CN104185476A - 流感病毒疫苗及其应用 - Google Patents

流感病毒疫苗及其应用 Download PDF

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Publication number
CN104185476A
CN104185476A CN201280057023.5A CN201280057023A CN104185476A CN 104185476 A CN104185476 A CN 104185476A CN 201280057023 A CN201280057023 A CN 201280057023A CN 104185476 A CN104185476 A CN 104185476A
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Prior art keywords
polypeptide
influenza virus
influenza
domain
virus
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Pending
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CN201280057023.5A
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Chinese (zh)
Inventor
阿道夫·加西亚-塞斯特
彼得·帕雷斯
佛罗莱恩·克拉默
纳塔利·皮卡
德克·艾根克
拉法尔·A·麦迪纳-席尔瓦
海容
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Icahn School of Medicine at Mount Sinai
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Mount Sinai School of Medicine
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Application filed by Mount Sinai School of Medicine filed Critical Mount Sinai School of Medicine
Priority to CN202310147642.3A priority Critical patent/CN116162175A/zh
Priority to CN201710930398.2A priority patent/CN108164602A/zh
Publication of CN104185476A publication Critical patent/CN104185476A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/521—Bacterial cells; Fungal cells; Protozoal cells inactivated (killed)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • C—CHEMISTRY; METALLURGY
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    • C07K2319/00—Fusion polypeptide
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    • C12N2710/14011—Baculoviridae
    • C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
    • C12N2710/14141—Use of virus, viral particle or viral elements as a vector
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16123—Virus like particles [VLP]
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    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16161—Methods of inactivation or attenuation
    • C12N2760/16162—Methods of inactivation or attenuation by genetic engineering
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16171—Demonstrated in vivo effect

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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN201280057023.5A 2011-09-20 2012-09-19 流感病毒疫苗及其应用 Pending CN104185476A (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN202310147642.3A CN116162175A (zh) 2011-09-20 2012-09-19 流感病毒疫苗及其应用
CN201710930398.2A CN108164602A (zh) 2011-09-20 2012-09-19 流感病毒疫苗及其应用

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US201161536924P 2011-09-20 2011-09-20
US61/536,924 2011-09-20
US201161565899P 2011-12-01 2011-12-01
US61/565,899 2011-12-01
US201261607526P 2012-03-06 2012-03-06
US61/607,526 2012-03-06
US201261648525P 2012-05-17 2012-05-17
US61/648,525 2012-05-17
US201261670108P 2012-07-10 2012-07-10
US61/670,108 2012-07-10
US201261684481P 2012-08-17 2012-08-17
US61/684,481 2012-08-17
PCT/US2012/056122 WO2013043729A1 (en) 2011-09-20 2012-09-19 Influenza virus vaccines and uses thereof

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CN202310147642.3A Division CN116162175A (zh) 2011-09-20 2012-09-19 流感病毒疫苗及其应用
CN201710930398.2A Division CN108164602A (zh) 2011-09-20 2012-09-19 流感病毒疫苗及其应用

Publications (1)

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CN104185476A true CN104185476A (zh) 2014-12-03

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CN202310147642.3A Pending CN116162175A (zh) 2011-09-20 2012-09-19 流感病毒疫苗及其应用
CN201710930398.2A Pending CN108164602A (zh) 2011-09-20 2012-09-19 流感病毒疫苗及其应用
CN201280057023.5A Pending CN104185476A (zh) 2011-09-20 2012-09-19 流感病毒疫苗及其应用

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CN201710930398.2A Pending CN108164602A (zh) 2011-09-20 2012-09-19 流感病毒疫苗及其应用

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US (2) US10131695B2 (enExample)
EP (2) EP4241785A3 (enExample)
JP (4) JP6498439B2 (enExample)
KR (1) KR20140068205A (enExample)
CN (3) CN116162175A (enExample)
AR (1) AR090392A1 (enExample)
AU (2) AU2012312529B2 (enExample)
BR (1) BR112014006694A2 (enExample)
CA (1) CA2849434A1 (enExample)
EA (1) EA201490659A1 (enExample)
ES (1) ES2953393T3 (enExample)
HK (1) HK1200102A1 (enExample)
IL (2) IL231547B (enExample)
IN (1) IN2014CN02114A (enExample)
MX (1) MX2014003308A (enExample)
SG (1) SG11201400743VA (enExample)
WO (1) WO2013043729A1 (enExample)

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CN109073639A (zh) * 2016-02-03 2018-12-21 Cg探索股份有限公司 具有异源表位和/或改变的成熟切割位点的流感血凝素的组合物
CN109641041A (zh) * 2016-06-15 2019-04-16 西奈山伊坎医学院 流感病毒血细胞凝集素蛋白及其用途
CN110167585A (zh) * 2016-09-02 2019-08-23 美国卫生与公众服务部 稳定化的第2组流感血凝素茎区三聚体及其用途
CN110191949A (zh) * 2016-11-08 2019-08-30 中央研究院 重组病毒、包含该重组病毒的组合物以及其用途
CN112111503A (zh) * 2020-08-24 2020-12-22 河北省动物疫病预防控制中心 同时预防禽流感h5和h9亚型的腺病毒载体二价苗及其制备方法
CN113082187A (zh) * 2021-04-09 2021-07-09 北京红太阳药业有限公司 小柴胡提取物与阿奇霉素联合在治疗病毒性肺炎中的应用
US12030928B2 (en) 2017-04-07 2024-07-09 Icahn School Of Medicine At Mount Sinai Anti-influenza B virus neuraminidase antibodies and uses thereof
US12364746B2 (en) 2018-06-21 2025-07-22 Icahn School Of Medicine At Mount Sinai Mosaic influenza virus hemagglutinin polypeptides and uses thereof

