KR910002835A - 인돌 유도체 - Google Patents
인돌 유도체 Download PDFInfo
- Publication number
- KR910002835A KR910002835A KR1019900010521A KR900010521A KR910002835A KR 910002835 A KR910002835 A KR 910002835A KR 1019900010521 A KR1019900010521 A KR 1019900010521A KR 900010521 A KR900010521 A KR 900010521A KR 910002835 A KR910002835 A KR 910002835A
- Authority
- KR
- South Korea
- Prior art keywords
- compound
- methoxyindole
- butyl
- salts
- methoxyphenylpiperazino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
내용 없음.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (6)
- 3-[4-(4-p-메톡시페닐피페라지노)부틸]-5-메톡시인돌 (I) 및 그의 염.
- 하기 일반식(Ⅱ) 화합물을 하기 일반식(Ⅲ)의 화합물과 반응시키거나, 또는 하나이상의 수소원자나 하나이상의 환원성 또는 가수소분해적으로 절단할 수 있는 그룹 및/또는 하나이상의 부가적 C-C 및/똔느 C-N결합에 의해 치환됨을 제외하고는 3-[4-(4-p-메톡시페닐피페라지노)부틸]-5-메톡시인돌 (I)에 따른 화합물을 환원제로 처리하거나, 또는 하나의 수소원자가 가용매 분해적으로 절단할 수 있는 그룹에 의해 치환됨을 제외하고는 (I)에 따른 화합물을 가용매 분해제로 처리하고/하거나 생성된 염기(I)을 산처리함으로써 그의 염중의 하나로 전환시키고/시키거나 염기처리함으로써 그의 염중의 하나를 유리시킴을 특징으로 하는 3-[4-(4-p-메톡시페닐피페라지노)부틸]-5-메톡시인돌 (I) 및 그의 염의 제조방법;3-(4-X1-부틸)-5-메톡시인돌 (Ⅱ)X2-CH2CH2CH(p-CH2O-C6H4)-CH2CH2X3(Ⅲ)상기식에서, X1은 X또는 NH2이고 X는 Cl, Br, I, OH 또는 작용적으로 변형되어 반응성 그룹을 형성하는 OH 그룹이며, X2및 X3는 동일하거나 또는 다를수 있고 X1=NH2인 경우에는 각각 X이거나 또는 다른 경우에는 함께 NH이다.
- 제1항에 따른 화합물 및/또는 하나의 그의 생체 적합성 염을 적어도 하나의 고체상, 액상 또는 반액상의 부형제 또는 보조제와 함께 적당한 투여 형태로 전환시킴을 특징으로 하는 약학적 제제의 제조방법.
- 제1항에 따른 화합물(I) 및/또는 하나의 그의 생체 적합성 염을 함유함을 특징으로 하는 약학적 제제.
- 약제 제조용의 제1항에 따른 화합물(I) 또는 그의 생체적합성 염의 용도.
- 질병 억제용의 제1항에 따른 화합물(I) 또는 그의 생체적합성 염의 용도.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3923045A DE3923045A1 (de) | 1989-07-13 | 1989-07-13 | Indolderivate |
DEP39230457 | 1989-07-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR910002835A true KR910002835A (ko) | 1991-02-26 |
Family
ID=6384882
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019900010521A KR910002835A (ko) | 1989-07-13 | 1990-07-12 | 인돌 유도체 |
Country Status (11)
Country | Link |
---|---|
US (1) | US5106850A (ko) |
EP (1) | EP0407844B1 (ko) |
JP (1) | JPH0352859A (ko) |
KR (1) | KR910002835A (ko) |
AU (1) | AU622340B2 (ko) |
CA (1) | CA2020936A1 (ko) |
DE (2) | DE3923045A1 (ko) |
ES (1) | ES2062202T3 (ko) |
HU (1) | HU206340B (ko) |
IE (1) | IE902553A1 (ko) |
ZA (1) | ZA905524B (ko) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9249862B2 (en) | 2013-01-14 | 2016-02-02 | Karen PARK | Differential bevel gear speed reducer |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8830312D0 (en) * | 1988-12-28 | 1989-02-22 | Lundbeck & Co As H | Heterocyclic compounds |
FR2672052B1 (fr) * | 1991-01-28 | 1995-05-24 | Esteve Labor Dr | Derives d'aryl (ou heteroaryl)-piperazinyl-alkyl-azoles, leur preparation et leur application en tant que medicaments. |
DE4101686A1 (de) * | 1991-01-22 | 1992-07-23 | Merck Patent Gmbh | Indolderivate |
DE4127849A1 (de) * | 1991-08-22 | 1993-02-25 | Merck Patent Gmbh | Benzodioxanderivate |
ES2050623B1 (es) * | 1992-11-06 | 1994-12-16 | Merck Patent Gmbh | Derivados de 1,4-benzodioxano. |
EP1757292A1 (en) * | 1997-09-05 | 2007-02-28 | Pfizer Products Inc. | Method of treating ocd and tic disorders |
IL125951A (en) * | 1997-09-05 | 2003-09-17 | Pfizer Prod Inc | A pharmaceutical composition comprising a piperazinyl-heterocyclic compound for treating tourette's syndrome, obsessive compulsive disorder, chronic motor or vocal tic disorder in a mammal |
