ATE426031T1 - Produktion von lysosomalen enzymen in pflanzlichen expressionssystemen - Google Patents
Produktion von lysosomalen enzymen in pflanzlichen expressionssystemenInfo
- Publication number
- ATE426031T1 ATE426031T1 AT96931569T AT96931569T ATE426031T1 AT E426031 T1 ATE426031 T1 AT E426031T1 AT 96931569 T AT96931569 T AT 96931569T AT 96931569 T AT96931569 T AT 96931569T AT E426031 T1 ATE426031 T1 AT E426031T1
- Authority
- AT
- Austria
- Prior art keywords
- human
- recombinant
- lysosomal enzymes
- plant expression
- production
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01045—Glucosylceramidase (3.2.1.45), i.e. beta-glucocerebrosidase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
- C12N15/8237—Externally regulated expression systems
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01018—Exo-alpha-sialidase (3.2.1.18), i.e. trans-sialidase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01022—Alpha-galactosidase (3.2.1.22)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01024—Alpha-mannosidase (3.2.1.24)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01049—Alpha-N-acetylgalactosaminidase (3.2.1.49)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01076—L-Iduronidase (3.2.1.76)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Pharmacology & Pharmacy (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US373795P | 1995-09-14 | 1995-09-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE426031T1 true ATE426031T1 (de) | 2009-04-15 |
Family
ID=21707341
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT96931569T ATE426031T1 (de) | 1995-09-14 | 1996-09-13 | Produktion von lysosomalen enzymen in pflanzlichen expressionssystemen |
Country Status (7)
Country | Link |
---|---|
US (1) | US5929304A (de) |
EP (1) | EP0865499B1 (de) |
AT (1) | ATE426031T1 (de) |
AU (1) | AU7071196A (de) |
DE (1) | DE69637875D1 (de) |
ES (1) | ES2326705T3 (de) |
WO (1) | WO1997010353A1 (de) |
Families Citing this family (91)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6660500B2 (en) | 1988-02-26 | 2003-12-09 | Large Scale Biology Corporation | Production of peptides in plants as viral coat protein fusions |
US20040093646A1 (en) * | 1988-02-26 | 2004-05-13 | Erwin Robert L. | Production of lysosomal enzymes in plants by transient expression |
US6846968B1 (en) | 1988-02-26 | 2005-01-25 | Large Scale Biology Corporation | Production of lysosomal enzymes in plants by transient expression |
IL155588A0 (en) * | 2003-04-27 | 2003-11-23 | Metabogal Ltd | Methods for expression of enzymatically active recombinant lysosomal enzymes in transgenic plant root cells and vectors used thereby |
US20050032211A1 (en) * | 1996-09-26 | 2005-02-10 | Metabogal Ltd. | Cell/tissue culturing device, system and method |
US7361331B2 (en) * | 1996-10-18 | 2008-04-22 | Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of Agriculture And Agri-Food | Plant bioreactors |
ES2138924B1 (es) * | 1998-01-23 | 2000-10-01 | Consejo Superior Investigacion | Promotor y secuencias reguladoras de ha ds10 g1: un gen lea de girasol expresado exclusivamente en semillas desde la fase de maduracion. |
US6096546A (en) * | 1998-01-30 | 2000-08-01 | Board Of Trustees, Rutgers, The State University Of New Jersey | Methods for recovering polypeptides from plants and portions thereof |
