YU49345B - Postupak dobijanja n,n-dimetil-2-[5-(1,2,4 triazol-1-ilmetil)-1h-indol-3-il] etilamina kroz paladijumom katalizovano zatvaranje prstena triazolil triptamina - Google Patents
Postupak dobijanja n,n-dimetil-2-[5-(1,2,4 triazol-1-ilmetil)-1h-indol-3-il] etilamina kroz paladijumom katalizovano zatvaranje prstena triazolil triptaminaInfo
- Publication number
- YU49345B YU49345B YU33495A YU33495A YU49345B YU 49345 B YU49345 B YU 49345B YU 33495 A YU33495 A YU 33495A YU 33495 A YU33495 A YU 33495A YU 49345 B YU49345 B YU 49345B
- Authority
- YU
- Yugoslavia
- Prior art keywords
- ring closure
- indol
- triazol
- ylmethyl
- ethylamine
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
- Inorganic Insulating Materials (AREA)
Abstract
Postupak dobijanja N,N-dimetil-2-[5-(1,2,4 triazol-1-ilmetil)-1H-indol-3-il] etilamina, strukture V iz jedinjenja strukture la naznačen time, što se sastoji od sledećih faza: a) reakcija jedinjenja strukture la sa jodirajućim sredstvom da se dobije jedinjenje strukture I b) spajanje jedinjenja strukture I sa jedinjenjem strukture II gde je R1: H ili hidroksi zaštitne grupe odabrane od silil liganda SiRa3, pri čemu je svaki Ra nezavisno izabran iz linearnog ili razgranatog C1-C4 alkila ili fenila, ili tetrahidropiranila i R2 predstavlja SiRa3, gde je Ra kao što je gore definisano da se dobije jedinjenje strukture III gde su R1 i R2 definisani kako je gore navedeno c) tretiranje jedinjenja strukture III sa srednje jakom kiselinom da se dobije jedinjenje strukture IV d) dovodjenje u kontakt jedinjenja strukture IV najpre sa alkilsulfonil hloridom, zatim sa dimetilaminom da se dobije jedinjenje strukture V, koja je gore prikazana. Prijava sadrži još 11 zavisnih zahteva.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/248,288 US5567824A (en) | 1994-05-24 | 1994-05-24 | Palladium catalyzed ring closure of triazolyltryptamine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| YU33495A YU33495A (sh) | 1998-07-10 |
| YU49345B true YU49345B (sh) | 2005-07-19 |
Family
ID=22938473
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU33495A YU49345B (sh) | 1994-05-24 | 1995-05-23 | Postupak dobijanja n,n-dimetil-2-[5-(1,2,4 triazol-1-ilmetil)-1h-indol-3-il] etilamina kroz paladijumom katalizovano zatvaranje prstena triazolil triptamina |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US5567824A (sh) |
| EP (1) | EP0763032B1 (sh) |
| JP (1) | JP3947216B2 (sh) |
| KR (1) | KR100385027B1 (sh) |
| CN (2) | CN1157390C (sh) |
| AT (1) | ATE252095T1 (sh) |
| AU (1) | AU688505B2 (sh) |
| DE (1) | DE69531939T2 (sh) |
| DK (1) | DK0763032T3 (sh) |
| ES (1) | ES2207648T3 (sh) |
| FI (1) | FI116899B (sh) |
| HK (2) | HK1009045A1 (sh) |
| HR (1) | HRP950304B1 (sh) |
| HU (1) | HU226460B1 (sh) |
| MX (1) | MX9605838A (sh) |
| NZ (1) | NZ285539A (sh) |
| PT (1) | PT763032E (sh) |
| RO (1) | RO118586B1 (sh) |
| RU (1) | RU2138496C1 (sh) |
| SK (1) | SK284495B6 (sh) |
| TW (1) | TW300221B (sh) |
| UA (1) | UA52586C2 (sh) |
| WO (1) | WO1995032197A1 (sh) |
| YU (1) | YU49345B (sh) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA965837B (en) * | 1995-07-11 | 1997-01-31 | Merck & Co Inc | A triazolylmethyl-indole ethylamine bisulfate salt |
| DE69616335T2 (de) * | 1995-07-11 | 2002-07-11 | Merck & Co Inc | Ein triazolylmethyl-indol-ethylamin-bisulfat-salz |
| US5811551A (en) * | 1996-08-13 | 1998-09-22 | Merck & Co., Inc. | Palladium catalyzed indolization |
| US5808064A (en) * | 1996-08-13 | 1998-09-15 | Merck & Co., Inc. | Palladium catalyzed indolization |
| US5877329A (en) * | 1996-08-13 | 1999-03-02 | Merck & Co., Inc. | Palladium catalyzed indolization |
| ATE228137T1 (de) * | 1996-08-13 | 2002-12-15 | Merck & Co Inc | Palladiumkatalysierte indolisierung |
