CN104520324A - Dll3调节剂及其使用方法 - Google Patents

Dll3调节剂及其使用方法 Download PDF

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Publication number
CN104520324A
CN104520324A CN201380010475.2A CN201380010475A CN104520324A CN 104520324 A CN104520324 A CN 104520324A CN 201380010475 A CN201380010475 A CN 201380010475A CN 104520324 A CN104520324 A CN 104520324A
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CN
China
Prior art keywords
antibody
dll3
modulator
antibodies
seq
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Pending
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CN201380010475.2A
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English (en)
Chinese (zh)
Inventor
R·A·司徒尔
L·萨乌恩德斯
S·J·戴拉
O·弗尔德
D·刘
M·托尔果夫
邵辉
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Abbo Wisch Te Musen Tex LLC
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Stemcentrx inc
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Application filed by Stemcentrx inc filed Critical Stemcentrx inc
Publication of CN104520324A publication Critical patent/CN104520324A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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