CN1077104C - 钯催化的三唑基色胺闭环反应 - Google Patents

钯催化的三唑基色胺闭环反应 Download PDF

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Publication number
CN1077104C
CN1077104C CN95194106A CN95194106A CN1077104C CN 1077104 C CN1077104 C CN 1077104C CN 95194106 A CN95194106 A CN 95194106A CN 95194106 A CN95194106 A CN 95194106A CN 1077104 C CN1077104 C CN 1077104C
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CN
China
Prior art keywords
compound
palladium
silyl
structural formula
indol
Prior art date
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Expired - Lifetime
Application number
CN95194106A
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English (en)
Chinese (zh)
Other versions
CN1152920A (zh
Inventor
C·Y·陈
R·D·拉森
T·R·费尔霍文
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
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Merck and Co Inc
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Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of CN1152920A publication Critical patent/CN1152920A/zh
Application granted granted Critical
Publication of CN1077104C publication Critical patent/CN1077104C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Inorganic Insulating Materials (AREA)
CN95194106A 1994-05-24 1995-05-19 钯催化的三唑基色胺闭环反应 Expired - Lifetime CN1077104C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/248,288 US5567824A (en) 1994-05-24 1994-05-24 Palladium catalyzed ring closure of triazolyltryptamine
US08/248,288 1994-05-24

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CNB011034440A Division CN1157390C (zh) 1994-05-24 1995-05-19 吲哚衍生物

Publications (2)

Publication Number Publication Date
CN1152920A CN1152920A (zh) 1997-06-25
CN1077104C true CN1077104C (zh) 2002-01-02

Family

ID=22938473

Family Applications (2)

Application Number Title Priority Date Filing Date
CN95194106A Expired - Lifetime CN1077104C (zh) 1994-05-24 1995-05-19 钯催化的三唑基色胺闭环反应
CNB011034440A Expired - Lifetime CN1157390C (zh) 1994-05-24 1995-05-19 吲哚衍生物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CNB011034440A Expired - Lifetime CN1157390C (zh) 1994-05-24 1995-05-19 吲哚衍生物

Country Status (24)

Country Link
US (1) US5567824A (enExample)
EP (1) EP0763032B1 (enExample)
JP (1) JP3947216B2 (enExample)
KR (1) KR100385027B1 (enExample)
CN (2) CN1077104C (enExample)
AT (1) ATE252095T1 (enExample)
AU (1) AU688505B2 (enExample)
DE (1) DE69531939T2 (enExample)
DK (1) DK0763032T3 (enExample)
ES (1) ES2207648T3 (enExample)
FI (1) FI116899B (enExample)
HK (1) HK1041262B (enExample)
HR (1) HRP950304B1 (enExample)
HU (1) HU226460B1 (enExample)
MX (1) MX9605838A (enExample)
NZ (1) NZ285539A (enExample)
PT (1) PT763032E (enExample)
RO (1) RO118586B1 (enExample)
RU (1) RU2138496C1 (enExample)
SK (1) SK284495B6 (enExample)
TW (1) TW300221B (enExample)
UA (1) UA52586C2 (enExample)
WO (1) WO1995032197A1 (enExample)
YU (1) YU49345B (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA965837B (en) * 1995-07-11 1997-01-31 Merck & Co Inc A triazolylmethyl-indole ethylamine bisulfate salt
CA2225416C (en) * 1995-07-11 2009-02-24 Merck & Co., Inc. A triazolylmethyl-indole ethylamine bisulfate salt
US5811551A (en) * 1996-08-13 1998-09-22 Merck & Co., Inc. Palladium catalyzed indolization
US5877329A (en) * 1996-08-13 1999-03-02 Merck & Co., Inc. Palladium catalyzed indolization
EA003244B1 (ru) * 1996-08-13 2003-02-27 Мерк Энд Ко., Инк. Катализируемая палладием индолизация
US5808064A (en) * 1996-08-13 1998-09-15 Merck & Co., Inc. Palladium catalyzed indolization
BR0011997A (pt) * 1999-06-28 2002-03-05 Janssen Pharmaceutica Nv Inibidores da replicação do vìrus sincicial respiratório
ES2204303B2 (es) * 2002-08-07 2004-12-16 Laboratorios Vita, S.A. Procedimiento para la obtencion de un compuesto farmaceuticamente activo.
EP1709032A2 (en) 2004-01-09 2006-10-11 Ratiopharm GmbH Crystalline forms of rizatriptan benzoate
ES2340861T3 (es) 2004-01-28 2010-06-10 Ratiopharm Gmbh Procedimientos de sintesis e intermedios para la fabricacion de rizatriptan.
GT200500065A (es) * 2004-03-26 2005-10-24 Procedimientos para la preparacion de compuestos aminoarilos yodados
WO2006082598A2 (en) * 2005-02-01 2006-08-10 Natco Pharma Limited Novel crystalline forms of rizatriptan benzoate
WO2006137083A1 (en) * 2005-06-20 2006-12-28 Natco Pharma Limited Improved process for the preparation of rizatriptan benzoate
WO2007054979A1 (en) * 2005-11-14 2007-05-18 Matrix Laboratories Ltd Process for the large scale production of rizatriptan benzoate
EP1981860B1 (en) * 2006-01-19 2011-05-25 Matrix Laboratories Ltd Conversion of aromatic diazonium salt to aryl hydrazine
AU2008259518A1 (en) * 2007-06-04 2008-12-11 Generics [Uk] Limited Novel process
US12194158B2 (en) 2016-01-27 2025-01-14 Instar Technologies A.S. Oromucosal nanofiber carriers for therapeutic treatment

