CN107033339A - 免疫调节剂‑聚合物化合物 - Google Patents
免疫调节剂‑聚合物化合物 Download PDFInfo
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- CN107033339A CN107033339A CN201611027629.0A CN201611027629A CN107033339A CN 107033339 A CN107033339 A CN 107033339A CN 201611027629 A CN201611027629 A CN 201611027629A CN 107033339 A CN107033339 A CN 107033339A
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- polymer
- alkyl
- heterocycle
- compound
- carbon atom
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- 0 *C(NC1=C2N=C(*)N(*)C2=CC(C2=*C2)C(*)=N1)=O Chemical compound *C(NC1=C2N=C(*)N(*)C2=CC(C2=*C2)C(*)=N1)=O 0.000 description 5
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/91—Polymers modified by chemical after-treatment
- C08G63/912—Polymers modified by chemical after-treatment derived from hydroxycarboxylic acids
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
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Cited By (1)
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|---|---|---|---|---|
| CN119505213A (zh) * | 2024-11-25 | 2025-02-25 | 吉林大学 | 一种聚碳酸酯聚合物及其制备方法、纳米佐剂和疫苗 |
Families Citing this family (100)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030129251A1 (en) * | 2000-03-10 | 2003-07-10 | Gary Van Nest | Biodegradable immunomodulatory formulations and methods for use thereof |
| US6993506B2 (en) | 2000-12-05 | 2006-01-31 | Jgr Acquisition, Inc. | Method and device utilizing polymorphic data in e-commerce |
| JP4817599B2 (ja) * | 2003-12-25 | 2011-11-16 | 独立行政法人科学技術振興機構 | 免疫活性増強剤とこれを用いた免疫活性の増強方法 |
| ES2915692T3 (es) | 2008-08-13 | 2022-06-24 | California Inst Of Techn | Nanopartículas portadoras y composiciones, métodos y sistemas relacionados |
| US11446374B2 (en) | 2008-12-09 | 2022-09-20 | Novavax, Inc. | Modified RSV F proteins and methods of their use |
| CN102333538B (zh) * | 2008-12-09 | 2014-01-15 | 科勒制药集团有限公司 | 免疫刺激性寡核苷酸 |
| EP3067064B1 (en) | 2008-12-09 | 2020-05-13 | Novavax, Inc. | Modified rsv f proteins and methods of their use |
| WO2010123569A2 (en) * | 2009-04-21 | 2010-10-28 | Selecta Biosciences, Inc. | Immunonanotherapeutics providing a th1-biased response |
| AU2010254549B2 (en) | 2009-05-27 | 2016-10-20 | Selecta Biosciences, Inc. | Nanocarriers possessing components with different rates of release |
| MX343908B (es) * | 2009-08-26 | 2016-11-28 | Selecta Biosciences Inc * | Composiciones que inducen la ayuda de las células t. |
| CN105194665A (zh) | 2010-05-26 | 2015-12-30 | 西莱克塔生物科技公司 | 具有不偶合的佐剂的纳米载体组合物 |
| WO2012061717A1 (en) | 2010-11-05 | 2012-05-10 | Selecta Biosciences, Inc. | Modified nicotinic compounds and related methods |
| JP5909745B2 (ja) | 2010-11-12 | 2016-04-27 | クール ファーマシューティカルズ ディベロップメント カンパニー | 炎症性疾患の治療薬、ならびにウイルスまたは細菌感染疾患の治療薬 |
| EP2648756A4 (en) * | 2010-12-10 | 2016-06-08 | California Inst Of Techn | ATTAINING THE MESANGIUM WITH NANOPARTICLES OF DEFINED DIAMETER |
| EP2495567A1 (en) * | 2011-03-04 | 2012-09-05 | Erasmus University Medical Center Rotterdam | Methods and means for monitoring disruption of tissue homeostasis in the total body |
| EP2694040A4 (en) * | 2011-03-25 | 2014-09-03 | Selecta Biosciences Inc | SYNTHETIC NANOTRACKERS WITH OSMOTICALLY MEDIATED RELEASE |
| ES2647902T3 (es) | 2011-04-18 | 2017-12-27 | University Of Georgia Research Foundation, Inc. | Método de administración de vacunas |
| CN118078979A (zh) | 2011-04-29 | 2024-05-28 | 西莱克塔生物科技公司 | 用于降低针对治疗性蛋白的免疫应答的致耐受性合成纳米载体 |
| CA2843274A1 (en) | 2011-07-29 | 2013-02-07 | Selecta Biosciences, Inc. | Synthetic nanocarriers that generate humoral and cytotoxic t lymphocyte (ctl) immune responses |
| SMT202200355T1 (it) | 2011-12-16 | 2022-11-18 | Modernatx Inc | Composizioni di mrna modificato |
| CN108949772A (zh) | 2012-04-02 | 2018-12-07 | 现代泰克斯公司 | 用于产生与人类疾病相关的生物制剂和蛋白质的修饰多核苷酸 |
| EP2834260A4 (en) | 2012-04-02 | 2016-08-10 | Moderna Therapeutics Inc | MODIFIED POLYNUCLEOTIDES FOR THE PREPARATION OF MEMBRANE PROTEINS |
| BR112014032207B1 (pt) | 2012-06-21 | 2021-07-27 | Northwestern University | Composição compreendendo um antígeno acoplado a uma partícula transportadora e uso de um antígeno acoplado a uma partícula transportadora |
| EP2922554B1 (en) | 2012-11-26 | 2022-02-23 | ModernaTX, Inc. | Terminally modified rna |
| US9468681B2 (en) | 2013-03-01 | 2016-10-18 | California Institute Of Technology | Targeted nanoparticles |
| EP2968584A1 (en) | 2013-03-11 | 2016-01-20 | Cristal Delivery B.V. | Vaccination composition |
| IL303425A (en) | 2013-03-13 | 2023-08-01 | Cour Pharmaceuticals Dev Company | Secondary vaccine particles for the treatment of inflammation |
| EP2971010B1 (en) | 2013-03-14 | 2020-06-10 | ModernaTX, Inc. | Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| US10434088B2 (en) * | 2013-05-03 | 2019-10-08 | Selecta Biosciences, Inc. | Methods related to administering immunosuppressants and therapeutic macromolecules at a reduced pharmacodynamically effective dose |
| CA2910579C (en) * | 2013-05-03 | 2023-09-26 | Selecta Biosciences, Inc. | Dosing combinations for reducing undesired humoral immune responses |
| DK3003306T3 (da) * | 2013-06-04 | 2020-11-30 | Selecta Biosciences Inc | Gentagen indgivelse af ikke-immunosupressive antigenspecifikke immunterapeutika |
| PL3019619T3 (pl) | 2013-07-11 | 2022-01-10 | Modernatx, Inc. | Kompozycje zawierające syntetyczne polinkleotydy kodujące białka powiązane z crispr i syntetyczne sgrna oraz sposoby ich stosowania |
| EP3033102B2 (en) | 2013-08-13 | 2023-12-20 | Northwestern University | Peptide conjugated particles |
| CA2923029A1 (en) | 2013-09-03 | 2015-03-12 | Moderna Therapeutics, Inc. | Chimeric polynucleotides |
| EP3041938A1 (en) | 2013-09-03 | 2016-07-13 | Moderna Therapeutics, Inc. | Circular polynucleotides |
| DE102013015112B4 (de) | 2013-09-13 | 2016-07-14 | Holger Frey | Spaltbare Polyethylenglykol-(PEG)-Makromoleküle zum Einschluss von (Glyko-) Proteinen/Antigenen/Allergenen in abbaubaren Polyethylenglykol-(PEG)-Nanopartikeln sowie Verfahren zu ihrer Herstellung |
| US9603944B2 (en) | 2013-09-27 | 2017-03-28 | Massachusetts Institute Of Technology | Carrier-free biologically-active protein nanostructures |
| EP3071696B1 (en) | 2013-11-22 | 2019-08-07 | Mina Therapeutics Limited | C/ebp alpha short activating rna compositions and methods of use |
| EP3094314B1 (en) | 2014-01-16 | 2021-06-23 | MUSC Foundation For Research Development | Targeted nanocarriers for the administration of immunosuppressive agents |
| US9919058B2 (en) | 2014-07-15 | 2018-03-20 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Polyketal particles including a CpG oligodeoxynucleotide for the treatment of lung cancer |
| EP3171895A1 (en) | 2014-07-23 | 2017-05-31 | Modernatx, Inc. | Modified polynucleotides for the production of intrabodies |
| US20170348402A1 (en) * | 2014-07-30 | 2017-12-07 | The Research Foundation For The State University Of New York | System and method for delivering genetic material or protein to cells |