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US8524220B1 (en) 2010-02-09 2013-09-03 David Gordon Bermudes Protease inhibitor: protease sensitivity expression system composition and methods improving the therapeutic activity and specificity of proteins delivered by bacteria
US9597379B1 (en) 2010-02-09 2017-03-21 David Gordon Bermudes Protease inhibitor combination with therapeutic proteins including antibodies
US8771669B1 (en) 2010-02-09 2014-07-08 David Gordon Bermudes Immunization and/or treatment of parasites and infectious agents by live bacteria
JP2013520172A (ja) 2010-02-18 2013-06-06 モウント シナイ スクール オフ メディシネ インフルエンザウイルス疾患の予防及び治療で用いるためのワクチン
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ES2953393T3 (es) 2011-09-20 2023-11-10 Icahn School Med Mount Sinai Vacunas contra el virus de la influenza y sus usos
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US9908930B2 (en) 2013-03-14 2018-03-06 Icahn School Of Medicine At Mount Sinai Antibodies against influenza virus hemagglutinin and uses thereof
CN113667013B (zh) * 2013-10-02 2024-04-09 免疫医疗有限责任公司 中和抗甲型流感抗体及其用途
US9737592B1 (en) 2014-02-14 2017-08-22 David Gordon Bermudes Topical and orally administered protease inhibitors and bacterial vectors for the treatment of disorders and methods of treatment
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JP2018504412A (ja) 2015-01-23 2018-02-15 アイカーン スクール オブ メディシン アット マウント サイナイ インフルエンザウイルスワクチン接種レジメン
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US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
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WO2016205347A1 (en) * 2015-06-16 2016-12-22 Icahn School Of Medicine At Mount Sinai Influenza virus vaccines and uses thereof
US20190015509A1 (en) 2016-01-13 2019-01-17 Medimmune, Llc Method of treating influenza a
US10063211B2 (en) 2016-02-03 2018-08-28 Qualcomm Incorporated Compact bypass and decoupling structure for millimeter-wave circuits
JP6868763B2 (ja) * 2016-04-01 2021-05-12 パナソニックＩｐマネジメント株式会社 インフルエンザウィルスに結合する抗体
CA3026094A1 (en) * 2016-06-03 2017-12-07 Sanofi Pasteur Inc. Modification of engineered influenza hemagglutinin polypeptides
EP3463447A4 (en) * 2016-06-03 2020-05-27 Icahn School of Medicine at Mount Sinai INFLUENZA VIRUS PROTECTION Vaccines
WO2018085488A1 (en) 2016-11-02 2018-05-11 Iowa State University Research Foundation, Inc. Universal mammalian influenza vaccine
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
WO2018175560A1 (en) * 2017-03-22 2018-09-27 The Scripps Research Institute Nanoparticle immunogens to elicit responses against the influenza receptor binding site on the hemagglutinin head domain
MX2020010199A (es) * 2018-04-03 2021-01-08 Sanofi Sa Polipeptidos antigenicos del virus sincitial respiratorio.
JP2021519596A (ja) 2018-04-03 2021-08-12 サノフイＳａｎｏｆｉ フェリチンタンパク質
US12304928B2 (en) 2018-05-18 2025-05-20 Cz Biohub Sf, Llc Epitope restriction for antibody selection
US20210225457A1 (en) * 2018-07-13 2021-07-22 University Of Georgia Research Foundation Methods for generating pan-epitopic immunogens of influenza h3 virus, compositions and methods of use thereof
MY204234A (en) 2018-08-27 2024-08-16 Regeneron Pharma Use of raman spectroscopy in downstream purification
CN109096376A (zh) * 2018-09-20 2018-12-28 扬州大学 流感病毒ha多肽、klh偶联多肽及多克隆抗体的制备方法
KR102098585B1 (ko) * 2018-11-21 2020-04-08 고려대학교 산학협력단 교차 면역원성을 갖는 h2 아형 인플루엔자 바이러스 및 이를 포함하는 백신
CN115605491A (zh) 2019-04-05 2023-01-13 刘扶东（Us） 抗唾液酸酶的糖类、其制造方法及用途
KR20220036909A (ko) * 2019-04-06 2022-03-23 알티뮨 인크. 광범위하고 오래 지속되는 인플루엔자 백신
TWI817041B (zh) * 2019-09-20 2023-10-01 中央研究院 嵌合血球凝集素蛋白質及包含其之疫苗組成物
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US12285437B2 (en) 2019-10-30 2025-04-29 The Research Foundation For The State University Of New York Reversing the undesirable pH-profile of doxorubicin via activation of a disubstituted maleamic acid prodrug at tumor acidity
CN116075315B (zh) 2020-05-08 2025-12-19 周美吟 嵌合流感疫苗
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