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1085555A (zh) * 1992-07-22 1994-04-20 默克·夏普-道姆公司 制备含1，2，4-三唑-1-基取代基的吲哚衍生物的方法
CN1085556A (zh) * 1991-12-19 1994-04-20 布里斯托尔-迈尔斯斯奎布公司 抗偏头痛的吲哚-3-基烷基哌嗪的4-嘧啶基和吡啶基衍生物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK278998B6 (sk) * 1991-02-01 1998-05-06 Merck Sharp & Dohme Limited Deriváty imidazolu, triazolu a tetrazolu, spôsob i

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1085556A (zh) * 1991-12-19 1994-04-20 布里斯托尔-迈尔斯斯奎布公司 抗偏头痛的吲哚-3-基烷基哌嗪的4-嘧啶基和吡啶基衍生物
CN1085555A (zh) * 1992-07-22 1994-04-20 默克·夏普-道姆公司 制备含1，2，4-三唑-1-基取代基的吲哚衍生物的方法

Also Published As

Publication number Publication date
CN1157390C (zh) 2004-07-14
HK1009045A1 (en) 1999-05-21
YU33495A (sh) 1998-07-10
FI964669L (fi) 1996-11-22
ES2207648T3 (es) 2004-06-01
MX9605838A (es) 1997-12-31
YU49345B (sh) 2005-07-19
TW300221B (enExample) 1997-03-11
KR100385027B1 (ko) 2003-08-14
AU2467195A (en) 1995-12-18
FI964669A0 (fi) 1996-11-22
DK0763032T3 (da) 2004-02-09
ATE252095T1 (de) 2003-11-15
WO1995032197A1 (en) 1995-11-30
US5567824A (en) 1996-10-22
HU226460B1 (en) 2008-12-29
RO118586B1 (ro) 2003-07-30
CN1152920A (zh) 1997-06-25
EP0763032B1 (en) 2003-10-15
CN1322725A (zh) 2001-11-21
SK284495B6 (sk) 2005-05-05
HK1041262A1 (en) 2002-07-05
JPH10500680A (ja) 1998-01-20
HRP950304B1 (en) 2004-12-31
SK149896A3 (en) 1997-09-10
HK1041262B (zh) 2005-04-15
JP3947216B2 (ja) 2007-07-18
KR970703336A (ko) 1997-07-03
HUT76469A (en) 1997-09-29
HRP950304A2 (en) 1997-08-31
HU9603236D0 (en) 1997-01-28
AU688505B2 (en) 1998-03-12
DE69531939T2 (de) 2004-07-29
EP0763032A1 (en) 1997-03-19
NZ285539A (en) 1998-06-26
RU2138496C1 (ru) 1999-09-27
UA52586C2 (uk) 2003-01-15
PT763032E (pt) 2004-02-27
DE69531939D1 (de) 2003-11-20
FI116899B (fi) 2006-03-31

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C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C56 Change in the name or address of the patentee

Owner name: MERCK & CO. INC.

Free format text: FORMER NAME OR ADDRESS: MERCK + CO., INC.

CP01 Change in the name or title of a patent holder

Address after: New jersey, USA

Patentee after: MERCK & Co.,Inc.

Address before: New jersey, USA

Patentee before: MERCK & Co.,Inc.

C56 Change in the name or address of the patentee
CP01 Change in the name or title of a patent holder

Address after: New jersey, USA

Patentee after: MERCK SHARP & DOHME Corp.

Address before: New jersey, USA

Patentee before: MERCK & Co.,Inc.

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Owner name: SCHERING CORP (US)

Free format text: FORMER OWNER: MSD CORP.

Effective date: 20121107

C41 Transfer of patent application or patent right or utility model
C56 Change in the name or address of the patentee

Owner name: MSD CORP.

Free format text: FORMER NAME: SCHERING CORP (US)

CP01 Change in the name or title of a patent holder

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TR01 Transfer of patent right

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C17 Cessation of patent right
CX01 Expiry of patent term

Expiration termination date: 20150519

Granted publication date: 20020102