| WO2016037165A1 (en) | 2014-09-07 | 2016-03-10 | Selecta Biosciences, Inc. | Methods and compositions for attenuating exon skipping anti-viral transfer vector immune responses |
| JP6914860B2 (ja) | 2015-07-01 | 2021-08-04 | カリフォルニア インスティチュート オブ テクノロジー | カチオン性粘液酸ポリマー系デリバリーシステム |
| JP6887685B2 (ja) | 2015-08-12 | 2021-06-16 | マサチューセッツ インスティテュート オブ テクノロジー | ナノ粒子の細胞表面共役 |
| AU2016315478B2 (en) | 2015-09-03 | 2023-07-13 | Novavax, Inc. | Vaccine compositions having improved stability and immunogenicity |
| EP3347047A1 (en) * | 2015-09-09 | 2018-07-18 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Expression vector delivery system and use thereof for inducing an immune response |
| EP4349405A3 (en) | 2015-10-22 | 2024-06-19 | ModernaTX, Inc. | Respiratory virus vaccines |
| WO2017086794A1 (en) | 2015-11-20 | 2017-05-26 | Cristal Delivery B.V. | Nanoparticles with active targeting |
| LT3394093T (lt) | 2015-12-23 | 2022-04-25 | Modernatx, Inc. | Ox40 ligandus koduojančių polinukleotidų naudojimo būdai |
| WO2017120612A1 (en) | 2016-01-10 | 2017-07-13 | Modernatx, Inc. | Therapeutic mrnas encoding anti ctla-4 antibodies |
| KR20180114946A (ko) * | 2016-03-02 | 2018-10-19 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | 면역요법을 위한 sting 활성화 나노백신 |
| AU2017283480A1 (en) | 2016-06-13 | 2019-01-24 | Torque Therapeutics, Inc. | Methods and compositions for promoting immune cell function |
| US11433123B2 (en) | 2016-07-21 | 2022-09-06 | Case Western Reserve University | Sustained release cowpea mosaic virus or virus-like particle therapeutic constructs for the treatment of cancer |
| EP3568162A1 (en) | 2017-01-10 | 2019-11-20 | Nektar Therapeutics | Multi-arm polymer conjugates of tlr agonist compounds and related immunotherapeutic treatment methods |
| CA3055936A1 (en) | 2017-03-11 | 2018-09-20 | Selecta Biosciences, Inc. | Methods and compositions related to combined treatment with anti-inflammatories and synthetic nanocarriers comprising an immunosuppressant |
| US12121573B2 (en) | 2019-07-14 | 2024-10-22 | Tianxin Wang | Methods and agents including STING agonist to treat tumor |
| ES3028362T3 (en) | 2017-07-24 | 2025-06-19 | Novavax Inc | Methods and compositions for treating respiratory disease |
| EP3678701A4 (en) | 2017-09-05 | 2021-12-01 | Torque Therapeutics, Inc. | THERAPEUTIC PROTEIN COMPOSITIONS AND METHODS FOR PREPARING AND USING THE SAME |
| EP3679139B1 (en) | 2017-09-08 | 2022-11-02 | MiNA Therapeutics Limited | Stabilized hnf4a sarna compositions and methods of use |
| EP3679140B1 (en) | 2017-09-08 | 2022-11-16 | MiNA Therapeutics Limited | Stabilized cebpa sarna compositions and methods of use |
| SG11202009206QA (en) | 2018-03-19 | 2020-10-29 | Novavax Inc | Multivalent influenza nanoparticle vaccines |
| US11566246B2 (en) | 2018-04-12 | 2023-01-31 | Mina Therapeutics Limited | SIRT1-saRNA compositions and methods of use |
| WO2019222545A1 (en) | 2018-05-16 | 2019-11-21 | Synthego Corporation | Methods and systems for guide rna design and use |
| TWI807036B (zh) * | 2018-05-30 | 2023-07-01 | 南韓商韓國億諾生物有限公司 | 用於預防或治療癌症之包含作為活性成分之cd300e抑制劑的藥學組成物 |
| JP7483193B2 (ja) | 2018-06-13 | 2024-05-15 | カリフォルニア・インスティテュート・オブ・テクノロジー | 血脳バリアを越えるためのナノ粒子とそれを用いた治療法 |
| US20210317461A1 (en) | 2018-08-09 | 2021-10-14 | Verseau Therapeutics, Inc. | Oligonucleotide compositions for targeting ccr2 and csf1r and uses thereof |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| SG11202105835YA (en) * | 2019-01-04 | 2021-07-29 | Ascendis Pharma Oncology Div A/S | Conjugates of pattern recognition receptor agonists |
| WO2020141225A1 (en) * | 2019-01-04 | 2020-07-09 | Ascendis Pharma A/S | Minimization of systemic inflammation |
| GB2597377A (en) | 2019-01-25 | 2022-01-26 | Synthego Corp | Systems and methods for modulating CRISPR activity |
| US20220211740A1 (en) | 2019-04-12 | 2022-07-07 | Mina Therapeutics Limited | Sirt1-sarna compositions and methods of use |
| GB2603223A (en) | 2019-07-19 | 2022-08-03 | Synthego Corp | Stabilized Crispr complexes |
| CN111249453B (zh) * | 2020-02-26 | 2021-11-19 | 浙江大学 | 一种纳米疫苗及其制备方法 |
| WO2021231702A1 (en) * | 2020-05-15 | 2021-11-18 | Rutgers, The State University Of New Jersey | Compositions and methods for treating wounds |
| EP4175618A4 (en) * | 2020-07-01 | 2024-08-07 | Cello Therapeutics, Inc. | Platelet membrane coated nanoparticles and uses thereof |
| IL315371A (en) * | 2020-08-31 | 2024-11-01 | Rav Bariach 08 Industries Ltd | Multi-bolt electromechanical locking system for remote operation |
| US11952492B2 (en) * | 2020-11-20 | 2024-04-09 | Encapsys, Llc | Biodegradable, controlled release microcapsules |
| GB2603454A (en) | 2020-12-09 | 2022-08-10 | Ucl Business Ltd | Novel therapeutics for the treatment of neurodegenerative disorders |
| CN112494460B (zh) * | 2020-12-10 | 2022-03-11 | 浙江大飞龙动物保健品股份有限公司 | 替米考星粉剂及其制备方法 |
| US20220226465A1 (en) | 2021-01-18 | 2022-07-21 | ConserV Bioscience | Coronavirus Immunogenic Compositions, Methods and Uses Thereof |
| TW202305133A (zh) | 2021-03-26 | 2023-02-01 | 英商米納治療有限公司 | Tmem173 sarna組合物及其使用方法 |
| WO2022221529A1 (en) | 2021-04-16 | 2022-10-20 | Asklepios Biopharmaceutical, Inc. | Rational polyploid aav virions that cross the blood brain barrier and elicit reduced humoral response |
| WO2023024500A1 (en) | 2021-08-27 | 2023-03-02 | Peking University | Constructs and methods for preparing circular rna |
| CA3223230A1 (en) * | 2021-09-17 | 2023-03-23 | Jessica WALSH | Reagent compositions, methods, cartridges, and systems |
| WO2023099884A1 (en) | 2021-12-01 | 2023-06-08 | Mina Therapeutics Limited | Pax6 sarna compositions and methods of use |
| GB202117758D0 (en) | 2021-12-09 | 2022-01-26 | Ucl Business Ltd | Therapeutics for the treatment of neurodegenerative disorders |
| JP2025508467A (ja) | 2022-02-24 | 2025-03-26 | アイオー バイオテック エーピーエス | 癌治療のヌクレオチド送達 |
| US20230202978A1 (en) | 2022-03-04 | 2023-06-29 | Reset Pharmaceuticals, Inc. | Co-crystal or salt |
| WO2023170435A1 (en) | 2022-03-07 | 2023-09-14 | Mina Therapeutics Limited | Il10 sarna compositions and methods of use |
| KR20240076105A (ko) * | 2022-11-23 | 2024-05-30 | 주식회사 바임 | 생분해성 고분자 분산체 및 이의 제조방법 |
| TW202440929A (zh) | 2022-12-14 | 2024-10-16 | 加拿大商普羅維登斯治療控股公司 | 用於感染性疾病的組合物和方法 |
| WO2024134199A1 (en) | 2022-12-22 | 2024-06-27 | Mina Therapeutics Limited | Chemically modified sarna compositions and methods of use |
| WO2024196783A1 (en) * | 2023-03-21 | 2024-09-26 | The Board Of Regents Of The University Of Texas System | Bioengineered colon-specific immune niche for the treatment of ulcerative colitis |
| CN117224699B (zh) * | 2023-09-05 | 2024-03-19 | 贵州大学 | 一种纳米复合物及其制备方法和用途 |
| EP4520345A1 (en) | 2023-09-06 | 2025-03-12 | Myneo Nv | Product |
| WO2025256977A1 (en) | 2024-06-13 | 2025-12-18 | Bayer Aktiengesellschaft | Novel igm and igg cleaving enzymes |