IL139616A0 (en) * | 1998-05-13 | 2002-02-10 | Harbor Ucla | Recombinant (alpha)-l-iduronidase, methods for producing and purifying the same and methods for treating, diseases caused by deficiencies thereof |
DE69924110D1 (de) * | 1998-06-26 | 2005-04-14 | Croptech Dev Corp | Herstellung von urokinase in pflanzlichen expressionssystemen |
DE69940103D1 (de) * | 1999-06-22 | 2009-01-29 | Korea Kumho Petrochem Co Ltd | Farnesylpyrophosphat-Synthase (FPS) aus Setzlingen der Sonnenblume (Helianthus annus) |
US6642038B1 (en) | 1999-09-14 | 2003-11-04 | Genzyme Glycobiology Research Institute, Inc. | GlcNAc phosphotransferase of the lysosomal targeting pathway |
US6770468B1 (en) | 1999-09-14 | 2004-08-03 | Genzyme Glycobiology Research Institute, Inc. | Phosphodiester-α-GlcNAcase of the lysosomal targeting pathway |
US6585971B1 (en) | 1999-11-12 | 2003-07-01 | Harbor-Ucla Research And Education Institute | Recombinant α-L-iduronidase, methods for producing and purifying the same and methods for treating disease caused by deficiencies thereof |
US6569661B1 (en) | 1999-11-12 | 2003-05-27 | Biomarin Pharmaceutical Inc. | Recombinant α-L-iduronidase, methods for producing and purifying the same and methods for treating diseases caused by deficiencies thereof |
US6426208B1 (en) | 1999-11-12 | 2002-07-30 | Harbor-Ucla Research And Education Institute | Recombinant α-L-iduronidase, methods for producing and purifying the same and methods for treating diseases caused by deficiencies thereof |
WO2001056596A1 (en) * | 2000-02-04 | 2001-08-09 | Children's Hospital Research Foundation | Use of lysosomal acid lipase for treating atherosclerosis and related diseases |
US20020061309A1 (en) * | 2000-03-08 | 2002-05-23 | Garger Stephen J. | Production of peptides in plants as N-terminal viral coat protein fusions |
WO2001077307A2 (en) * | 2000-04-06 | 2001-10-18 | Exegenics, Inc. | Expression system for efficiently producing clinically effective lysosomal enzymes (glucocerebrosidase) |
US7138262B1 (en) * | 2000-08-18 | 2006-11-21 | Shire Human Genetic Therapies, Inc. | High mannose proteins and methods of making high mannose proteins |
WO2002099067A2 (en) * | 2001-06-05 | 2002-12-12 | Oishi Karen K | Gene expression and production of tgf-b proteins including bioactive mullerian inhibiting substance from plants |
US20040162420A1 (en) * | 2002-10-16 | 2004-08-19 | U.S. Smokeless Tobacco Company | Cloning of cytochrome p450 genes from nicotiana |
US20040117869A1 (en) * | 2002-01-11 | 2004-06-17 | U.S. Smokeless Tobacco Company | Cloning of cytochrome P450 genes from Nicotiana |
US7700851B2 (en) * | 2001-11-13 | 2010-04-20 | U.S. Smokeless Tobacco Company | Tobacco nicotine demethylase genomic clone and uses thereof |
US10266836B2 (en) | 2001-11-13 | 2019-04-23 | U.S. Smokeless Tobacco Company Llc | Tobacco nicotine demethylase genomic clone and uses thereof |
US7855318B2 (en) * | 2001-11-13 | 2010-12-21 | U.S. Smokeless Tobacco Company | Cloning of cytochrome P450 genes from Nicotiana |
US20040111759A1 (en) * | 2001-11-13 | 2004-06-10 | U.S. Smokeless Tobacco Company | Identification and use of cytochrome P450 nucleic acid sequences from tobacco |
