | Ｃｄ８２陽性心筋前駆細胞 |
| WO2015172037A1 (en) | 2014-05-09 | 2015-11-12 | Becton, Dickinson And Company | Cell surface signature for processing cardiomyocyte subsets from heterogeneous cell samples |
| US10596200B2 (en) | 2014-08-22 | 2020-03-24 | Procella Therapeutics Ab | Use of LIFR or FGFR3 as a cell surface marker for isolating human cardiac ventricular progenitor cells |
| JP6738808B2 (ja) | 2014-08-22 | 2020-08-12 | プロセラ セラピューティクス アーベー | ヒト心室前駆体細胞を単離するための細胞表面マーカーとしてのＪａｇｇｅｄ１／Ｆｒｉｚｚｌｅｄ４の使用 |
| US9765299B2 (en) | 2014-09-10 | 2017-09-19 | Wisconsin Alumni Research Foundation | Chemically defined albumin-free conditions for cardiomyocyte differentiation of human pluripotent stem cells |
| EP3259348A4 (en) | 2015-02-17 | 2018-07-18 | University Health Network | Methods for making and using sinoatrial node-like pacemaker cardiomyocytes and ventricular-like cardiomyocytes |
| FI3417073T3 (fi) | 2016-02-19 | 2023-11-01 | Procella Therapeutics Ab | Geenimarkkereita humaanien sydämen kammion progenitorisolujen siirtämiselle |
| US10508263B2 (en) | 2016-11-29 | 2019-12-17 | Procella Therapeutics Ab | Methods for isolating human cardiac ventricular progenitor cells |
| JP7275109B2 (ja) | 2017-08-23 | 2023-05-17 | プロセラ セラピューティクス アーベー | ニューロピリン－１（ｎｒｐ１）のヒト心室前駆細胞を単離するための細胞表面マーカーとしての使用 |
-
2017
- 2017-02-15 FI FIEP17708364.9T patent/FI3417073T3/fi active
- 2017-02-15 PT PT177083649T patent/PT3417073T/pt unknown
- 2017-02-15 EP EP17708364.9A patent/EP3417073B1/en active Active
- 2017-02-15 US US15/433,713 patent/US10612094B2/en active Active
- 2017-02-15 DK DK17708364.9T patent/DK3417073T3/da active
- 2017-02-15 WO PCT/US2017/017952 patent/WO2017172086A1/en active Application Filing
- 2017-02-15 EP EP23191629.7A patent/EP4269566A3/en active Pending
- 2017-02-15 JP JP2018543315A patent/JP7097814B2/ja active Active
-
2020
- 2020-03-03 US US16/807,943 patent/US11725244B2/en active Active
-
2022
- 2022-05-16 JP JP2022080199A patent/JP7386290B2/ja active Active
-
2023
- 2023-08-14 US US18/233,741 patent/US20230383345A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| FI3417073T3 (fi) | 2023-11-01 |
| JP7386290B2 (ja) | 2023-11-24 |
| US10612094B2 (en) | 2020-04-07 |
| US20230383345A1 (en) | 2023-11-30 |
| PT3417073T (pt) | 2023-10-26 |
| EP3417073A1 (en) | 2018-12-26 |
| JP2022097752A (ja) | 2022-06-30 |
| JP2019505221A (ja) | 2019-02-28 |
| US20200270685A1 (en) | 2020-08-27 |
| JP7097814B2 (ja) | 2022-07-08 |
| US20170240964A1 (en) | 2017-08-24 |
| EP4269566A2 (en) | 2023-11-01 |
| EP4269566A3 (en) | 2024-01-10 |
| EP3417073B1 (en) | 2023-09-20 |
| US11725244B2 (en) | 2023-08-15 |
| WO2017172086A1 (en) | 2017-10-05 |
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