| WO2025256978A1 (en) | 2024-06-13 | 2025-12-18 | Bayer Aktiengesellschaft | Variants of igm and igg cleaving enzymes |
| CN119823126A (zh) * | 2025-01-09 | 2025-04-15 | 沈阳药科大学 | 一种雷西莫特没食子酰基衍生物及其合成方法和应用 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6329381B1 (en) * | 1997-11-28 | 2001-12-11 | Sumitomo Pharmaceuticals Company, Limited | Heterocyclic compounds |
| US20070166384A1 (en) * | 2004-04-09 | 2007-07-19 | Zarraga Isidro Angelo E | Methods , composition and preparations for delivery of immune response modifiers |
| US20080160089A1 (en) * | 2003-10-14 | 2008-07-03 | Medivas, Llc | Vaccine delivery compositions and methods of use |
| WO2009051837A2 (en) * | 2007-10-12 | 2009-04-23 | Massachusetts Institute Of Technology | Vaccine nanotechnology |
| CN102245201A (zh) * | 2008-10-12 | 2011-11-16 | 麻省理工学院 | 免疫纳米疗法中的佐剂整合 |
Family Cites Families (255)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR7461M (cg-RX-API-DMAC7.html) | 1968-06-19 | 1970-01-05 | ||
| GB1355961A (en) * | 1970-02-27 | 1974-06-12 | Wellcome Found | Preparation of immunosuppressive antilymphocytic serum |
| CH594444A5 (cg-RX-API-DMAC7.html) | 1972-12-04 | 1978-01-13 | Gerd Birrenbach | |
| DK143689C (da) | 1975-03-20 | 1982-03-15 | J Kreuter | Fremgangsmaade til fremstilling af en adsorberet vaccine |
| US4756907A (en) | 1978-10-17 | 1988-07-12 | Stolle Research & Development Corp. | Active/passive immunization of the internal female reproductive organs |
| US4946929A (en) | 1983-03-22 | 1990-08-07 | Massachusetts Institute Of Technology | Bioerodible articles useful as implants and prostheses having predictable degradation rates |
| US6309669B1 (en) | 1984-03-16 | 2001-10-30 | The United States Of America As Represented By The Secretary Of The Army | Therapeutic treatment and prevention of infections with a bioactive materials encapsulated within a biodegradable-biocompatible polymeric matrix |
| US4638045A (en) | 1985-02-19 | 1987-01-20 | Massachusetts Institute Of Technology | Non-peptide polyamino acid bioerodible polymers |
| US4631211A (en) | 1985-03-25 | 1986-12-23 | Scripps Clinic & Research Foundation | Means for sequential solid phase organic synthesis and methods using the same |
| US4806621A (en) | 1986-01-21 | 1989-02-21 | Massachusetts Institute Of Technology | Biocompatible, bioerodible, hydrophobic, implantable polyimino carbonate article |
| JPS63122620A (ja) | 1986-11-12 | 1988-05-26 | Sanraku Inc | ポリ乳酸マイクロスフエア及びその製造方法 |
| CA1340581C (en) | 1986-11-20 | 1999-06-08 | Joseph P. Vacanti | Chimeric neomorphogenesis of organs by controlled cellular implantation using artificial matrices |
| US5736372A (en) | 1986-11-20 | 1998-04-07 | Massachusetts Institute Of Technology | Biodegradable synthetic polymeric fibrous matrix containing chondrocyte for in vivo production of a cartilaginous structure |
| US5759830A (en) | 1986-11-20 | 1998-06-02 | Massachusetts Institute Of Technology | Three-dimensional fibrous scaffold containing attached cells for producing vascularized tissue in vivo |
| FR2608988B1 (fr) | 1986-12-31 | 1991-01-11 | Centre Nat Rech Scient | Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanoparticules |
| US5912017A (en) | 1987-05-01 | 1999-06-15 | Massachusetts Institute Of Technology | Multiwall polymeric microspheres |
| US5229490A (en) | 1987-05-06 | 1993-07-20 | The Rockefeller University | Multiple antigen peptide system |
| US5019379A (en) | 1987-07-31 | 1991-05-28 | Massachusetts Institute Of Technology | Unsaturated polyanhydrides |
| US6130082A (en) | 1988-05-05 | 2000-10-10 | American Cyanamid Company | Recombinant flagellin vaccines |
| US4929624A (en) * | 1989-03-23 | 1990-05-29 | Minnesota Mining And Manufacturing Company | Olefinic 1H-imidazo(4,5-c)quinolin-4-amines |
| US5010167A (en) | 1989-03-31 | 1991-04-23 | Massachusetts Institute Of Technology | Poly(amide-and imide-co-anhydride) for biological application |
| US5114703A (en) * | 1989-05-30 | 1992-05-19 | Alliance Pharmaceutical Corp. | Percutaneous lymphography using particulate fluorocarbon emulsions |
| US5733572A (en) | 1989-12-22 | 1998-03-31 | Imarx Pharmaceutical Corp. | Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles |
| GB9016885D0 (en) | 1990-08-01 | 1990-09-12 | Scras | Sustained release pharmaceutical compositions |
| US5389640A (en) | 1991-03-01 | 1995-02-14 | Minnesota Mining And Manufacturing Company | 1-substituted, 2-substituted 1H-imidazo[4,5-c]quinolin-4-amines |
| NZ242220A (en) | 1991-04-02 | 1994-04-27 | Biotech Australia Pty Ltd | Complex for oral delivery of a substance to the circulatory or lymphatic drainage system comprising microparticle coupled to at least one carrier, the substance being encapsulated by the microparticle |
| US5811447A (en) * | 1993-01-28 | 1998-09-22 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| US6235313B1 (en) | 1992-04-24 | 2001-05-22 | Brown University Research Foundation | Bioadhesive microspheres and their use as drug delivery and imaging systems |
| JPH07509467A (ja) | 1992-07-21 | 1995-10-19 | ザ ゼネラル ホスピタル コーポレーション | リンパ組織への薬物輸送システム |
| GB9216082D0 (en) | 1992-07-28 | 1992-09-09 | Univ Nottingham | Lymphatic delivery composition |
| US6608201B2 (en) | 1992-08-28 | 2003-08-19 | 3M Innovative Properties Company | Process for preparing 1-substituted, 2-substituted 1H-imidazo[4,5-c]quinolin-4-amines |
| FR2695563B1 (fr) * | 1992-09-11 | 1994-12-02 | Pasteur Institut | Microparticules portant des antigènes et leur utilisation pour l'induction de réponses humorales ou cellulaires. |
| AU4932493A (en) | 1992-09-25 | 1994-04-26 | Dynagen, Inc. | An immunobooster for delayed release of immunogen |
| US5399665A (en) | 1992-11-05 | 1995-03-21 | Massachusetts Institute Of Technology | Biodegradable polymers for cell transplantation |
| CA2153391C (en) | 1993-01-11 | 2000-08-15 | Kenneth Rock | Inducing cytotoxic t lymphocyte responses |
| US5512600A (en) | 1993-01-15 | 1996-04-30 | Massachusetts Institute Of Technology | Preparation of bonded fiber structures for cell implantation |
| US5514378A (en) | 1993-02-01 | 1996-05-07 | Massachusetts Institute Of Technology | Biocompatible polymer membranes and methods of preparation of three dimensional membrane structures |
| DE69411154T2 (de) * | 1993-02-22 | 1998-10-22 | Alza Corp., Palo Alto, Calif. | Mittel zur oralen gabe von wirkstoffen |
| WO1994021240A2 (de) | 1993-03-17 | 1994-09-29 | Silica Gel Ges.M.B.H | Superparamagnetische teilchen, verfahren zu ihrer herstellung und verwendung derselben |
| US5565215A (en) | 1993-07-23 | 1996-10-15 | Massachusettes Institute Of Technology | Biodegradable injectable particles for imaging |
| WO1995003035A1 (en) | 1993-07-23 | 1995-02-02 | Massachusetts Institute Of Technology | Polymerized liposomes with enhanced stability for oral delivery |
| US5543158A (en) | 1993-07-23 | 1996-08-06 | Massachusetts Institute Of Technology | Biodegradable injectable nanoparticles |