US7700834B2 (en) * | 2001-11-13 | 2010-04-20 | U.S. Smokless Tobacco Company | Nicotiana nucleic acid molecules and uses thereof |
US8592663B2 (en) | 2001-11-13 | 2013-11-26 | U.S. Smokeless Tobacco Company Llc | Tobacco nicotine demethylase genomic clone and uses thereof |
US7812227B2 (en) | 2001-11-13 | 2010-10-12 | U.S. Smokeless Tobacco Company | Cloning of cytochrome p450 genes from nicotiana |
US6800472B2 (en) * | 2001-12-21 | 2004-10-05 | Genzyme Glycobiology Research Institute, Inc. | Expression of lysosomal hydrolase in cells expressing pro-N-acetylglucosamine-1-phosphodiester α-N-acetyl glucosimanidase |
US20030124652A1 (en) * | 2001-12-21 | 2003-07-03 | Novazyme Pharmaceuticals, Inc. | Methods of producing high mannose glycoproteins in complex carbohydrate deficient cells |
US6905856B2 (en) * | 2001-12-21 | 2005-06-14 | Genzyme Glycobiology Research Institute, Inc. | Soluble GlcNAc phosphotransferase |
ITRM20020115A1 (it) * | 2002-03-01 | 2003-09-01 | Plantechno S R L | Espressione di enzimi lisosomiali in seme. |
CA2490781A1 (en) | 2002-06-28 | 2004-01-08 | University Of Guelph | Harvest-inducible genes from alfalfa (medicago sativa) and methods of use thereof |
US7329798B2 (en) * | 2002-06-28 | 2008-02-12 | University Of Guelph | Harvest-inducible regulatory elements and methods of using same |
JP2004140323A (ja) * | 2002-08-20 | 2004-05-13 | Sharp Corp | 半導体レーザ装置およびその製造方法 |
US6920521B2 (en) * | 2002-10-10 | 2005-07-19 | International Business Machines Corporation | Method and system of managing virtualized physical memory in a data processing system |
US7388079B2 (en) * | 2002-11-27 | 2008-06-17 | The Regents Of The University Of California | Delivery of pharmaceutical agents via the human insulin receptor |
US7951557B2 (en) * | 2003-04-27 | 2011-05-31 | Protalix Ltd. | Human lysosomal proteins from plant cell culture |
US20100196345A1 (en) * | 2003-04-27 | 2010-08-05 | Protalix | Production of high mannose proteins in plant culture |
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US7442372B2 (en) * | 2003-08-29 | 2008-10-28 | Biomarin Pharmaceutical Inc. | Delivery of therapeutic compounds to the brain and other tissues |
US8637731B2 (en) * | 2003-10-16 | 2014-01-28 | U.S. Smokeless Tobacco Company | Nicotiana nucleic acid molecules and uses thereof |
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AU2004297259A1 (en) * | 2003-12-09 | 2005-06-23 | Ventria Bioscience | High-level expression of fusion polypeptides in plant seeds utilizing seed-storage proteins as fusion carriers |
US8586837B2 (en) | 2004-04-29 | 2013-11-19 | U.S. Smokeless Tobacco Company Llc | Nicotiana nucleic acid molecules and uses thereof |
US20080034455A1 (en) * | 2004-05-21 | 2008-02-07 | Simon Fraser University | Production Of A Protein Localized To The Endoplasmic Reticulum Protein Bodies In A Transgenic Plant And Seed |
DE102004043207C5 (de) * | 2004-09-03 | 2010-09-09 | Südzucker AG Mannheim/Ochsenfurt | Wurzel- und xylemparenchymspezifischer Promotor |
EP1851317B1 (de) | 2005-02-23 | 2011-10-26 | North Carolina State University | Veränderung des alkaloidgehaltes in tabak durch modifikation spezifischer cytochrome p450 gene. |
EP1896593A4 (de) * | 2005-05-09 | 2010-07-28 | Univ Fraser Simon | Verbesserte vegetative proteinproduktion in transgenen pflanzenzellen unter verwendung samenspezifischer promotoren |
