JP6089047B2 - Ｄｌｌ３モジュレーター及び使用方法 - Google Patents

Ｄｌｌ３モジュレーター及び使用方法 Download PDF

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JP6089047B2
JP6089047B2 JP2014558882A JP2014558882A JP6089047B2 JP 6089047 B2 JP6089047 B2 JP 6089047B2 JP 2014558882 A JP2014558882 A JP 2014558882A JP 2014558882 A JP2014558882 A JP 2014558882A JP 6089047 B2 JP6089047 B2 JP 6089047B2
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Japan
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seq
antibody
dll3
cells
modulator
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JP2014558882A
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Japanese (ja)
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JP2015509947A5 (enExample
JP2015509947A (ja
Inventor
ロバート エー． ストゥル，
ロバート エー． ストゥル，
ローラ サウンダース，
ローラ サウンダース，
スコット ジェイ． ディラ，
スコット ジェイ． ディラ，
オリット フォード，
オリット フォード，
デイビッド リウ，
デイビッド リウ，
マイケル トーゴフ，
マイケル トーゴフ，
ホイ シャオ，
ホイ シャオ，
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アッヴィ・ステムセントルクス・エル・エル・シー
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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