| US5798340A (en) * | 1993-09-17 | 1998-08-25 | Gilead Sciences, Inc. | Nucleotide analogs |
| US5500161A (en) * | 1993-09-21 | 1996-03-19 | Massachusetts Institute Of Technology And Virus Research Institute | Method for making hydrophobic polymeric microparticles |
| WO1995022963A1 (en) | 1994-02-28 | 1995-08-31 | Medinova Medical Consulting Gmbh | Drug targeting system, method for preparing same and its use |
| GB9412273D0 (en) * | 1994-06-18 | 1994-08-10 | Univ Nottingham | Administration means |
| CA2560114A1 (en) | 1994-07-15 | 1996-02-01 | The University Of Iowa Research Foundation | Immunomodulatory oligonucleotides |
| US6239116B1 (en) | 1994-07-15 | 2001-05-29 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US6007845A (en) | 1994-07-22 | 1999-12-28 | Massachusetts Institute Of Technology | Nanoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers |
| US5716404A (en) | 1994-12-16 | 1998-02-10 | Massachusetts Institute Of Technology | Breast tissue engineering |
| AU4755696A (en) | 1995-01-05 | 1996-07-24 | Board Of Regents Acting For And On Behalf Of The University Of Michigan, The | Surface-modified nanoparticles and method of making and using same |
| US6123727A (en) | 1995-05-01 | 2000-09-26 | Massachusetts Institute Of Technology | Tissue engineered tendons and ligaments |
| WO1997004747A1 (en) | 1995-07-27 | 1997-02-13 | Dunn James M | Drug delivery systems for macromolecular drugs |
| CA2230494A1 (en) | 1995-08-31 | 1997-03-06 | Alkermes Controlled Therapeutics Inc. | Composition for sustained release of an agent |
| US6095148A (en) | 1995-11-03 | 2000-08-01 | Children's Medical Center Corporation | Neuronal stimulation using electrically conducting polymers |
| US5902599A (en) | 1996-02-20 | 1999-05-11 | Massachusetts Institute Of Technology | Biodegradable polymer networks for use in orthopedic and dental applications |
| US5874064A (en) | 1996-05-24 | 1999-02-23 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
| US5922695A (en) | 1996-07-26 | 1999-07-13 | Gilead Sciences, Inc. | Antiviral phosphonomethyoxy nucleotide analogs having increased oral bioavarilability |
| US6368598B1 (en) | 1996-09-16 | 2002-04-09 | Jcrt Radiation Oncology Support Services, Inc. | Drug complex for treatment of metastatic prostate cancer |
| EP0938315B9 (en) | 1996-10-25 | 2008-02-20 | Minnesota Mining And Manufacturing Company | Immune response modifier compounds for treatment of th2 mediated and related diseases |
| US6042820A (en) | 1996-12-20 | 2000-03-28 | Connaught Laboratories Limited | Biodegradable copolymer containing α-hydroxy acid and α-amino acid units |
| CA2281838A1 (en) | 1997-02-28 | 1998-09-03 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated cpg dinucleotide in the treatment of lps-associated disorders |
| DE69841122D1 (de) | 1997-03-10 | 2009-10-15 | Coley Pharm Gmbh | Verwendung von nicht-methyliertem CpG Dinukleotid in Kombination mit Aluminium als Adjuvantien |
| US6211159B1 (en) | 1997-04-11 | 2001-04-03 | University Of Toronto | Flagellin gene, FlaC of campylobacter |
| US6060082A (en) * | 1997-04-18 | 2000-05-09 | Massachusetts Institute Of Technology | Polymerized liposomes targeted to M cells and useful for oral or mucosal drug delivery |
| EP1003531B1 (en) | 1997-05-20 | 2007-08-22 | Ottawa Health Research Institute | Processes for preparing nucleic acid constructs |
| US5837752A (en) | 1997-07-17 | 1998-11-17 | Massachusetts Institute Of Technology | Semi-interpenetrating polymer networks |
| US6989435B2 (en) | 1997-09-11 | 2006-01-24 | Cambridge University Technical Services Ltd. | Compounds and methods to inhibit or augment an inflammatory response |
| DE19745950A1 (de) | 1997-10-17 | 1999-04-22 | Dds Drug Delivery Service Ges | Arzneistoffträgerpartikel für die gewebespezifische Arzneistoffapplikation |
| US6197229B1 (en) * | 1997-12-12 | 2001-03-06 | Massachusetts Institute Of Technology | Method for high supercoiled DNA content microspheres |
| US6254890B1 (en) | 1997-12-12 | 2001-07-03 | Massachusetts Institute Of Technology | Sub-100nm biodegradable polymer spheres capable of transporting and releasing nucleic acids |
| FR2775435B1 (fr) * | 1998-02-27 | 2000-05-26 | Bioalliance Pharma | Nanoparticules comprenant au moins un polymere et au moins un compose apte a complexer un ou plusieurs principes actifs |
| US6232287B1 (en) * | 1998-03-13 | 2001-05-15 | The Burnham Institute | Molecules that home to various selected organs or tissues |
| US6632922B1 (en) | 1998-03-19 | 2003-10-14 | The Regents Of The University Of California | Methods and compositions for controlled polypeptide synthesis |
| US6686446B2 (en) | 1998-03-19 | 2004-02-03 | The Regents Of The University Of California | Methods and compositions for controlled polypeptide synthesis |
| US6506577B1 (en) | 1998-03-19 | 2003-01-14 | The Regents Of The University Of California | Synthesis and crosslinking of catechol containing copolypeptides |
| EP1067956B1 (en) | 1998-04-03 | 2007-03-14 | University Of Iowa Research Foundation | Methods and products for stimulating the immune system using immunotherapeutic oligonucleotides and cytokines |
| EP1077708A1 (en) | 1998-05-06 | 2001-02-28 | University Of Iowa Research Foundation | Methods for the prevention and treatment of parasitic infections and related diseases using cpg oligonucleotides |
| DE19827164A1 (de) | 1998-06-18 | 1999-12-23 | Merck Patent Gmbh | Katalytisch Titan(IV)-oxid vermittelte geminale symmetrische Dialkylierung von Carbonsäureamiden |
| US6242589B1 (en) | 1998-07-14 | 2001-06-05 | Isis Pharmaceuticals, Inc. | Phosphorothioate oligonucleotides having modified internucleoside linkages |
| ATE321535T1 (de) | 1998-07-29 | 2006-04-15 | Chiron Corp | Mikropartikel mit adsorbenten oberflächen, verfahren zu ihrer herstellung und ihrer verwendung |
| DE19839214C1 (de) * | 1998-08-28 | 2000-05-25 | Aventis Res & Tech Gmbh & Co | Verfahren zur Herstellung von sphärischen Mikropartikeln mit glatter Oberfläche, die ganz oder teilweise aus mindestens einem wasserunlöslichen linearen Polysaccharid bestehen, sowie mit diesem Verfahren erhältliche Mikropartikel und deren Verwendung |
| US6306640B1 (en) | 1998-10-05 | 2001-10-23 | Genzyme Corporation | Melanoma antigenic peptides |
| PL205109B1 (pl) | 1998-11-02 | 2010-03-31 | Elan Pharma Int Ltd | Wielocząstkowa kompozycja metylofenidatu o modyfikowanym uwalnianiu i jej zastosowanie |
| US7521068B2 (en) | 1998-11-12 | 2009-04-21 | Elan Pharma International Ltd. | Dry powder aerosols of nanoparticulate drugs |
| US7238711B1 (en) | 1999-03-17 | 2007-07-03 | Cambridge University Technical Services Ltd. | Compounds and methods to inhibit or augment an inflammatory response |
| US6444192B1 (en) | 1999-02-05 | 2002-09-03 | The Regents Of The University Of California | Diagnostic imaging of lymph structures |
| HUP0201425A3 (en) * | 1999-04-23 | 2006-07-28 | Hadasit Med Res Service | Conjugate having a cleavable linkage for use in a liposome |
