MX9605838A - Cierre de anillo de triazoliltriptamina catalizado con paladio. - Google Patents

Cierre de anillo de triazoliltriptamina catalizado con paladio.

Info

Publication number
MX9605838A
MX9605838A MX9605838A MX9605838A MX9605838A MX 9605838 A MX9605838 A MX 9605838A MX 9605838 A MX9605838 A MX 9605838A MX 9605838 A MX9605838 A MX 9605838A MX 9605838 A MX9605838 A MX 9605838A
Authority
MX
Mexico
Prior art keywords
ring closure
tryptamine
triazolyl
catalyzed ring
palladium catalyzed
Prior art date
Application number
MX9605838A
Other languages
English (en)
Inventor
Cheng Y Chen
Robert D Larsen
Thomas R Verhoeven
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of MX9605838A publication Critical patent/MX9605838A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Inorganic Insulating Materials (AREA)

Abstract

Se describe un nuevo procedimiento para la síntesis de triazoliltriptamina (alfa) y compuestos relacionados; el procedimiento incluye un cierre de anillo catalizado por paladio entre una yodoanilina substituido y 1-alquinol protegido; el procedimiento se lleva a cabo a alta temperatura, por ejemplo 100 degree 8C en un solvente inerte seco, por ejemplo DMF y en la presencia de un aceptor de protones, por ejemplo Na2CO3 o una trialquilamina; la triazoliltriptamina, así como las sales de adicion de ácido de la misma, son agonistas del receptor 5HT1 D que tienen propiedades contra migraña.
MX9605838A 1994-05-24 1995-05-19 Cierre de anillo de triazoliltriptamina catalizado con paladio. MX9605838A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/248,288 US5567824A (en) 1994-05-24 1994-05-24 Palladium catalyzed ring closure of triazolyltryptamine
PCT/US1995/005506 WO1995032197A1 (en) 1994-05-24 1995-05-19 Palladium catalyzed ring closure of triazolyl tryptamine

Publications (1)

Publication Number Publication Date
MX9605838A true MX9605838A (es) 1997-12-31

Family

ID=22938473

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9605838A MX9605838A (es) 1994-05-24 1995-05-19 Cierre de anillo de triazoliltriptamina catalizado con paladio.

Country Status (24)

Country Link
US (1) US5567824A (es)
EP (1) EP0763032B1 (es)
JP (1) JP3947216B2 (es)
KR (1) KR100385027B1 (es)
CN (2) CN1157390C (es)
AT (1) ATE252095T1 (es)
AU (1) AU688505B2 (es)
DE (1) DE69531939T2 (es)
DK (1) DK0763032T3 (es)
ES (1) ES2207648T3 (es)
FI (1) FI116899B (es)
HK (2) HK1009045A1 (es)
HR (1) HRP950304B1 (es)
HU (1) HU226460B1 (es)
MX (1) MX9605838A (es)
NZ (1) NZ285539A (es)
PT (1) PT763032E (es)
RO (1) RO118586B1 (es)
RU (1) RU2138496C1 (es)
SK (1) SK284495B6 (es)
TW (1) TW300221B (es)
UA (1) UA52586C2 (es)
WO (1) WO1995032197A1 (es)
YU (1) YU49345B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA965837B (en) * 1995-07-11 1997-01-31 Merck & Co Inc A triazolylmethyl-indole ethylamine bisulfate salt
JPH11508916A (ja) * 1995-07-11 1999-08-03 メルク エンド カンパニー インコーポレーテッド トリアゾリルメチル−インドールエチルアミン重硫酸塩
US5808064A (en) * 1996-08-13 1998-09-15 Merck & Co., Inc. Palladium catalyzed indolization
US5877329A (en) * 1996-08-13 1999-03-02 Merck & Co., Inc. Palladium catalyzed indolization
US5811551A (en) * 1996-08-13 1998-09-22 Merck & Co., Inc. Palladium catalyzed indolization
WO1998006725A1 (en) * 1996-08-13 1998-02-19 Merck & Co., Inc. Palladium catalyzed indolization
EA004746B1 (ru) * 1999-06-28 2004-08-26 Янссен Фармацевтика Н.В. Производные бензимидазола и имидазопиридина в качестве ингибиторов репликации респираторно-синцитиального вируса
ES2204303B2 (es) * 2002-08-07 2004-12-16 Laboratorios Vita, S.A. Procedimiento para la obtencion de un compuesto farmaceuticamente activo.
US7777049B2 (en) * 2004-01-09 2010-08-17 Ratiopharm Gmbh Crystalline forms of Rizatriptan benzoate
DK1751104T3 (da) 2004-01-28 2010-06-07 Ratiopharm Gmbh Syntesemetoder og mellemprodukter til fremstilling af rizatriptan
GT200500065A (es) * 2004-03-26 2005-10-24 Procedimientos para la preparacion de compuestos aminoarilos yodados
WO2006082598A2 (en) * 2005-02-01 2006-08-10 Natco Pharma Limited Novel crystalline forms of rizatriptan benzoate
WO2006137083A1 (en) * 2005-06-20 2006-12-28 Natco Pharma Limited Improved process for the preparation of rizatriptan benzoate
WO2007054979A1 (en) * 2005-11-14 2007-05-18 Matrix Laboratories Ltd Process for the large scale production of rizatriptan benzoate
EP1981860B1 (en) * 2006-01-19 2011-05-25 Matrix Laboratories Ltd Conversion of aromatic diazonium salt to aryl hydrazine
WO2008149152A1 (en) * 2007-06-04 2008-12-11 Generics [Uk] Limited Novel process
AU2017211684B2 (en) 2016-01-27 2022-10-06 Instar Technologies A.S. Oromucosal nanofiber carriers for therapeutic treatment