BRPI0410378A (pt) * | 2003-05-16 | 2006-06-13 | Pfizer Prod Inc | tratamento de distúrbios psicóticos e depressivos |
CN103570698B (zh) * | 2012-08-01 | 2016-08-03 | 江苏恩华药业股份有限公司 | 用于制备维拉佐酮的化合物及其中间体和应用 |
EP3027607B1 (en) | 2013-07-29 | 2020-08-26 | Sunshine Lake Pharma Co., Ltd. | Substituted heteroaryl compounds and methods of use thereof |
WO2015090235A1 (en) | 2013-12-20 | 2015-06-25 | Sunshine Lake Pharma Co., Ltd. | Substituted piperazine compounds and methods of use thereof |
US10316025B2 (en) | 2015-06-03 | 2019-06-11 | Sunshine Lake Pharma Co., Ltd. | Substituted piperazine compounds and methods of use and use thereof |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3468882A (en) * | 1966-10-07 | 1969-09-23 | Sterling Drug Inc | Phenylhydrazone derivatives as intermediates for preparing indoles |
DE2138865A1 (de) * | 1970-08-15 | 1973-02-22 | Sumitomo Chemical Co | 3-indolylpiperazine, verfahren zu ihrer herstellung und arzneimittel |
DE2337461A1 (de) * | 1973-07-24 | 1975-02-06 | Boehringer Mannheim Gmbh | Neue indolderivate und verfahren zu deren herstellung |
US4089853A (en) * | 1977-02-09 | 1978-05-16 | American Cyanamid Company | Process for the preparation of cis-5,6-dimethoxy-2-methyl-3-[2-(4-phenyl-1-piperazinyl)-ethyl]indoline |
US4883795A (en) * | 1988-01-22 | 1989-11-28 | Pfizer Inc. | Piperazinyl-heterocyclic compounds |
GB8830312D0 (en) * | 1988-12-28 | 1989-02-22 | Lundbeck & Co As H | Heterocyclic compounds |
-
1989
- 1989-07-13 DE DE3923045A patent/DE3923045A1/de not_active Withdrawn
-
1990
- 1990-06-30 EP EP90112539A patent/EP0407844B1/de not_active Expired - Lifetime
- 1990-06-30 DE DE90112539T patent/DE59005241D1/de not_active Expired - Fee Related
- 1990-06-30 ES ES90112539T patent/ES2062202T3/es not_active Expired - Lifetime
- 1990-07-11 CA CA002020936A patent/CA2020936A1/en not_active Abandoned
- 1990-07-12 JP JP2182888A patent/JPH0352859A/ja active Pending
- 1990-07-12 US US07/551,816 patent/US5106850A/en not_active Expired - Fee Related
- 1990-07-12 HU HU904184A patent/HU206340B/hu not_active IP Right Cessation
- 1990-07-12 KR KR1019900010521A patent/KR910002835A/ko not_active Application Discontinuation
- 1990-07-12 IE IE255390A patent/IE902553A1/en unknown
- 1990-07-12 AU AU58951/90A patent/AU622340B2/en not_active Ceased
- 1990-07-13 ZA ZA905524A patent/ZA905524B/xx unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9249862B2 (en) | 2013-01-14 | 2016-02-02 | Karen PARK | Differential bevel gear speed reducer |
Also Published As
Publication number | Publication date |
---|---|
HU206340B (en) | 1992-10-28 |
DE59005241D1 (de) | 1994-05-11 |
CA2020936A1 (en) | 1991-01-14 |
ZA905524B (en) | 1991-05-29 |
EP0407844A1 (de) | 1991-01-16 |
DE3923045A1 (de) | 1991-01-17 |
ES2062202T3 (es) | 1994-12-16 |
JPH0352859A (ja) | 1991-03-07 |
AU622340B2 (en) | 1992-04-02 |
EP0407844B1 (de) | 1994-04-06 |
HU904184D0 (en) | 1990-12-28 |
AU5895190A (en) | 1991-01-17 |
IE902553A1 (en) | 1991-02-27 |
HUT55382A (en) | 1991-05-28 |
US5106850A (en) | 1992-04-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |