CN104185476A - 流感病毒疫苗及其应用 - Google Patents

流感病毒疫苗及其应用 Download PDF

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Publication number
CN104185476A
CN104185476A CN201280057023.5A CN201280057023A CN104185476A CN 104185476 A CN104185476 A CN 104185476A CN 201280057023 A CN201280057023 A CN 201280057023A CN 104185476 A CN104185476 A CN 104185476A
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polypeptide
influenza virus
influenza
domain
virus
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CN201280057023.5A
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Chinese (zh)
Inventor
阿道夫·加西亚-塞斯特
彼得·帕雷斯
佛罗莱恩·克拉默
纳塔利·皮卡
德克·艾根克
拉法尔·A·麦迪纳-席尔瓦
海容
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Icahn School of Medicine at Mount Sinai
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Mount Sinai School of Medicine
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Application filed by Mount Sinai School of Medicine filed Critical Mount Sinai School of Medicine
Priority to CN202310147642.3A priority Critical patent/CN116162175A/zh
Priority to CN201710930398.2A priority patent/CN108164602A/zh
Publication of CN104185476A publication Critical patent/CN104185476A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/521—Bacterial cells; Fungal cells; Protozoal cells inactivated (killed)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2319/00—Fusion polypeptide
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    • C12N2710/14011—Baculoviridae
    • C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
    • C12N2710/14141—Use of virus, viral particle or viral elements as a vector
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16123—Virus like particles [VLP]
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    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16161—Methods of inactivation or attenuation
    • C12N2760/16162—Methods of inactivation or attenuation by genetic engineering
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16171—Demonstrated in vivo effect

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Wood Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
CN201280057023.5A 2011-09-20 2012-09-19 流感病毒疫苗及其应用 Pending CN104185476A (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN202310147642.3A CN116162175A (zh) 2011-09-20 2012-09-19 流感病毒疫苗及其应用
CN201710930398.2A CN108164602A (zh) 2011-09-20 2012-09-19 流感病毒疫苗及其应用

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US201161536924P 2011-09-20 2011-09-20
US61/536,924 2011-09-20
US201161565899P 2011-12-01 2011-12-01
US61/565,899 2011-12-01
US201261607526P 2012-03-06 2012-03-06
US61/607,526 2012-03-06
US201261648525P 2012-05-17 2012-05-17
US61/648,525 2012-05-17
US201261670108P 2012-07-10 2012-07-10
US61/670,108 2012-07-10
US201261684481P 2012-08-17 2012-08-17
US61/684,481 2012-08-17
PCT/US2012/056122 WO2013043729A1 (en) 2011-09-20 2012-09-19 Influenza virus vaccines and uses thereof

Related Child Applications (2)

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CN202310147642.3A Division CN116162175A (zh) 2011-09-20 2012-09-19 流感病毒疫苗及其应用
CN201710930398.2A Division CN108164602A (zh) 2011-09-20 2012-09-19 流感病毒疫苗及其应用

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CN104185476A true CN104185476A (zh) 2014-12-03

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CN201280057023.5A Pending CN104185476A (zh) 2011-09-20 2012-09-19 流感病毒疫苗及其应用
CN201710930398.2A Pending CN108164602A (zh) 2011-09-20 2012-09-19 流感病毒疫苗及其应用

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EP (2) EP2758075B1 (enExample)
JP (4) JP6498439B2 (enExample)
KR (1) KR20140068205A (enExample)
CN (3) CN116162175A (enExample)
AR (1) AR090392A1 (enExample)
AU (2) AU2012312529B2 (enExample)
BR (1) BR112014006694A2 (enExample)
CA (1) CA2849434A1 (enExample)
EA (1) EA201490659A1 (enExample)
ES (1) ES2953393T3 (enExample)
HK (1) HK1200102A1 (enExample)
IL (2) IL231547B (enExample)
IN (1) IN2014CN02114A (enExample)
MX (1) MX2014003308A (enExample)
SG (1) SG11201400743VA (enExample)
WO (1) WO2013043729A1 (enExample)

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CN109073639A (zh) * 2016-02-03 2018-12-21 Cg探索股份有限公司 具有异源表位和/或改变的成熟切割位点的流感血凝素的组合物
CN109641041A (zh) * 2016-06-15 2019-04-16 西奈山伊坎医学院 流感病毒血细胞凝集素蛋白及其用途
CN110167585A (zh) * 2016-09-02 2019-08-23 美国卫生与公众服务部 稳定化的第2组流感血凝素茎区三聚体及其用途
CN110191949A (zh) * 2016-11-08 2019-08-30 中央研究院 重组病毒、包含该重组病毒的组合物以及其用途
CN112111503A (zh) * 2020-08-24 2020-12-22 河北省动物疫病预防控制中心 同时预防禽流感h5和h9亚型的腺病毒载体二价苗及其制备方法
CN113082187A (zh) * 2021-04-09 2021-07-09 北京红太阳药业有限公司 小柴胡提取物与阿奇霉素联合在治疗病毒性肺炎中的应用
US12030928B2 (en) 2017-04-07 2024-07-09 Icahn School Of Medicine At Mount Sinai Anti-influenza B virus neuraminidase antibodies and uses thereof
US12364746B2 (en) 2018-06-21 2025-07-22 Icahn School Of Medicine At Mount Sinai Mosaic influenza virus hemagglutinin polypeptides and uses thereof

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JP5941841B2 (ja) 2009-05-26 2016-06-29 アイカーン スクール オブ メディシン アット マウント サイナイ 周期的投与によって作製されたインフルエンザウイルスに対するモノクローナル抗体及びその使用
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US9597379B1 (en) 2010-02-09 2017-03-21 David Gordon Bermudes Protease inhibitor combination with therapeutic proteins including antibodies
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CN109096376A (zh) * 2018-09-20 2018-12-28 扬州大学 流感病毒ha多肽、klh偶联多肽及多克隆抗体的制备方法
KR102098585B1 (ko) * 2018-11-21 2020-04-08 고려대학교 산학협력단 교차 면역원성을 갖는 h2 아형 인플루엔자 바이러스 및 이를 포함하는 백신
CN115605491A (zh) 2019-04-05 2023-01-13 刘扶东（Us） 抗唾液酸酶的糖类、其制造方法及用途
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TWI817041B (zh) * 2019-09-20 2023-10-01 中央研究院 嵌合血球凝集素蛋白質及包含其之疫苗組成物
JP2022553258A (ja) * 2019-10-15 2022-12-22 ヤンセン ファッシンズ アンド プリベンション ベーフェー インフルエンザウイルスワクチン及びその使用
US12285437B2 (en) 2019-10-30 2025-04-29 The Research Foundation For The State University Of New York Reversing the undesirable pH-profile of doxorubicin via activation of a disubstituted maleamic acid prodrug at tumor acidity
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