| US7238368B2 (en) | 1999-04-23 | 2007-07-03 | Alza Corporation | Releasable linkage and compositions containing same |
| US6800296B1 (en) | 1999-05-19 | 2004-10-05 | Massachusetts Institute Of Technology | Modification of surfaces using biological recognition events |
| US6815170B1 (en) | 1999-06-30 | 2004-11-09 | John Wayne Cancer Institute | Methods for lymph node identification |
| WO2001012071A1 (en) | 1999-08-13 | 2001-02-22 | Point Biomedical Corporation | Microparticles useful as ultrasonic contrast agents and for lymphatic system |
| CA2391534A1 (en) | 1999-11-15 | 2001-05-25 | Drug Innovation & Design, Inc. | Selective cellular targeting: multifunctional delivery vehicles |
| EP1294930B1 (en) | 2000-01-13 | 2011-03-30 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
| US8202979B2 (en) | 2002-02-20 | 2012-06-19 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid |
| US20050032733A1 (en) | 2001-05-18 | 2005-02-10 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SiNA) |
| US20050020525A1 (en) * | 2002-02-20 | 2005-01-27 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
| JP4751556B2 (ja) | 2000-02-28 | 2011-08-17 | ジーンシーグス, インコーポレイテッド | ナノカプセルカプセル化システムおよび方法 |
| US7129222B2 (en) | 2000-03-10 | 2006-10-31 | Dynavax Technologies Corporation | Immunomodulatory formulations and methods for use thereof |
| US20030129251A1 (en) | 2000-03-10 | 2003-07-10 | Gary Van Nest | Biodegradable immunomodulatory formulations and methods for use thereof |
| US7192725B2 (en) | 2000-05-19 | 2007-03-20 | University Of Toronto | Flagellin gene, flaC of Campylobacter |
| AU2001297913A1 (en) | 2000-10-13 | 2002-12-23 | Ligocyte Pharmaceuticals, Inc. | Polyvalent nanoparticles |
| GB0025414D0 (en) | 2000-10-16 | 2000-11-29 | Consejo Superior Investigacion | Nanoparticles |
| AU2002245205B2 (en) | 2000-10-19 | 2007-07-19 | Ecole Polytechnique Federale De Lausanne | Block copolymers for multifunctional self-assembled systems |
| US7592008B2 (en) | 2000-11-20 | 2009-09-22 | The Board Of Trustees Of The University Of Illinois, A Body Corporate And Politic Of The State Of Illinois | Membrane scaffold proteins |
| US7097837B2 (en) | 2001-02-19 | 2006-08-29 | Pharmexa A/S | Synthetic vaccine agents |
| US20030175950A1 (en) | 2001-05-29 | 2003-09-18 | Mcswiggen James A. | RNA interference mediated inhibition of HIV gene expression using short interfering RNA |
| WO2004030608A2 (en) | 2001-06-05 | 2004-04-15 | The Regents Of The University Of Michigan | Nanoemulsion vaccines |
| NZ530315A (en) | 2001-07-10 | 2007-01-26 | Corixa Corp | Compositions and methods for delivery of proteins and adjuvants encapsulated in microspheres |
| JP4607452B2 (ja) | 2001-08-07 | 2011-01-05 | ダイナバックス テクノロジーズ コーポレイション | 免疫調節性組成物、製剤およびその使用方法 |
| US6818732B2 (en) | 2001-08-30 | 2004-11-16 | The Regents Of The University Of California | Transition metal initiators for controlled poly (beta-peptide) synthesis from beta-lactam monomers |
| US8088388B2 (en) | 2002-02-14 | 2012-01-03 | United Biomedical, Inc. | Stabilized synthetic immunogen delivery system |
| CA2476626A1 (en) | 2002-02-20 | 2003-08-28 | Chiron Corporation | Microparticles with adsorbed polypeptide-containing molecules |
| US20030232013A1 (en) | 2002-02-22 | 2003-12-18 | Gary Sieckman | Therapeutic and diagnostic targeting of cancers cells with tumor homing peptides |
| US7635463B2 (en) * | 2002-02-27 | 2009-12-22 | Pharmain Corporation | Compositions for delivery of therapeutics and other materials |
| IL164354A0 (en) | 2002-04-04 | 2005-12-18 | Coley Pharm Gmbh | Immunostimulatory g,u-containing oligoribonucleotides |
| US20040038303A1 (en) | 2002-04-08 | 2004-02-26 | Unger Gretchen M. | Biologic modulations with nanoparticles |
| US7285289B2 (en) * | 2002-04-12 | 2007-10-23 | Nagy Jon O | Nanoparticle vaccines |
| US20080233181A1 (en) | 2002-04-12 | 2008-09-25 | Nagy Jon O | Nanoparticle adjuvants for sub-unit vaccines |
| ATE394674T1 (de) | 2002-04-22 | 2008-05-15 | Univ Florida | Funktionalisierte nanopartikel und verwendungsverfahren |
| CA2487424C (en) | 2002-05-30 | 2011-01-04 | The Scripps Research Institute | Copper-catalysed ligation of azides and acetylenes |
| US20040092470A1 (en) | 2002-06-18 | 2004-05-13 | Leonard Sherry A. | Dry powder oligonucleotide formualtion, preparation and its uses |
| US20040142887A1 (en) | 2002-07-10 | 2004-07-22 | Chengji Cui | Antigen-polymer compositions |
| NZ537003A (en) | 2002-07-18 | 2008-03-28 | Cytos Biotechnology Ag | Hapten-carrier conjugates comprising virus like particles and uses thereof |
| US7488792B2 (en) * | 2002-08-28 | 2009-02-10 | Burnham Institute For Medical Research | Collagen-binding molecules that selectively home to tumor vasculature and methods of using same |
| US20060189554A1 (en) | 2002-09-24 | 2006-08-24 | Russell Mumper | Nanoparticle-Based vaccine delivery system containing adjuvant |
| US7008411B1 (en) * | 2002-09-30 | 2006-03-07 | Advanced Cardiovascular Systems, Inc. | Method and apparatus for treating vulnerable plaque |
| NO20024755D0 (no) | 2002-10-03 | 2002-10-03 | Amersham Health As | Metode |
| SE0203687D0 (sv) | 2002-12-13 | 2002-12-13 | Ian Harwigsson Med Adagit Fa | Pharmaceutical Porous Particles |
| US20040156846A1 (en) | 2003-02-06 | 2004-08-12 | Triton Biosystems, Inc. | Therapy via targeted delivery of nanoscale particles using L6 antibodies |
| US8575110B2 (en) | 2003-02-17 | 2013-11-05 | Alpha-O Peptides G | Peptidic nanoparticles as drug delivery and antigen display systems |
| US20040191215A1 (en) | 2003-03-25 | 2004-09-30 | Michael Froix | Compositions for induction of a therapeutic response |
| US20060233883A1 (en) | 2003-03-26 | 2006-10-19 | Tsutomu Ishihara | Intravenous nanoparticles for targeting drug delivery and sustained drug release |
| EP1605972A2 (en) * | 2003-03-26 | 2005-12-21 | Cytos Biotechnology AG | Hiv-peptide-carrier-conjugates |
| US7731967B2 (en) | 2003-04-30 | 2010-06-08 | Novartis Vaccines And Diagnostics, Inc. | Compositions for inducing immune responses |
| US7727969B2 (en) | 2003-06-06 | 2010-06-01 | Massachusetts Institute Of Technology | Controlled release nanoparticle having bound oligonucleotide for targeted delivery |
| US20060182793A1 (en) | 2003-07-22 | 2006-08-17 | Cytos Biotechnology Ag | Cpg-packaged liposomes |
| US20050042298A1 (en) | 2003-08-20 | 2005-02-24 | Pardridge William M. | Immunonanoparticles |
| CA2537900A1 (en) * | 2003-09-03 | 2005-04-28 | Dendritherapeutics, Inc. | Multiplex vaccines |
| US7943179B2 (en) | 2003-09-23 | 2011-05-17 | Massachusetts Institute Of Technology | pH triggerable polymeric particles |
| US7829119B2 (en) | 2003-10-20 | 2010-11-09 | William Marsh Rice University | Method to fabricate microcapsules from polymers and charged nanoparticles |
| EP1691780A2 (en) | 2003-11-21 | 2006-08-23 | Alza Corporation | Gene delivery mediated by liposome-dna complex with cleavable peg surface modification |