CA2615218A1 (en) * | 2005-07-18 | 2007-01-25 | Protalix Ltd. | Mucosal or enteral administration of biologically active macromolecules |
US20090297496A1 (en) * | 2005-09-08 | 2009-12-03 | Childrens Hospital Medical Center | Lysosomal Acid Lipase Therapy for NAFLD and Related Diseases |
SI1986612T1 (sl) | 2006-02-07 | 2013-01-31 | Shire Human Genetic Therapies, Inc. | Stabilizirana spojina glukocerebrosidaze |
US7871624B2 (en) * | 2006-06-27 | 2011-01-18 | Saint Louis University | Chimeral polypeptide composition for cross-placenta delivery |
US8784833B2 (en) | 2006-06-27 | 2014-07-22 | Saint Louis University | Prenatal enzyme replacement therapy for hypophosphatasia |
US11332753B2 (en) | 2006-12-15 | 2022-05-17 | U.S. Smokeless Tobacco Company Llc | Tobacco plants having reduced nicotine demethylase activity |
US8319011B2 (en) * | 2006-12-15 | 2012-11-27 | U.S. Smokeless Tobacco Company Llc | Tobacco plants having reduced nicotine demethylase activity |
SI2150608T1 (en) * | 2007-05-07 | 2018-04-30 | Protalix Ltd. | An extensive disposable bioreactor |
EP2192924B1 (de) | 2007-08-20 | 2017-10-11 | Protalix Ltd. | Saccharid-haltige protein-konjugate und ihre verwendungen |
BRPI0820042B1 (pt) | 2007-11-12 | 2020-05-19 | North Carolina State University | método de obtenção de uma planta de tabaco, ou célula ou parte desta, tendo níveis reduzidos de nornicotina, produto de tabaco, método para fabricar um produto de tabaco, polinucleotídeo isolado, cassete de expressão, polipetpídeo isolado e método de obtenção de uma planta, ou parte de planta desta, do gênero nicotiana |
ITUD20080055A1 (it) | 2008-03-13 | 2009-09-14 | Transactiva S R L | Procedimento per la produzione di una proteina umana in pianta, in particolare un enzima lisosomiale umano ricombinante in endosperma di cereali |
CN102686237B (zh) | 2009-07-28 | 2018-10-19 | 夏尔人类遗传性治疗公司 | 用于治疗戈谢病的组合物 |
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US9194011B2 (en) | 2009-11-17 | 2015-11-24 | Protalix Ltd. | Stabilized alpha-galactosidase and uses thereof |
CN102858983B (zh) | 2010-01-15 | 2015-08-12 | 北卡罗来纳州立大学 | 最小化烟草中去甲烟碱合成的组合物和方法 |
PT3205351T (pt) | 2010-04-23 | 2023-06-28 | Alexion Pharma Inc | Enzima de doença de armazenamento lisossomal |
EP2595651B1 (de) | 2010-07-19 | 2017-03-29 | Shire Human Genetic Therapies, Inc. | Kodonoptimierte zelllinie für den mannoserezeptor-c vom typ 1 (mrc1) und anwendungen davon |
CN105457018A (zh) | 2010-09-09 | 2016-04-06 | 辛那杰瓦生物制药股份有限公司 | 使用溶酶体酸性脂肪酶来治疗患者的溶酶体酸性脂肪酶缺乏 |
PT3272861T (pt) | 2011-01-20 | 2020-03-26 | Protalix Ltd | Construção de ácido nucleico para expressão de alfα-galactosidase em plantas e células de plantas |
WO2012112681A1 (en) | 2011-02-15 | 2012-08-23 | Shire Human Genetic Therapies, Inc. | Methods for treating lysosomal acid lipase deficiency |
BR112013021962A2 (pt) | 2011-02-28 | 2018-06-26 | Altria Client Services Inc | plantas albex1f e albex1ms inatas de tabaco |
JP2014515596A (ja) | 2011-02-28 | 2014-07-03 | ノース カロライナ ステイト ユニヴァーシティ | タバコ近交系植物ncbex1f、ncbex1ms、及びncex90 |
TWI620816B (zh) * | 2011-03-23 | 2018-04-11 | 苜蓿股份有限公司 | 植物衍生蛋白回收方法 |
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CA2849434A1 (en) | 2011-09-20 | 2013-03-28 | Mount Sinai School Of Medicine | Influenza virus vaccines and uses thereof |
CN104519905A (zh) | 2012-03-02 | 2015-04-15 | 夏尔人类遗传性治疗公司 | 用于治疗iii型戈谢病的组合物和方法 |
EP2854834A4 (de) | 2012-05-30 | 2016-05-18 | Biostrategies LC | Pflanzenlektine als träger entsprechender wirkstoffe in tierischen und menschlichen zellen |
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CN105517430A (zh) | 2013-01-11 | 2016-04-20 | 北卡罗莱纳州立大学 | 烟草近交植物k326 src、cms k326 src、k346 src、cms k346 src、nc1562-1 src、nctg-61 src、cms nctg-61 src和杂交种nc196 src |
EP2964016A1 (de) | 2013-03-05 | 2016-01-13 | North Carolina State University | Durch inzucht erzeugter tabak und hybridpflanzen und verwendungen davon |
US9908930B2 (en) | 2013-03-14 | 2018-03-06 | Icahn School Of Medicine At Mount Sinai | Antibodies against influenza virus hemagglutinin and uses thereof |
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JP2017508462A (ja) | 2014-03-03 | 2017-03-30 | ノース カロライナ ステイト ユニヴァーシティ | タバコ近交系植物およびハイブリッド植物ならびにそれらから作られたタバコ製品 |
WO2015134438A1 (en) | 2014-03-03 | 2015-09-11 | North Carolina State University | Tobacco inbred and hybrid plants and tobacco products made thereof |
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CN109641041A (zh) | 2016-06-15 | 2019-04-16 | 西奈山伊坎医学院 | 流感病毒血细胞凝集素蛋白及其用途 |
US11254733B2 (en) | 2017-04-07 | 2022-02-22 | Icahn School Of Medicine At Mount Sinai | Anti-influenza B virus neuraminidase antibodies and uses thereof |
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NL8800725A (nl) * | 1988-03-23 | 1989-10-16 | Mogen International N V En Rij | Recombinant dna; getransformeerde microorganismen, plantecellen en planten; werkwijze voor het produceren van een polypeptide of eiwit m.b.v. planten of plantecellen; werkwijze voor het produceren van planten met virusresistentie. |
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US5543576A (en) * | 1990-03-23 | 1996-08-06 | Mogen International | Production of enzymes in seeds and their use |
US5422108A (en) * | 1991-09-19 | 1995-06-06 | Smart Plants International Inc. | Protection of plants against plant pathogens |
EP0646173A4 (de) * | 1992-05-22 | 1997-02-26 | Agen Ltd | Reagenz zur messung der agglutination. |
US5670349A (en) * | 1993-08-02 | 1997-09-23 | Virginia Tech Intellectual Properties, Inc. | HMG2 promoter expression system and post-harvest production of gene products in plants and plant cell cultures |
-
1996
- 1996-09-13 ES ES96931569T patent/ES2326705T3/es not_active Expired - Lifetime
- 1996-09-13 AT AT96931569T patent/ATE426031T1/de not_active IP Right Cessation
- 1996-09-13 WO PCT/US1996/014730 patent/WO1997010353A1/en active Application Filing
- 1996-09-13 AU AU70711/96A patent/AU7071196A/en not_active Abandoned
- 1996-09-13 DE DE69637875T patent/DE69637875D1/de not_active Expired - Lifetime
- 1996-09-13 EP EP96931569A patent/EP0865499B1/de not_active Expired - Lifetime
- 1996-09-13 US US08/713,928 patent/US5929304A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0865499A4 (de) | 2004-06-16 |
EP0865499B1 (de) | 2009-03-18 |
DE69637875D1 (de) | 2009-04-30 |
AU7071196A (en) | 1997-04-01 |
US5929304A (en) | 1999-07-27 |
EP0865499A1 (de) | 1998-09-23 |
ES2326705T3 (es) | 2009-10-16 |
WO1997010353A1 (en) | 1997-03-20 |
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