KR880011098A - 4-페닐피페리딘 화합물, 이의 제조방법 및 용도 - Google Patents

4-페닐피페리딘 화합물, 이의 제조방법 및 용도 Download PDF

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Publication number
KR880011098A
KR880011098A KR1019880003338A KR880003338A KR880011098A KR 880011098 A KR880011098 A KR 880011098A KR 1019880003338 A KR1019880003338 A KR 1019880003338A KR 880003338 A KR880003338 A KR 880003338A KR 880011098 A KR880011098 A KR 880011098A
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KR
South Korea
Prior art keywords
compound
formula
alkyl
phenylpiperidine
give
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KR1019880003338A
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English (en)
Inventor
웨트젠 프랑크
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죄르젠 부스 라센
에이/에스 페로산
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Publication of KR880011098A publication Critical patent/KR880011098A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C07D211/28—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms to which a second hetero atom is attached

Abstract

내용 없음

Description

4-페닐피페리딘 화합물, 이의 제조방법 및 용도
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (9)

  1. 하기 일반식 (Ⅰ)의 4-페닐피페리딘 화합물.
    상기 식에서, R1은 수소, (C1-6-알콕시아릴)알킬, 디페닐메톡시-C1-6-알킬, C1-8알킬, C4-10-사이클로알킬알킬, 페녹시-C1-8-알킬 또는 C1-6-알콕시-C1-6알킬이고 R은또는 CH=NOR'이고 R'는 C1-6-알킬, C3-7-사이클로알킬, C1-6-알콕시-C1-6-알킬, 아릴-C0-6-알킬(이는 하나이상의 할로겐 및 C1-5-알콕시로 임의 치환될 수 있다), 티에틸 또는 C4-7-사이클로알킬알킬이다.
  2. (a)일반식 (Ⅱ)의 화합물의 반응성 유도체를 일반식 (Ⅲ)의 화합물과 반응시켜 일반식 (Ⅰ)의 화합물을 수득하거나, (b)일반식 (Ⅳ)의 화합물을 일반식 (Ⅴ)의 화합물과 반응시켜 일반식 (Ⅵ)의 화합물을 생성시킨 후 생성된 화합물을 하이드록실아민 또는 다른 아미노화제와 반응시켜 일반식 (Ⅰ)의 화합물을 수득하거나, (c)일반식 (Ⅶ)의 화합물을 일반식 NH2-O-R'의 화합물과 반응시켜 일반식 (Ⅰ)의 화합물을 수득하거나, (d)일반식 (Ⅷ)의 화합물을 탈알킬화제와 반응시켜 R'이 수소인 일반식 (Ⅰ)의 화합물을 수득하거나, (e)일반식 (Ⅸ)의 화합물을 알킬화제와 반응시켜 일반식 (Ⅰ)의 화합물을 수득함을 특징으로 하여, 제1항에 따른 화합물을 제조하는 방법.
    상기 식에서, R, R1및 R'는 전술한 바와 같으나, 단, 일반식 (Ⅷ)에서 R1은 수소가 아니다.
  3. 제1항에 있어서, 1-메틸-4-(3-페닐-1,2,4-옥사디아졸-5-일)-4-페닐피페리딘인 화합물.
  4. 제1항에 있어서, 4-(3-사이클로프로필-1,2,4-옥사디아졸-5-일)-4-페닐피페리딘인 화합물.
  5. 제1항에 있어서, 4-메톡시이미노메틸-1-메틸-4-페닐피페리딘인 화합물.
  6. 제1항에 있어서, 4-(3-사이클로프로필-1,2,4-옥사디아졸-5-일)-1-(2-에톡시에틸)-4-페닐피페리딘인 화합물.
  7. 통증을 완화시키기에 유효한 양의 제1항에 따른 화합물을 약학적으로 허용되는 담체 또는 희석제와 함께 함유하는 통증 치료용 약학적 조성물.
  8. 제7항에 있어서, 1 내지 100mg의 활성화합물을 함유하는 경구투여용 단위용량형태인 조성물.
  9. 통증을 완화시키기에 유효한 양의 제1항에 따른 화합물을 이를 필요로 하는 대상에게 투여함을 특징으로 하여, 통증을 치료하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880003338A 1987-03-31 1988-03-28 4-페닐피페리딘 화합물, 이의 제조방법 및 용도 KR880011098A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK1620/87 1987-03-31
DK162087A DK162087D0 (da) 1987-03-31 1987-03-31 Piperidinforbindelser, deres fremstilling og anvendelse

Publications (1)

Publication Number Publication Date
KR880011098A true KR880011098A (ko) 1988-10-26

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ID=8106610

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019880003338A KR880011098A (ko) 1987-03-31 1988-03-28 4-페닐피페리딘 화합물, 이의 제조방법 및 용도

Country Status (12)

Country Link
US (1) US4845095A (ko)
EP (1) EP0285032A1 (ko)
JP (1) JPS63258456A (ko)
KR (1) KR880011098A (ko)
AU (1) AU1379488A (ko)
DK (1) DK162087D0 (ko)
FI (1) FI881410A (ko)
IL (1) IL85612A0 (ko)
NO (1) NO881388L (ko)
PH (1) PH24620A (ko)
PT (1) PT87031B (ko)
ZA (1) ZA881799B (ko)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE170174T1 (de) * 1994-01-13 1998-09-15 Merck Sharp & Dohme Gem-bissubstituierte azazyclische tachykinin- antagonisten
US6107313A (en) * 1998-10-02 2000-08-22 Combichem, Inc. Dopamine receptor antagonists
TW200403058A (en) * 2002-04-19 2004-03-01 Bristol Myers Squibb Co Heterocyclo inhibitors of potassium channel function
US7202259B2 (en) * 2002-11-18 2007-04-10 Euro-Celtique S.A. Therapeutic agents useful for treating pain
GB0510142D0 (en) * 2005-05-18 2005-06-22 Addex Pharmaceuticals Sa Novel compounds A1
US11976050B1 (en) 2023-10-11 2024-05-07 King Faisal University N′-(2-(5-(4-chlorophenyl)-1,3,4-oxadiazol-2-ylthio)acetoxy)-1-naphthimidamide as an antimicrobial compound

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4016170A (en) * 1975-07-28 1977-04-05 Sandoz, Inc. Oxadiazolyl benzamides

Also Published As

Publication number Publication date
DK162087D0 (da) 1987-03-31
FI881410A (fi) 1988-10-01
US4845095A (en) 1989-07-04
NO881388D0 (no) 1988-03-29
JPS63258456A (ja) 1988-10-25
FI881410A0 (fi) 1988-03-24
PT87031A (pt) 1988-04-01
ZA881799B (en) 1988-09-05
PH24620A (en) 1990-08-17
PT87031B (pt) 1992-06-30
AU1379488A (en) 1988-09-29
EP0285032A1 (en) 1988-10-05
IL85612A0 (en) 1988-08-31
NO881388L (no) 1988-10-03

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