| WO2005055949A2 (en) | 2003-12-09 | 2005-06-23 | The Children's Hospital Of Philadelphia | Sustained release preparations composed of biocompatible complex microparticles |
| KR20120105062A (ko) | 2003-12-19 | 2012-09-24 | 더 유니버시티 오브 노쓰 캐롤라이나 엣 채플 힐 | 소프트 또는 임프린트 리소그래피를 이용하여 분리된 마이크로- 및 나노- 구조를 제작하는 방법 |
| US20050191294A1 (en) | 2003-12-31 | 2005-09-01 | Board Of Regents, The University Of Texas System | Compositions and methods of use of targeting peptides for diagnosis and therapy |
| US20070087986A1 (en) | 2004-01-26 | 2007-04-19 | Brett Premack | Compositions and methods for enhancing immunity by chemoattractant adjuvants |
| EP2415481A3 (en) | 2004-02-19 | 2012-04-18 | Coley Pharmaceutical Group, Inc. | Immunostimulatory viral RNA oligonucleotides |
| ES2246695B1 (es) | 2004-04-29 | 2007-05-01 | Instituto Cientifico Y Tecnologico De Navarra, S.A. | Composicion estimuladora de la respuesta inmunitaria que comprende nanoparticulas a base de un copolimero de metil vinil eter y anhidrido maleico. |
| US20060017339A1 (en) * | 2004-06-03 | 2006-01-26 | Lalit Chordia | Brushless canned motor |
| DK1767216T3 (da) | 2004-06-11 | 2012-09-03 | Riken | Lægemiddel med regulatorisk celleligand indeholdt i liposom |
| US7713550B2 (en) | 2004-06-15 | 2010-05-11 | Andrx Corporation | Controlled release sodium valproate formulation |
| EP1768692B8 (en) | 2004-07-01 | 2015-06-17 | Yale University | Targeted and high density drug loaded polymeric materials |
| WO2006014579A2 (en) | 2004-07-08 | 2006-02-09 | The Regents Of California | Enhancing class i antigen presentation with synthetic sequences |
| US8017151B2 (en) * | 2004-09-07 | 2011-09-13 | Board Of Regents Of The University Of Nebraska By And Behalf Of The University Of Nebraska Medical Center | Amphiphilic polymer-protein conjugates and methods of use thereof |
| CN1692943A (zh) | 2004-09-17 | 2005-11-09 | 四川大学 | CpG DNA分子抗感染免疫制剂的制备和应用 |
| GB0421296D0 (en) | 2004-09-24 | 2004-10-27 | Angiogene Pharm Ltd | Bioreductively-activated prodrugs |
| EP1793863B1 (en) | 2004-10-01 | 2017-04-12 | Midatech Ltd. | Nanoparticles comprising antigens and adjuvants capable of stimulating t helper cells |
| US20090004118A1 (en) * | 2004-10-07 | 2009-01-01 | Shuming Nie | Multifunctional Nanoparticle Conjugates And Their Use |
| WO2007001448A2 (en) | 2004-11-04 | 2007-01-04 | Massachusetts Institute Of Technology | Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals |
| US9789171B2 (en) | 2004-11-05 | 2017-10-17 | The General Hospital Corporation | Anti-fugetactic agents for the treatment of ovarian cancer |
| ES2434029T3 (es) | 2004-11-15 | 2013-12-13 | Novartis Vaccines And Diagnostics, Inc. | Composiciones inmunogénicas que contiene antígeno de antrax, micropartículas de polímero biodegradable, y adyuvante inmunológico que contiene polinucleótido |
| US20060111271A1 (en) | 2004-11-24 | 2006-05-25 | Cerny Erich H | Active and passive immunization against pharmacologically active hapten molecules using a synthetic carrier compound composed of similar elements |
| ATE544774T1 (de) | 2004-12-14 | 2012-02-15 | Alnylam Pharmaceuticals Inc | Rnai-modulation von mll-af4 und verwendungen dafür |
| US20060257359A1 (en) | 2005-02-28 | 2006-11-16 | Cedric Francois | Modifying macrophage phenotype for treatment of disease |
| CN101189339A (zh) | 2005-03-22 | 2008-05-28 | 美得思达健康有限公司 | 诊断和治疗心血管疾病的递送系统和方法 |
| US20080305161A1 (en) | 2005-04-13 | 2008-12-11 | Pfizer Inc | Injectable depot formulations and methods for providing sustained release of nanoparticle compositions |
| US20060241076A1 (en) | 2005-04-26 | 2006-10-26 | Coley Pharmaceutical Gmbh | Modified oligoribonucleotide analogs with enhanced immunostimulatory activity |
| WO2006117217A2 (de) | 2005-05-04 | 2006-11-09 | Noxxon Pharma Ag | Neue verwendung von spiegelmeren |
| EP1893661B1 (en) * | 2005-05-10 | 2012-01-18 | Emory University | Strategies for delivery of active agents using micelles and particles |
| WO2006122127A1 (en) * | 2005-05-10 | 2006-11-16 | Naomi Balaban | Compositions for administering rnaiii-inhibiting peptides |
| US9290617B2 (en) | 2005-07-06 | 2016-03-22 | Molly S. Shoichet | Method of biomolecule immobilization on polymers using click-type chemistry |
| ES2556974T3 (es) | 2005-08-12 | 2016-01-21 | Jiang Liu | Dispositivos para la orientación al sistema linfático |
| JP2009507049A (ja) * | 2005-09-09 | 2009-02-19 | 北京徳科瑞医薬科技有限公司 | リン脂質のポリエチレングリコール誘導体に包み込まれたビンカアルカロイド系制癌剤のナノミセル製剤 |
| EP2883957A1 (en) | 2005-11-25 | 2015-06-17 | Zoetis Belgium S.A. | Immunostimmulatory oligoribonucleotides |
| ES2564241T3 (es) | 2005-12-02 | 2016-03-21 | Glaxosmithkline Biologicals Sa | Nanopartículas para su uso en composiciones inmunogénicas |
| US20070184068A1 (en) | 2005-12-14 | 2007-08-09 | Cytos Biotechnology Ag | Immunostimulatory nucleic acid packaged particles for the treatment of hypersensitivity |
| US9267937B2 (en) | 2005-12-15 | 2016-02-23 | Massachusetts Institute Of Technology | System for screening particles |
| US7842312B2 (en) | 2005-12-29 | 2010-11-30 | Cordis Corporation | Polymeric compositions comprising therapeutic agents in crystalline phases, and methods of forming the same |
| WO2007089870A2 (en) * | 2006-01-31 | 2007-08-09 | Medivas, Llc | Vaccine delivery compositions and methods of use |
| US8021689B2 (en) * | 2006-02-21 | 2011-09-20 | Ecole Polytechnique Federale de Lausanne (“EPFL”) | Nanoparticles for immunotherapy |
| CA2643322C (en) | 2006-02-24 | 2015-07-21 | Novartis Ag | Microparticles containing biodegradable polymer and cationic polysaccharide for use in immunogenic compositions |
| JP2009534309A (ja) | 2006-03-31 | 2009-09-24 | マサチューセッツ インスティテュート オブ テクノロジー | 治療剤の標的化送達のためのシステム |
| CA2649149A1 (en) | 2006-04-11 | 2007-10-25 | Koko Kosmetikvertrieb Gmbh & Co. Kg | Nanoparticle containing nicotine and/or cotinine, dispersions, and use thereof |
| JP5630998B2 (ja) | 2006-05-15 | 2014-11-26 | マサチューセッツ インスティテュート オブ テクノロジー | 機能的粒子のためのポリマー |
| WO2007137117A2 (en) | 2006-05-17 | 2007-11-29 | Massachusetts Institute Of Technology | Aptamer-directed drug delivery |
| EP2530086B1 (en) | 2006-06-12 | 2019-03-20 | Kuros Biosciences AG | Processes for packaging oligonucleotides into virus-like particles of RNA bacteriophages |
| JP2010502766A (ja) * | 2006-06-16 | 2010-01-28 | フロリダ アトランティック ユニヴァーシティ | アジュバントとしてのキチン微粒子 |
| US9381477B2 (en) * | 2006-06-23 | 2016-07-05 | Massachusetts Institute Of Technology | Microfluidic synthesis of organic nanoparticles |
| WO2008019142A2 (en) | 2006-08-04 | 2008-02-14 | Massachusetts Institute Of Technology | Oligonucleotide systems for targeted intracellular delivery |
| WO2008019366A2 (en) | 2006-08-07 | 2008-02-14 | Ludwig Institute For Cancer Research | Methods and compositions for increased priming of t-cells through cross-presentation of exogenous antigens |
