YU33495A - Paladijumom katalizovano zatvaranje prstena triazolil triptamina - Google Patents

Paladijumom katalizovano zatvaranje prstena triazolil triptamina

Info

Publication number
YU33495A
YU33495A YU33495A YU33495A YU33495A YU 33495 A YU33495 A YU 33495A YU 33495 A YU33495 A YU 33495A YU 33495 A YU33495 A YU 33495A YU 33495 A YU33495 A YU 33495A
Authority
YU
Yugoslavia
Prior art keywords
ring
triazolyl
triptamine
paladium
catalyzed
Prior art date
Application number
YU33495A
Other languages
English (en)
Other versions
YU49345B (sh
Inventor
Chen
Larsen
Verhoeven
Original Assignee
Merck And Co.Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck And Co.Inc. filed Critical Merck And Co.Inc.
Publication of YU33495A publication Critical patent/YU33495A/sh
Publication of YU49345B publication Critical patent/YU49345B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Inorganic Insulating Materials (AREA)

Abstract

Opisan je nov postupak za sintezu triazolil triptamina: i srodnih jedinjenja. Postupak obuhvata paladijumom katalizovano zatvaranje prstena izmedju supstituisanog ortojodanilina i zaštićenog 1-alkinola. Postupak se izvodi na visokoj temperaturi, na pr., 100В°C, u suvom inertnom rastvaraču, na pr., DMF i u prisustvu akceptora protona, na pr., Na2C03 ili trialkilamina. Triazolil triptamin, kao i njegove adicione soli sa kiselinama, je 5 HT,D agonist receptora koji ima anti-migrenične osobine.
YU33495A 1994-05-24 1995-05-23 Postupak dobijanja n,n-dimetil-2-[5-(1,2,4 triazol-1-ilmetil)-1h-indol-3-il] etilamina kroz paladijumom katalizovano zatvaranje prstena triazolil triptamina YU49345B (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/248,288 US5567824A (en) 1994-05-24 1994-05-24 Palladium catalyzed ring closure of triazolyltryptamine

Publications (2)

Publication Number Publication Date
YU33495A true YU33495A (sh) 1998-07-10
YU49345B YU49345B (sh) 2005-07-19

Family

ID=22938473

Family Applications (1)

Application Number Title Priority Date Filing Date
YU33495A YU49345B (sh) 1994-05-24 1995-05-23 Postupak dobijanja n,n-dimetil-2-[5-(1,2,4 triazol-1-ilmetil)-1h-indol-3-il] etilamina kroz paladijumom katalizovano zatvaranje prstena triazolil triptamina

Country Status (24)

Country Link
US (1) US5567824A (sh)
EP (1) EP0763032B1 (sh)
JP (1) JP3947216B2 (sh)
KR (1) KR100385027B1 (sh)
CN (2) CN1157390C (sh)
AT (1) ATE252095T1 (sh)
AU (1) AU688505B2 (sh)
DE (1) DE69531939T2 (sh)
DK (1) DK0763032T3 (sh)
ES (1) ES2207648T3 (sh)
FI (1) FI116899B (sh)
HK (2) HK1009045A1 (sh)
HR (1) HRP950304B1 (sh)
HU (1) HU226460B1 (sh)
MX (1) MX9605838A (sh)
NZ (1) NZ285539A (sh)
PT (1) PT763032E (sh)
RO (1) RO118586B1 (sh)
RU (1) RU2138496C1 (sh)
SK (1) SK284495B6 (sh)
TW (1) TW300221B (sh)
UA (1) UA52586C2 (sh)
WO (1) WO1995032197A1 (sh)
YU (1) YU49345B (sh)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA965837B (en) * 1995-07-11 1997-01-31 Merck & Co Inc A triazolylmethyl-indole ethylamine bisulfate salt
JPH11508916A (ja) * 1995-07-11 1999-08-03 メルク エンド カンパニー インコーポレーテッド トリアゾリルメチル−インドールエチルアミン重硫酸塩
US5808064A (en) * 1996-08-13 1998-09-15 Merck & Co., Inc. Palladium catalyzed indolization
US5877329A (en) * 1996-08-13 1999-03-02 Merck & Co., Inc. Palladium catalyzed indolization
US5811551A (en) * 1996-08-13 1998-09-22 Merck & Co., Inc. Palladium catalyzed indolization
WO1998006725A1 (en) * 1996-08-13 1998-02-19 Merck & Co., Inc. Palladium catalyzed indolization
EA004746B1 (ru) * 1999-06-28 2004-08-26 Янссен Фармацевтика Н.В. Производные бензимидазола и имидазопиридина в качестве ингибиторов репликации респираторно-синцитиального вируса
ES2204303B2 (es) * 2002-08-07 2004-12-16 Laboratorios Vita, S.A. Procedimiento para la obtencion de un compuesto farmaceuticamente activo.
US7777049B2 (en) * 2004-01-09 2010-08-17 Ratiopharm Gmbh Crystalline forms of Rizatriptan benzoate
DK1751104T3 (da) 2004-01-28 2010-06-07 Ratiopharm Gmbh Syntesemetoder og mellemprodukter til fremstilling af rizatriptan
GT200500065A (es) * 2004-03-26 2005-10-24 Procedimientos para la preparacion de compuestos aminoarilos yodados
WO2006082598A2 (en) * 2005-02-01 2006-08-10 Natco Pharma Limited Novel crystalline forms of rizatriptan benzoate
WO2006137083A1 (en) * 2005-06-20 2006-12-28 Natco Pharma Limited Improved process for the preparation of rizatriptan benzoate
WO2007054979A1 (en) * 2005-11-14 2007-05-18 Matrix Laboratories Ltd Process for the large scale production of rizatriptan benzoate
EP1981860B1 (en) * 2006-01-19 2011-05-25 Matrix Laboratories Ltd Conversion of aromatic diazonium salt to aryl hydrazine
WO2008149152A1 (en) * 2007-06-04 2008-12-11 Generics [Uk] Limited Novel process
AU2017211684B2 (en) 2016-01-27 2022-10-06 Instar Technologies A.S. Oromucosal nanofiber carriers for therapeutic treatment

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK278998B6 (sk) * 1991-02-01 1998-05-06 Merck Sharp & Dohme Limited Deriváty imidazolu, triazolu a tetrazolu, spôsob i
CA2084531A1 (en) * 1991-12-19 1993-06-20 David W. Smith Antimigraine 4-pyrimidinyl and pyridinyl derivatives of indol-3yl-alkyl piperazines
GB9215526D0 (en) * 1992-07-22 1992-09-02 Merck Sharp & Dohme Chemical process

Also Published As

Publication number Publication date
CN1322725A (zh) 2001-11-21
JP3947216B2 (ja) 2007-07-18
DE69531939T2 (de) 2004-07-29
HU226460B1 (en) 2008-12-29
FI964669A0 (fi) 1996-11-22
KR970703336A (ko) 1997-07-03
JPH10500680A (ja) 1998-01-20
HK1041262B (zh) 2005-04-15
YU49345B (sh) 2005-07-19
RU2138496C1 (ru) 1999-09-27
UA52586C2 (uk) 2003-01-15
PT763032E (pt) 2004-02-27
TW300221B (sh) 1997-03-11
KR100385027B1 (ko) 2003-08-14
SK284495B6 (sk) 2005-05-05
ES2207648T3 (es) 2004-06-01
AU2467195A (en) 1995-12-18
HUT76469A (en) 1997-09-29
AU688505B2 (en) 1998-03-12
HK1041262A1 (en) 2002-07-05
FI116899B (fi) 2006-03-31
FI964669A (fi) 1996-11-22
DK0763032T3 (da) 2004-02-09
HRP950304A2 (en) 1997-08-31
HRP950304B1 (en) 2004-12-31
MX9605838A (es) 1997-12-31
NZ285539A (en) 1998-06-26
HK1009045A1 (en) 1999-05-21
CN1077104C (zh) 2002-01-02
CN1152920A (zh) 1997-06-25
CN1157390C (zh) 2004-07-14
EP0763032A1 (en) 1997-03-19
EP0763032B1 (en) 2003-10-15
WO1995032197A1 (en) 1995-11-30
US5567824A (en) 1996-10-22
RO118586B1 (ro) 2003-07-30
HU9603236D0 (en) 1997-01-28
DE69531939D1 (de) 2003-11-20
ATE252095T1 (de) 2003-11-15
SK149896A3 (en) 1997-09-10

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