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK278998B6 (sk) * 1991-02-01 1998-05-06 Merck Sharp & Dohme Limited Deriváty imidazolu, triazolu a tetrazolu, spôsob i
CA2084531A1 (en) * 1991-12-19 1993-06-20 David W. Smith Antimigraine 4-pyrimidinyl and pyridinyl derivatives of indol-3yl-alkyl piperazines
GB9215526D0 (en) * 1992-07-22 1992-09-02 Merck Sharp & Dohme Chemical process

Also Published As

Publication number Publication date
CN1322725A (zh) 2001-11-21
JP3947216B2 (ja) 2007-07-18
DE69531939T2 (de) 2004-07-29
HU226460B1 (en) 2008-12-29
FI964669A0 (fi) 1996-11-22
KR970703336A (ko) 1997-07-03
JPH10500680A (ja) 1998-01-20
HK1041262B (zh) 2005-04-15
YU49345B (sh) 2005-07-19
RU2138496C1 (ru) 1999-09-27
UA52586C2 (uk) 2003-01-15
PT763032E (pt) 2004-02-27
TW300221B (es) 1997-03-11
KR100385027B1 (ko) 2003-08-14
SK284495B6 (sk) 2005-05-05
ES2207648T3 (es) 2004-06-01
AU2467195A (en) 1995-12-18
HUT76469A (en) 1997-09-29
AU688505B2 (en) 1998-03-12
HK1041262A1 (en) 2002-07-05
FI116899B (fi) 2006-03-31
FI964669A (fi) 1996-11-22
DK0763032T3 (da) 2004-02-09
HRP950304A2 (en) 1997-08-31
HRP950304B1 (en) 2004-12-31
NZ285539A (en) 1998-06-26
HK1009045A1 (en) 1999-05-21
CN1077104C (zh) 2002-01-02
CN1152920A (zh) 1997-06-25
CN1157390C (zh) 2004-07-14
EP0763032A1 (en) 1997-03-19
EP0763032B1 (en) 2003-10-15
YU33495A (sh) 1998-07-10
WO1995032197A1 (en) 1995-11-30
US5567824A (en) 1996-10-22
RO118586B1 (ro) 2003-07-30
HU9603236D0 (en) 1997-01-28
DE69531939D1 (de) 2003-11-20
ATE252095T1 (de) 2003-11-15
SK149896A3 (en) 1997-09-10

Similar Documents

Publication Publication Date Title
MX9605838A (es) Cierre de anillo de triazoliltriptamina catalizado con paladio.
ATE284853T1 (de) Ureido-thiobuttersäurederivate als ppar-agonisten
EA200000393A1 (ru) Химические соединения
FI873631A0 (fi) --alkyl-4-amino-3-kinolinmetanoler och 1-(4-aralkylamino-3-kinolinyl)alkanoler, foerfarande foer deras framstaellning och deras anvaendning som laekemedel.
ATE178065T1 (de) Kondensierte imidazol- und triazolderivate als 5- hta rezeptoragonisten
PT74626B (en) Process for preparing 9-<2-(3-indolyl)ethyl>-1-oxa-4,9-diazas- piro<5,5>undecan-3-ones
ZA916652B (en) Piperazinyl derivatives
MX9602979A (es) Compuestos heterociclicos terapeuticos.
GB9004301D0 (en) Indolebutyric acid derivatives and process for preparation thereof
ATE48835T1 (de) Chinolylglycinamidderivate, verfahren zu ihrer herstellung und therapeutische verwendung als psychotrope.
ES2007747A6 (es) Procedimiento de preparacion de 5,6-dihidroxiindol y de su derivado alquilado en posicion 3 y compuestos intermedios.
AR240700A1 (es) Procedimiento para preparar derivados de (imidazolil-2)-2-pirrol3,2,1-ij quinolina o de (imidazolil-2)-2-azepin3,2,1-hi-indol
KR910002835A (ko) 인돌 유도체
YU217181A (en) Process for preparing 2-(1,4-benzodioxane-2-ylalkyl)-imidazoles
NO178030C (no) Analogifremgangsmåte ved fremstilling av terapeutisk aktive metylenbisfosfonsyrederivater
JPS5359663A (en) 2-halogeno methyl indole derivatives and process for praparation of the same
CA2190851A1 (en) Palladium catalyzed ring closure of triazolyl tryptamine
DE69906243T2 (de) 2-Indanmethanolderivate und ihre Verwendung als Riechstoffe
ES2160909T3 (es) Procedimiento para la preparacion de 4-amino-1,2,4-triazoles.
AR246511A1 (es) Acido 2-azabiciclo (2.2.1)hept-5-eno-2-acetico y derivados del mismo, procedimiento para su preparacion y procedimiento para preparar n-fosfonometilglicina con los mismos.
EP0716088A4 (en) METHOD FOR PRODUCING 2- (TETRAZOL-5-YL) -4-OXO-4H-BENZOPYRANES
ES8602786A1 (es) Derivados de pirimidoisoquinolina
JPS57206661A (en) Acetaminobenzamide derivative
SU1823467A1 (ru) Способ получения полидиметилсилана
HUP0000144A2 (hu) Eljárás hidroxi-heteroaromás vegyületek aril-aminokká való átalakítására