| CN101500937A (zh) | 2006-08-11 | 2009-08-05 | 万能药生物有限公司 | 用于递送活性成分的粒子及其制备方法和组合物 |
| WO2008033432A2 (en) | 2006-09-12 | 2008-03-20 | Coley Pharmaceutical Group, Inc. | Immune modulation by chemically modified ribonucleosides and oligoribonucleotides |
| JP2010505883A (ja) | 2006-10-12 | 2010-02-25 | ザ ユニバーシティー オブ クイーンズランド | 免疫応答を調節するための組成物および方法 |
| WO2008147456A2 (en) | 2006-11-20 | 2008-12-04 | Massachusetts Institute Of Technology | Drug delivery systems using fc fragments |
| US20080213377A1 (en) | 2006-12-08 | 2008-09-04 | Bhatia Sangeeta N | Delivery of Nanoparticles and/or Agents to Cells |
| WO2008071774A1 (en) | 2006-12-14 | 2008-06-19 | Cytos Biotechnology Ag | Purification process for coat protein of rna bacteriophages |
| US20080149123A1 (en) * | 2006-12-22 | 2008-06-26 | Mckay William D | Particulate material dispensing hairbrush with combination bristles |
| SI2510946T1 (sl) * | 2007-02-07 | 2015-12-31 | The Regents Of The University Of California | Konjugati sintetičnih agonistov TLR in njihove uporabe |
| EP2134830A2 (en) | 2007-02-09 | 2009-12-23 | Massachusetts Institute of Technology | Oscillating cell culture bioreactor |
| WO2008115641A2 (en) | 2007-02-15 | 2008-09-25 | Yale University | Modular nanoparticles for adaptable vaccines |
| WO2008118861A2 (en) | 2007-03-23 | 2008-10-02 | The University Of North Carolina At Chapel Hill | Discrete size and shape specific organic nanoparticles designed to elicit an immune response |
| US11246831B2 (en) | 2007-03-30 | 2022-02-15 | Particle Sciences, Inc. | Particle formulations and uses thereof |
| WO2008124634A1 (en) | 2007-04-04 | 2008-10-16 | Massachusetts Institute Of Technology | Polymer-encapsulated reverse micelles |
| WO2008124639A2 (en) | 2007-04-04 | 2008-10-16 | Massachusetts Institute Of Technology | Poly (amino acid) targeting moieties |
| WO2008124165A2 (en) | 2007-04-09 | 2008-10-16 | Chimeros, Inc. | Self-assembling nanoparticle drug delivery system |
| AU2008239795A1 (en) * | 2007-04-12 | 2008-10-23 | Emory University | Novel strategies for delivery of active agents using micelles and particles |
| US8394914B2 (en) | 2007-08-24 | 2013-03-12 | Board Of Trustees Of Michigan State University | Functional polyglycolide nanoparticles derived from unimolecular micelles |
| WO2009038685A1 (en) | 2007-09-18 | 2009-03-26 | The Scripps Research Institute | Ligands for copper-catalyzed azide-alkyne cycloaddition reactions |
| WO2009052837A2 (en) * | 2007-10-24 | 2009-04-30 | Tallinn University Of Technology | Maldi ms-based high-throughput screening method for substances inhibiting aggregation of alzheimer's amyloid beta peptides |
| WO2009076158A1 (en) * | 2007-12-07 | 2009-06-18 | Novartis Ag | Compositions for inducing immune responses |
| JP6088123B2 (ja) | 2008-02-01 | 2017-03-01 | アルファ−オー・ペプチドズ・アーゲーAlpha−O Peptides Ag | ワクチンとして有用な自己会合ペプチドナノ粒子 |
| WO2009106999A2 (en) | 2008-02-28 | 2009-09-03 | Deutsches Krebsforschungszentrum, Stiftung Des Öffentlichen Rechts | Hollow nanoparticles and uses thereof |
| JP2011525477A (ja) | 2008-03-04 | 2011-09-22 | リクイディア・テクノロジーズ・インコーポレーテッド | 免疫調節剤粒子および処置方法 |
| US20090297621A1 (en) | 2008-06-03 | 2009-12-03 | Abbott Cardiovascular Systems Inc. | Microparticles For The Treatment Of Disease |
| HUE047004T2 (hu) | 2008-06-16 | 2020-04-28 | Pfizer | Hatóanyaggal töltött polimer nanorészecskék és eljárások elõállításukra és alkalmazásukra |
| US8613951B2 (en) | 2008-06-16 | 2013-12-24 | Bind Therapeutics, Inc. | Therapeutic polymeric nanoparticles with mTor inhibitors and methods of making and using same |
| WO2010003009A2 (en) * | 2008-07-01 | 2010-01-07 | Emory University | Synergistic induction of humoral and cellular immunity by combinatorial activation of toll-like receptors |
| JP5667566B2 (ja) | 2008-08-06 | 2015-02-12 | ノバルティス アーゲー | 免疫原性組成物における使用のための微粒子 |
| EP2324025A1 (en) | 2008-08-11 | 2011-05-25 | Smithkline Beecham Corporation | Purine derivatives for use in the treatment of allergic, inflammatory and infectious diseases |
| ES2433371T3 (es) | 2008-08-11 | 2013-12-10 | Glaxosmithkline Llc | Derivados de purina para uso en el tratamiento de enfermedades alérgicas, inflamatorias e infecciosas |
| UA103195C2 (uk) | 2008-08-11 | 2013-09-25 | Глаксосмитклайн Ллк | Похідні пурину для застосування у лікуванні алергій, запальних та інфекційних захворювань |
| WO2010018132A1 (en) | 2008-08-11 | 2010-02-18 | Smithkline Beecham Corporation | Compounds |
| US8323696B2 (en) * | 2008-08-29 | 2012-12-04 | Ecole Polytechnique Federale De Lausanne | Nanoparticles for immunotherapy |
| US8889635B2 (en) | 2008-09-30 | 2014-11-18 | The Regents Of The University Of Michigan | Dendrimer conjugates |
| US8591905B2 (en) | 2008-10-12 | 2013-11-26 | The Brigham And Women's Hospital, Inc. | Nicotine immunonanotherapeutics |
| US8277812B2 (en) | 2008-10-12 | 2012-10-02 | Massachusetts Institute Of Technology | Immunonanotherapeutics that provide IgG humoral response without T-cell antigen |
| US8343497B2 (en) * | 2008-10-12 | 2013-01-01 | The Brigham And Women's Hospital, Inc. | Targeting of antigen presenting cells with immunonanotherapeutics |
| CA2756996C (en) | 2009-04-01 | 2018-12-11 | University Of Miami | Vaccine compositions and methods of use thereof |
| WO2010123569A2 (en) | 2009-04-21 | 2010-10-28 | Selecta Biosciences, Inc. | Immunonanotherapeutics providing a th1-biased response |
| US9797000B2 (en) | 2009-05-01 | 2017-10-24 | Qiagen Gaithersburg Inc. | Non-target amplification method for detection of RNA splice-forms in a sample |
| AU2010254549B2 (en) * | 2009-05-27 | 2016-10-20 | Selecta Biosciences, Inc. | Nanocarriers possessing components with different rates of release |
| EP3058953A1 (en) | 2009-07-07 | 2016-08-24 | The Research Foundation Of State University Of New York | Lipidic compositions for induction of immune tolerance |
| MX343908B (es) | 2009-08-26 | 2016-11-28 | Selecta Biosciences Inc * | Composiciones que inducen la ayuda de las células t. |
| EP2515942B1 (en) | 2009-12-15 | 2020-02-12 | Pfizer Inc. | Therapeutic polymeric nanoparticle compositions with high glass transition temperature or high molecular weight copolymers |
| US20110171248A1 (en) | 2010-01-08 | 2011-07-14 | Selecta Biosciences, Inc. | Synthetic virus-like particles conjugated to human papillomavirus capsid peptides for use as vaccines |
| US20110229556A1 (en) | 2010-03-19 | 2011-09-22 | Massachusetts Institute Of Technology | Lipid-coated polymer particles for immune stimulation |
| US20110262491A1 (en) | 2010-04-12 | 2011-10-27 | Selecta Biosciences, Inc. | Emulsions and methods of making nanocarriers |
| US20110272836A1 (en) | 2010-04-12 | 2011-11-10 | Selecta Biosciences, Inc. | Eccentric vessels |
| CN105194665A (zh) | 2010-05-26 | 2015-12-30 | 西莱克塔生物科技公司 | 具有不偶合的佐剂的纳米载体组合物 |
| AU2011291522A1 (en) | 2010-08-20 | 2013-01-24 | Selecta Biosciences, Inc. | Synthetic nanocarrier vaccines comprising peptides obtained or derived from human influenza A virus M2E |