| DE60033859T2 (de) * | 1999-06-28 | 2007-11-08 | Janssen Pharmaceutica N.V. | Hemmer des Respiratorischen Syncytial Virus |
| ES2204303B2 (es) * | 2002-08-07 | 2004-12-16 | Laboratorios Vita, S.A. | Procedimiento para la obtencion de un compuesto farmaceuticamente activo. |
| US7777049B2 (en) * | 2004-01-09 | 2010-08-17 | Ratiopharm Gmbh | Crystalline forms of Rizatriptan benzoate |
| ATE461916T1 (de) * | 2004-01-28 | 2010-04-15 | Ratiopharm Gmbh | Syntheseverfahren und zwischenprodukte zur herstellung von rizatriptan |
| GT200500065A (es) * | 2004-03-26 | 2005-10-24 | Procedimientos para la preparacion de compuestos aminoarilos yodados | |
| WO2006082598A2 (en) * | 2005-02-01 | 2006-08-10 | Natco Pharma Limited | Novel crystalline forms of rizatriptan benzoate |
| WO2006137083A1 (en) * | 2005-06-20 | 2006-12-28 | Natco Pharma Limited | Improved process for the preparation of rizatriptan benzoate |
| US20090062550A1 (en) * | 2005-11-14 | 2009-03-05 | Matrix Laboratories Ltd | Process for the Large Scale Production of Rizatriptan Benzoate |
| WO2007083320A2 (en) * | 2006-01-19 | 2007-07-26 | Matrix Laboratories Ltd | Conversion of aromatic diazonium salt to aryl hydrazine |
| WO2008149152A1 (en) * | 2007-06-04 | 2008-12-11 | Generics [Uk] Limited | Novel process |
| EP3407869A1 (en) | 2016-01-27 | 2018-12-05 | Instar Technologies A.S. | Oromucosal nanofiber carriers for therapeutic treatment |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SK278998B6 (sk) * | 1991-02-01 | 1998-05-06 | Merck Sharp & Dohme Limited | Deriváty imidazolu, triazolu a tetrazolu, spôsob i |
| CA2084531A1 (en) * | 1991-12-19 | 1993-06-20 | David W. Smith | Antimigraine 4-pyrimidinyl and pyridinyl derivatives of indol-3yl-alkyl piperazines |
| GB9215526D0 (en) * | 1992-07-22 | 1992-09-02 | Merck Sharp & Dohme | Chemical process |
-
1994
- 1994-05-24 US US08/248,288 patent/US5567824A/en not_active Expired - Lifetime
-
1995
- 1995-05-16 TW TW084104806A patent/TW300221B/zh not_active IP Right Cessation
- 1995-05-19 EP EP95918939A patent/EP0763032B1/en not_active Expired - Lifetime
- 1995-05-19 NZ NZ285539A patent/NZ285539A/en not_active IP Right Cessation
- 1995-05-19 HU HU9603236A patent/HU226460B1/hu unknown
- 1995-05-19 ES ES95918939T patent/ES2207648T3/es not_active Expired - Lifetime
- 1995-05-19 MX MX9605838A patent/MX9605838A/es unknown
- 1995-05-19 DE DE69531939T patent/DE69531939T2/de not_active Expired - Lifetime
- 1995-05-19 AU AU24671/95A patent/AU688505B2/en not_active Expired
- 1995-05-19 AT AT95918939T patent/ATE252095T1/de active
- 1995-05-19 DK DK95918939T patent/DK0763032T3/da active
- 1995-05-19 RO RO96-02190A patent/RO118586B1/ro unknown
- 1995-05-19 WO PCT/US1995/005506 patent/WO1995032197A1/en active IP Right Grant
- 1995-05-19 JP JP53030995A patent/JP3947216B2/ja not_active Expired - Lifetime
- 1995-05-19 CN CNB011034440A patent/CN1157390C/zh not_active Expired - Lifetime
- 1995-05-19 UA UA96124773A patent/UA52586C2/uk unknown
- 1995-05-19 SK SK1498-96A patent/SK284495B6/sk not_active IP Right Cessation
- 1995-05-19 KR KR1019960706634A patent/KR100385027B1/ko not_active IP Right Cessation
- 1995-05-19 PT PT95918939T patent/PT763032E/pt unknown
- 1995-05-19 CN CN95194106A patent/CN1077104C/zh not_active Expired - Lifetime
- 1995-05-19 RU RU96124486A patent/RU2138496C1/ru active
- 1995-05-23 YU YU33495A patent/YU49345B/sh unknown
- 1995-05-23 HR HR08/248,288 patent/HRP950304B1/xx not_active IP Right Cessation
-
1996
- 1996-11-22 FI FI964669A patent/FI116899B/fi not_active IP Right Cessation
-
1998
- 1998-08-11 HK HK98109812A patent/HK1009045A1/xx not_active IP Right Cessation
-
2002
- 2002-04-15 HK HK02102830.8A patent/HK1041262B/zh not_active IP Right Cessation
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