HRP950304B1 - Palladium catalyzed ring closure of triazolyl tryptamine - Google Patents

Palladium catalyzed ring closure of triazolyl tryptamine

Info

Publication number
HRP950304B1
HRP950304B1 HRP950304A HRP950304B1 HR P950304 B1 HRP950304 B1 HR P950304B1 HR P950304 A HRP950304 A HR P950304A HR P950304 B1 HRP950304 B1 HR P950304B1
Authority
HR
Croatia
Prior art keywords
ring closure
tryptamine
triazolyl
catalyzed ring
palladium catalyzed
Prior art date
Application number
Other languages
English (en)
Inventor
Cheng Y Chen
Robert D Larsen
Thomas R Verhoeven
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of HRP950304A2 publication Critical patent/HRP950304A2/xx
Publication of HRP950304B1 publication Critical patent/HRP950304B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Inorganic Insulating Materials (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
HR08/248,288 1994-05-24 1995-05-23 Palladium catalyzed ring closure of triazolyl tryptamine HRP950304B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/248,288 US5567824A (en) 1994-05-24 1994-05-24 Palladium catalyzed ring closure of triazolyltryptamine

Publications (2)

Publication Number Publication Date
HRP950304A2 HRP950304A2 (en) 1997-08-31
HRP950304B1 true HRP950304B1 (en) 2004-12-31

Family

ID=22938473

Family Applications (1)

Application Number Title Priority Date Filing Date
HR08/248,288 HRP950304B1 (en) 1994-05-24 1995-05-23 Palladium catalyzed ring closure of triazolyl tryptamine

Country Status (24)

Country Link
US (1) US5567824A (es)
EP (1) EP0763032B1 (es)
JP (1) JP3947216B2 (es)
KR (1) KR100385027B1 (es)
CN (2) CN1157390C (es)
AT (1) ATE252095T1 (es)
AU (1) AU688505B2 (es)
DE (1) DE69531939T2 (es)
DK (1) DK0763032T3 (es)
ES (1) ES2207648T3 (es)
FI (1) FI116899B (es)
HK (2) HK1009045A1 (es)
HR (1) HRP950304B1 (es)
HU (1) HU226460B1 (es)
MX (1) MX9605838A (es)
NZ (1) NZ285539A (es)
PT (1) PT763032E (es)
RO (1) RO118586B1 (es)
RU (1) RU2138496C1 (es)
SK (1) SK284495B6 (es)
TW (1) TW300221B (es)
UA (1) UA52586C2 (es)
WO (1) WO1995032197A1 (es)
YU (1) YU49345B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA965837B (en) * 1995-07-11 1997-01-31 Merck & Co Inc A triazolylmethyl-indole ethylamine bisulfate salt
WO1997003068A1 (en) * 1995-07-11 1997-01-30 Merck & Co., Inc. A triazolylmethyl-indole ethylamine bisulfate salt
US5808064A (en) * 1996-08-13 1998-09-15 Merck & Co., Inc. Palladium catalyzed indolization
US5877329A (en) * 1996-08-13 1999-03-02 Merck & Co., Inc. Palladium catalyzed indolization
ES2185983T3 (es) * 1996-08-13 2003-05-01 Merck & Co Inc Indolizacion catalizada con paladio.
US5811551A (en) * 1996-08-13 1998-09-22 Merck & Co., Inc. Palladium catalyzed indolization
AU774829B2 (en) * 1999-06-28 2004-07-08 Janssen Pharmaceutica N.V. Respiratory syncytial virus replication inhibitors
ES2204303B2 (es) * 2002-08-07 2004-12-16 Laboratorios Vita, S.A. Procedimiento para la obtencion de un compuesto farmaceuticamente activo.
CA2552663A1 (en) 2004-01-09 2005-07-28 Ratiopharm Gmbh Crystalline forms of rizatriptan benzoate
WO2005075422A1 (en) * 2004-01-28 2005-08-18 Ratiopharm Gmbh Synthesis methods and intermediates for the manufacture of rizatriptan
PA8626701A1 (es) * 2004-03-26 2006-05-16 Wyeth Corp Procedimientos para la preparacion de compuestos aminoarilos yodados
WO2006082598A2 (en) * 2005-02-01 2006-08-10 Natco Pharma Limited Novel crystalline forms of rizatriptan benzoate
WO2006137083A1 (en) * 2005-06-20 2006-12-28 Natco Pharma Limited Improved process for the preparation of rizatriptan benzoate
EP1951713A1 (en) * 2005-11-14 2008-08-06 Matrix Laboratories Ltd Process for the large scale production of rizatriptan benzoate
WO2007083320A2 (en) * 2006-01-19 2007-07-26 Matrix Laboratories Ltd Conversion of aromatic diazonium salt to aryl hydrazine
EP2160390A1 (en) * 2007-06-04 2010-03-10 Generics Ýuk¨Limited Novel process
EP3407869A1 (en) 2016-01-27 2018-12-05 Instar Technologies A.S. Oromucosal nanofiber carriers for therapeutic treatment