| MX2013002173A (es) * | 2010-08-23 | 2013-05-06 | Selecta Biosciences Inc | Formas farmaceuticas dirigidas de epitopos multiples para la induccion de una respuesta inmunologica frente a antigenos. |
| WO2012061717A1 (en) | 2010-11-05 | 2012-05-10 | Selecta Biosciences, Inc. | Modified nicotinic compounds and related methods |
| US20120171229A1 (en) | 2010-12-30 | 2012-07-05 | Selecta Biosciences, Inc. | Synthetic nanocarriers with reactive groups that release biologically active agents |
| EP2694040A4 (en) | 2011-03-25 | 2014-09-03 | Selecta Biosciences Inc | SYNTHETIC NANOTRACKERS WITH OSMOTICALLY MEDIATED RELEASE |
| CN118078979A (zh) | 2011-04-29 | 2024-05-28 | 西莱克塔生物科技公司 | 用于降低针对治疗性蛋白的免疫应答的致耐受性合成纳米载体 |
| CA2843274A1 (en) | 2011-07-29 | 2013-02-07 | Selecta Biosciences, Inc. | Synthetic nanocarriers that generate humoral and cytotoxic t lymphocyte (ctl) immune responses |
| WO2013036302A1 (en) * | 2011-09-06 | 2013-03-14 | Selecta Biosciences, Inc. | Induced tolerogenic dendritic cells for generating cd8+ regulatory t cells |
| US10434088B2 (en) | 2013-05-03 | 2019-10-08 | Selecta Biosciences, Inc. | Methods related to administering immunosuppressants and therapeutic macromolecules at a reduced pharmacodynamically effective dose |
| DK3003306T3 (da) | 2013-06-04 | 2020-11-30 | Selecta Biosciences Inc | Gentagen indgivelse af ikke-immunosupressive antigenspecifikke immunterapeutika |
| US20160220501A1 (en) | 2015-02-03 | 2016-08-04 | Selecta Biosciences, Inc. | Tolerogenic synthetic nanocarriers to reduce immune responses to therapeutic proteins |
| US20150359865A1 (en) | 2014-06-17 | 2015-12-17 | Selecta Biosciences, Inc. | Tolerogenic synthetic nanocarriers for t-cell-mediated autoimmune disease |
| EA201692512A1 (ru) | 2014-06-25 | 2017-07-31 | Селекта Байосайенсиз, Инк. | Способы и композиции для лечения синтетическими наноносителями и ингибиторами иммунной контрольной точки |
| WO2016037165A1 (en) | 2014-09-07 | 2016-03-10 | Selecta Biosciences, Inc. | Methods and compositions for attenuating exon skipping anti-viral transfer vector immune responses |
| HUE054894T2 (hu) | 2014-11-05 | 2021-10-28 | Selecta Biosciences Inc | Rapamicint stabil, túltelített állapotban tartalmazó szintetikus nanohordozókkal kapcsolatos módszerek és készítmények |
-
2010
- 2010-05-26 AU AU2010254549A patent/AU2010254549B2/en not_active Ceased
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- 2010-05-26 US US12/788,260 patent/US20110020388A1/en not_active Abandoned
- 2010-05-26 CA CA2762650A patent/CA2762650A1/en not_active Abandoned
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- 2010-05-26 EA EA201171478A patent/EA028288B1/ru not_active IP Right Cessation
- 2010-05-26 MX MX2011012597A patent/MX2011012597A/es active IP Right Grant
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- 2010-05-26 US US12/788,261 patent/US20100303850A1/en not_active Abandoned
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- 2010-05-26 CN CN201611196015.5A patent/CN107096018A/zh active Pending
- 2010-05-26 EP EP10726348A patent/EP2435095A2/en not_active Withdrawn
- 2010-05-26 MX MX2014000083A patent/MX350667B/es unknown
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- 2010-05-26 BR BRPI1010674A patent/BRPI1010674A2/pt not_active IP Right Cessation
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- 2010-05-26 EP EP10723818A patent/EP2435092A2/en not_active Withdrawn
- 2010-05-26 KR KR1020187006038A patent/KR20180026572A/ko not_active Ceased
- 2010-05-26 WO PCT/US2010/001561 patent/WO2010138194A2/en not_active Ceased
- 2010-05-26 MX MX2011012599A patent/MX2011012599A/es active IP Right Grant
- 2010-05-26 CN CN2010800281096A patent/CN102481374A/zh active Pending
- 2010-05-26 CA CA2762653A patent/CA2762653A1/en not_active Abandoned
- 2010-05-26 BR BRPI1012034A patent/BRPI1012034A2/pt not_active Application Discontinuation
- 2010-05-26 EP EP10726347A patent/EP2435094A2/en not_active Withdrawn
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- 2010-05-26 US US12/788,266 patent/US8629151B2/en not_active Expired - Fee Related
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2011
- 2011-11-23 IL IL216548A patent/IL216548B/en active IP Right Grant
- 2011-11-23 IL IL216550A patent/IL216550A/en not_active IP Right Cessation
- 2011-11-23 IL IL216549A patent/IL216549A0/en unknown
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2013
- 2013-07-22 US US13/948,129 patent/US20140030344A1/en not_active Abandoned
- 2013-12-23 US US14/138,601 patent/US9006254B2/en not_active Expired - Fee Related
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2014
- 2014-05-08 US US14/273,099 patent/US20140242173A1/en not_active Abandoned
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2015
- 2015-03-13 US US14/658,040 patent/US9884112B2/en not_active Expired - Fee Related
- 2015-10-02 JP JP2015197067A patent/JP2016041708A/ja active Pending
- 2015-10-16 JP JP2015204808A patent/JP6236048B2/ja not_active Expired - Fee Related
- 2015-11-09 JP JP2015219625A patent/JP2016094411A/ja active Pending
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2016
- 2016-01-11 AU AU2016200137A patent/AU2016200137B2/en not_active Ceased
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2017
- 2017-01-20 AU AU2017200383A patent/AU2017200383A1/en not_active Abandoned
- 2017-01-20 AU AU2017200388A patent/AU2017200388A1/en not_active Abandoned
- 2017-05-25 JP JP2017104002A patent/JP2017200925A/ja active Pending
- 2017-10-27 JP JP2017207967A patent/JP2018065808A/ja active Pending
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2018
- 2018-02-05 US US15/889,014 patent/US20180256709A1/en not_active Abandoned
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2020
- 2020-01-27 US US16/773,551 patent/US20200390881A1/en not_active Abandoned
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6329381B1 (en) * | 1997-11-28 | 2001-12-11 | Sumitomo Pharmaceuticals Company, Limited | Heterocyclic compounds |
| US20080160089A1 (en) * | 2003-10-14 | 2008-07-03 | Medivas, Llc | Vaccine delivery compositions and methods of use |
| US20070166384A1 (en) * | 2004-04-09 | 2007-07-19 | Zarraga Isidro Angelo E | Methods , composition and preparations for delivery of immune response modifiers |
| WO2009051837A2 (en) * | 2007-10-12 | 2009-04-23 | Massachusetts Institute Of Technology | Vaccine nanotechnology |
| CN102245201A (zh) * | 2008-10-12 | 2011-11-16 | 麻省理工学院 | 免疫纳米疗法中的佐剂整合 |
Non-Patent Citations (2)
| Title |
|---|
| DAVID M. HAMMERBECK: "Administration of a dual toll-like receptor 7 and toll-like receptor 8 agonist protects against influenza in rats", 《ANTIVIRAL RESEARCH》 * |
| 张国林: "聚氨基酸共聚物合成研究进展", 《高分子材料与工程》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN119505213A (zh) * | 2024-11-25 | 2025-02-25 | 吉林大学 | 一种聚碳酸酯聚合物及其制备方法、纳米佐剂和疫苗 |
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