CN110832075A - 用于免疫肿瘤学的组合物和方法 - Google Patents

用于免疫肿瘤学的组合物和方法 Download PDF

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CN110832075A
CN110832075A CN201880033344.9A CN201880033344A CN110832075A CN 110832075 A CN110832075 A CN 110832075A CN 201880033344 A CN201880033344 A CN 201880033344A CN 110832075 A CN110832075 A CN 110832075A
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chr4
seq
cell
nucleic acid
grna molecule
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Chinese (zh)
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J·布罗格顿
陈名伟
H·利姆
Y·杨
M·斯图尔特
S·赫西
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Novartis AG
Intellia Therapeutics Inc
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Novartis AG
Intellia Therapeutics Inc
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CN201880033344.9A 2017-03-22 2018-03-21 用于免疫肿瘤学的组合物和方法 Pending CN110832075A (zh)

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US201762475024P 2017-03-22 2017-03-22
US62/475,024 2017-03-22
PCT/US2018/023631 WO2018175636A2 (en) 2017-03-22 2018-03-21 Compositions and methods for immunooncology

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KR (1) KR20190130608A (enExample)
CN (1) CN110832075A (enExample)
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CN109415687A (zh) * 2016-04-07 2019-03-01 蓝鸟生物公司 嵌合抗原受体t细胞组合物
US20210180091A1 (en) * 2017-10-26 2021-06-17 Vertex Pharmaceuticals Incorporated Materials and methods for treatment of hemoglobinopathies
WO2023274386A1 (zh) * 2021-07-01 2023-01-05 宁波茂行生物医药科技有限公司 靶向egfr的通用型car-t细胞及其制备方法
WO2025260975A1 (zh) * 2024-06-17 2025-12-26 浙江康佰裕生物科技有限公司 一种造血干细胞基因编辑的方法、组合物及其应用

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MX2017012939A (es) 2015-04-08 2018-05-22 Novartis Ag Terapias cd20, terapias cd22 y terapias de combinacion con una celula que expresa un receptor quimerico de antigeno (car) de cd19.
CN108699557B (zh) 2015-12-04 2025-08-15 诺华股份有限公司 用于免疫肿瘤学的组合物和方法
WO2018067992A1 (en) 2016-10-07 2018-04-12 Novartis Ag Chimeric antigen receptors for the treatment of cancer
US20210347851A1 (en) * 2018-09-28 2021-11-11 Novartis Ag Cd19 chimeric antigen receptor (car) and cd22 car combination therapies
EP3880216B1 (en) 2018-11-16 2025-04-09 Rapa Therapeutics, LLC Methods for treating cancer with manufactured t cells
US20220145333A1 (en) * 2019-03-11 2022-05-12 Sorrento Therapeutics, Inc. Improved process for integration of dna constructs using rna-guided endonucleases
MX2021013218A (es) 2019-05-01 2021-12-10 Pact Pharma Inc Composiciones y metodos para el tratamiento del cancer usando una terapia con celulas t modificadas con tet2.
EP3965829A4 (en) 2019-05-06 2023-05-24 Malcolm, Thomas ADAPTED HYPOIMMUNE NANOVESICULAR DELIVERY SYSTEM FOR CANCER TUMORS
EP4438729A3 (en) * 2019-12-09 2025-03-26 Caribou Biosciences, Inc. Crispr abasic restricted nucleotides and crispr accuracy via analogs
CA3171369A1 (en) * 2020-02-28 2021-09-02 Wisconsin Alumni Research Foundation Nonviral generation of genome edited chimeric antigen receptor t cells
EP4170020A4 (en) * 2020-06-17 2025-01-22 Kyoto University IMMUNOCOMPETENT CELLS WITH CHIMERIC ANTIGEN RECEPTOR EXPRESSION
EP4204575A4 (en) * 2020-08-28 2025-07-09 Arsenal Biosciences Inc IMMUNE CELLS MODIFIED WITH PRIMING RECEPTORS
CN114164231B (zh) * 2020-09-10 2024-05-17 上海邦耀生物科技有限公司 对细胞中的靶位点进行基因编辑的方法
CN120025983A (zh) * 2020-11-03 2025-05-23 南京北恒生物科技有限公司 靶向cd7的嵌合抗原受体及其用途
WO2022137181A1 (en) * 2020-12-23 2022-06-30 Crispr Therapeutics Ag Co-use of lenalidomide with car-t cells
CN113846070B (zh) * 2021-10-18 2023-05-16 翌圣生物科技(上海)股份有限公司 高活性的mTET2酶突变体、其编码DNA及其应用
KR102521500B1 (ko) * 2021-12-02 2023-04-14 한국화학연구원 증진된 효능을 갖는 면역세포
CA3267171A1 (en) * 2022-09-30 2024-04-04 Contera Pharma A/S Antisense oligonucleotides for the treatment of Canavan disease
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