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ283018B6 (cs) * 1991-02-01 1997-12-17 Merck Sharp And Dohme Limited Deriváty imidazolu, triazolu a tetrazolu a farmaceutické přípravky na jejich bázi
CA2084531A1 (en) * 1991-12-19 1993-06-20 David W. Smith Antimigraine 4-pyrimidinyl and pyridinyl derivatives of indol-3yl-alkyl piperazines
GB9215526D0 (en) * 1992-07-22 1992-09-02 Merck Sharp & Dohme Chemical process

Also Published As

Publication number Publication date
HU226460B1 (en) 2008-12-29
ATE252095T1 (de) 2003-11-15
CN1152920A (zh) 1997-06-25
EP0763032A1 (en) 1997-03-19
KR100385027B1 (ko) 2003-08-14
FI964669A0 (fi) 1996-11-22
AU688505B2 (en) 1998-03-12
FI964669A (fi) 1996-11-22
HUT76469A (en) 1997-09-29
RU2138496C1 (ru) 1999-09-27
UA52586C2 (uk) 2003-01-15
HU9603236D0 (en) 1997-01-28
TW300221B (es) 1997-03-11
CN1157390C (zh) 2004-07-14
YU33495A (sh) 1998-07-10
KR970703336A (ko) 1997-07-03
NZ285539A (en) 1998-06-26
CN1077104C (zh) 2002-01-02
CN1322725A (zh) 2001-11-21
PT763032E (pt) 2004-02-27
US5567824A (en) 1996-10-22
WO1995032197A1 (en) 1995-11-30
FI116899B (fi) 2006-03-31
ES2207648T3 (es) 2004-06-01
JPH10500680A (ja) 1998-01-20
SK284495B6 (sk) 2005-05-05
YU49345B (sh) 2005-07-19
HK1041262A1 (en) 2002-07-05
HK1041262B (zh) 2005-04-15
JP3947216B2 (ja) 2007-07-18
EP0763032B1 (en) 2003-10-15
RO118586B1 (ro) 2003-07-30
HK1009045A1 (en) 1999-05-21
DE69531939T2 (de) 2004-07-29
DK0763032T3 (da) 2004-02-09
DE69531939D1 (de) 2003-11-20
SK149896A3 (en) 1997-09-10
AU2467195A (en) 1995-12-18
MX9605838A (es) 1997-12-31
HRP950304A2 (en) 1997-08-31

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Legal Events

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A1OB Publication of a patent application
AIPI Request for the grant of a patent on the basis of a substantive examination of a patent application
B1PR Patent granted
PNAN Change of the applicant name, address/residence

Owner name: MERCK SHARP & DOHME CORP., US

PNAN Change of the applicant name, address/residence

Owner name: SCHERING CORPORATION, US

Owner name: MERCK SHARP & DOHME CORP., US

ODRP Renewal fee for the maintenance of a patent

Payment date: 20140515

Year of fee payment: 20

PB20 Patent expired after termination of 20 years

Effective date: 20150523